• 제목/요약/키워드: science laboratory

검색결과 15,981건 처리시간 0.042초

Identification of urinary metabolite(s) of CKD-712 by gas chromatography/mass spectrometry in rats

  • Jean, Hee-Kyung;Choi, Hae-Yeon;Kim, Youn-Jung;Kwon, Oh-Seung;Ryu, Jae-Chun
    • 대한약학회:학술대회논문집
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    • 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.1
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    • pp.314.1-314.1
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    • 2003

  • Examination was made of the urinary metabolite(s) of CKD-712, which is a chiral compound, named S-YS49 derived from higenamine (one component of Aconite spp.) derivatives. First of all. to analyze the metabolite(s) of CKD-712, a simple and sensitive detection method for CKD-712 was developed by using gas chromatography-mass spectrometry(GC/MS). (omitted)

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Antiplatelet Effects of Cordycepin-Enriched WIB-801CE from Cordyceps militaris: Involvement of Thromboxane A2, Serotonin, Cyclooxygenase-1, Thromboxane A2 Synthase, Cytosolic Phospholipase A2

  • Ok, Woo Jeong;Nam, Gi Suk;Kim, Min Ji;Kwon, Hyuk-Woo;Kim, Hyun-Hong;Shin, Jung-Hae;Lim, Deok Hwi;Kwon, Ho-Kyun;Lee, Chang-Hwan;Chung, Soo-Hak;Kim, Jong-Lae;Park, Hwa-Jin
    • 대한의생명과학회지
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    • 제22권4호
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    • pp.127-139
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    • 2016

  • A species of the fungal genus Cordyceps has been used as an ingredient of traditional Chinese medicine. In this study, we prepared cordycepin-enriched WIB-801CE, an ethanol extract from culture solution of Cordyceps militaris-hypha, and evaluated its antiplatelet effects on human platelet aggregation. WIB-801CE dose-dependently inhibited ADP-, collagen-, and thrombin-induced platelet aggregation. These antiplatelet effects by WIB-801CE were associated with the attenuation of thromboxane $A_2$ ($TXA_2$) production and serotonin release by ADP, collagen, and thrombin. The inhibition of $TXA_2$ production by WIB-801CE was due to the inhibition of cyclooxygenase-1, $TXA_2$ synthase, and cytosolic phospholipase $A_2$ activity. Therefore, these data suggest that WIB-801CE may be a beneficial component against protection from platelet aggregation-mediated thrombotic disease.

  • https://doi.org/10.15616/BSL.2016.22.4.127 인용 PDF KSCI

Factors Affecting the Job Performance of Clinical Laboratory Scientists

  • 심문정
    • 대한임상검사과학회지
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    • 제41권3호
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    • pp.140-144
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    • 2009

  • Clinical laboratory testing plays a crucial role in the detection, diagnosis, and treatment of disease. Clinical laboratory scientists evaluate test results, develop and modify procedures, and establish and monitor programs, to ensure the accuracy of tests. It is clear that over the past decade the role of the clinical laboratory scientists has expanded and this process will be continued into the future. The purpose of this study is to clarify the factors influencing the job performance of clinical laboratory scientists and aim to provide the role and duties of clinical laboratory scientists. To examine the frequency of work context and the importance of task, the surveys were conducted on 168 clinical laboratory scientists. The questionnaire items were used 10 score by Likert scale. According to the results of this study, the important factor affecting the job performance was "Analyze laboratory findings to check the accuracy of the results", and the next factors were "Establish and monitor quality assurance programs", "Enter data from analyzer into computer", "Calibrate and maintain equipment". And the factors of "repeating same tasks" and "spend time making repetitive motions" were answered the highest. This study will provide strategies for improving work environment, developing education curriculum and method, and role of clinical laboratory scientists. We must continually upgrade our knowledge, and identify the new trends in technology and science and accept changes.

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