• 한국전문물리치료학회지
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• 제2권1호
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• pp.36-43
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• 1995

The purpose of this study was to determine whether the vastus medialis oblique muscle(VMO) had greater electrical activity than the vastus lateralis muscle(VL) when hip adduction and knee extension exercise were performed. Electrical activity of the VMO and VL was measured on 42 healthy subjects (28 men, 14 women) during maximal voluntary isometric contractions of hip adduction and knee extension by an EMG-BIOFEEDBACK. The results showed that the electromyographic activity of the VMO was significantly greater than that of the VL during the hip adduction exercise. Differences noted with knee extension by performing hip adduction exercises. Isometric hip adduction exercises, therefore, may be advisable in the treatment of patients with patellofemoral pain.

• Fashion, Industry and Education
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• 제15권2호
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• pp.36-52
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• 2017

In this study, we tried to understand preschooler clothing trends and identify the purchase behaviors of various consumers, such as grandparents, aunts, uncles, and parents, who are the main consumers of the preschooler clothing market. We conducted in-depth interviews with consumers who were interested in preschooler clothing, purchased it frequently, and bought preschooler clothing within the last three months. Their purchase motivations and purchase behaviors were analyzed through exploratory and inductive analysis. The analysis was conducted by integrating categories into one process centered on core categories through open coding, axial coding, and selective coding. The results of this study included that 1) a variety of clothing purchase behaviors appeared as a central phenomenon, 2) the causal conditions that contributed to this phenomenon were the buyers' childcare experiences, purchase experiences, the personal consumption values of individuals, and income levels, 3) in response to the central phenomenon, the parents' action/interaction strategies were acceptance and rejection of purchased clothing, 4) contextual and Intervening conditions affecting action/interaction strategy were family environment changes, the VIB (Very Important Baby) phenomenon, parents' clothing involvement, and the relationship with the buyers, and acceptance by the users, and 5) as a result of the strategy expressed as acceptance and rejection, various clothing behaviors emerged. In this study, we identified that there are various influencers, apart from parents, involved in children's clothing consumption. Therefore, we need to keep in mind that various purchase behaviors and clothing trends that appear during one's childhood may affect the individual's clothing behavior in the future.

• 패션비즈니스
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• 제16권2호
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• pp.124-137
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• 2012

This study aims to identify the meaning and formation cause of a style, and the essential elements of style formation, through psychobiological research as well as an analysis of the designs of Iris Van Herpen, a fashion designer, who in just 6 years has developed into a world-renowned new designer. As a result, it has been found that the psychobiological causes to form a style stem from the action of 'long-term memory', which is consolidated by 'selective attention', 'perceptional subjectivity', the principle of the 'neuron's connection specificity and invariance', and the principle of a 'neuronal signal's unilateral flow'. With such action, Herpen could develop her own original composition techniques. The formative shapes created by such composition techniques are characterized by enumeration, superposition, and hanging. The study has also found that the essential elements for a designer to be able to form his/her own style include 'aesthetic originality' in which the designer views the property of a thing from his/her inherent perspective, and finds the uniqueness from the thing that only he/she can express, 'technical differences' that are creative and original, and 'formative specificity' that is summarized into one property through an impressive shape.

• The Korean Journal of Physiology and Pharmacology
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• 제25권3호
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• pp.189-195
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• 2021

Fluoxetine (FLX), a selective serotonin reuptake inhibitor antidepressant, exhibits various other mechanisms of action in numerous cell types and has been shown to induce cell death in cancer cells, paving the way for its potential use in cancer therapy. The aim of this study was to determine the off-target effects of the anti-depressant drug FLX, on the human ovarian granulosa tumor COV434 cells stimulated by forskolin (FSK), by measuring the real-time kinetics of intracellular cyclic AMP (cAMP), ATP level, cytoplasmic calcium ([Ca2+]cyt) and survival of COV434 cells. We show that incubating COV434 cells with FLX (between 0.6 and 10 μM) induces a decrease in intracellular cAMP response to FSK, a drop in ATP content and stimulates cytoplasmic Ca2+ accumulation in COV434 cells. Only the highest concentrations of FLX (5-10 μM) diminished cell viability. The present report is the first to identify an action mechanism of FLX in human tumor ovarian cells COV434 cells and thus opening the way to potential use of fluoxetine as a complementary tool, in granulosa tumor treatments.

• 한국미생물·생명공학회지
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• 제48권4호
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• pp.429-438
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• 2020

The emergence of multi-drug resistant, pathogenic methicillin-resistant Staphylococcus aureus (MRSA) is a threat to global health and has created a need for novel functional therapeutic agents. In this study, we evaluated the underlying mechanisms of the anti-MRSA effect of an azaphilone pigment, sclerotiorin (SCL) from Penicillium sclerotiorum. The antimicrobial activity of SCL was evaluated using agar disc diffusion, broth microdilution, time-kill assays and biophysical studies. SCL exhibits selective activity against Gram positive bacteria including MRSA (range, MIC = 128-1028 ㎍/ml) and exhibited rapid bactericidal action against MRSA with a > 4 log reduction in colony forming units within three hours of administration. Biophysical studies, using fluorescent probes and laser or electron microscopy, demonstrated a SCL dose-dependent alternation in membrane potential (62.6 ± 5.0.4% inhibition) and integrity (> 95 ± 2.3%), and the release of UV260 absorbing materials within 60 min (up to 3.2 fold increase, p < 0.01) of exposure. Further, SCL localized to the cytoplasm and hydrolyzed plasmid DNA. While in vitro checkerboard studies revealed that SCL potentiated the antimicrobial activity of topical antimicrobials such as polymixin, neomycin, and bacitracin (Fractional Inhibitory Concentration Index range, 0.26-0.37). Taken together these results suggest that SCL targets the membrane and DNA of MRSA to facilitate its anti-MRSA antimicrobial effect.

• Journal of Acupuncture Research
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• 제23권2호
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• pp.91-102
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• 2006

Objectives : Ulmus davidiana Planch (UD) has long been known to have anti-inflammatory and protective effects on damaged tissue, inflammation and bone among other functions. Methods : This study was undertaken to address whether the water extract of the bark of UD could modulate proliferation of mouse osteoclasts in vitro and to investigate its effect on cyclooxygenase-2 (COX-2), which converts arachidonic acid to prostaglandin E2 (PGE2) and is highly expressed in osteoclasts. Mouse osteoclasts were tested in vitro for growth inhibition, proliferation cell nuclear antigen expression, and COX-2 activity and expression after treatment with UD extract. Results : Its effects were compared with those of indomethacin (a nonselective COX inhibitor) and celecoxib (a selective COX-2 inhibitor) by Cell viability assay, Cell cycle analysis, Immunohistochemical analysis of PCNA expression, Western blot analysis and PGE2 Enzyme immunoassay (EIA). UD demonstrated a strong growth inhibitory action in both tested osteoclasts cells. The IC50s were $10\;{\mu}g/ml$ for UD, $6\;{\mu}M$ for celecoxib and $42\;{\mu}M$ for indomethacin. UD, as well as celecoxib and indomethacin, suppressed proliferation cell nuclear antigen expression and PGE2 synthesis in osteoclasts. UD inhibited COX-2 expression, whereas celecoxib inhibited COX-2 activity directly. Conclusion : UD selectively and effectively inhibits osteoclasts cell growth in vitro. Inhibitory action of PGE2 synthesis via suppression of COX-2 expression may be responsible for its anti-inflammatory activity.

• International Journal of Oral Biology
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• 제43권1호
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• pp.43-51
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• 2018

$K^+$ channels are key components of the primary and secondary basolateral $Cl^-$ pump systems, which are important for secretion from the salivary glands. Paroxetine is a selective serotonin reuptake inhibitor (SSRI) for psychiatric disorders that can induce QT prolongation, which may lead to torsades de pointes. We studied the effects of paroxetine on a human $K^+$ channel, human ether-a-go-go-related gene (hERG), expressed in Xenopus oocytes and on action potential in guinea pig ventricular myocytes. The hERG encodes the pore-forming subunits of the rapidly-activating delayed rectifier $K^+$ channel ($I_{Kr}$) in the heart. Mutations in hERG reduce $I_{Kr}$ and cause type 2 long QT syndrome (LQT2), a disorder that predisposes individuals to life-threatening arrhythmias. Paroxetine induced concentration-dependent decreases in the current amplitude at the end of the voltage steps and hERG tail currents. The inhibition was concentration-dependent and time-dependent, but voltage-independent during each voltage pulse. In guinea pig ventricular myocytes held at $36^{\circ}C$, treatment with $0.4{\mu}M$ paroxetine for 5 min decreased the action potential duration at 90% of repolarization ($APD_{90}$) by 4.3%. Our results suggest that paroxetine is a blocker of the hERG channels, providing a molecular mechanism for the arrhythmogenic side effects of clinical administration of paroxetine.

• 한국엔터테인먼트산업학회논문지
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• 제5권2호
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• pp.77-86
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• 2011

본 논문은 커뮤니티를 주된 목적으로 하고 있는 SNG(Social Network Game)에 대한 사용자의 행동과 그 선택적 행동을 유발하는 동기와의 연관관계를 분석하고 있다. 게임제작기술에 대한 연구 및 활용에 비해, 게임 사용자에 대한 연구는 미비했으며 그 주제 또한 게임의 특정목표(예를 들면, "전투"를 통한 레벨상승 및 보상)수행에 대한 사용자의 행동유형을 관찰하는 데 그치고 있다. 따라서 SNG 게임사용자 행동을 문제해결 방식의 관점에서 접근하는 것이 아니라, 인간의 다양한 동기로 인한 행동의 선택 관점에서 연구할 필요가 있다. 이를 위해 첫째, 사회적 속성으로써 Lazzaro의 people fun 모델과 SNS(Social Network Service) 사용자의 동기이론에 대해 고찰한다. 둘째, SNG 13종에 대한 분석 자료를 수집하고 게임이벤트와 사용자의 기능적 행동(functional actions)을 분류한다. 셋째, 분류된 자료를 근거로 SNG 사용자의 주된 행동을 8종류로 설정하고 동기-행동 패턴을 정립한다.

• 약학회지
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• 제43권2호
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• pp.228-232
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• 1999

The combination effect of anethole with amphotericin B, fluconazole, miconazole, or 5-fluorocytosine was investigated against Saccharomyces cerevisiae. When combined with $\frac{1}{2}$ minimum inhibitory concentration (MIC) or $\frac{1}{2}$ minimum fungicidal concentration (MFC) of anethole, the antifungal activities of fluconazole and 5-fluorocytosine were not changed, but the fungistatic and the fungicidal activities of miconazole were increased 64-fold, respectively. In the case of amphotericin B, the fungistatic activity was increased 2-fold, while the fungicidal activity was decreased 2-fold. The combination effect of anethole with miconazole or amphotericin B was also investigated at the various concentrations using the macrobroth dilution checkerboard method. The fractional inhibitory concentration (FIC) and the fractional fungicidal concentration (FFC) index between B exhibited the FIC index of 8.25 and the FFC of 32.06, respectively. Thus, it is analyzed that the combination of anethole with miconazole or amphotericin B on the antifungal action shows synergism and antagonism, respectively.

• Journal of Communications and Networks
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• 제12권5호
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• pp.510-517
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• 2010

In this paper, an adaptive MAC protocol (variable load adaptive (VLA)-MAC) is proposed for wireless sensor networks. This protocol can achieve high energy efficiency and provide low latency under variable-traffic-load conditions. In the case of VLA-MAC, traffic load is measured online and used for adaptive adjustment. Sensor nodes transmit packets in bursts under high load conditions to alleviate packet accumulation and reduce latency. This also removes unnecessary listen action and decreases energy consumption in low load conditions. Simulation results show that the energy efficiency, latency, and throughput achieved by VLA-MAC are higher than those achieved by some traditional approaches.