• International Journal of Aeronautical and Space Sciences
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• v.12 no.4
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• pp.385-395
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• 2011

An ejector was developed for man-portable missiles. The ejector can be separated from the missile after the completion of the ejection function even without any additional separation devices. This paper introduces the particular separation mechanism of the ejector and presents the methodology, based on a probabilistic design method, to predict the ejection-and-separation reliability. This approach using Monte Carlo simulation can also be applicable to the reliability prediction of one-shot items suffering from difficulties in estimating or in demonstrating their reliability due to the lack of the number of tests available.

• BMB Reports
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• v.49 no.10
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• pp.529-535
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• 2016

The NLRP3 inflammasome is activated by a variety of external or host-derived stimuli and its activation initiates an inflammatory response through caspase-1 activation, resulting in inflammatory cytokine IL-1β maturation and secretion. The NLRP3 inflammasome activation is a kind of innate immune response, most likely mediated by myeloid cells acting as a host defense mechanism. However, if this activation is not properly regulated, excessive inflammation induced by overactivated NLRP3 inflammasome can be detrimental to the host, causing tissue damage and organ dysfunction, eventually causing several diseases. Previous studies have suggested that mitochondrial damage may be a cause of NLRP3 inflammasome activation and autophagy, which is a conserved self-degradation process that negatively regulates NLRP3 inflammasome activation. Recently, mitochondria-selective autophagy, termed mitophagy, has emerged as a central player for maintaining mitochondrial homeostasis through the elimination of damaged mitochondria, leading to the prevention of hyperinflammation triggered by NLRP3 inflammasome activation. In this review, we will first focus on the molecular mechanisms of NLRP3 inflammasome activation and NLRP3 inflammasome-related diseases. We will then discuss autophagy, especially mitophagy, as a negative regulator of NLPP3 inflammasome activation by examining recent advances in research.

• Journal of Korea Society of Digital Industry and Information Management
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• v.16 no.3
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• pp.37-47
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• 2020

The In the 4^th industrial revolution, cyber space will evolve into hyper-connectivity, super-convergence, and super-intelligence due to the development of advanced information and communication technologies, which will connect the nation's core infrastructure into a single network. As applying the 4^th industrial revolution technology to the cyber attack technique, it is evolving in an intelligent and sophisticate method. In order to response intelligent cyber attacks, it is difficult to guarantee self-defense in cyberspace by policy-oriented, preplanned-centric and hierarchical cyber response strategies. Therefore, this research aims to propose a situation-flexible & action-oriented cyber response mechanism that can respond flexibly by selecting the most optimal smart security solution according to changes in the cyber attack steps. The proposed cyber response mechanism operates the smart security solutions according to the action-oriented detailed strategies. In addition, artificial intelligence-based decision-making systems are used to select the smart security technology with the best responsiveness.

• International Journal of Computer Science & Network Security
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• v.22 no.11
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• pp.291-293
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• 2022

The implementation of the legal mechanism to protect the rights and interests of entrepreneurs in Russia has its unique features. When the rights and interests of a businessman are threatened with infringement, specific legal remedies may be applied, by means of which the violated rights and interests are restored and, thereby, the opportunity to resume entrepreneurial activity is created. The paper explores extrajudicial ways to protect the rights and interests of entrepreneurs in Russia. The study analyzes the forms of self-help, arbitral tribunal, resolution of applications and complaints by executive authorities, the notariate, and work with the business ombudsman and civil society institutions.

• Journal of Crop Science and Biotechnology
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• v.10 no.2
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• pp.112-116
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• 2007

Kinetin(KN) is an inducer of rice(Oryza sativa L.) defense/stress responses, as evidenced by the induction of inducible secondary metabolite and defense/stress protein markers in leaf. We show a novel light-dependent effect of KN-triggered defense stress responses in rice leaf. Leaf segments treated with KN(100 ${\mu}M$) show hypersensitive-like necrotic lesion formation only under continuous light illumination. Potent accumulation of two phytoalexins, sakuranetin and momilactone A(MoA) by KN that peaks at 48 h after treatment under continuous light is completely suppressed by incubation under continuous dark. Using two-dimensional gel electrophoresis we identified KN-induced changes in ribulose-1, 5-bisphosphate carboxylase/oxygenase, energy- and pathogenesis-related proteins(OsPR class 5 and 10 members) by N-terminal amino acid sequencing and mass spectrometry. These changes were light-inducible and could not be observed in the dark(and control). Present results provide a new dimension(light modulation/regulation) to our finding that KN has a potential role in the rice plant self-defense mechanism.

• Journal of the Korea Institute of Military Science and Technology
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• v.24 no.3
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• pp.328-338
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• 2021

A study on common modular design based on open standards to reduce the life cycle cost of ground weapon system is underway. Since the ground weapon system includes major mission equipment such as fire control system, it is essential to apply the concept of fault tolerance through automatic reconfiguration and blocking unspecified equipment through connectivity control. However, it is difficult to generalize due to the difference in operating characteristics for each system. In this paper, we propose a plug-and-play framework, which includes plug-and-play architecture and mechanism. The proposed method can be used in common by the application of each component as it is divided into a common service layer. In addition, the proposed connectivity control and autonomous reconfiguration method facilitates reflection of operating characteristics for each system. We constructed a verification environment that can simulate ground weapon systems and components, and verified that the proposed framework works through scenario-based functional tests.

• Journal of Powder Materials
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• v.19 no.2
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• pp.134-139
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• 2012

P/M coppers are subjected to the isothermal compression tests at the strain rate ranging from 0.01 to 10.0 $s^{-1}$ and the temperature from 200 to $800^{\circ}C$. The processing map reveals the dynamic recrystallization (DRX) domain in the following temperature and strain rate ranges: $600-800^{\circ}C$ and 0.01-10.0 $s^{-1}$, respectively. In the domain, the region at temperature of $600^{\circ}C$ and strain rate of $10^{-2}s^{-1}$ shows peak efficiency. From the kinetic analysis, the apparent activation energy in the DRX domain is 190.67 kJ/mol and it suggests that lattice self-diffusion is the rate controlling mechanism.

• Proceedings of the KSAR Conference
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• 2003.06a
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• pp.21-21
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• 2003

Male germ cell apoptosis has been extensively explored in rodent. In contrast, very little is known about their susceptibility to apoptosis stimuli of developing germ cell stages at the time when germ cell depletion after busulfan treatment occurs. Furthermore, it is still unanswered how spermatogonial stem cells are resistant to busulfan treatment. We examined the change of gene expression in detail using cDNA microarray analysis of mouse testis treated with busulfan. A subtoxic dose of busulfan (40mg/kg of body weight) transiently increased 228 mRNA levels among of the 8000 genes analyzed. TagMan analysis confirmed that the mRNA levels such as defensive protein, support protein, enzymatic protein, transport protein, and hormonal protein were rapidly increased. These results were re-confirmed by real-time PCR analysis. However, the expression levels of these genes induced by busulfan treatment were significantly reduced in control testis, indicating that both of male germ cells and somatic cells after busulfan treatment induces self-defense mechanism for protection of testicular cell death. Among them, we conclude that defense proteins play a key role in testis injury induced by busulfan.

• Molecules and Cells
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• v.42 no.7
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• pp.503-511
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• 2019

As sessile organisms, plants have developed sophisticated system to defend themselves against microbial attack. Since plants do not have specialized immune cells, all plant cells appear to have the innate ability to recognize pathogens and turn on an appropriate defense response. The plant innate immune system has two major branches: PAMPs (pathogen associated molecular patterns)-triggered immunity (PTI) and effector-triggered immunity (ETI). The ability to discriminate between self and non-self is a fundamental feature of living organisms, and it is a prerequisite for the activation of plant defenses specific to microbial infection. Arabidopsis cells express receptors that detect extracellular molecules or structures of the microbes, which are called collectively PAMPs and activate PTI. However, nucleotidebinding site leucine-rich repeats (NB-LRR) proteins mediated ETI is induced by direct or indirect recognition of effector molecules encoded by avr genes. In Arabidopsis, plasmamembrane localized multifunctional protein RIN4 (RPM1-interacting protein 4) plays important role in both PTI and ETI. Previous studies have suggested that RIN4 functions as a negative regulator of PTI. In addition, many different bacterial effector proteins modify RIN4 to destabilize plant immunity and several NB-LRR proteins, including RPM1 (resistance to Pseudomonas syringae pv. maculicola 1), RPS2 (resistance to P. syringae 2) guard RIN4. This review summarizes the current studies that have described signaling mechanism of RIN4 function, modification of RIN4 by bacterial effectors and different interacting partner of RIN4 in defense related pathway. In addition, the emerging role of the RIN4 in plant physiology and intercellular signaling as it presents in exosomes will be discussed.

• Journal of Korean Society of Transportation
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• v.30 no.4
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• pp.107-118
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• 2012

This paper investigated habitual drunk drivers' characteristics by grouping them by the number of DUI records, and customized countermeasures for each group. Theoretical models to accommodate underlying causes for drunk driving, which adopted the form of a path analysis, were developed based on psychological variables. According to the psychological paths to drunk driving, each group showed different defense mechanisms and different senses of guilty, shame and embarrassment. This provided a rationale for differentiating countermeasures for each group. Habitual drunk drivers were found to have a strong propensity of self-justification due to their defense mechanism. Thereby, it would be useless to simply discourage them from drinking and driving. Rather, more active measures such as locking devices, invalidation of driver license, and group counseling should be taken to stop habitual drunk driving. Furthermore, since habitual drunk drivers showed high projection propensity, it is necessary to force them to participate in a sensibility training program, which might entail the amendment of related laws or regulations.