• Asian Pacific Journal of Cancer Prevention
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• 제13권7호
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• pp.3379-3383
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• 2012

Objective: To investigate uPA and VEGF expression in esophageal cancer and relations with tumorous invasion and metastasis. Methods: Immunohistochemistry was used to detect uPA and VEGF expression in the normal epithelial tissue of esophageal mucosa and cancer tissue and detect CD34 labeled micrangium and analyze the relationships with clinical pathological features and tumor angiogenesis. Results: Positive rates for uPA and VEGF protein expression were significantly greater in esophageal cancer than normal epithelial tissue (P < 0.05), the two being linked (P <0.05). In addition, uPA and VEGF protein expression of the high microvessel density (MVD) group was significantly lower than in the low MVD group (P < 0.05), with relation to clinical pathological staging, differentiation and lymph node metastasis (P < 0.05). Conclusion: In esophageal cancer tissue, uPA and VEGF proteins are overexpressed and promote tumor angiogenesis, indicative of a poor prognosis.

• Clinical and Experimental Pediatrics
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• 제59권10호
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• pp.408-413
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• 2016

Purpose: This study investigated predictors of unresponsiveness to second-line intravenous immunoglobulin (IVIG) treatment for Kawasaki disease (KD). Methods: This was a single-center analysis of the medical records of 588 patients with KD who had been admitted to Asan Medical Center between 2006 and 2014. Related clinical and laboratory data were analyzed by univariate and multivariate logistic regression analyses. Results: Eighty (13.6%) of the 588 patients with KD were unresponsive to the initial IVIG treatment and received a second dose. For these 80 patients, univariate analysis of the laboratory results obtained before administering the second-line IVIG treatment showed that white blood cell count, neutrophil percent, hemoglobin level, platelet count, serum protein level, albumin level, potassium level, and C-reactive protein level were significant predictors. The addition of methyl prednisolone to the second-line regimen was not associated with treatment response (odds ratio [OR], 0.871; 95% confidence interval [CI], 0.216-3.512; P=0.846). Multivariate analysis revealed serum protein level to be the only predictor of unresponsiveness to the second-line treatment (OR, 0.160; 95% CI, 0.028-0.911; P=0.039). Receiver operating characteristic curve analysis to determine predictors of unresponsiveness to the second dose of IVIG showed a sensitivity of 100% and specificity of 72% at a serum protein cutoff level of <7.15 g/dL. Conclusion: The serum protein level of the patient prior to the second dose of IVIG is a significant predictor of unresponsiveness. The addition of methyl prednisolone to the second-line regimen produces no treatment benefit.

• 대한세포병리학회지
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• 제19권2호
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• pp.99-106
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• 2008

Background : Second opinion diagnosis of outside pathology slides is a common practice for efficient and proper patient management. We analyzed cytology slides from outside hospitals submitted for a second opinion diagnosis to determine whether the second opinion diagnosis had any influence on patient care. Methods : We reviewed 1,153 outside cytology slides referred to Asan Medical Center for second opinions from January, 2007, to December, 2007. All cases were categorized into three groups; no diagnostic discrepancy, minor diagnostic discrepancies (no impact on the management), and major diagnostic discrepancies (significant impact on the management and subsequent follow-up). Results : The thyroid was the most common organ system (933 cases, 80.9%), Forty cases (3.6%) belonged to the major diagnostic discrepancy group and 149 cases (12.8%) to the minor discrepancy group. For validation of second opinion diagnoses in major discrepancy cases, subsequent biopsy or surgical resection specimens and clinical information were reviewed, which were available in 29 cases. The second opinion diagnoses resulted in alteration of clinical management in 21 of 29 cases. Conclusion : For all referred patients, second opinion diagnosis is important and mandatory for appropriate patient care.

• 한국환경과학회지
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• 제28권4호
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• pp.441-454
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• 2019

The present study analyzes the characteristics of 43 typhoons that affected the Korean Peninsula between 2002 and 2015. The analysis was based on 3-second gust measurements, which is the maximum wind speed relevant for typhoon disaster prevention, using a typhoon disaster prevention model. And the distribution and characteristics of the 3-second gusts of four typhoons, RUSA, MAEMI, KOMPASU, and BOLAVEN that caused great damage, were also analyzed. The analysis show that between May and October during which typhoons affected the Korean Peninsula, the month with the highest frequency was August(13 times), followed by July and September with 12 occurrences each. Furthermore, the 3-second gust was strongest at 21.2 m/s in September, followed by 19.6 m/s in August. These results show that the Korean Peninsula was most frequently affected by typhoons in August and September, and the 3-second gusts were also the strongest during these two months. Typhoons MAEMI and KOMPASU showed distribution of strong 3-second gusts in the right area of the typhoon path, whereas typhoons RUSA and BOLAVEN showed strong 3-second gusts over the entire Korean Peninsula. Moreover, 3-second gusts amount of the ratio of 0.7 % in case of RUSA, 0.8 % at MAEMI, 3.3 % at KOMPASU, and 21.8 % at BOLAVEN showed as "very strong", based on the typhoon intensity classification criteria of the Korea Meteorological Administration. Based on the results of this study, a database was built with the frequencies of the monthly typhoons and 3-second gust data for all typhoons that affected the Korean Peninsula, which could be used as the basic data for developing a typhoon disaster prevention system.

• 한국간담췌외과학회지
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• 제27권4호
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• pp.415-422
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• 2023

Backgrounds/Aims: Although cancer survivors are at higher risk of developing second primary malignancies, cancer surveillance strategies for them have not yet been established. This study aimed to identify first primary cancers that had high risks of developing second primary exocrine pancreatic cancer (EPC). Methods: Data on individuals diagnosed with primary cancers between 1993 and 2017 were obtained from the Korea Central Cancer Registry. The standardized incidence ratios (SIRs) of second primary EPCs were analyzed according to the primary tumor sites and follow-up periods. Results: Among the 3,205,840 eligible individuals, 4,836 (0.15%) had second primary EPCs, which accounted for 5.8% of the total EPC patients in Korea. Between 1 and 5 years after the diagnosis of first primary cancers, SIRs of second primary EPCs were increased in patients whose first primary cancers were in the bile duct (males 2.99; females 5.03) in both sexes, and in the small intestine (3.43), gallbladder (3.21), and breast (1.26) in females. Among those who survived 5 or more years after the diagnosis of first primary cancers, SIRs of second primary EPCs were elevated in patients whose first primary cancers were in the bile duct (males 2.61; females 2.33), gallbladder (males 2.29; females 2.22), and kidney (males 1.39; females 1.73) in both sexes, and ovary (1.66) and breast (1.38) in females. Conclusions: Survivors of first primary bile duct, gallbladder, kidney, ovary, and female breast cancer should be closely monitored for the occurrence of second primary EPCs, even after 5 years of follow-up.

• 정보처리학회논문지C
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• 제10C권2호
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• pp.141-144
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• 2003

인가된 사용자가 패스워드를 입력하는 과정이 타인에게 관찰되어도 패스워드가 노출되지 않는 세계 최초의 패스워드 시스템인 듀얼 패스워드 시스템을 제안하고, 듀얼 패스워드 시스템이 사용자를 인증하는 과정을 제시한다. 듀얼 패스워드 시스템의 패스워드 입력은 first password와 second password의 동일한 위치에 있는 두 기호를 매칭하는 과정을 반복하여 이루어진다. 따라서, 패스워드로부터 first password와 second password를 유도하는 방법은 듀얼 패스워드 시스템에서 중요한 의미를 갖는다. 패스워드로부터 first password와 second password를 유도하는 방법과 관련하여 dual password derivation 문제를 정의하며, dual password derivation 문제의 해에 대한 평가 척도들을 제시한다.

• Journal of Information Technology Applications and Management
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• 제22권1호
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• pp.153-163
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• 2015

The purpose of this study is to investigate the relationship among factors that expand the win-win growth between domestic finished goods-making manufacturers and subcontractors. One-hundred twenty six firms participated for this study and were used for the data analysis. As a result of analysis, first, it was found that the win-win growth between first-tier suppliers and second-tier suppliers has positive effects on the win-win growth made by second-tier suppliers helping the third-tier suppliers. Second, it was found that the win-win growth policies supported by the government for the positive relationship between first-tier suppliers and second-tier suppliers for the finished goods-making manufacturers have positive effects on the win-win growth between second-tier suppliers and third-tier suppliers. Third, the results also showed that the win-win growth between second-tier suppliers and third-tier suppliers has a positive influence both on the financial and on the non-financial performances of the second-tier suppliers. Based on the results of this study, it is recommended to (1) construct infrastructure by sector through partnership between finished goods-making manufacturers and subcontractors, (2) draw in active support through the governmental win-win growth policies, (3) induce increasing productivities through information sharing, manpower support, technical support and educational support, and (4) strengthen and cultivate the culture of the small- and medium-sized companies.

• 한국전문물리치료학회지
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• 제8권3호
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• pp.77-95
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• 2001

The purpose of this study was to investigate the effects of resting periods between exercise sets during isokinetic contraction on recovery from muscle fatigue, strength, heart rate, blood pressure, and lactate level. Sixteen women performed 10 repetitions of isokinetic exercise for three sets in three different conditions. During the sets, they rested 50, 100, and 150 seconds in each condition. And the results were: 1) In this population, the peak torque of extensor during the isokinetic exercise in 100 second resting condition was significantly higher than that in 50 and 150 second resting conditions (p<.01). The total work of extensor was significant in the second and third sets in 50 and 100 second resting conditions (p<.01). 2) During the isokinetic exercise, the heart rate was progressively increased as the sets were advanced in all resting conditions (p<.01). And the increase was significant during the second and third sets than the first in 50 second resting condition (p<.01), while it was significantly greater after the third set than the first in 100 and 150 second resting conditions (p<.01). 4) No difference was found between the resting periods in blood lactate level and blood pressure during the isokinetic exercise. However, differences were found between the sets in these variables (p<.01).

• 한국컴퓨터정보학회논문지
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• 제22권10호
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• pp.47-54
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• 2017

In this paper, we propose a connected car platform architecture called Mobile Second for developing of verity convergence services. A Mobile Second platform architecture is designed to provide more powerful and diverse convergence services for vehicles and drivers by applying technologies of Connected Car and ICT Convergence in various ways. The Mobile Second platform is implemented by applying Tizen IVI and Android to hardware platforms for IVI, Nexcom's VTC1010 and Freescale's i.MX6q/dl respectively. The Mobile Second platform provides the driver with the vehicle's information via IVI devices, mobile devices and PCs, etc., and provides Vehicle Selective Gateway(VSG) and Vehicle Control Framework for the driver to control his/her vehicle, and also provides a web framework to enable the use of VSG's APIs for the monitoring and controlling the vehicle information in various mobile environments as well as IVI devices. Since the Mobile Second platform aims to create new variety of services for Connected Car, it includes service frameworks for Smart Care / Self diagonostics, Mood & Entertainment services, and Runtime, libraries and APIs needed for the development of related applications. The libraries given by the Mobile Second Platform provides both a native library for native application support and a Java Script-based library for web application support, minimizing the dependency on the platform and contributing the convenience of developers at the same time.

• Journal of Contemporary Eastern Asia
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• 제4권1호
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• pp.1-7
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• 2005

In this paper uses Kaname Akamatsu's 'Flying Geese' model to analyse Japan's role in East Asian integration. Japan made the first attempt to lead Asian countries before the Second World War. At that time, the Japanese Government embarked on a brutally expansionist policy the result of which was creation of the first gaggle of 'flying geese' under the name of the 'Greater East Asia Co-Prosperity Sphere.' During the 'flight' Japan was forcefully imposing its own ideals and values on the rest of the 'gaggle.' At the same time, the Japanese Government assumed hostile attitude toward Western countries. Japan's defeat in the Second World War signified the end of flight for the first 'flying geese' gaggle. After the war, Japan made another attempt at regional integration. This time it was done through establishing a production network in East Asia. Thus the second gaggle of 'flying geese' came into existence. During the flight of the 'second gaggle' of geese, Japan was fostering good ties with Western countries as well, especially the United States. However, some leaders of the 'second gaggle's' member-countries emboldened by their countries' economic success proclaimed that future belongs to Asia and put forward the 'Asian values' argument. The Asian economic crisis of 1997 interrupted the flight of the 'second gaggle' and effectively put an end to the 'Asian values' debate. It is interesting to note that some elements of the 'Asian values' argument resembled ultranationalist discourse that had been dominant in Japan before and during the Second World War. This paper compares historical patterns of East Asian regional integration and highlights future challenges for Japan's Asia policy.