• 제목/요약/키워드: serum alkaline phosphatase

검색결과 629건 처리시간 0.029초

식물성생리활성물질(植物性生理活性物質)의 간보호작용(肝保護作用)(I) -한약처방(韓藥處方)의 간보호작용(肝保護作用)- (Hepatoprotective Activities of Biologically Active Agents from Crude Drugs(I) -Hepatoprotective Activities of Traditional Korean Herbal Prescriptions-)

  • 김창종;조승길;최충식;최윤석
    • 생약학회지
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    • 제21권3호
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    • pp.223-234
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    • 1990
  • Hepatoprotective activities of 26 traditional Korean herbal prescriptions described in Donghibogam were evaluated in vivo and in vitro screening system. Twenty one prescriptions appeared to be active. Six prescriptions among them showed highly significant hepatoprotective activities; Shihogyegy-Tang(柴胡桂枝湯), Soshiho-Tang(小柴胡湯), Shiho plus Younggolmoryo-Tang(柴胡加龍骨牡蠣湯), Yinjinho-Tang(茵蔯蒿湯), Yinsam-Tang(人蔘湯) and Shashim-Tang(瀉心湯). Shihogyegy-Tang was most active. They reduced the release of transaminases from dissociated hepatocytes by thioacetamide, and serum transaminases and alkaline phosphatase activities of rat with carbontetrachloride-induced hepatitis. They inhibited significantly lipid peroxidation and cellular fatty change of liver by carbontetrachloride.

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난소를 절제한 나이가 다른 흰쥐에서 식이 칼슘 수준이 골격 대사에 미치는 영향 (The Effects of Dietary Ca Levels on Ca and Skeletal Metabolism in Ovariectomized Rats of Different Age)

  • 김화영
    • Journal of Nutrition and Health
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    • 제31권4호
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    • pp.716-728
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    • 1998
  • To investigate the effect of dietary Ca levels on metabolic changes of Ca and skeleton in postmenopausal women, 10-month-old ovariectomized female rats were compared with 2 month old rats. The rats were fed either 0.2% or 1.2% Ca diets for 16 weeks. Food intake and weight gain as higher in rats fed high Ca diets and in ovariectomized rats. Apparent Ca absorption as higher, and Ca balance was lower in the low Ca groups. Vertebrae density was higher in old rats or those fed a high Ca diets. The old rats and ovariectomized rats showed decreased bone formation, increased bone resorption and kidney function deterioration resulting in increased urinary Ca excretion. Contradictory to the above observation, old rats and ovariectomized rats still showed higher bone mass and bone ash content. Therefore aging was not fully onging in 10-month-old rats. Bone weights, mineral contents, and mineral/wt ratio were lower in ovariectomized rats. Dietary Ca level did not affect urinary Ca excretion, urinary protein excretion, GFR, serum alkaline phosphatase, or urinary hydroxyporline excretion. This means that dietary Ca level did not influence kidney function or bone turnover. However Ca content and the ash content of femur, 4th vertebra, and scapula were increased in high Ca groups. Therefore, it is considered that decreased bone formation and accelerated bone resorption may account for the increased osteoporotic risk in women in menopause after middle age. However, Ca metabolism can be improved and bone components can be maintained if Ca is supplemented.

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닭의장풀 추출액의 혈당강하 및 효소활성 변화에 미치는 영향 (Effect of Commelina communis Extract on Blood Glucose Level and Changes in Enzymatic Activity in Alloxan-Diabetic Rats)

  • 김옥경;박수영;조경혜
    • 생약학회지
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    • 제22권4호
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    • pp.225-232
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    • 1991
  • The hypoglycemic and metabolic effects of Commelina communis L. extract were investigated in alloxan-diabetic rats. The increased blood glucose level in the diabetic rats was significantly lowered and the loss of body weight in the diabetic rats was recovered with the treatments of the crude extract. Administration of the extract elicited the significant increase of glucose-6-phosphate dehydrogenase activity and liver weight which were decreased in the alloxan-treated rat serum and liver. On the other hand, the kidney weight and glucose-6-phosphate dehydrogenase activity were increased in the alloxan treated rat kidney and were potentiated by the treatment of the extract. In both liver and kidney, together with serum, alkaline phosphatase and ATPase activities were increased in the alloxan diabetic rats and were not recovered, rather potentiated by the administration of the extract.

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Polychlorinated biphenyls 중독 해독제의 개발에 관한 연구 (Studies on the Development of Detoxicating Agents of Polychlorinated biphenyls Toxicity)

  • 정기화;장판섭
    • 한국식품위생안전성학회지
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    • 제2권2호
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    • pp.51-56
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    • 1987
  • PCBs 투여로 중독된 rat에 대한 천문동, 황정, 백복령, 인삼, 오가피 등의 ethanol 추출물의 효과는 다음과 같다. 1. 생약추출물의 병용투여로 PCBs 중독으로 감소된 체중이 증가하였으나 간장중량의 현저한 회복효과는 볼 수 없었다. 2. 생약추출물을 병용투여함으로써 PCBs 중독으로 감소된 RBC, WBC, Hgb 및 Het의 값이 상승하였으며 특히 백복령과 인삼 추출물의 경우 회복효과가 컸다. 3. PCBs로 증가된 혈청중 cholesterol치와 total lipids가 생약추출물을 투여함으로써 감소되었다. 4. PCBs 투여로 증가된 혈청중 GOT, GPT 및 ALP의 활성도 생약추출물의 투여로 정상치에 가깝게 감소되었다.

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B형 간염 보균자에서 골감소증의 빈도 및 간기능검사와의 연관성 (Incidence of Osteopenia in Female HBV Carrier and its Correlation with Liver Function Test)

  • 나은희;박재영;김상인
    • 한국건강관리협회지
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    • 제3권2호
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    • pp.181-188
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    • 2005
  • Background : Osteopenia has been recognized as one of potential complication of chronic liver diseases. Its correlation with hepatits B virus(HBV) carrier, however, has not been reported. Thus this study was aimed to clarify the relationship between the osteopenia and HBV carrier. Methods : Bone densities in 192 HBV carrier women and 200 healthy women were measured; the lumbar spine and three sites of the proximal femur(neck, Ward's triangle, greater trochanter) by dual-photon absorptiometry. And liver function tests(AST, ALT, Albumin, GGT, ALP) were also performed. Results : Bone densities at the four sites measured, were significantly correlated with one another(r=0.34 to 0.99, P<0.01). Compared with control group, HBV carriers had significant decreases in bone densities of femur(P<0.05), particularly marked at Ward's triangle. A negative correlations between bone densities and serum total alkaline phosphatase were also found(r=-0.44, P<0.01). Conclusions : Osteopenia was more prevalent in HBV carrier, particularly in the groups before-fifties. Serum total alkaline phosphatase was higher in those with reduced bone densities Thus measurement of bone densities seems to be necessary in female HBV carriers.

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가미독활기생탕(加味獨活寄生湯)의 경구투여(經口投與)와 지실(志室).현종(懸鍾) 전침(電鍼) 병용(倂用) 시술(施術)이 흰 쥐의 골다공증(骨多孔症)에 미치는 영향(影響) (Effects of the Gamidokwalgisaeng-tang(GDS) Oral Administration and Electro-acupuncture at Chishil$(BL_{52})$, Hyonjong$(GB_{39})$ on Osteoporotic Rats Induced by Ovariectomy)

  • 조명래;채우석;최원확
    • Journal of Acupuncture Research
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    • 제23권3호
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    • pp.1-19
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    • 2006
  • Objectives : This study was carried out to determine the effects of Gamidokwalgisaeng-tang(GDS) oral administration and electro-acupuncture at $BL_{52}$ & $GB_{39}$ on the postmenopausal osteoporosis. Methods: In order to study the effects of the Gamidokwalgisaeng-tang(GDS) oral administration and electro-acupuncture at $BL_{52}$, $GB_{39}$ on osteoporotic rats induced by ovariectomy, body weight, femur weight, uterine weight, serum level of osteocalcin, alkaline phosphatase(ALP), cholesterol, triglyceride, estradiol, androstenedione, testosterone and urinary excretions of calcium & phosphorus were measured. Results : 1. Body weight in all experimental group decreased significantly in comparison with ovariectomized group(OVX). 2. The weight of femur compared with body increased significantly in GDS oral administration and combination treatment group in comparison with ovariectomized group(OVX). 3. Uterine endometrial morphology is caused by ovariectomy and the weight of uterus decreased significantly in control and all experimental group in comparison with sham. 4. The serum level of osteocalcin decreased in all experimental group in comparison with OVX, but significantly in electro-acupuncture and combination treatment group. 5. The serum alkaline phosphatase(ALP) activity decreased in electro-acupuncture and combination treatment group in comparison with OVX, but only significantly in electro-acupuncture group. 6. The serum level of cholesterol increased significantly in OVX in comparison with sham and decreased in all experimental group in comparison with OVX, not insignificantly. The serum level of triglyceride increased in all experimental group in comparison with OVX, not insignificantly. 7. Urinary excretions of calcium and phosphorus decreased significantly in all experimental group in comparison with OVX. Conclusion : We suggest that GDS oral administration and electro-acupuncture at $BL_{52}$ & $GB_{39}$ are available for prevention and curing about the postmenopausal osteoporosis.

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단백질과 마그네슘 공급수준이 흰쥐의 혈청중 지질함량 및 효소활성에 미치는 영향 (Effect of Dietary Protein and Magnesium Levels on Serum Lipid Contents and Enzyme Activities in Rats)

  • 정복미
    • Journal of Nutrition and Health
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    • 제26권8호
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    • pp.925-932
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    • 1993
  • To study the effects of dietary protein and magnesium level on serum lipid contents and enzyme activities, male Sprague-Dawley rats were divided into six groups. Six groups of animals were fed six experimental diets different with protein(8% and 20%) and magnesium levels (Mg-free, 400mg/kg diet and 800mg/kg diet). The serum lipid contents and enzyme activities of rats fed different dietary protein and magnesium levels were examined. Serum triglyceride contents was significantly decreased as the dietary magnesium level was increased. Serum phospholipid contents was significantly higher in magnesium deficient group than those in the other groups. Serum alkaline phosphatase activity was significantly decreased in magnesium dificient group compared with other groups, but serum glutamic oxaloacetic transaminase and glutamic pyruvic transaminase activities was significantly increased in magnesium dificient group than other groups. In conclusion, serum triglyceride contents in low protein level was remarkably decreased as the dietary magnesium level was increased.

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혈청 25-hydroxyvitamin D 수준이 낮은 폐경 후 여성에서 나타난 위험 인자 분석 (Investigation of Risk Factors of Low Serum 25-hydroxyvitamin D Levels in Korean Menopausal Women)

  • 문주재
    • Journal of Nutrition and Health
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    • 제29권9호
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    • pp.981-990
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    • 1996
  • To define the risk facots of subclinical vitamin D deficiency in postmenopausal women, circulating serum 25-hydroxyvitamin D levels, known to be the indicator of vitamin D status, were measured and risk faxtors affecting it were investigated in 27 women with low 25-hydoxyvitamin d level(ie, the study group : serum 25-hydroxyvitamin D<10ng/ml) by comparing to 55 age-matched control(the control group) were analyzed. The serum level of 25-hydorxyvitamin D was analyzed by HPLC(High Pressure Liquid Chor-matography) and analyzed biochemical parameter. The following information was obtained by interviews : sociodemographic charateristics, the intake of food containing vitamin D, proxy measure of sunlight exposure(time spent outdoors), and reprocuctive histpry of the subjects. The study group had significantly lower levels of serum calcium, increased levels of iPTH and alkaline phosphatase, Among the dietary determents, energy, protein, fat, calcium, phophorus, and vitamin D intakes were lower in the study group than the normal group. The time spent outdoors in a day was not significantly different between the two groups. However, during the day, a specific time of time spent out doors between 12:00 and 14:00 was significantly lower in the study group. Logistic analysis revealed that vitamin D and calcium intake were more important affecting factors than the time spent outdoors in post menopausal women.

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Na-alginate 투여가 白鼠의 鉛과 카드뮴 독성에 미치는 영향 (Effects of Na-alginate on the Toxicity Induced by Lead and Cadmium in Albino Rats)

  • Lee, Sang Bong
    • 한국환경보건학회지
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    • 제12권2호
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    • pp.17-26
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    • 1986
  • Earlier studies have shown that the administration of Na-alginate, a water-soluble, non absorbable acidic polysaccharide, effectively reduces the absorption of radioactive strontium, cadmium and other bivalent metals. In this study the effects of Na-alginate on the Toxicity induced by Lead and Cadmium were examined in rats and the following results were obtained. 1. The elevations of the activities of serum GOT, GPT by Pb and Cd administration in the experimental animals. However, the administration of Na-alginate significantly inhibited the elevation of serum GOT, GPT. 2. Generally serum TBA values were significantly elevated in Pb and Cd group in comparison with the control group. However, the administration of Na-alginate inhibited the elevation of serum TBA values. 3. The activity of Alkaline phosphatase was also significantly elevated in Cd group in comparison with the control group. However, the administration of Na-alginate significantly inhibited the elevation of serum alkaline phsphatase. 4. Furthermore, the activity of $\delta$-aminolevulinic acid dehydratase in red blood cells was also significantly inhibited by Pb and this inhibition was stimulated by the administration of Na-alginate. 5. The concentrations of Pb in liver and Cd in kidney were markedly increased by Pb and Cd. However, the administration of Na-alginate significantly inhibited the elevation of them.

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옻나무 목부로부터 분리한 Favonoids가 Paraquat 독성의 경감기전 검색 (Protective Mechanism of Flavonoids Isolated from Rhus Vernicifiua on the Paraquat Toxicity Reducing Agent and its Inhibition Mechanism)

  • 김정수;조희숙;강혜옥;한갑이;정민화;최종원
    • 생명과학회지
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    • 제13권6호
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    • pp.775-781
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    • 2003
  • 옻나무(Rhus verniciflua Stokes)로부터 제초제인 paraquat(PQ)의 독성 경감기전을 추구할 목적으로 ethylacetate 분획에서 분리한 fustin 및 sulfuretin을 실험동물에 투여하고서 혈액학적 변화 및 간장 중 활성산소에 미치는 영향 검토한 결과 혈액 생화학적 인자 분석을 종합해 보면 옻나무의 메탄을 엑스(250 mg/kg), 에틸아세테이트 엑스(250 mg/kg), fustin(10 mg/kg) 및 sulfuretin(10 mg/kg)을 2주간 각각 경구투여 하고서 PQ를 투여하므로서 PQ의 독성이 유의성 있게 억제되었다. in vivo에서 옻나무의 분획 및 성분의 투여는 혈액생화학적 검사에서 PQ에 의해 유도된 간독성 지표인 s-GPT, s-GOT치, 신장독성지표인 BUN, creatinine치 및 조직손상의 지표인 ALP, MDA치를 억제하였다 폐조직중의 MDA함량, ALP활성 및 collagen함량도 억제하였다. 이로써 옻나무에는 PQ의 폐독성 및 각 장기의 독성을 효과적으로 경감시켜 줄 수 있는 물질이 함유되어 있는 것으로 사료된다.