• 제목/요약/키워드: second-line

검색결과 2,332건 처리시간 0.037초

Design of Body RF Coil with Multiple Strips for Open MRI System by Pseudo Electric Dipole Radiation

  • 김경락;류승학;류연철;양형진;오창현
    • 대한자기공명의과학회:학술대회논문집
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    • 대한자기공명의과학회 2002년도 제7차 학술대회 초록집
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    • pp.76-76
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    • 2002
  • Purpose: The purpose of this study is to optimize the configuration of body RF coil composed of 4 planar subcoils for low field open MRI. Method: Our low field RE coil is composed of 4 subcoils assumed to be located at both the bottom and top sides of permanent magnet. Each subcoils has 3 main strips. The coil system has mirror inversion symmetry. First, the currents on the strips are obtained by inductance calculation and circuit analysis, Second, all the strips are divided into line strip elements across the strips, the self Inductances of line strip elements and the mutual inductances among the line strip elements are calculated, and current distributions of strip are obtained by circuit analysis, where each strip is considered as parallel combination of line strip elements. Finally all the line strip elements are segmented, magnetic field has been calculated by pseudo electric dipole radiation method, where the current elements are regarded as pseudo electric dipole radiation sources. We have performed above procedures for various configurations of RE coil. The field homogeneity is calculated in the 25 cm DSV.

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Process Metamorphosis and On-Line FEM for Mathematical Modeling of Metal Rolling-Part II: Application

  • Zamanian, A.;Nam, S.Y.;Shin, T.J.;Hwang, S.M.
    • 소성∙가공
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    • 제28권2호
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    • pp.89-97
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    • 2019
  • In this paper, we examine the application of a new concept - on-line FE model in various metal rolling processes. This technology allows for completion of process simulation within a tiny fraction of a second without losing the high level of prediction accuracy inherent to FEM. The procedure is systematically demonstrated through the design of actual on-line models for the prediction of the width spread in horizontal rolling of the slab using a dog bone profile and horizontal rolling of the strip with a strip profile. The validity and the prediction accuracy of the on-line FE models were analyzed and discussed.

Gemcitabine Plus Paclitaxel as Second-line Chemotherapy in Patients with Advanced Non-Small Cell Lung Cancer

  • Baykara, Meltem;Coskun, Ugur;Berk, Veli;Ozkan, Metin;Kaplan, Muhammet Ali;Benekli, Mustafa;Karaca, Halit;Inanc, Mevlude;Isikdogan, Abdurrahman;Sevinc, Alper;Elkiran, Emin Tamer;Demirci, Umut;Buyukberber, Suleyman
    • Asian Pacific Journal of Cancer Prevention
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    • 제13권10호
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    • pp.5119-5124
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    • 2012
  • Purpose: The aim of this retrospective study was to determine response rates, progression-free survival (PFS), overall survival (OS) and toxicity of gemcitabine and paclitaxel combinations with advanced or metastatic non-small cell lung cancer patients (NSCLC) who have progressive disease after platinum-based first-line chemotherapy. Methods: We retrospectively evaluated the file records of patients treated with gemcitabine plus paclitaxel in advanced or metastatic NSCLC cases in a second-line setting. The chemotherapy schedule was as follows: gemcitabine $1500mg/m^2$ and paclitaxel 150 mg/m2 administered every two weeks. Results: Forty-eight patients (45 male, 3 female) were evaluated; stage IIIB/IV 6/42; PS0, 8.3%, PS1, 72.9%, PS2, 18.8%; median age, 56 years old (range 38-76). Six (12.5%) patients showed a partial response (PR), 13 (27.1%) stable disease (SD), and 27 (56.3%) progressive disease (PD). The median OS was 6.63 months (95% CI 4.0-9.2); the median PFS was 2.7 months (95% CI 1.8-3.6). Grade 3 and 4 hematologic toxicities, including neutropenia (n=4, 8.4%), and anemia (n=3, 6.3%) were encountered, but no grade 3 or 4 thrombocytopenia. One patient developed febrile neutropenia. There were no interruption for reasons of toxicity and no exitus related to therapy. Conclusion: The combination of two-weekly gemcitabine plus paclitaxel was an effective and well-tolerated second-line chemotherapy regimen for advanced or metastatic NSCLC patients previously treated with platinum-containing chemotherapy. Although the most common and dose limiting toxicities were neutropenia and neuropathy, this regimen was tolerated well by the patients.

온라인 게임 캐릭터 복식 색채와 패션 트렌드 색채의 비교 분석 (Comparative Analysis of On-Line Game Characters' Costumes and Fashion Trend Color)

  • 신하나;이민선;유지헌
    • 복식문화연구
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    • 제18권3호
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    • pp.436-451
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    • 2010
  • The purpose of this study is to come up with ways that cooperate between on-line game design and fashion design by analyzing trend color and on-line game character's costume color in on-line game. As for the research methodology, First, on-line games were selected with reference to www.ranky.com. Second, 2009 SS trend color palettes suggested by Copenhagen International Fashion Fair was used as a criterion of fashion trend. Third, on-line game character's costume colors were analyzed in relation to the degree of reflection of trend and the game character's type. The results are as follows. Each on-line game character costume's colors were made in accordance with typical character types. But we can find a one-to-one correspondence between fashion trend colors and game character costume's colors. That's because both trends and character types are the results of the continuing interactions between human-beings and societies. In comparison with fashion trend colors, game character costume colors are partly raw and inharmonious. Therefore, it is necessary to apply fashion trend color in game character costume design for enhancing competitiveness in the world market.

Hypoxia-Inducible Factor 1 Promoter-Induced JAB1 Overexpression Enhances Chemotherapeutic Sensitivity of Lung Cancer Cell Line A549 in an Anoxic Environment

  • Hu, Ming-Dong;Xu, Jian-Cheng;Fan, Ye;Xie, Qi-Chao;Li, Qi;Zhou, Chang-Xi;Mao, Mei;Yang, Yu
    • Asian Pacific Journal of Cancer Prevention
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    • 제13권5호
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    • pp.2115-2120
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    • 2012
  • The presence of lung cancer cells in anoxic zones is a key cause od chemotherapeutic resistance. Thus, it is necessary to enhance the sensitivity of such lung cancer cells. However, loss of efficient gene therapeutic targeting and inefficient objective gene expression in the anoxic zone in lung cancer are dilemmas. In the present study, a eukaryotic expression plasmid pUC57-HRE-JAB1 driven by a hypoxia response elements promoter was constructed and introduced into lung cancer cell line A549. The cells were then exposed to a chemotherapeutic drug cis-diamminedichloroplatinum (C-DDP). qRT-PCR and western blotting were used to determine the mRNA and protein level and flow cytometry to examine the cell cycle and apoptosis of A549 transfected pUC57-HRE-JAB1. The results showed that JAB1 gene in the A549 was overexpressed after the transfection, cell proliferation being arrested in G1 phase and the apoptosis ratio significantly increased. Importantly, introduction of pUC57-HRE-JAB1 significantly increased the chemotherapeutic sensitivity of A549 in an anoxic environment. In conclusion, JAB1 overexpression might provide a novel strategy to overcome chemotherapeutic resistance in lung cancer.

우리나라 수준노선에서 실측중력에 의한 정사보정량 계산 (Calculation of orthometric correction by observed gravity at Korean benchmark line)

  • 김철영;이석배
    • 한국측량학회지
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    • 제29권3호
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    • pp.319-325
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    • 2011
  • 우리나라의 수준점은 성과계산에 있어서 실측중력에 의한 정사보정량 계산을 실시하지 않고 정규중력을 이용한 정사보정량 계산을 함으로써 정확한 정표고가 아닌 정규정표고를 사용하여 왔다. 본 연구에서는 우리나라 1,2등 수준노선을 대상으로 직접 중력을 관측하고 정사보정량을 계산하였으며, 그 결과에 따라 우리나라 수준점 체계개선방안을 제시하고자 하였다. 연구를 위하여 강원도 지역의 속초~강를구간의 1등수준 노선과 속사~인제구간의 2등 수준노선을 대상으로 CG5 디지털중력계를 이용하여 직접 중력관측을 실시하고 상대중력성과를 계산하였으며, 중력성과에 기초하여 정사보정량을 계산한 결과 1등 수준노선에서 최대 -0.349mm, 최대 -44.060mm의 값을 보였다. 따라서 우리나라에서 보다 정확한 수준점 체계로 개선하기 위해서는 실측중력에 의한 정사보정량의 계산과 정사보정량을 고려한 정표고 산정이 필요한 것으로 확인되었다.

사립대학도서관의 직제 현황에 관한 연구 (A study on the current status of private university library's line and staff organization)

  • 김성수
    • 한국도서관정보학회지
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    • 제24권
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    • pp.301-334
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    • 1996
  • This study is aimed at examination and analysis of current status of university library's line and staff organization especially the private university's. Motivation for this study is based on the following facts : First, the library work now is changing from the conventional one to automated one. Second, librarians in the front line must be trained in the newly set work because of the separation of work process in automated libraries. Methodologies of this study, apart from theoretical aspects, were visiting and interviewing librarians at 30 university libraries, examining the current status and problems of the line and staff organization of the university libraries. The result from the study is as follows: First, interviewing reveals that 35% of the 75 private university library is having 'associate directorship by librarian' system. Benefits from this system are described, recommending other University libraries adopt this system. This system su n.0, pplements the weak point of concurrent director's office of lay professor, as well as encourages librarian's morale by promotion. Second, the current organization of the university libraries are to be reformed. Namely, 1) the name of each division must be newly and a n.0, ppropriately set of changed suiting for the work of automated library, thus reforming the division. This must be conducted via collection of opinions of the Korean Library and Information Science Society' and associated organizations. 2) Newly formed division(for example, administrative division or division of operation and management, division conducting digital library work, etc.) must be added to the line and staff organization. 3) For information service division, there must be a certain number of subject specialists. 4) Status of the directorship of university library, librarianship, issue of renaming of university library are also described.

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서울지역 지하철역의 공기 중 오염인자의 노선별 분포 특성 (Distribution Characteristics between Line and Line for Indoor Air Pollutant Factors at Subway Stations in Seoul Area)

  • 김민영;라승훈;신도철;한규문;최금숙;정일현
    • 한국환경보건학회지
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    • 제24권2호
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    • pp.134-144
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    • 1998
  • A comprehensive air quality monitoring was carried out to investigate the criteria concentration of air pollutant in indoor of subway stations of Seoul City. The samples were collected twice per year (the first and the second half of the year) at each sampling point from February to September in 1997. Sampling point of subway stations was ticket office and platform. The measurement of indoor air pollutants such as sulfur dioxide(SO$_2$), nitrogen dioxide(NO$_2$), carbon monoxide(CO), carbon dioxide(CO$_2$), total suspended particulate(TSP) was performed to determine the indoor air quality. Heavy metals(Pb, Cd, Cu, Cr, As, Hg) were also measured together with those air pollutants. The annual average concentration of CO$_2$ and TSP in subway stations were relatively high while those of heavy metals were within 10% of environmental recommended standard concentration in all stations. As results of regression analysis between line and line of air factors, the concentrations of CO, CO$_2$, TSP, Pb, Cd, Cr and Cu were highly correlated, but those of $SO_2, NO_2$ and Hg were not correlated. As results of regression analysis between ticket office and platform, the concentrations of heavy metals such as Cr and Cu were highly correlated. Results of oneway analysis of variance between the first and the second half of the year air factors also indicated that CO, CO$_2$, Cd, Cu, Hg were significant($\alpha$=0.01), respectively. The average contration of total suspended particulate(TSP) in subway line No. 1 was shown high concentration(200 $\mu g/m^3\cdot$ day) level.

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Transmission-Line Transformer와 Harmonic Filter를 이용한 13.56 MHz 고효율 전류 모드 D급 전력증폭기 설계 (Design of High-Efficiency Current Mode Class-D Power Amplifier Using a Transmission-Line Transformer and Harmonic Filter at 13.56 MHz)

  • 서민철;정인오;이휘섭;양영구
    • 한국전자파학회논문지
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    • 제23권5호
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    • pp.624-631
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    • 2012
  • 본 논문은 Guanella의 1:1 transmission-line transformer와 harmonic filtering 방식을 이용한 13.56 MHz 고효율 전류 모드 D급(CMCD) 전력증폭기를 제안한다. 출력 정합 네트워크에 기존의 D급 전력증폭기의 부하 네트워크를 변형하여 harmonic filtering 방식을 포함시킴으로써 낮은 2차와 3차 고조파 특성을 얻었다. 제작된 CMCD 전력증폭기는 13.56 MHz의 CW 입력 신호를 사용하여 측정하였을 때, 13.4 dB의 전력 이득을 가지며, 44.4 dBm의 출력에서 84.6 %의 높은 PAE 특성을 나타내었다. 같은 출력에서 2차 3차 고조파는 각각 -50.3 dBc와 -46.4 dBc를 나타냈다.

한국어의 발화 길이 및 절 경계와 초점에 의한 점진하강(declination) 연구 (A Study on the Declination According to Length of Utterance, Clause Boundary and Focus in Korean)

  • 곽숙영
    • 말소리와 음성과학
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    • 제2권3호
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    • pp.11-22
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    • 2010
  • The present study attempts to investigate declination in Korean and its relevant aspects to the length of utterance, the clause boundary, and focus. More specifically, I examine the relation of declination with the length of utterance, the declination reset at the clause boundary, and the effect of focus on declination. Results showed that the length of utterance had no relation with the first and last pitch values of the utterance but that they were consistent regardless of the length of utterance. However, the declination slope changed to be relatively gentle from the fourth accentual phrase to the end of the whole intonational phrase. There was a reset of declination in such a way that the first pitch in the second phrase was always lower than that of the first phrase, but the first pitch in the third phrase was not always lower than that of the second phrase when the whole utterance was composed of three phrases. Finally, the pitch values of the focusing words decreased as their position went back in a sentence. One declination line was formed in the case of focused utterance, but in the case of an utterance that contained a clause boundary, a new declination line was formed at the start of each new clause. These findings can be applied to developing a Korean speech synthesizer that contains natural prosody; they can be also utilized for teaching Korean prosody.

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