• Title/Summary/Keyword: sensitivity ranking

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Expression of DOG1, CD117 and PDGFRA in Gastrointestinal Stromal Tumors and Correlations with Clinicopathology

  • Sun, Xiu-Wei;Feng, Zhan-Jun;Huang, Peng;Hao, Wang;Sui, Xing-Ling
    • Asian Pacific Journal of Cancer Prevention
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    • v.13 no.4
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    • pp.1389-1393
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    • 2012
  • Objective: To discuss the significance of DOG1, CD117 and PDGFRA in the diagnosis of gastrointestinal stromal tumors (GISTs), and analyze their correlations with clinicopathological features and risk ranking. Method: DOG1, CD117 and PDGFRA were detected with IHC Envision ldpe-g-nvp in 63 GISTs and 43 cases of non-GISTs, and analyzed for relations with clinicopathological factors (gender, age, location, tumor size, mitotic phase, histology) and risk degree. Results: The positive expression rate of DOG1, CD117 and PDGFRA in GISTs was 84.1% (53/63), 90.5% (57/63), 53.2% (33/63), respectively. Among the 6 CD117 negative cases, all were DOG1 positive and 5 were PDGFRA positive. Rates in patients with non-GISTs was 11.6%, 16.3%, 6.98%, respectively. Expression of DOG1 and PDGFRA demonstrated no significant variation with gender, age, position, tumor size, mitotic phase, histology, and risk rank. However, CD117 was related with position and histology (P=0.008 and P=0.045), those in the mesentery having a higher positive rate than those derived from stomach, small intestine, colon and rectum (50.0% vs 94.7%, P=0.008). Furthermore CD117 was also highly expressed in spindle and epithele types. Conclusions: DOG1 had a good sensitivity and specificity as a kind of newly discovered marker, especially for KIT negative GISTs. However, DOG1, CD117 and PDGFRA cannot be used for assessing the rish of patients.

Automatic Calibration of SWAT Model Using LH-OAT Sensitivity Analysis and SCE-UA Optimization Method (LH-OAT 민감도 분석과 SCE-UA 최적화 방법을 이용한 SWAT 모형의 자동보정)

  • Lee Do-Hun
    • Journal of Korea Water Resources Association
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    • v.39 no.8 s.169
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    • pp.677-690
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    • 2006
  • The LH-OAT (Latin Hypercube One factor At a Time) method for sensitivity analysis and SCE-UA (Shuffled Complex Evolution at University of Arizona) optimization method were applied for the automatic calibration of SWAT model in Bocheong-cheon watershed. The LH-OAT method which combines the advantages of global and local sensitivity analysis effectively identified the sensitivity ranking for the parameters of SWAT model over feasible parameter space. Use of this information allows us to select the calibrated parameters for the automatic calibration process. The performance of the automatic calibration of SWAT model using SCE-UA method depends on the length of calibration period, the number of calibrated parameters, and the selection of statistical error criteria. The performance of SWAT model in terms of RMSE (Root Mean Square Error), NSEF (Nash-Sutcliffe Model Efficiency), RMAE (Relative Mean Absolute Error), and NMSE (Normalized Mean Square Error) becomes better as the calibration period and the number of parameters defined in the automatic calibration process increase. However, NAE (Normalized Average Error) and SDR (Standard Deviation Ratio) were not improved although the calibration period and the number of calibrated parameters are increased. The result suggests that there are complex interactions among the calibration data, the calibrated parameters, and the model error criteria and a need for further study to understand these complex interactions at various representative watersheds.

A Development of Monitoring and Control System for Improved the Voltage Stability in the Power System (전력계통의 전압안정도향상을 위한 감시제어시스템 개발)

  • Lee, Hyun-Chul;Jeoung, Ki-Suk;Park, Ji-Ho;Baek, Young-Sik
    • The Transactions of The Korean Institute of Electrical Engineers
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    • v.62 no.4
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    • pp.437-443
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    • 2013
  • This paper was developed a monitoring and control system to use reactive power control algorithm. This algorithm could be improved voltage stability in power system. This method was controlled the voltage for stability improvement, effective usage of reactive power, and the increase of the power quality. PMS(Power Management System) has been calculate voltage sensitivity, and control reactive power compensation device. The voltage control was used to the FACTS, MSC/MSR(Mechanically Switched Capacitors/Reactors), and tap of transformer in power system. The reactive power devices in power system were control by voltage sensitivity ranking of each bus. Also, to secure momentary reactive power, it had been controlled as the rest of reactive power in the each bus. In here, reactive power has been MSC/MSR. The simulation result, First control was voltage control as fast response control of FACTS. Second control was voltage control through the necessary reactive power calculation as slow response control of MSR/MSR. Third control was secured momentary reactive reserve power. This control was method by cooperative control between FACTS and MSR/MSC. Therefore, the proposed algorithm was had been secured the suitable reactive reserve power in power system.

An Efficient Taguchi Approach for the Performance Optimization of Health, Safety, Environment and Ergonomics in Generation Companies

  • Azadeh, Ali;Sheikhalishahi, Mohammad
    • Safety and Health at Work
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    • v.6 no.2
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    • pp.77-84
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    • 2015
  • Background: A unique framework for performance optimization of generation companies (GENCOs) based on health, safety, environment, and ergonomics (HSEE) indicators is presented. Methods: To rank this sector of industry, the combination of data envelopment analysis (DEA), principal component analysis (PCA), and Taguchi are used for all branches of GENCOs. These methods are applied in an integrated manner to measure the performance of GENCO. The preferred model between DEA, PCA, and Taguchi is selected based on sensitivity analysis and maximum correlation between rankings. To achieve the stated objectives, noise is introduced into input data. Results: The results show that Taguchi outperforms other methods. Moreover, a comprehensive experiment is carried out to identify the most influential factor for ranking GENCOs. Conclusion: The approach developed in this study could be used for continuous assessment and improvement of GENCO's performance in supplying energy with respect to HSEE factors. The results of such studies would help managers to have better understanding of weak and strong points in terms of HSEE factors.

A Comprehensive Measure of Evaluation for Non-Normal Process Capability with Beta Distributions (베타분포를 하는 비정규 공정능력평가의 종합적 측도)

  • 김홍준;김진수;전창희
    • Journal of Korean Society of Industrial and Systems Engineering
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    • v.22 no.52
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    • pp.69-79
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    • 1999
  • The main objective of this study are to propose two methods that would be a comprehensive measure of evaluation for non-normal process capability with Beta distributions. First method is introduced using process capability index $C_{psk}$ by the Pearson system and Johnson system. The Pearson system and the Johnson System selected for process capability index calculation have a equivalent result of this study that the ranking of the seven indices in terms of sensitivity to departure of the process median from the target value from the most sensitive one up to the least sensitive are $C^{*}_{pm}$ , $C_{psk}$ , $C_{s}$ , $C_{pmk}$ , $C_{pm}$ , $C_{pk}$ , $C_{p}$ . Second method show using the percentage nonconforming by the Pearson, Johnson and Burr functions. In thus study, we find that the Pearson system and the Burr system are a reasonable method to estimate percentage nonconforming. But, the exact procedure for deriving this estimate will be based on Beta distribution. Accordingly, if a process is not normally distributed , but normal-based techniques are used serious errors can result.

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A New Measure of Process Capability for Non-Normal Process : $C_{psk}$ (비정규 공정에 대한 공정능력의 새로운 측도: $C_{psk}$)

  • 김홍준;송서일
    • Journal of Korean Society for Quality Management
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    • v.26 no.1
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    • pp.48-60
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    • 1998
  • This paper proposes a fourth generation index $C_{psk}$, constructed from $C_{psk}$, by introducing the factor|$\mu$-T| in the numerator as an extra penalty for the departure of the process mean from the preassigned target value T. The motivation behind the introduction of $C_{psk}$ is that when $T\neqM$ process shifts away from target are evaluated without respect to direction. All indices that are now in use assume normally distributed data, and any use of the indices on non-normal data results in inaccurate capability measurements. In this paper, a new process capability index $C_{psk}$ is introduced for non-normal process. The Pearson curve and the Johnson curve are selected for capability index calculation and data modeling the normal-based index $C_{psk}$ is used as the model for non-normal process. A significant result of this research find that the ranking of the six indices, $C_{p}$, $C_{pk}$, $C_{pm}$, ${C^*}_{psk}$, $C_{pmk}$, $C_{psk}$in terms of sensitivity to departure of the process median from the target value from the most sensitive one up to the least sensitive are $C_{psk}$, $C_{pmk}$, ${C^*}_{psk}$,$C_{pm}$, $C_{pk}$, $C_{p}$.

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Sensitivity analysis of normalization methods for indicators (지표의 표준화 방법에 대한 민감도 분석)

  • Yang, So-Hye;Choi, Si-Jung;Lee, Dong-Ryul
    • Proceedings of the Korea Water Resources Association Conference
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    • 2011.05a
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    • pp.460-460
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    • 2011
  • 국내에서는 수자원 정보화 사업에 일환으로 국가수자원종합정보시스템(WAMIS)을 개발하여 수자원에 관련된 많은 기초 자료 정보를 일반에 공개 제공하고 있으나, 주 이용 계층은 수자원관련 종사자 또는 연구자들이 대부분이다. 국가수자원종합정보시스템에서 제공하는 양질의 수자원 정보를 일반 국민들이 보다 쉽게 이해하고, 이용할 수 있도록 국내에서는 이들 기초자료를 바탕으로 다양한 수자원 지표 및 지수를 개발하였다. 이러한 수자원 관련 지표 및 지수를 개발하기 위해서는 서로 다른 단위와 특성을 가진 자료들을 모아 하나의 지표로 정의하는 과정이 필요하며, 하나의 지표로 정의되기 위해서는 반드시 표준화(normalization)과정이 필요하다. 국내에서 가장 보편적으로 사용하고 있는 방법은 Z-score법이며, 이외에도 가장 단순하고 간단한 방법인 Ranking 법, 자료의 극값(최대값, 최소값)을 이용하는 Re-scaling법, 일정 지표를 기준으로 하는 Distance to a reference country법 등이 있다. 표준화 방법은 각기 다른 장 단점을 가지고 있으며, 그 특성에 따라 정의되는 지표값은 다르게 나타날 수 있기에 지수값의 변화를 야기시킬 수 있다. 본 연구에서는 기 개발된 물이용안전성지수를 이용하여 기존 분석과 다양한 표준화 방법을 이용하여 지표를 산정하였을 때 표준화 방법에 따른 변화를 분석해 보고자 한다. 기존 연구에서 사용된 표준화 방법은 Z-score법이며, 다른 표준화 방법을 적용해 봄으로서 기존 산정 결과와의 차이를 비교 분석하였다. 지수를 구성하는 세부지표에 따라 수집되는 기초자료의 단위 및 특성은 다양하기 때문에 적합한 표준화 방법을 찾는 과정은 매우 중요하며, 이는 지표를 보다 정확하게 산정할 수 있도록 한다. 합리적인 표준화 방법을 통해 올바른 지수를 도출할 수 있고 객관적으로 수자원 환경을 평가할 수 있으며, 또한 수자원 계획 및 정책 개발에 있어 중요한 기준으로서 적용 할 수 있을 것으로 기대된다.

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Estimation of ultimate bearing capacity of shallow foundations resting on cohesionless soils using a new hybrid M5'-GP model

  • Khorrami, Rouhollah;Derakhshani, Ali
    • Geomechanics and Engineering
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    • v.19 no.2
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    • pp.127-139
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    • 2019
  • Available methods to determine the ultimate bearing capacity of shallow foundations may not be accurate enough owing to the complicated failure mechanism and diversity of the underlying soils. Accordingly, applying new methods of artificial intelligence can improve the prediction of the ultimate bearing capacity. The M5' model tree and the genetic programming are two robust artificial intelligence methods used for prediction purposes. The model tree is able to categorize the data and present linear models while genetic programming can give nonlinear models. In this study, a combination of these methods, called the M5'-GP approach, is employed to predict the ultimate bearing capacity of the shallow foundations, so that the advantages of both methods are exploited, simultaneously. Factors governing the bearing capacity of the shallow foundations, including width of the foundation (B), embedment depth of the foundation (D), length of the foundation (L), effective unit weight of the soil (${\gamma}$) and internal friction angle of the soil (${\varphi}$) are considered for modeling. To develop the new model, experimental data of large and small-scale tests were collected from the literature. Evaluation of the new model by statistical indices reveals its better performance in contrast to both traditional and recent approaches. Moreover, sensitivity analysis of the proposed model indicates the significance of various predictors. Additionally, it is inferred that the new model compares favorably with different models presented by various researchers based on a comprehensive ranking system.

A Comparative Study on Economic Effects on the Korean Economy by Transport Mode Using Input-Output Analysis (산업연관분석에 의한 운송부문별 국민경제적 파급효과의 상호비교 분석)

  • Lee, Tae-Woo;Chang, Young-Tae;Shin, Sung-Ho
    • Proceedings of the Korea Port Economic Association Conference
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    • 2006.08a
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    • pp.103-124
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    • 2006
  • This paper is concerned with a comparative study on the economic effects upon the Korean economy by transport mode, ie road, rail, air, and coastal and inland water transportation between 1990 and 2000, using input-output analysis. The economic effects consist of backward and forward linkage effects, production inducing and import-inducing effects. The data employed for this study come from the Bank of Korea database for Input-Output structure of the Korean economy. The major findings in this study are, among others:(1) the power of dispersion(=backward linkage effect) of coastal and inland water transportation sector is the highest among the four transport sectors, while road cargo transport mode showed the highest the degree of sensitivity (=forward linkage effect); (2) rail cargo transport recorded the highest production inducing effects; and (3) air transport mode achieved the highest ranking in the import-inducing effects.

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Image Color, Brightness, Saturation Similarity Validation Study of Emotion Computing (이미지 색상, 명도, 채도 감성컴퓨팅의 유사성 검증 연구)

  • Lee, Yean-Ran
    • Cartoon and Animation Studies
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    • s.40
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    • pp.477-496
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    • 2015
  • Emotional awareness is the image of a person is represented by different tendencies. Currently, the emotion computing to objectively evaluate the emotion recognition research is being actively studied. However, existing emotional computing research has many problems to run. First, the non-objective in emotion recognition if it is inaccurate. Second, the correlation between the emotion recognition is unclear points. So to test the regularity of image sensitivity to the need of the present study is to control emotions in the computing system. In addition, the screen number of the emotion recognized for the purpose of this study, applying the method of objective image emotional computing system and compared with a similar degree of emotion of the person. The key features of the image emotional computing system calculates the emotion recognized as numbered digital form. And to study the background of emotion computing is a key advantage of the effect of the James A. Russell for digitization of emotion (Core Affect). Pleasure emotions about the core axis (X axis) of pleasure and displeasure, tension (Y-axis) axis of tension and relaxation of emotion, emotion is applied to the computing research. Emotional axis with associated representative sensibility very happy, excited, elated, happy, contentment, calm, relaxing, quiet, tired, helpless, depressed, sad, angry, stress, anxiety, pieces 16 of tense emotional separated by a sensibility ComputingIt applies. Course of the present study is to use the color of the color key elements of the image computing formula sensitivity, brightness, and saturation applied to the sensitivity property elements. Property and calculating the rate sensitivity factors are applied to the importance weight, measured by free-level sensitivity score (X-axis) and the tension (Y-axis). Emotion won again expanded on the basis of emotion crossed point, and included a representative selection in Sensibility size of the top five ranking representative of the main emotion. In addition, measuring the emotional image of a person with 16 representative emotional score, and separated by a representative of the top five senses. Compare the main representative of the main representatives of Emotion and Sensibility people aware of the sensitivity of the results to verify the similarity degree computing emotion emotional emotions depending on the number of representative matches. The emotional similarity computing results represent the average concordance rate of major sensitivity was 51%, representing 2.5 sensibilities were consistent with the person's emotion recognition. Similar measures were the degree of emotion computing calculation and emotion recognition in this study who were given the objective criteria of the sensitivity calculation. Future research will need to be maintained weight room and the study of the emotional equation of a higher concordance rate improved.