• Asian Pacific Journal of Cancer Prevention
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• v.14 no.12
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• pp.7761-7762
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• 2013

Alternative strategies such as visual inspection of cervix with acetic acid, are real time, economical and easily implemented methods for cervical cancer screening. However, variable sensitivity and specificity have been observed in various community based studies. The possible reasons could include variation in man power training, light source used for visualization, and preparation of diluted (4-5%) acetic acid and its storage. A standardized protocol for training, teaching material (easy to understand in the local language) for trainees, supervision and reinforcement by intermittent and supplementary training to check the quality of their observation, a standard protocol for preparation dilute acetic acid and its storage and a standard good light source (equivalent to day light) are needed to minimize the variation in sensitivity and specificity of VIA in community settings.

• Nuclear Engineering and Technology
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• v.51 no.4
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• pp.968-976
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• 2019

This paper presents a number of verification case studies for a recently developed sensitivity/uncertainty code package. The code package, ROMUSE (Reduced Order Modeling based Uncertainty/Sensitivity Estimator) is an effort to provide an analysis tool to be used in conjunction with reactor core simulators, in particular the Virtual Environment for Reactor Applications (VERA) core simulator. ROMUSE has been written in C++ and is currently capable of performing various types of parameter perturbations and associated sensitivity analysis, uncertainty quantification, surrogate model construction and subspace analysis. The current version 2.0 has the capability to interface with the Design Analysis Kit for Optimization and Terascale Applications (DAKOTA) code, which gives ROMUSE access to the various algorithms implemented within DAKOTA, most importantly model calibration. The verification study is performed via two basic problems and two reactor physics models. The first problem is used to verify the ROMUSE single physics gradient-based range finding algorithm capability using an abstract quadratic model. The second problem is the Brusselator problem, which is a coupled problem representative of multi-physics problems. This problem is used to test the capability of constructing surrogates via ROMUSE-DAKOTA. Finally, light water reactor pin cell and sodium-cooled fast reactor fuel assembly problems are simulated via SCALE 6.1 to test ROMUSE capability for uncertainty quantification and sensitivity analysis purposes.

• Journal of the Korean Magnetic Resonance Society
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• v.21 no.1
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• pp.1-6
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• 2017

Enhancements in NMR sensitivity have been the main driving force to extend the boundaries of NMR applications. Recently, techniques to shift the thermally populated nuclear spin states are employed to gain high NMR signals. Here, we introduce a technique called photochemically induced dynamic nuclear polarization (photo-CIDNP) and discuss its progresses in enhancing the solution-state NMR sensitivity.

• Journal of the Korean Society for Industrial and Applied Mathematics
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• v.3 no.2
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• pp.161-171
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• 1999

Aerodynamic sensitivity analysis codes are developed via the hand-differentiation using a direct differentiation method and an adjoint method respectively from discrete two-dimensional compressible Navier-Stokes equations. Unlike previous other researches, Baldwin-Lomax algebraic turbulence model is also differentiated by hand to obtain design sensitivities with respect to design variables of interest in turbulent flows. Discrete direct sensitivity equations and adjoint equations are efficiently solved by the same time integration scheme adopted in the flow solver routine. The required memory for the adjoint sensitivity code is greatly reduced at the cost of the computational time by allowing the large banded flux jacobian matrix unassembled. Direct sensitivity code results are found to be exactly coincident with sensitivity derivatives obtained by the finite difference. Adjoint code results of a turbulent flow case show slight deviations from the exact results due to the limitation of the algebraic turbulence model in implementing the adjoint formulation. However, current adjoint sensitivity code yields much more accurate sensitivity derivatives than the adjoint code with the turbulence eddy viscosity being kept constant, which is a usual assumption for the prior researches.

• Coupled systems mechanics
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• v.11 no.2
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• pp.133-149
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• 2022

The accurate prediction of elastoplasticity under prescribed workloads is essential in the optimization of engineering structures. Mechanical experiments are carried out with the goal of obtaining reliable sets of material parameters for a chosen constitutive law via inverse identification. In this work, two sample geometries made of high strength steel plates were evaluated to determine the optimal configuration for the identification of Ludwik's nonlinear isotropic hardening law. Finite element model updating(FEMU) was used to calibrate the material parameters. FEMU computes the parameter changes based on the Hessian matrix, and the sensitivity fields that report changes of computed fields with respect to material parameter changes. A sensitivity analysis was performed to determine the influence of the sample geometry on parameter identifiability. It was concluded that the sample with thinned gauge region with a large curvature radius provided more reliable material parameters.

• Transactions on Electrical and Electronic Materials
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• v.15 no.4
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• pp.182-188
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• 2014

When the windowed DFT algorithm is applied in harmonic measurements, the problem of initial-phase sensitivity will be encountered, this has an effect on harmonic amplitude accuracy. In this paper, the origin of initial-phase sensitivity is analyzed and the main factors that influence the level of initial-phase sensitivity are demonstrated. A method of reducing initial-phase sensitivity is proposed to increase the stability of harmonic measurements. We found that initial-phase sensitivity is determined by the side lobe peak level of the window functions when synchronous deviation is fixed. In addition, increasing the length of the time recorded can be used to remove initial-phase sensitivity. The correctness and validity of our conclusions have been confirmed through numerical results and field tests.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.6
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• pp.2327-2331
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• 2015

Purpose: To determine the accuracy of visual inspection with acetic acid (VIA) in detecting high-grade cervical intraepithelial neoplasia (CIN) in pre- and post-menopausal women with atypical squamous cells of undetermined significance (ASC-US) and low grade squamous intraepithelial lesion (LSIL) Papanicolaou (Pap) smears. Materials and Methods: Two hundred women (150 pre-menopausal and 50 post-menopausal) with ASC-US and LSIL cytology who attended the colposcopy clinic, Thammasat University Hospital, between March 2013 and August 2014 were included. All women underwent VIA testing and colposcopy by gynecologic oncologists. Diagnostic values of VIA testing including sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) for detecting high-grade CIN were determined using the histopathology obtained from colposcopic-directed biopsy as a gold standard. Results: VIA testing was positive in 54/150 (36%) pre-menopausal women and 5/50 (10%) post-menopausal women. Out of 54 pre-menopausal women with positive VIA testing, 15 (27.8%) had high-grade CIN and 39 (72.2%) had either CIN 1 or insignificant pathology. Ten (10.4%), 43 (44.8%) and 43 (44.8%) out of the remaining 96 pre-menopausal women with negative VIA testing had high-grade CIN, CIN 1 and insignificant pathology, respectively. Out of 5 post-menopausal women with positive VIA testing, there were 4 (80%) women with high-grade CIN, and 1 (20%) women with insignificant pathology. Out of 45 VIA-negative post-menopausal women, 42 (93.3%) women had CIN 1 and insignificant pathology, and 3 (6.7%) had high-grade CIN. Sensitivity, specificity, PPV and NPV of the VIA testing were 59.4%, 76.2%, 32.2% and 90.8%, respectively (60%, 68.8%, 27.8% and 89.6% in pre-menopausal women and 57.1%, 97.7%, 80% and 93.3% in post-menopausal women). Conclusions: VIA testing may be used as a screening tool for detecting high-grade CIN in women with minor cervical cytological abnormalities in a low-resource setting in order to lower the rate of colposcopy referral.

• Human Ecology Research
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• v.56 no.6
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• pp.619-626
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• 2018

This study investigated the impact of the amount of time online on cyberbullying perpetration of middle school students as well as examined if the justice sensitivity (victim sensitivity and penetrator sensitivity) moderated the relationship between the amount of time online and cyberbullying perpetration. The participants in this study were 236 students (120 boys and 116 girls) from two middle schools located in Seoul and Incheon. The levels of cyberbullying perpetration and justice sensitivity were measured by scales developed by Campfield (2008) and Schmitt et al. (2010), respectively. The participants were also asked to report on how much time they spent online a day. The data were analyzed via descriptive statistics, hierarchical regression, and procedures mentioned by Baron and Kenny (1986). The results revealed that the more the students used the Internet, the more likely they were to become a cyberbullying perpetrator. However, such a tendency was observed only for the students who had a higher level of victim sensitivity, and not for those with a lower level of victim sensitivity. This suggested that victim sensitivity moderated the effect of the amount of time spent on the Internet on cyberbullying perpetration; but, penetrator sensitivity had no moderating effect.

• Nuclear Engineering and Technology
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• v.56 no.7
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• pp.2790-2798
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• 2024

In this research, thermoluminescent pellets were prepared by adding Mg, Cu, Na and Si impurities to lithium fluoride (LiF) crystal powder via melting and quenching methods to study dosimetric characteristics. Here, its reproducibility, dose response, dosimeter sensitivity, thermal and optical fading were investigated and the obtained results were compared with the properties of LiF: Cu, Mg, P crystal nominated as GR-200.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.12
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• pp.7607-7611
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• 2013

Background: Cervical cancer continues to be a major problem in Bangladesh with approximately 18,000 new cases annually of which over 10,000 women die from it. Visual inspection of the cervix after 3-5% acetic acid (VIA) application is a simple and easy to learn method for cervical cancer screening, although cytology-based screening is more often applied in developed countries where it has successfully reduced the prevalence of cervical cancer. Objective: To compare the efficacy of VIA and cytology-based primary methods for cervical cancer screening in Bangladesh. Materials and Methods: This hospital based comparative study was conducted at the VIA centre and Colposcopy Clinic of Bangabandhu Sheikh Mujib Medical University (BSMMU) from October 2008 to October 2010. Results: Among 650 women, 74 (11.4%) were VIA+ve and 8 (1.2%) had abnormalities in their Pap smear reports. During colposcopy, 38 (7.7%) women had different grades of CIN and 4 (0.6%) had cervical cancer. The gold standard histology findings proved 20 women had CIN I, 14 had CIN II/II and 4 had cervical cancer. Among the 38 histology diagnosed abnormalities, VIA test could identify 30 abnormalities including two cervical cancers. However, Pap smear could detect only 8 cases of histological abnormalities (2 low grade and 6 had high grade lesion) and it missed all the cervical cancer cases. The sensitivity and specificity of VIA were 88.9% and 52.1%. The positive predictive value (PPV) and negative predictive value (NPV) were 41.0%, and 92.6% respectively. Moreover, the sensitivity, specificity, PPV and NPV of Pap smear were 33.3%, 95.8%, 75.0% and 79.3%, respectively. Conclusions: VIA test should be used as the primary screening tool even with its low sensitivity and specificity in low resource countries like Bangladesh. False positive results may be greater, but overtreatment can be minimized by colposcopy evaluation of the VIA positive women.