• 한국식품영양학회지
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• 제19권2호
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• pp.169-175
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• 2006

단세포 조류 생물인 Chlorella vulgaris(클로렐라)는 다양한 생리 활성을 가진 기능성 소재로 이용되고 있다. 본 연구에서는 강제 수영 부하 실험과 혈액 생화학적 지표에 대한 클로렐라의 효과에 대해 연구하였다. 혈액 생화학적 지표로는 Blood urea nitrogen(BUN), creatine kinase(CK), lactic dehydrogenase(LDH), glucose(Glc), total protein(TP), albumin을 혈액 생화학적 지표로 측정하였다. 매일 0.05, 0.1, 0.15 g/kg 농도의 클로렐라를 각각 실험 군별로 마우스에 구강 투여했다. 클로렐라를 투여한지 3일, 7일째 되는 날 강제 수영 부하 실험을 시행한 결과 0.15 g/kg 클로렐라를 투여한 그룹에서 유의적으로 부동시간을 감소시켰다. 또한 혈청 중 BUN 수치를 낮췄으며, CK, LDH 수치는 감소하는 경향을 나타냈다. 클로렐라 투여 시 혈 중 Glc 수치는 높아졌으나, TP 와 albumin 수치는 변화가 없었다. 이상의 결과들은 클로렐라가 육체적 지구력 향상 효과가 있는 것을 시사하고 있다.

• 한국어병학회지
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• 제30권1호
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• pp.25-39
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• 2017

A total number of 668 apparently healthy fish were obtained from farm to study the effect of two heavy metals in a form of (Copper sulfate and Mercuric chloride) on some hematological and biochemical parameters of blood. The $LC_{50}$ /96 hr. of Cu and Hg were estimated and fish exposed to $\text\tiny{^1/_2}$ $LC_{50}$ for 7 days and for $1/_{10}$ $LC_{50}$ for 8 weeks from each product separately. Results showed decrease in RBCs count, PCV% and Hb in acute and chronic mercury while a significant increase was shown in acute and chronic copper toxicity, total leucocytic count showed decrease in acute mercury toxicity and increase in the chronic case, while in copper toxicity non-significant decrease in acute and significant decrease in chronic toxicity was noticed. Elevated serum urea and creatinine in both acute and chronic mercury and copper toxicity was detected. No changes in total bilirubin in the acute mercury and chronic copper toxicity while significant increase in chronic mercury and acute copper. Elevation of serum AST and ALT in some days of acute toxicity of mercury and copper while in chronic mercury toxicity a significant elevation of both serums AST and ALT were detected .while in chronic copper toxicity serum AST was fluctuated and ALT showed no significant changes. CK study revealed significant decrease in acute mercury with fluctuation in the chronic toxicity while in copper toxicity it showed fluctuation in acute and significant decrease in chronic toxicity. Glucose value decreased in acute and chronic mercury toxicity while in copper toxicity it showed significant increase in the acute and increase followed by significant decrease in the chronic copper toxicity.

• 한국동물위생학회지
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• 제44권4호
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• pp.239-246
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• 2021

The fertility of dairy cows has been declining worldwide. The number of services per conception has increased, and repeat breeder (RB) cows are considered important in the dairy industry. However, there has been little research on RB cows in Korea. The objective of this study was to investigate the relationship between serum biochemical profiles and RB Holstein cattle in Korea and compare the results with those of studies conducted abroad. In addition, we investigated hidden factors that are needed for RB cattle to become pregnant. Overall, 34 Korean Holstein Friesian cows were divided into three groups: pregnant with normal cycling (PNC), pregnant with repeat breeder (PRB), and non-pregnant with repeat breeder (NRB). Blood samples were collected from the jugular vein, and serum parameters (ALT, AST, ALP, GGT, LD, CK, TP, ALB, GLOB, TBIL, BUN, CRE, GLU, TC, TG, NEFA, CA, MG, and IP) were analyzed. GGT levels were significantly different among groups (P=0.01). The concentration of GGT was the highest in the NRB and the lowest in the PNC. In contrast to the findings of other studies, there were no differences in GLU, TP, TC, and BUN levels. This study is the first to investigate serum biochemistry in RB cattle and provides results that differ from those of previous studies; these findings would help establish a novel approach to improve fertility of RB cattle.

• 대한임상독성학회지
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• 제15권1호
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• pp.40-46
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• 2017

Purpose: Glufosinate ammonium (GA; phosphinothricin) can induce neurological complications such as altered mental status, amnesia, and convulsions. This study was conducted to evaluate whether blood lipid profiles can help predict convulsions in patients with GA poisoning. Methods: This study was a retrospective review of data acquired at a tertiary academic university hospital from March 2014 to July 2016. Independent t-test, Mann-Whitney test and Analysis of covariance (ANCOVA) of demographic and laboratory findings of 50 patients with GA poisoning were performed to identify correlations of general characteristics and laboratory findings, including blood lipid profiles of GA-poisoned patients between with and without convulsions. Results: Convulsion as a GA complication showed a significant association with poison volume, age, white blood cell count, and creatine phosphokinase (CK), albumin, lactate dehydrogenase (LDH), low-density lipoprotein (LDL), and high-density lipoprotein (HDL) content in blood according to an independent t-test and Mann-Whitney test. However, ANCOVA demonstrated significant association with LDL and triglyceride. Conclusion: Blood lipid profiles, especially serum LDL and triglyceride, were useful in predicting convulsions in patients with GA poisoning.

• Asian-Australasian Journal of Animal Sciences
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• 제27권1호
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• pp.123-130
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• 2014

The A-type lamin deficient mouse line ($Lmna^{-/-}$) has become one of the most frequently used models for providing insights into many different aspects of A-type lamin function. To elucidate the function of Lmna in the growth and metabolism of mice, tissue growth and blood biochemistry were monitored in Lmna-deficient mice, heterozygous ($Lmna^{+/-}$) and wide-type ($Lmna^{+/+}$) backcrossed to C57BL/6 background. At 4 weeks after birth, the weight of various organs of the $Lmna^{-/-}$, $Lmna^{+/-}$ and $Lmna^{+/+}$ mice was measured. A panel of biochemical analyses consisting of 15 serological tests was examined. The results showed that Lmna deficient mice had significantly decreased body weight and increased the ratio of organ to body weight in most of tissues. Compared with $Lmna^{+/+}$ and $Lmna^{+/-}$ mice, $Lmna^{-/-}$ mice exhibited lower levels of ALP (alkaline phosphatase), Chol (cholesterol), CR (creatinine), GLU (glucose), HDL (high-density lipoprotein cholesterol) and higher levels of ALT (alanine aminotransferase) (p<0.05). $Lmna^{-/-}$ mice displayed higher AST (aspartate aminotransferase) values and lower LDL (lowdensity lipoprotein cholesterol), CK-MB (creatine kinase-MB) levels than $Lmna^{+/+}$ mice (p<0.05). There were no significant differences among the three groups of mice with respect to BUN (blood urea nitrogen), CK (creatine kinase), Cyc C (cystatin C), TP (total protein), TG (triacylglycerols) and UA (uric acid) levels (p>0.05). These changes of serological parameters may provide an experimental basis for the elucidation of Lmna gene functions.

• 대한두경부종양학회지
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• 제36권2호
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• pp.73-77
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• 2020

Ovarian cancer is common malignant disease with high mortality in the female. However, lymph node metastasis in the head and neck of ovarian cancer is very rare than in para-aortic, pelvic lymph node. A 49-year-old female patient came to our clinic with a left neck mass. After total thyroidectomy and left selective neck dissection for the cervical neck level II, III, IV, V, VI for ovarian cancer and thyroid cancer, she had already undergone chemotherapy (Paclitaxel+Carboplatin) 18 month ago. CT scan showed only lymph node enlargement in left neck level II. Positron emission tomography-computed tomography (PET-CT) revealed a hypermetabolic lesion in same area but no other hypermetabolic lesion, especially in the pelvic and abdominal cavity. Fine needle aspiration cytology revealed metastatic carcinoma. The serum level of CA-125 was elevated to 43.8U/mL, whereas other tumor markers (CA 19-9, CEA) were in the normal range. She underwent a revision of selective neck lymph node dissection for the cervical neck levels I, II, and III, and on the review of surgical pathology, metastatic carcinoma was suspected. Thus, we performed immunohistochemical staining for the tissue; as a result, it was finally diagnosed as metastatic ovarian cancer (positive for CK7, ER and PR, and negative for CK20). Adjuvant chemotherapy (Paclitaxel+Carboplatin) was planned on the tumor board, and the patient successfully received chemotherapy.

• 한국임상수의학회지
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• 제27권2호
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• pp.198-201
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• 2010

본 증례는 8개월령의 암컷 붉은목왈라비에서 발생한 포획근병증으로, 피부병 치료를 위하여 약욕 후 침울, 파행, 기립불능증의 임상증상을 보이다 14일 후에 폐사하였다. 왈라비가 기립불능 증상을 보인 다음날 실시한 혈액검사 에서, CK, ALT, AST의 상승을 확인하였다. 폐사 후 실시한 조직검사에서, 골격근과 심근의 근섬유가 퇴행되고, 괴사 된 소견을 발견할 수 있었다. 동거 개체로부터의 압박과 비타민 E의 부족이 의심되는 급여력, 약욕시의 스트레스등과혈액검사와 조직검사 결과 포획근병증으로 진단하였다. 포획근병증은 유대류에서 호발하는 질병으로 알려져 있으나 국내에서의 발병보고는 본 증례가 최초로, 포획근병증의 관리에 도움이 될 것이다.

• 한국임상수의학회지
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• 제25권4호
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• pp.245-248
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• 2008

한약제는 사람의 많은 질병의 치료를 위하여 사용되어 왔으나, 개 안면신경마비에 대한 한약제의 치료 효과는 현재까지 검토된 바 없다. 개 안면신경마비에 대한 오약순기산의 치료 효과를 조사하였다. 인공적으로 안면신경마비를 유발한 총 10두 대조군(5두)과 한약제 치료군(5두,오약순기산 치료군)으로 나누어 공시하였다. 대조군은 아무런 처치를 하지 않았으며,오약순기산 치료군은 1일 2회, 총 2주간 오약순기산(50 mg/kg)을 경구 투여하였다. 오약순기산 치료군의 임상 지표는 대조군에 비하여 14일(p<0.05)에 유의성 있는 개선을 보였다. 오약순기산 치료군의 혈청 CK 활성 변화는 대조군에 비하여 낮은 경향을 나타냈지만 유의성은 인정되지 않았다. 결론적으로, 오약순기산은 개 안면신경마비 치료에 유효한 것으로 판단되었다.

• Journal of Applied Biological Chemistry
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• 제63권1호
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• pp.69-74
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• 2020

The fruit, leaves, and roots of Elaeagnus multiflora Thunb. have been used in traditional Chinese medicine to treat cough, diarrhea, and itching. However, the anti-fatigue effects of E. multiflora fruit (EMF) extract have not been studied in detail. The aim of this study was to examine the effect of EMF on fatigue and exercise performance in BALB/c mice. EMF was orally administered to mice at four doses (10, 50, 100, and 200 mg/kg/day) for 2 weeks. The anti-fatigue activity was evaluated by determining the exhaustive swimming time. Blood lactate and glucose levels and serum lactate levels after a 10 min swimming time, as well as ammonia, creatine kinase (CK), blood urea nitrogen (BUN), lactate dehydrogenase (LDH), and glycogen contents after exhaustive swimming time were measured. The exhaustive swimming time of the EMF 200 group was significantly increased (p <0.01). The EMF groups showed significantly low levels of CK, BUN, LDH, and lactate compared with the control group (p <0.05). Increased liver glycogen was observed in the EMF 200 group (p <0.05). These results suggest that EMF can be utilized as an efficacious natural resource for its anti-fatigue effects.

• Tuberculosis and Respiratory Diseases
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• 제46권1호
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• pp.89-95
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• 1999

저자들은 40세 남자환자에서 고열과 호흡곤란, 기침을 주소로 내원하여 개흉 폐생검상 폐쇄성 세기관지염 기질화 폐렴 진단 후 스테로이드 치료로 호전을 보이다가 임상증상의 재발과 함께 다발성근염을 보인 후 재차 스테로이드 치료에 반응을 보인 1예를 경험하였기에 이를 보고하는 바이다.