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Elastic Liposome Formulation for Transdermal Delivery of Rutin (루틴의 피부 흡수 증진을 위한 탄성 리포좀 제형 연구)

  • Lim, Myoung-Sun;Han, Seat-Byeol;Kwon, Soon-Sik;Park, Min-A;Park, Soo-Nam
    • Journal of the Society of Cosmetic Scientists of Korea
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    • v.38 no.2
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    • pp.147-154
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    • 2012
  • In this study, we prepared elastic liposome containing rutin, known as antioxidants, and evaluated the physical characterization and enhanced skin permeation effect. The elastic liposome was prepared using the different ratios of egg phospholipids and $Tego^{(R)}$ care 450. The mean diameter of rutin loaded elastic liposomes formulations ranged between 205.7 ~ 298.0 nm and deforability 20.9 ~ 42.5, The loading efficiency was observed to be 52.0 ~ 71.0 %. The highest loading efficiency (71.0 %) and deformability (42.5) were observed at the optimal ratio of 85 : 15 (egg phospholipids : $Tego^{(R)}$ care 450) in the 0.1 % rutin loaded elastic liposome formulations. The elastic liposome formulation was selected for further transdermal permeation study. The elastic liposome(129.9 ${\mu}g/cm^2$) exhibited a significantly higher skin permeation compared with general liposome (98.0 ${\mu}g/cm^2$) and 1,3-butylene glycol (76.3 ${\mu}g/cm^2$) solution. These results suggest that the elastic liposome formulation using $Tego^{(R)}$ care 450 as a major edge activator could be useful for the delivery of active ingredient through the skin barrier.

Cellular Protective Effect and Liposome Formulation for Enhanced Transdermal Delivery of Isoquercitrin (Isoquercitrin의 세포 보호 작용과 피부 흡수 증진을 위한 리포좀 제형 연구)

  • Jo, Na-Rae;Gu, Hyun-A;Park, Su-Ah;Han, Seat-Byeol;Park, Soo-Nam
    • Journal of the Society of Cosmetic Scientists of Korea
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    • v.38 no.2
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    • pp.103-118
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    • 2012
  • In this study, the cellular protective effect of isoquercitrin against $H_2O_2$ and rose bengal-indued HaCaT cell damage was investigated. The ethosome and elastic liposome for enhanced transdermal delivery were prepared. Particle size, loading efficiency and cumulative permeated amounts of them were evaluated. Isoquercitrin didn't show any characteristic cytotoxicity at 50 ${\mu}M$. When HaCaT cells were treated with 5 mM $H_2O_2$ and 25 ${\mu}M$ rose bengal, isoquercitrin protected the cells against the oxidative damage in a concentration dependent manner (6.25 ~ 50 ${\mu}M$). The size of 0.03 % isoquercitrin loaded ethosome was 222.85 nm and the loading efficiency was 82.26 %. The ethosome loaded with 0.03 % isoquercitrin was stable and maintained the constant particle size for 2 weeks after being prepared. The ethosome exhibited more enhanced skin permeability than general liposome and ethanol solution. The optimal ratio of lipid to surfactant of 0.1 % isoquercitrin loaded elastic liposomes was observed to be 89 : 5 through evaluating particle size (341.2 nm), deformability index (59.89), loading efficiency (54.3 %), and skin permeability (54.4 %).

Factors Influencing Crash Severity by the Types of Bus Transportation Services Using Ordered Probit Models (순서형 프로빗 모형을 이용한 버스 운송사업 유형 별 사고심각도 영향요인 분석)

  • YOON, Sangwon;KHO, Seung-Young;KIM, Dong-Kyu
    • Journal of Korean Society of Transportation
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    • v.36 no.1
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    • pp.13-22
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    • 2018
  • Buses, one of the representative public transportation modes, are divided into a vareity of service types according to the purpose of operation, operating distance, and management agencies. Although bus-involved crashes may cause large amount of damage due to the higher number of passengers boarded on a bus, prior research has little focused on crash severity according to bus service types. This study aims to investigate factors influencing crash severity in bus-involved crashes and to present policy implications to reduce crash severity by bus service type. To do this, bus-involved crash data from the Traffic Accident Analysis System (TAAS) during five-year period are used. Ordered probit models for three types of bus service, i.e., city bus, suburban and express buses, and charter buses, are estimated to analyze the factors of accident severity. The results show that there are significant differences of factors affecting crash severity among the types of bus services while speed and road surface influence all the types of buses. In case of local buses, time of day, roadway alignment, and installation of a traffic signal are found to be statistically significant factors. Seat belt and road class have significant effects on injury severity of the intercity and express buses. Chartered buses have time of day, driving experience, seatbelt, traffic signal, and day of week as the significant factors. The results of this study are expected to contribute to the reduction of the crash severity by each bus service type.

Phytotoxicity of imazosulfuron+fentrazamide in different cultivation type of rice (Imazosulfuron+fentrazamide 혼합제의 재배양식에 따른 벼의 약해)

  • Won, OK Jae;Kang, Kwang Sik;Park, Su Hyuk;Eom, Min Yong;Hwang, Ki Seon;Suh, Su Jeong;Pyon, Jong Yeong;Park, Kee Woong
    • Korean Journal of Agricultural Science
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    • v.42 no.1
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    • pp.15-22
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    • 2015
  • This study was conducted to evaluate the phytotoxicity of imazosulfuron+fentrazamide mixture in rice field. It is recommended that safe herbicide application was obtained at 3 cm of transplanting depth and in sandy loam or loam soil type. In the direct water seeding of rice, imazosulfuron+fentrazamide SC should be applied at least 10 days before sowing land ower than 25+100 g ai/ha. In case of imazosulfuron+fentrazamide SC application after sowing, If we use the herbicide 15 days after sowing, no herbicide symptoms will be detected even though the amounts of the herbicide increase. In the rice transplanting, it is recommended that imazosulfuron+fentrazamide GR is applied 5 days after transplanting. In case of sequential herbicide application, the imazosulfuron+fentrazamide SC application at 75+300 g ai/ha 15 or 20 days after transplanting after the application at 25+100 g ai/ha or 50+200 g ai/ha 3 days before sowing increases weed control efficacy and gives no phytotoxicity in the rice growth.

Experiences of Ambulatory People with Disabilities on the Bus -Focus on Experiences of People with Disabilities Living in Rural Areas by Bus- (보행 가능한 장애인의 버스 이용 경험에 관한 질적 연구 - 시골지역 거주 장애인의 버스 이용 경험을 중심으로 -)

  • Yoo, Doo-Han;Park, Hun-kyung;Jeon, Byoung-Jin
    • The Journal of Korean society of community based occupational therapy
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    • v.1 no.1
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    • pp.7-17
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    • 2011
  • Objective : This study aimed to understand the experience of taking a bus, investigate successful strategies to overcome the psychological difficulties of people with disabilities. Method : In this study, a phenomenological and hermeneutic approach was used to gain a deeper understanding of the behavior, the language, the process. For participants through interviews and participant observation data were collected. Phenomenological interpretation of the way through technology and to evaluate the results. Result : Ambulatory persons with disabilities in the community have confidence in the bus-independent movement in the community possible. And get on and off the bus at the moment of urgent strategies to use in the bus seats were taken. To cope with unexpected situations like that do not put stress was confirmed. In addition, by bus and go sit on the seat to look at the patient's burden was to. Conclusion : Ambulant disabled people's confidence in the bus had a significant impact on the independent movement. Always on the lookout for falling, and many psychological difficulties and to overcome unforeseen circumstances to predict and know that public transportation could be.

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The Effects of Different Backrest Pivot Positions on the Human Body During Reclining of the Office Chair (사무용 의자에서 등판의 회전축 위치가 틸트시 인체에 미치는 영향)

  • Chung, Kyung-Ryul;Hyeong, Joon-Ho;Choi, Chun-Ho;Kim, Sa-Yup;Hong, Gyu-Seog
    • Transactions of the Korean Society of Mechanical Engineers A
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    • v.34 no.2
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    • pp.167-174
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    • 2010
  • In this study, the optimal position for the backrest pivot of an office chair was investigated by evaluating its performance in terms of the lumbar support and sliding distance of the back from the backrest during tilting motions. The simulation was performed using a mathematical model, which included a human body and a chair. Forty-two backrest pivot points were selected on the sagittal plane around the hip joint of a sitting model. A motion analysis study was also performed using a prototype of an office chair (A-type) with a backrest pivot located on the hip joint of a normal Korean model and a typical office chair (B-type) with its pivot located under the seat. The simulation results showed that both the lordosis angle and the slide distance of the back were minimized when the backrest pivot was positioned close to the hip joint. The experimental results showed that the slide distance and gap between the sitter's lumbar and the backrest was smaller with the A-type than the B-type. Based on the simulation and experimental results, it can be concluded that the backrest can support the sitter's lumbar area more effectively as the pivot position for reclining approaches closer to the hip joint. In this position, the sitter can maintain a comfortable and healthy sitting posture. This paper presents the methods and guidelines for designing an office chair with ergonomic considerations.

Global Trends of Sciences Information on the Sour Gas (사워가스 학술정보 동향)

  • Cho, Jin Dong
    • Economic and Environmental Geology
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    • v.48 no.1
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    • pp.89-101
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    • 2015
  • The sour gas is natural gas containing components such as hydrogen sulphide and carbon dioxide that form acids when mixed with water. Element sulfur precipitates from sour gas when reservoir pressure and temperature decrease. According to the International Energy Agency, about 43% of the world's natural gas reserves(2,580 tcf or 73.057 tcm), excluding North America, are sour. The sour gas is often derived from the Germanic word 'sauer or acidic' and the etymology referred to as 'sour'. Sour gas requires special handling and infrastructure because it contains significant amounts of hydrogen sulphide, making it highly corrosive, flammable and explosive, and there fore more costly and dangerous to process. So the business of sour gas is affected by two important factors: the economic value of the gas, and the methods used in its production. According to be analyzed in the academic literature to sour gas(2000~2014) by the program of 'web of science', the research activities 145 papers in sour gas.

Prospects for Worldwide CBM(Coalbed Methane) Development (세계 석탄층메탄가스(CBM) 개발전망)

  • Kim, Young-In
    • Economic and Environmental Geology
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    • v.48 no.1
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    • pp.65-75
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    • 2015
  • The CBM(Coalbed Methane) development technology being developed in mid 1980s is the technology to produce the methane gas absorbed in the coal bed. CBM is easy to be developed and its coal deposit is abundant. Therefore, the CBM industry has a large potential as an energy source as well as to deal with the global regulations for reducing greenhouse gas emission. In order to produce coal, the CBM should first be developed as a preliminary action for mine security. So CBM is advantageous in reducing the global greenhouse gas as well as its advantage not being influenced by the changes in gas market. The ECBM (Enhanced Coalbed Methane) is a new technique producing the methane gas which is substituted and disorbed from coal by injecting $CO_2$ or $N_2$ gas into a coal bed. Especially, $CO_2$-ECMB is a low-carbon, green-growth technology, so can expect to the effect of green gas reduction as well as the improved productivity of methane gas. CBM technology is being developed in about 40 nations including Canada, Australia, China, India, Indonesia and Viet Nam, and the coal output using this technology is continually being increased. The CBM is expected to contribute in changing the energy source paradigm from current coal & petroleum energy to unconventional gas.

Fuel cell based CHP technologies for residential sector (연료전지와 마이크로 열병합 발전기술)

  • Son, Young Mok
    • Journal of Energy Engineering
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    • v.25 no.4
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    • pp.251-258
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    • 2016
  • This article reports current status of micro fuel cell-combined heat and power (${\mu}FC$-CHP) systems which utilize both power and heat generated by fuel cells. There are several options for constructing CHP systems and among them, fuel cells are the most useful and their total energy efficiency combining heat and power can reach up to about 90%. Fuel cells are classified as five types based on the electrolyte, but the most suitable fuel cell types for the ${\mu}FC$-CHP system are proton exchange membrane fuel cells (PEMFCs) and solid oxide fuel cells (SOFCs). ${\mu}FC$-CHP systems have several advantages such as decrease of the transmission-distribution loss, reduced costs of electricity due to distributed power generation, and environmental-friendliness owing to zero emission. The main drawback of the ${\mu}FC$-CHP systems is the high initial investment, however, it keeps decreasing as the technology development reduces production costs. Currently, Japan is the most leading country of the ${\mu}FC$-CHP market, however, Korea tries to expand the market by planning the deployment of 1 million units of ${\mu}FC$-CHP systems and governmental subsidiary supporting of half of the install price. In this report, integration technologies for connecting FC and CHP, and technology trends of leading countries are presented as well.

Resistance to ACCase Inhibitor Cyhalofop-butyl in Echinochloa oryzicola Collected in Gyeongsangnam-do Province of Korea (ACCase 저해 제초제 cyhalofop-butyl에 대한 경남지방 수집종 피의 저항성)

  • Won, Jong Chan;Won, Ok Jae;Ha, Jun;Im, Il-Bin;Kang, Kwang Sik;Pyon, Jong Yeong;Park, Kee Woong;Lee, Jeung Joo
    • Weed & Turfgrass Science
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    • v.7 no.2
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    • pp.166-169
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    • 2018
  • Repeated use of ACCase inhibiting herbicides for a long time has resulted in increases of resistant Echinochloa oryzicola populations in paddy fields in middle west area of Korea. This study aims to investigate current status of herbicide resistant E. oryzicola in Gyeongsangnam-do, in which there is less information about herbicide resistance. For resistance frequency and dose-response study, seeds from 100 individual plants of E. oryzicola in Gyeongsangnam-do were collected and tested with cyhalofop-butyl. Seven percent of plants from Gyeongsangnam-do was resistant at a recommended rate of cyhalofop-butyl. $GR_{50}$ values (herbicide rates required to reduce plant growth 50%) for one representative resistant populations and five susceptible populations were $738g\;a.i.\;ha^{-1}$ and 66-234 (average 147)$g\;a.i.\;ha^{-1}$, respectively, indicating average 5 times difference in resistance. Although lower rate of frequency of herbicide resistance in Gyeongsangnam-do than in Jeollabuk-do, increases of herbicide resistance are expected in this area because of increases of direct seeded rice fields and increases of dependence on a specific herbicide. Therefore, it is necessary to monitor herbicide resistance regularly and conduct integrated herbicide resistance management in this area.