• 대한인간공학회지
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• 제15권1호
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• pp.1-14
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• 1996

Menu-driven interfaces are frequently employed for user interfaces on many electronic products. Due to space constraint, a single or multi-line display is popularly used to show menu items unlike the software interfaces. Single or multi-line display present 8 .approx. 21. characters on an LCD screen and the user selects items using a series of button pushes. Multi-line displays are different from the single-line ones in the following aspects. First, they can present multiple line of information at the same time. Second, they can present menu items in a various way compared to single-line ones. However, due to their space constraint multi-line displays have many limitations compared to ordinary displays which usually use 14" screens. Therefore, guidelines are necessary for designing efficent multi-line display menus interfaces. In this study, a human factors experiment was conducted to examine the effects of three design variables which might affect the usability of a multi-line display menus. Factors investigated include menu structure, number of lines on the display, and item presentation method. Usability of the multi-line display menus was measured quantitatively in terms of four different aspects: speed, accuracy, inefficiency and preference. The analysis of variance was used not only to analyze the main effects of the factors and their interactions but also to see the differences between the single-line display menus and multi-line display ones. A set of design guidelines drawn from this study can be applied to the design of the user interfaces of a various types of electronic consumer products.

• Journal of Digestive Cancer Research
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• 제6권1호
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• pp.25-31
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• 2018

Background: In Korea, stomach cancer is the second most common malignancy and the third leading cause of cancer-related deaths. the time of diagnosis is very important for treatment so early detection and surgery are currently considered the mainstay of treatment, when diagnosed advanced with tumor extension through the gastric wall and direct extension into other organs, with metastatic involvement. Recently, new drugs, drug combinations, and multimodal approaches have been used to treat this disease and In cancers over expressing or amplifying HER2, the combination of cisplatin-fluoropyrimidine-trastuzumab is considered to be the treatment of reference. but At present, the choice of treatment schedule for HER2-negative tumors is based on the medical institution's preferences and adverse effects profile. The aim of this study was to evaluate the effectiveness and safety of using FOLFOX regimen as a first-line therapy or a salvage therapy in the patients with HER2-negative advanced or metastatic gastric cancer. Methods: We retrospective reviewed the patient medical record from March 2012 to July 2017. This study evaluated 113 patients. Sixty-eight patients were treated with the FOLFOX regimen for the first time (first-line group) and 45 patients were treated with the FOLFOX regimen as a second (35 patients) or third (10 patients) chemotherapy (salvage group). Results: In the first-line group, the response rate was 54.9%. In the salvage therapy group, the response rate was 24.4% and The difference was statistically significant (p=0.205). The median TTP of the first-line group was 10.7 months (95% confidence interval [95% CI], 7.8-13.7 months) and that of salvage line group was 6.1 months (95% CI, 3.8-8.4 months). The median OS of the first-line group was 15.8 months (95% CI, 12.7-18.9 months) and that of the salvage therapy group was 10.2 months (95% CI, 8.2-11.9 months). drug toxicity was similar andtolerable between two groups. Conclusion: In patients with unresctable metastatic gastric cancer, after failing to respond to first-line therapy, most patients have no alternative other than second-line therapy because the disease is highly progressive. if the performance status of the patient is good enough to be eligible to treatments beyond best supportive care. FOLFOX regimen can be a considerable therapeutic option for salvage treatment.

• 한국초등수학교육학회지
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• 제20권3호
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• pp.431-456
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• 2016

본 연구는 수직선의 적절한 도입 시기와 활용 방법을 탐구하여 초등학생들의 수개념 학습 지도를 위한 시사점을 제공하고자 하였다. 이를 위하여 수 개념 형성을 위한 수학적 모델인 수직선, 빈 수직선, 이중 수직선과 수 세기와 수 개념의 발달유형에 대하여 고찰하였고, 실제 초등학생들의 수직선 도입 시기와 활용 방법에 대한 사례 연구 결과를 분석하였다. 첫째, 수직선 도입을 2학년부터 실시하여 수직선의 은유적 개념에 대한 이해를 통해 이어지는 수 개념 학습에 도움이 될 수 있도록 조정할 필요가 있다. 둘째, 덧셈과 뺄셈과 같은 연산과정에서 다양한 사고 전략을 시각적으로 그려낼 수 있는 수학적 모델인 빈 수직선과 곱셈적 비교 상황이나 나눗셈이 이루어지는 상황인 등분제와 포함제, 비율이나 비례배분의 이해를 위한 시각적 모델인 이중 수직선을 적극적으로 도입하고 활용할 필요가 있다. 셋째, 수직선이나 빈 수직선, 이중 수직선을 도입할 때, 수직선의 은유적 개념을 충분히 이해할 수 있도록 구체적인 안내와 활용 방법에 대한 학습의 필요성을 제안하였다.

• 대한인간공학회:학술대회논문집
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• 대한인간공학회 1995년도 추계학술대회논문집
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• pp.41-45
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• 1995

Menu-driven interfaces are frequently employed for user -system interfaces on many electronic products. Due to the space and budget constraint, a single or multi-line display is used to show menu items. Single or Multi-line display present 8 .approx. 21 characters on an LCD screen and users select items using a series of button pushes. Multi-line displays are different from the single-line ones in the following aspects. First, they can present multiple menu items at the same time. Second, they can present menu items in a various way, for example, same-depth presentation, sub-depth presentation, previous selection, etc. In this study, a human factors experiment is being conducted to examine the effects of three independent variables on the design of a multi-line display. Factors investigated include menu structure, number of lines on the display, item presentation methodl. Usability of the multi-line display is being measured quantitatively in terms of four different aspects: task completion time, accuracy, inefficiency, user preference. A set of design guidelines will be drawn from this study which can be applied to usef-system interfaces of a various types of consumer products.

• 한국의류학회지
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• 제24권8호
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• pp.1177-1186
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• 2000

The Study was consist of clothing shape(H-line, A-line, V-line, X-line, O-line) and color(Blace, Grey1, Grey2, White). The main purpose of this study is to analyze image differences due to shape variation, image differences due to observers characteristic differences. The main findings can be summarized as follow. First, image differences due to shape variation are statistically significant ar five factors - the maturity level, the degree of softness, attractiveness, the degree of recognition, and the activity. But the degree of recognition is found out to be the least significant factor. H-line is estimated the mature image, A·X-line is estimated young, feminine and active image. Second, image differences by observers characteristics are various depending on the shape of clothing.

• 대한산업공학회지
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• 제27권1호
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• pp.95-102
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• 2001

The design of automobile body assembly line is one of essential parts for improving the process performance. The major objective of this research is to develop a performance evaluation model for automobile assembly line using a closed queueing network(CQN) and simulation method. In this study we used a two-step approach to compute the performance of the assembly line : first, we used CQN model considering assembly line equipments and the line operating time under the assumption of no failure, and second we used a well-known simulator FACTOR/AIM. Finally we implemented this model on a K automobile company and we have shown the sample results of automobile body assembly line.

• 대한기계학회논문집A
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• 제30권6호
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• pp.631-636
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• 2006

In this study, a model of pneumatic cylinder position control system considering dynamic characteristics of transmission line is proposed. The transfer characteristics of transmission line are assumed to be second order transfer function because the effect of resonance characteristics of transmission line under high frequency range can be neglected by the friction force and low pass characteristics of the pneumatic cylinder driving system. Therefore, the position control system including transmission line can be modeled by using a model of pneumatic cylinder driving system and the model of transmission line. The effectiveness of the proposed model is proved by comparison of simulation results using proposed model with experimental results.

• Asian Pacific Journal of Cancer Prevention
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• 제15권16호
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• pp.6587-6590
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• 2014

Objective: To further observe the efficacy and safety of pemetrexed, combined with Irinotecan or oxaliplatin or cisplatin in treating patients with advanced gastric cancer as second-line or third-line chemotherapy. Methods: From September 2013 to February 2014 we recruited 50 patients with advanced gastric cancer, with stage IV disease or postoperative recurrence, or unresectable. Then treated with pemetrexed based chemotherapy. After two cycles of treatment, efficacy and toxicity were evaluated. Results: Pemetrexed based chemotherapy was used as second-line in 33 patients, RR(CR+PR) is 41.2%. And achieved 36.4% when used as third-line. Overall response rate of 50 patients treated with Pemetrexed based treatment was 38% (CR+PR). Treatment related side effects were bone marrow suppression, vomiting, hepatic dysfunction and malaise.No treatment related death occurred. Conclusions: Treatment with pemetrexed based chemotherapy is active and is well tolerated in patients with advanced gastric cancer.

• Tuberculosis and Respiratory Diseases
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• 제67권3호
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• pp.191-198
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• 2009

Background: Pemetrexed, a multi-targeted antifolate has been used as a second line treatment against non-small cell lung cancer (NSCLC). We aimed to clarify the efficacy and survival according to line of treatment, histologic type, and expression of thymidylate synthase (TS). Methods: Ninety-eight patients were treated with pemetrexed as a second line treatment (n=43) or as an additional course of treatment (n=55). TS expression was studied with immunohistochemistry and graded as 0 to 3 based on the extent of expression. Results: The response rate (RR) in 98 subjects was 10.2% and the disease control rate (DCR=PR+SD) was 30.6%. RR and DCR were 12.7% and 32.7% in non-squamous cell carcinoma (NSQC) compared to 7.0% and 27.9% in squamous cell carcinoma (SQC) (p>.05). No significant differences in RR and DCR were observed between a second line group (4.7%, 20.9%) and a further line group (14.5%, 38.2%). A similar trend was observed in the 88 response evaluable subjects. TS was expressed in 28.6% (grade 1), 24.5% (grade 2) and 7.1% (grade 3), respectively, and it was not expressed in 39.8% of subjects. TS expression rate was significantly higher in the SQC (72.1%) compared to NSQC (50.9%, p=0.033). However, the efficacy of pemetrexed was not significantly different by the extent of TS expression. Conclusion: Pemetrexed showed efficacy, not only in a second-line setting, but also in further lines of treatment for NSCLC. The efficacy of pemetrexed tended to be higher in patients with NSQC compared to SQC. TS expression rate was significantly higher in SQC compared to NSQC.

• Journal of Digestive Cancer Research
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• 제2권1호
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• pp.28-31
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• 2014

췌장암은 예후가 매우 불량한 암으로 gemcitabine을 근간으로 하는 항암화학요법이 진행성 췌장암에 대한 표준치료이지만, 이러한 일차 항암화학요법에 반응이 없을 경우의 이차 항암화학요법에 대해서는 아직까지 정립된 것이 없는 상태이다. FOLFIRINOX 병합용법은 최근 여러 연구에서 일차 항암화학요법으로서의 치료 효과가 보고되고 있고, gemcitabine 항암화학요법에 반응이 없는 진행성 췌장암에 대한 이차 항암화학요법으로도 시도되어 양호한 치료 효과가 보고되고 있다. 저자들은 gemcitabine을 근간으로 하는 병합요법에 대해 반응이 없는 진행성 췌장암 환자에 대한 이차 항암화학요법으로 FOLFIRINOX 병합요법을 시행하여 완전 관해를 획득한 증례를 문헌고찰과 함께 보고하는 바이다.