• Korean Journal of Clinical Pharmacy
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• v.30 no.3
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• pp.196-205
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• 2020

Background: The indication of denosumab for osteoporosis was expanded from second-line to first-line therapy in 2019. The aim of this study was to evaluate the efficacy of denosumab as both first- and second-line therapy in postmenopausal women with osteoporosis and osteopenia with risk factors by using the Fracture Risk Assessment Tool (FRAX). Methods: We conducted a medication use evaluation of denosumab in 98 patients who had been treated three or more times for osteoporosis or osteopenia at Chungnam National University Hospital from July 1^st, 2017 to January 31^st, 2020. Risk factors were identified using quantitative N-gram analyses of FRAX estimations. Patient information, including menopause status and results of bone mineral density tests (T-score), was obtained from electronic medical records. Results: Age, body mass index (BMI), prior medication use, and T-score were identified as risk factors and were included as variables in the evaluation of denosumab use. Since no significant differences were detected between groups, denosumab is likely effective regardless of age or BMI. In addition, no significant difference was detected in T-scores following denosumab treatment, between groups who took bisphosphonates and selective estrogen receptor modulators (SERMs) with denosumab as first-line therapy for postmenopausal osteoporosis. Denosumab may, therefore, be effective as second-line therapy. Conclusion: Efficacy of denosumab was evaluated in postmenopausal women with osteoporosis. Denosumab may be used as first- and second-line therapy regardless of age, BMI, and prior use of bisphosphonates and SERMs.

• Proceedings of the KSR Conference
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• 2011.10a
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• pp.498-508
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• 2011

First phase section of line 9 which had been constructed by first private capitalization business of Seoul city was opened on July 24, 2009. There are 25 stations of 25.5km operation distance between Gaehwa and Sinnonhyeon, running regular and express trains on the same track. The number of daily passenger demand has risen to above 200thousand passengers with record above 90% of anticipatied transport demand in 2010. The construction of second phase section(Sinnonhyeon~Bohoon Hospital : 14km, 13 stations) is currently under construction for opening in 2016. This study aims to suggest optimal operating patterns taking into consideration theoretical operating headways for regular and express trains, demand of rolling stocks mainly analyzed on record of first phase demand of line 9 and anticipated transport demand of second phase basic plan.

• Asian Pacific Journal of Cancer Prevention
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• v.13 no.6
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• pp.2771-2774
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• 2012

Aim: Tumors of upper gastrointestinal tract are among the cancers that have a quite lethal course. Cytotoxic chemotherapy is the most efficient therapeutic modality for metastatic gastric cancer. In patients who do not respond to first-line treatment, the response rate to second-line therapies is generally low and the toxicity rates high. This study concerned the efficacy and the side effect profile of second-line therapy with irinotecan in the patients who were being followed-up with the diagnosis of metastatic gastric cancer in $\dot{I}$zmir, Turkey. Materials and Methods: We retrospectively evaluated the efficacy and toxicity in 31 patients with metastatic gastric adenocarcinoma who presented to the polyclinic of Medical Oncology of Izmir Ataturk Education and Research Hospital between May 2008 and July 2011. All received chemotherapy regimens containing cisplatin, fluoropyrimidine (5-FU) and docetaxel as the first-line therapy for late stage disease. Irinotecan as a single agent was given at a dose of 210 mg/$m^2$ on each 21 days. Irinotecan (180 mg/$m^2$ on day 1), 5-FU (500 mg/$m^2$ on days 1-2) and leucovorin (LV; 60 mg/$m^2$ on days 1-2) as a combined regimen were given over a 14 day period. Results: Median age was 54 (range, 31-70). Irinotecan was given as a combined regimen for median 6 cycles (range, 3-12) and as a single agent for median 3 cycles (range, 1-10). Metastases were detected in one site in six patients (19%), in two different sites in 17 patients (55%) and in three or more sites in eight patients (26%). Four patients (12.9%) showed partial response and six patients (19.3%) showed stable disease. Progression-free survival (PFS) was found to be 3.26 months (95% CI, 2.3-4.2). Median overall survival (OS) was found to be 8.76 months (95% CI, 4.5-12.9). The most commonly seen grade 3/4 side effect was neutropenia but the the therapy was generally well-tolerated. Conclusions: In this study, it was demonstrated that second-line therapy with irinotecan given following the first-line therapy with cisplatin, fluoropyrimidine (5-FU) and docetaxel was efficient and safe. Further studies are needed for confirmation.

• International Journal of Railway
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• v.5 no.3
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• pp.103-113
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• 2012

Infrastructure costs could be greatly reduced if the need for bridges and tunnels was reduced, or if the line could be shortened. Tilting trains might be a less costly alternative to building new tracks with large curve radii, because tilting trains can negotiate tighter curves without having to decrease their speeds. Tracks built for tilting trains would be cheaper, as they require fewer bridges and tunnels. This paper compares the construction costs of two different options for the new Dodam-Yeoncheong section on the Central line, which includes 148.65 km of new electrified double-track with a design speed of 250 km/h. The first option is to straighten the high-speed line. The second option is to build a line with small radii curves and run tilting trains on the line. In the first option, tunnels would account for about 51% of the new section. In comparison, the second option would have shorter curves and fewer tunnels and bridges which would reduce construction costs. Furthermore, alignment modifications could be made to several segments on the straight line, making the most of the existing roadbed. The analysis concluded that the line suited to tilting trains would be 95.7 million USD cheaper to build the straight route. That is a savings of 2.8% of the total project cost. However, this option would increase the total travel time of the route by 1.2 minutes, which means it is not necessarily the best choice.

• Journal of the Korean Institute of Telematics and Electronics
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• v.9 no.2
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• pp.1-16
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• 1972

In this paper, the characteristics of linearly tapered strip-line filters, where the even-mode and odd-mode characteristic impedances vary linearly with the same degree along the lines, are analyzed. The Impedance parameters of linearly tapered coupled strip-line, which is made by connecting two linearly tapered unsymmetric coupled strip-lines In cascade and the I:no input and output terminals are made equal, are obtained. Using the above parameters, the Image parameters of linearly tapered coupled strip-line filters are derived. The result of analysis shows that the line length can be made shorter and also the stop-band width between the fundamental and second pass-band becomes wider, compared with the coupled strip-line filters which use uniform strip-lines. Furthermore, the difference of impedance levels in the fundsmental and second pass-band becomes larger with the degree of taper of the lines. This property is unique, in comparison with the case of uniform or exponentially tapered strip-line filters.

• The Korean Nurse
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• v.37 no.1
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• pp.107-115
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• 1998

There is an important concern regarding the First-line nurse manager's leadership because of the recognition that effectiveness of Leadership in this position results in benefits for the whole health care organization. So knowledge and practice of effective leadership behavior are now more essential to nursing than ever before. First-line Nurse Managers must be effective leaders to meet today's challenge because staff nurse, patient are affected by them. So the purpose of this study was to identify and to analyse the need for Leadership program of First-Line nurse managers in university hospitals. There were three major purposes of this study. First, identify First-line nurse managers general characteristic, second, identify their experience of leadership training, third, identify and analysis their demands for leadership training program. The subjects for this study was 167 First-line nurse manager randomly from 18 university hospitals in Korea. The data were collected through questionnaires from Oct. 13th to Nov. 20th, 1997, data was analysed using frequencies and percentages. Especially the steps of analysis of descriptions were as follows: Initial analysis centered on the identification of the demands of first-line nurse managers. Later analysis collapsed the demands into broad categories. From the collect data, 283 demands of first-line nurse managers were identified. These demands were then sorted into 3 broad categories that included : Self development as first-line nurse managers, relationship with others, and practice. The result of the study were as follows ; 1) Most of nurse managers(79.6%) had leadership training course and had good experience to improve self leadership. 2) Their demands of leadership training course are as follows First, for self as first-line nurse managers, they want to learn leadership theory, identify their leadership style and then develop their leadership skill. Second, for others as first-line nurse managers, they want to improve their communication skill, empowering others, relationship with others. Third, for patients as first-line nurse managers, improve their knowledge of practice. From the above finding, this study can be suggested the following; 1. Develope a leadership training course to improve first- line nurse manager's leadership skill according to their demands, so they will be better able to lead staff nurses for organization purposes. 2. When develope leadership training program, it must be contained the factors which first-line nurse managers want to learn.

• Journal of the Institute of Electronics Engineers of Korea TC
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• v.48 no.3
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• pp.68-73
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• 2011

In this paper, a compact-narrow open stub band-pass filter with parasitic-signal of low frequency range and second harmonics rejected using the parallel coupled line and FLCLM(Frquency Locked Controlled Length Method) is proposed. The characteristic of the parallel coupled line can be rejection for parasitic-signal of low frequency range and second harmonics. In last filter of experimental results show that insertion loss is 1.2 dB and return loss is 14.8 dB, and the fractional bandwidth is 10 % at the center frequency of 5.8 GHz. In additional, the rejection for parasitic-signal of low frequency range and second harmonics are 28.9 dB and 28.8 dB, respectively.

• Journal of Fisheries and Marine Sciences Education
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• v.21 no.2
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• pp.199-212
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• 2009

The purpose of this study is to analyze the cost-effectiveness analysis on on-line and off-line extra-curricula education(ECE). Based on a review of relevant literature, on-line ECE is defined as internet based learning, and off-line ECE is defined as on-site learning out of school such as private cram schools and private tutoring. The results of this study are as follows: First, sixty nine percent of the subjects were received ECE. Off-line ECE is more dominant than on-line ECE. Second, cost for off-line ECE is more expensive than on-line ECE. Third, off-line ECE is more effective than on-line ECE, when cost is ignored. Fourth, on-line ECE is more cost-effective than off-line ECE.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 2002.05a
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• pp.169-172
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• 2002

A vision sensor measure range data using laser light source. This sensor generally use patterned laser which shaped single line. But this vision sensor cannot satisfy new trend which feeds foster and more precise processing. The sensor's sampling rate increases as reduced image processing time. However, the sampling rate can not over 30fps, because a camera has mechanical sampling limit. If we use multi line laser pattern, we will measure multi range data in one image. In the case of using same sampling rate camera, number of 2D range data profile in one second is directly proportional to laser line's number. For example, the vision sensor using 5 laser lines can sample 150 profiles per second in best condition.

• Proceedings of the KWS Conference
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• 2002.05a
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• pp.49-52
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• 2002

A vision sensor measure range data using laser light source, This sensor generally use patterned laser which shaped single line. But this vision sensor cannot satisfy new trend which needs faster and more precise processing. The sensor's sampling rate increases as reduced image processing time. However, the sampling rate can not over 30fps, because a camera has mechanical sampling limit. If we use multi line laser pattern, we will measure multi range data in one image. In the case of using same sampling rate camera, number of 2D range data profile in one second is directly proportional to laser line's number. For example, the vision sensor using 5 laser lines can sample 150 profiles per second in best condition.