• Nuclear Medicine and Molecular Imaging
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• v.40 no.3
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• pp.141-147
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• 2006

PET detects only less than 50% of early gastric cancer and 62-98% of advanced gastric cancer. Therefore, mass screening programs are recommended for all adults over the age of 40 for early detection and early treatment of gastric cancer through endoscopy or various radiological tests. The most important step after being diagnosed with gastric cancer is accurate staging, which mainly evaluates tumor resectability to avoid unnecessary surgery. Important factors that affect tumor resectability are whether the tumor can be separated from adjacent organs or important blood vessels, the extent of lymph node metastasis, presence of peritoneal metastasis, or distant organ metastasis. To evaluate the extent of local tumor invasion, anatomical imaging that has superior spatial resolution is essential. There are a few studies on prognostic significance of FDG uptake with inconsistent results between them. In spite of lower sensitivities for lymph node staging, the specificities of CT and PET are very high, and the specificity for PET tends to be higher than that for CT. Limited data published so far show that PET seems less useful in the detection of lung and bone metastasis. In the evaluation of pleural or peritoneal metastasis, PET seems very specific but insensitive as well. When FDG uptake of the primary tumor is low, the distant metastasis is also known to show low FDG uptake reducing its detection. There are only a few data available in the evaluation of recurrence detection and treatment response using FDG PET.

• Journal of Korean Academic Society of Home Health Care Nursing
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• v.15 no.2
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• pp.75-81
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• 2008

Purpose: We analyzed the health care and health status of immigrant women married to Koreans in our community. Methods: We recruited 204 women who live in S Cityfrom 1st August to 30th September, 2008. A cross-sectional descriptive survey was done using a questionnaire through interviews and physical assessment by visiting nurses. Results: The average age of the subjects was 29.8 and most of them were housewives. Sixteen percent of them obese as measured by BMI. Moreover, most participants (86%) did not exercise at all. Over 13% complained of physical discomfort that was left untreated, and only 50% participated in cancer screening. Conclusions: Young, obese immigrant women require further health care monitoring. Caregivers also should ask about physical discomfort and cancer screenings. However, caregivers should do so in a culturally sensitive manner. In addition, the government should support cancer detection programs for immigrant women.

• Asian Oncology Nursing
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• v.5 no.2
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• pp.146-158
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• 2005

Purpose: This study was to obtain a understanding of breast cancer women with high risk for hereditary cancer syndrome. Method: A micro-ethnography was used, including participation observation, open-ended in-depth interviews. Results: Two major arguments were derived. First, When Korean women at high risk to hereditary breast cancer make a decision about whether to take a genetic test, they are strongly motivated by a desire to preserve close kinship bonds and "family love" among their siblings, parents and children. Second, Even after genetic risk assessment and counseling services, Korean women at high-risk for developing a hereditary breast cancer who have been informed that they are mutation carriers, still hold onto previous beliefs about cancer causation. Their cancer prevention strategies are constructed according to their unchanged perceptions and beliefs about cancer causation. Conclusion: More sensitive genetic counseling program needs to be developed. Referral programs and clinical services must be attentive to cultural values and beliefs otherwise cultural attitudes and practices toward genetic counseling will not change.

• Bulletin of the Korean Chemical Society
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• v.34 no.4
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• pp.1051-1054
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• 2013

Closo-carborane has been considered as an efficient boron-carrier for boron neutron capture therapy (BNCT) and an attractive surrogate of lipophilic phenyl or cyclohexyl ring in drug design. Despite a great number of carborane-containing ligands have been synthesized and evaluated, molecular modeling studies of carborane ligands with macromolecules have been rarely reported. We herein describe a facile docking and scoring-function strategy of 16 carborane ligands with an estrogen receptor by using the commercial Gaussian, Chem3D Pro and Discovery Studio (DS) computational programs. Docked poses of the carborane ligands in silico exhibited similar binding modes to that of the crystal ligand in the active site of estrogen receptor. Score analysis of the best docked pose for each ligand indicated that the Ligscore1 and the Dockscore have a moderate correlation with in vitro biological activity. This is the first report on the scoring-correlation studies of carborane ligands with macromolecules. The integrated Gaussian-DS approach has a potential application for virtual screening, De novo design, and optimization of carborane ligands in medicinal chemistry.

• Research in Community and Public Health Nursing
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• v.23 no.4
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• pp.386-394
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• 2012

Purpose: The purpose of this study is to investigate the factors influencing suicidal ideation in middle school students. Methods: Suicidal Ideation Questionnaire (SIQ) results, personal characteristics, child abuse experiences, and stress were obtained from a sample of 657 middle school students from 3 conveniently selected schools in S city. Results: Suicidal ideation of participants was positively correlated with child abuse experience, stress, psychosomatic symptoms, antisocial personality and depressive tendencies, whereas sociability and self-esteem were negatively correlated with suicidal ideation. Significant factors influencing suicidal ideation included an antisocial personality tendency, stress related to the family environment, mental abuse, gender (female), depressive trend, running away from home, sociability, and stress related to academic performance. These factors explained 39.9% of the variance. Conclusion: These results suggest that earlier screening and intervention programs for depression and stress in middle school students will be helpful in reducing suicidal ideation. Further studies are needed in which other strategies that could prevent suicidal ideation in middle school students are examined.

• Journal of Korean Academy of Nursing
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• v.38 no.6
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• pp.779-788
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• 2008

Purpose: This study was designed to construct a structural model explaining depression in university students. Methods: Data were collected from 1,640 university students by questionnaire, and analyzed using AMOS 5.0 to test the hypothetical model. Results: Fitness statistics for the modified model were GFI=.93, AGFI=.89, NFI=.91, and RMSEA=.081. All the 12 paths in the modified model proved to be statistically significant. Depression of university students accounted for 52% of the covariance by the factors. The factor that had the most influence on depression was individual vulnerability, and followed by sequence order, stress, social support, coping, and self-efficacy. Depression was influenced directly by individual vulnerability, stress, social support, and coping, and indirectly by individual vulnerability, stress, social support, and self-efficacy. Conclusion: A screening and management system for the high risk group is needed to effectively prevent depression and reduce rate of depression in university students. Detailed support programs which specifically deal with prevailing stressors should be developed to effectively reduce the harmful effects of individual vulnerability and stress. It is anticipated that the model constructed in this study could be utilized as a reference in developing various strategies to prevent and intervene depression in university students.

• Korean Journal of Plant Resources
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• v.27 no.3
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• pp.236-241
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• 2014

A sex-linked random amplified polymorphic DNA (RAPD) marker was identified from Asparagus officinalis L. and was converted into a sequence-characterized amplified regions (SCAR) marker for the large-scale screening of male and female plants. A total of 100 arbitrary decamer oligonucleotide primers were used for the RAPD analysis. Among them, the primer UBC347 amplified one female-specific 400 base pair DNA. Subsequently, the amplified RAPD fragment was cloned and sequenced. The fragment was abundant in AT and shared sequence homology with retrotransposon elements. On the basis of the sequence obtained, a pair of SCAR primer was designed. The amplification product, named F400, was the same size as the respective RAPD fragment from which it was derived. The F400 SCAR marker resulted to be female-specific in the three asparagus varieties tested in this study. This SCAR marker can be used for an early and rapid identification of female and male plants during breeding programs of asparagus.

• Research in Community and Public Health Nursing
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• v.17 no.3
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• pp.387-396
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• 2006

Purpose: This cross-sectional study was conducted to investigate the prevalence of health risk behaviors by gender and grade and to examine the correlation between health risk behaviors and self-efficacy in early adolescents. Method: The sample of this study consisted of 1.693 early adolescents recruited from 7 middle schools in S-Gu, Seoul, Korea. Health risk behaviors were measured by the Youth Risk Behavior Surveillance Survey (YRBS). Self-Efficacy was assessed by General Self-Efficacy (GSE). Results: About a third of the subjects had experience in drinking behavior about 19.4% in cigarette smoking (including cases of just one or two puffs), 25.9% in physical fight, 29.1% in thought about killing themselves (suicide-related behavior), 1.5% in drug. More than a half (60.5%) experienced at least one health risk behavior. Female students were more likely to report drinking experience and suicide-related experience. Health risk behaviors were not significantly correlated with self-efficacy in early adolescents. Conclusions: Many early adolescents had experience in health risk behaviors in the past. The findings of this research suggest the necessity of intensive prevention programs in middle school to motivate and prepare students to avoid these behaviors. In addition, these results may help health professionals plan appropriate screening and counselling for health problems in early adolescents.

• Journal of Korean society of Dental Hygiene
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• v.20 no.3
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• pp.257-268
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• 2020

Objectives: This purpose of this study was to examine the trends in interventional research and analyze the contents and results of intervention through a systematic literature review of the domestic research literature, suggesting the effect of an oral care program on elementary school students. Methods: A total of 262 articles were retrieved initially, and the duplicate articles were then removed, excluded after screening titles, abstracts, and full-text articles. Finally, a total of 16 papers were used in the review. Results: The study included 9 articles with the nonequivalent control group pretest-posttest design and 7 with the one-group pretest-posttest design. All articles were of non-randomized studies. The most common index of the interventional effect was dental plaque. Further, oral health behaviors and knowledge, perception, self-efficacy, and DMFT index were common indices. In the quality assessment, in the "blinding of outcome assessment" among six items of ROBANS, 12 studies showed a high risk of bias. Conclusions: In order to develop an interventional oral health care program for elementary school students and evaluate the effectiveness, a strict research design and qualitative improvement of research reports are required, and continuous research should be conducted to develop a systematic protocol.

• The Plant Pathology Journal
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• v.17 no.2
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• pp.67-70
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• 2001

Medicago truncatula is a diploid legume plant related to the forage crop alfalfa. Recently, it has been chosen as a model species for genomic studies due to its small genome, self-fertility, short generation time, and high transformation efficiency. M. truncatula engages in symbiosis with nitrogen-fixing soil bacterium Rhizobium meliloti. M. truncatula mutants that are defective in nodulation and developmental processes have been generated. Some of these mutants exhibited altered phenotypes in symbiotic responses such as root hair deformation, expression of nodulin genes, and calcium spiking. Thus, the genes controlling these traits are likely to encode functions that are required for Nod-factor signal transduction pathways. To facilitate genome analysis and map-based cloning of symbiotic genes, a bacterial artificial chromosome library was constructed. An efficient polymerase chain reaction-based screening of the library was devised to fasten physical mapping of specific genomic regions. As a genomics approach, comparative mapping revealed high levels of macro- and microsynteny between M. truncatula and other legume genomes. Expressed sequence tags and microarray profiles reflecting the genetic and biochemical events associated with the development and environmental interactions of M. truncatula are assembled in the databases. Together, these genomics programs will help enrich our understanding of the legume biology.