• Fire Science and Engineering
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• v.31 no.6
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• pp.16-22
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• 2017

In Korea, performance-based fire safety designs are being discussed to deal with the various risks of fire in complex and diverse types of structure. However, performance-based fire safety designs are not actively employed because it is difficult to estimate the fire characteristics related to the various factors in buildings. In this study, real scale fire tests were conducted based on fire severity levels and fire loads provided in He New Zealand Building Code, in order to use the results as guidelines and fundamental data for performance-based designs. In the real scale fire tests conducted in a 10MW full-scale calorimeter, wood cribs were placed in a $2.4(L){\times}3.6(W){\times}2.4(H)m$ mock-up of a compartment which had one $0.8(L){\times}2.0(H)$ opening for different fire loads and heating was continued until all of the wood cribs were burned down. The heat release rate started to increase rapidly 90 seconds after the wood cribs caught fire. In the test with a fire load level 1, the maximum heat release rate of 4743.4 kW was reached at 244 second. In the test with fire load level 2, a maximum heat release rate of 5050.9 kW was reached at 497 second. In the test with fire load level 3, a maximum heat release rate of 4446.9 kW was reached at 677 second.

• Journal of Applied Biological Chemistry
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• v.60 no.3
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• pp.227-234
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• 2017

Inflammatory bowel disease (IBD) is including Crohn's disease and ulcerative colitis. Sulfasalazine commonly used in IBD, possibly has various side effects after high dosage and long term intake. The present study aimed to investigate the sulfasalazine and combination with herbal medicine on 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced in mice model. TNBS-induced mice were injected through a flexible catheter 4 cm in length 1.6 mg TNBS. Animals were divided into five groups (n=12): Normal group, TNBS control group, Sulfasalazine (30 mg/kg) group, Sulfasalazine (60 mg/kg) group, Sulfasalazine (30 mg/kg)+Cinnamomi cortex and Bupleuri radix mixture (30 mg/kg) (SCB) group. Administration groups were fed extract during 7 days. The inflammatory, and apoptotic protein levels were determined using western blotting. SCB treatment showed an outstanding effectiveness in counteracting the IBD, as assessed by reduction of body weight loss, down-regulation of pro-inflammatory proteins and cytokines, and by inhibition of proteins related to apoptosis. This is the first report that sulfasalazine and Cinnamomi cortex plus Bupleuri radix mixture improve the severity of experimental IBD through the inhibition of both inflammation and apoptosis. We confirm that the SCB treatment instead of sulfasalazine alone may be promising as an alternative therapeutic plan against IBD, without any evidence of adverse effects.

• Journal of The Korean Society of Grassland and Forage Science
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• v.6 no.1
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• pp.65-70
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• 1986

This experiment was carried out to identify the main pathogens infected with Piper sudangrass and to evaluate the qualitative and quantitative damage of the plants infected with leaf blight (Helminthosporium turcicum PASS) under different levels of nitrogen fertilizer (20, 30 and 40 kg/10a). The experiment was design as a randomized block design with 4 replications at experimental field of Livestock Experiment Station in Suweon, 1984. The results obtained are summarized as follows: 1. The main fungi isolated from sudangrass were identified as Helminthoporium turcicum and Collectotricum graminicolum, but 1 species fungus was not identified. 2. Leaf blight was first found on June 20 and appeared extremely in the regrowth plants from July to September. The rate of attack was associated with increasing of nitrogen fertilization (P<0.01). 3. Fresh and dry matter yields were as much as 47 and 38 percentage lower in leaf blight infected plants (disease severity: V) than those of no visible infection. 4. Concentrations of crude fat and crude protein were decreased in the plants infected with Helminthosporium leaf blight, but lignin content was increased. Dry matter and organic matter digestibility of the plants were negative correlated with the infection of leaf blight(P<0.01).

• Archives of Plastic Surgery
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• v.35 no.4
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• pp.423-430
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• 2008

Purpose: Computed tomography theoretically should improve detection of foreign bodies and provide more information of adjacent soft tissues. And the CT scanner and PACS program proved to be an excellent instrument for detection and localization of most facial foreign bodies above certain minimum levels of detectability. The severity of injury in penetrating trauma to the face, it is often underestimated by physical examination. Diagnosis of a retained foreign object is always critical. Methods: From March, 2005 to February 2008 a study was done with 200 patients who had facial trauma. Axial and coronal CT images were obtained with a General Electric(Milwaukee, Wis) 9800 CT scanner at 130 kV, 90 mA, with a 2-mm section thickness and a $512{\times}512$ matrix. Results: Axial and coronal CT images at various window widths should be used as the first imaging modality to detect facial foreign bodies. The attenuation coefficients for the metallic and nonmetallic foreign bodies ranged from -437 to +3071 HU. As a general rule, metallic foreign bodies produced more Hounsfield artifacts than nonmetallic foreign bodies, thus providing a clue to their composition. All of the metallic foreign bodies were represented by a single peak and had a maximum attenuation coefficient of +3071 HU. Of the nonmetallic foreign bodies, glass had an attenuation coefficient that ranged from +105 to +2039, while plastic had a much lower coefficient that ranged from -62 to -35. wood had the lowest range of attenuation coefficients: -491 to -437. Conclusion: The PACS program allows one to distinguish metallic from nonmetallic foreign bodies and to individually identify the specific composition of many nonmetallic foreign bodies. This program does not, however, allow identification of the specific composition of a metallic foreign body. We recommend this type of software program for CT scanning of any patient with an injury to the face in which a foreign body is suspected.

• Korean Journal of Organic Agriculture
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• v.27 no.4
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• pp.437-452
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• 2019

The HACCP evaluation standards for the meat packaging plant are divided into general scale HACCP evaluation standard and small scale HACCP evaluation standard. There are 69 evaluation items in the general scale HACCP evaluation criteria, of which 54 items in the prerequisite management and 15 items in the HACCP management are included. The number of small scale HACCP evaluation items are 20 and about 29% of the general scale HACCP evaluation items. This may not be enough to produce a safety livestock products for the purpose of implementing the HACCP system due to the nature of the meat packaging plant, which does not show much difference in the production process or method of product depending on the scale. To improve the small scale HACCP evaluation standard, the importance of each item was compared with the small scale HACCP evaluation based on the rate of non-compliance and the severity levels in the general scale HACCP evaluation items. As a result of the study, 8 items were derived from the prerequisites management, 2 items were derived from the HACCP management, and some similar evaluation items were grouped together. Finally, 10 items were added to the 20 items of the existing small scale HACCP evaluation items. In this study, study on the safety management of domestic livestock products are continuously carried out, so that it is possible to provide safety livestock products to consumers and contributes to securing competitiveness of domestic livestock industry.

• Korean Journal of Ecology and Environment
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• v.43 no.2
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• pp.232-241
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• 2010

Epilithic diatom communities and water quality were monitored to evaluate the ecological impact of the inflow of Wonju-stream passing through the urban area in the Seom River Watershed. We selected the 14 sampling stations (5 main stream sites and 9 tributary sites), and collected diatom and water samples between October 2007 and September 2008, on the seasonal basis. The results indicate that most water quality parameters showed the site-specific patterns over the study, except for water temperature and dissolved oxygen. The levels of water quality parameters were highest at the site of Wonju stream, whereas the lowest in the upstream sites, and intermediate or gradually decreased in the downstream sites of the Seom river. One species, Achnanthes convergens, showed the highest biomass and frequency over the sites, while three saprophilous species-Navicula goeppertiana, Navicula subminuscula, Nitzschia palea were appeared only in Wonju Stream and other polluted sites. According to trophic diatom index (TDI) values, which were highly correlated with nutrients and EC, the study sites were classified into three classes: upstream and tributary (Class A and B), Wonju Stream (Class D), and mixed zone and downstream (Class C). A cluster analysis supported the result of TDI classification. Therefore, Wonju-stream located in populated urban area exerted the adverse ecological effects on the epilithic diatom community and water quality of the lower Seom River System, although its severity gradually decreased downstream.

• Tuberculosis and Respiratory Diseases
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• v.58 no.1
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• pp.25-30
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• 2005

Background : An insertion-deletion polymorphism of angiotensin converting enzyme (ACE) gene has been shown to be associated with enzyme activity levels of ACE. Reported results that have been mutually contradictory about asthmatic hypersensitiveness and occurrence according to ACE gene insertion (I)/deletion (D) polymorphism. Also, the involvement of the ACE genes as the genetic basis of bronchial asthma is currently controversy. We investigated whether there was any association between polymorphisms of the ACE genes and airway hyper-responsiveness in chronic obstructive pulmonary disease (COPD). Methods : A total of 100 patients with COPD were enrolled in this study. The ACE genotypes were determined in all subjects by polymerase chain reaction. Pulmonary function test including bronchodilator response (BDR), methacholine bronchial provocation test (MBPT) were done in those patients. Airway hyper-responsiveness include any findings of positive BDR or MBPT. Results : In COPD patients, the ACE genotype distribution did not differ significantly among groups of patients with severities of COPD, and with or without airway hyper-responsiveness. Conclusions : These results suggest that polymorphisms of the ACE gene may not be associated with airway hyper-responsiveness, development and severity of COPD.

• Journal of Ginseng Research
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• v.36 no.2
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• pp.135-145
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• 2012

Previously, we reported that Helicobacter pylori-associated gastritis and gastric cancer are closely associated with increased levels of hydrogen sulfide ($H_2S$) and that Korean red ginseng significantly reduced the severity of H. pylori-associated gastric diseases by attenuating $H_2S$ generation. Because the incubation of endothelial cells with $H_2S$ has been known to enhance their angiogenic activities, we hypothesized that the amelioration of $H_2S$-induced gastric inflammation or angiogenesis in human umbilical vascular endothelial cells (HUVECs) might explain the preventive effect of Korean red ginseng on H. pylori-associated carcinogenesis. The expression of inflammatory mediators, angiogenic growth factors, and angiogenic activities in the absence or presence of Korean red ginseng extracts (KRGE) were evaluated in HUVECs stimulated with the $H_2S$ generator sodium hydrogen sulfide (NaHS). KRGE efficiently decreased the expression of cystathionine ${\beta}$-synthase and cystathionine ${\gamma}$-lyase, enzymes that are essential for $H_2S$ synthesis. Concomitantly, a significant decrease in the expression of inflammatory mediators, including cyclooxygenase-2 and inducible nitric oxide synthase, and several angiogenic factors, including interleukin (IL)-8, hypoxia inducible factor-1a, vascular endothelial growth factor, IL-6, and matrix metalloproteinases, was observed; all of these factors are normally induced after NaHS. An in vitro angiogenesis assay demonstrated that NaHS significantly increased tube formation in endothelial cells, whereas KRGE pretreatment significantly attenuated tube formation. NaHS activated p38 and Akt, increasing the expression of angiogenic factors and the proliferation of HUVECs, whereas KRGE effectively abrogated this $H_2S$-activated angiogenesis and the increase in inflammatory mediators in vascular endothelial cells. In conclusion, KRGE was able to mitigate $H_2S$-induced angiogenesis, implying that antagonistic action against $H_2S$-induced angiogenesis may be the mechanism underlying the gastric cancer preventive effects of KRGE in H. pylori infection.

• Journal of Korean Academy of Nursing
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• v.26 no.3
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• pp.709-729
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• 1996

This study was done to analyze the trends of research on coping in Korea, to suggest future direction, for research on coping, and ultimately to contribute to an increase in explanation of adaptation. This article reviewed 79 nursing research papers on coping done since 1978 by examining them according to the period of publication or presentation, research design, type of subjects, measurement instruments, research for a degree or not, range of reliability, and association of coping and related variables. The results are as follows : The number of studies on coping increased rapidly from the mid-1980's and decreased slowly from the mid-1990's. The maority of the studies were surveys, comparative studies, or correlational studies. The subects of the 46 studies were healthy people, while those in the remaining studies were patients with a variety of illnesses. Thirth-eight studies on coping were done for master's thesis, three for dissertion, and 38 were not degrees. The Bell and Jalowiec coping scales have not been used since the early 1990's. In contrast, Lazarus and Folkman's W.C.C.L. has been used increasingly since that time. The reliabilities of the coping scale were reported in 37 cases and the Cronbach's alpha coefficients were .71 to .86. All subjects reported using more problem-oriented coping than emotion-oriented coping in short-term or emotion-oriented coping and healthy groups did more long-term coping. It was difficult to describe consistently the relationship between stress and coping according to the type of coping scale or research subjects, but generally moderate relationships were found. This was due to instrumental problems and no consideration of situational context. The subject group who used more short-term coping and less long-term coping reported poorer mental status, and higher scores in burnout and state anxiey than others. That is, the relationship between stress and adaptation increased the power of explanation with intervening the mediating effect of coping. The association of locus of control, mastery, social support, and self-concept with coping showed positive relationships : those of uncertainty and severity in illness with coping showed negativerelationships ; those of state anxiety and depression with short-term coping were positive, and those of self-esteem with long-term coping or problem-oriented coping were negative. There were significant differences in the scores of types of coping according to religion, level of education, and socio-economic status. That is, Presbyterians and Catholics, those with higher education levels and higher socio-economic status used more long-term or problem-oriented coping. On the basis of the above findings the following recommendations are made : 1. There is a need to test the mediating effect of coping variable in order to clarify the concept. 2. Longitudinal studies are needed to determine the patterns of change in coping strategies when stressful events are encountered. 3. It's necessary to develop a reliable and variable measurement tool for coping. 4. There is a need to identify subscales of coping to increase explanation of variance 5. It's necessary to consider personal, situational, and antecedent variables : the characteristics of subject populations, the natures of illness and treatment situations. 6. The power of explanation of studies designed to identify the stress-adaptation process should be increased using the combination model of process-oriented coping and cognitive-structural model.

• Proceedings of the KOR-BRONCHOESO Conference
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• 1977.06a
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• pp.5.2-5
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• 1977

Many persons, both children and adults, suffer from impaired hearing. The handicaps that arise from this are economic, educational and above all, social. These persons need help, both medical and educational. In order to plan facilities for the medical treat ment, the rehabilitation, and the special education required by those with impaired hearing, we must know how many persons with hearing problems there are and the severity of their handicaps. The first step in knowing these is to devide hearing impairent into categories of handicap. Historically, since Beasley (1940) proposed progressive stages of deafness in terms of social disability, there was no well organized classification. of hearing handicap except related material from Huzing (1959) and Silverman (1960). In 1965, Goodman advocated a guide hearing threshold levels and degres of relating hearing impairment. During recent one year, on the bases of Goodman classification of hearing impairment and the report from Illinois Comission on children (1968), we have studied about hearing handicaps and speech life for the 180 cases, who visited to our otolaryngology department with hearing impairment. Now, we report the results of study with the referred references.