• Journal of the Korean Applied Science and Technology
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• v.41 no.2
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• pp.292-304
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• 2024

This study compared and evaluated the antioxidant activities of Symphoricarpos albus(S. albus) extract and fermented extract. Antioxidant activity was measured by DPPH radical scavenging, FRAP, and ABTS. Concentrations were measured at 200, 100, 50, and 10 ㎍/mL, and antioxidant activity increased in a concentration-dependent manner. S. albus leaves fermented extracts had the highest antioxidant activity. And this study evaluated the safety and tail regeneration of S. albus extract using zebrafish model embryos. Zebrafish are in the spotlight as an alternative animal and can be used for cosmetic research. Zebrafish embryos were collected and evaluated for coagulation rate, hatching rate, and cardiotoxicity. As a result, it was toxic at concentrations above 100 ㎍/ml. The tail was cut and the regenerative effect was observed for 3 days. As a result, from 72 hours, S. albus 200ug/ml leaf extract showed a 17% regenerative effect compared to the control group. These results suggest that S. albus can be used as a natural material for antioxidant and regeneration for skin improvement.

• Tunnel and Underground Space
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• v.34 no.1
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• pp.1-14
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• 2024

An image-reconstruction technology, involving the deployment of an unmanned mobility equipped with high-speed LiDAR (Light Detection And Ranging) has been proposed to reconstruct the shape of abandoned mine. Unmanned mobility operation is remarkably useful in abandoned mines fraught with operational difficulties including, but not limited to, obstacles, sludge, underwater and narrow tunnel with the diameter of 1.5 m or more. For cases of real abandoned mines, quadruped robots, quadcopter drones and underwater drones are respectively deployed on land, air, and water-filled sites. In addition to the advantage of scanning the abandoned mines with 2D solid-state lidar sensors, rotation of radiation at an inclination angle offers an increased efficiency for simultaneous reconstruction of mineshaft shapes and detecting obstacles. Sensor and robot posture were used for computing rotation matrices that helped compute geographical coordinates of the solid-state lidar data. Next, the quadruped robot scanned the actual site to reconstruct tunnel shape. Lastly, the optimal elements necessary to increase utility in actual fields were found and proposed.

• Journal of the Society of Disaster Information
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• v.20 no.1
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• pp.20-31
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• 2024

Purpose: Research and development of high-strength concrete enables high-rise buildings and reduces the self-weight of the structure by reducing the cross-section, thereby reducing the thickness of beams and slabs to build more floors. A large effective space can be secured and the amount of reinforcement and concrete used to designate the base surface can be reduced. Method: In terms of field construction and quality, the effect of reducing the occurrence of drying shrinkage can be confirmed by studying the combination of low water bonding ratio and minimizing bleeding on the concrete surface. Result: The ease of site construction was confirmed due to the high self-charging property due to the increased fluidity by using high-performance water reducing agents, and the advantage of shortening the time to remove the formwork by expressing the early strength of concrete was confirmed. These experimental results show that the field application of ultra-high-strength concrete with a design standard strength of 100 MPa or higher can be expanded in high-rise buildings. Through this study, we experimented and evaluated whether ultra-high-strength concrete with a strength of 130 MPa or higher, considering the applicability of high-rise buildings with more than 120 floors in Korea, could be applied in the field. Conclusion: This study found the optimal mixing ratio studied by various methods of indoor basic experiments to confirm the applicability of ultra-high strength, produced 130MPa ultra-high strength concrete at a ready-mixed concrete factory similar to the real size, and tested the applicability of concrete to the fluidity and strength expression and hydration heat.

• Journal of the Society of Disaster Information
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• v.20 no.1
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• pp.169-176
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• 2024

Purpose: In this paper, an experimental study was conducted to analyze the difference in shear strength caused by the problem of excluding coarse particles due to the size of the test specimen in the direct shear test. Method: A large-scale direct shear test was conducted on three weathered soils containing coarse aggregates with a maximum diameter of 50mm. In addition, a small-scale direct shear test was performed using a sample with a maximum diameter of 5 mm, excluding coarse aggregates. Result: In the case of the small-scale direct shear test, compared to the results of the large-scale direct shear test containing large particles, the internal friction angle was about 2.3% smaller, and there was no significant difference. In terms of cohesion, compared to the large-scale direct shear test, the small-scale direct shear test derived about 80.3% smaller value, showing a relatively large difference. Conclusion: In the large-scale direct shear test, it was analyzed that the coarse particles had a greater impact on the cohesion than the internal friction angle. Therefore, granite weathered clay containing coarse particles is judged to have the same shear strength as the cohesive force that is not affected by vertical stress. In this study, it was analyzed that the small-scale direct shear test, which excludes the coarse particles that are commonly used, provides results on the safety side by excluding the effect of coarse particles.

• The Journal of Korean Medicine
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• v.44 no.4
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• pp.41-58
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• 2023

Objectives: This retrospective observational study aimed to investigate the efficacy and safety of Cheongpebaedok-tang, a traditional Korean herbal medicine, provided via telemedicine to patients with asymptomatic to mild COVID-19 in Korea. Methods: From February to April 2020, a retrospective analysis investigated COVID-19 patients treated via Korean telemedicine. The study involved asymptomatic to mild cases receiving Cheongpebaedok-tang more than three times, along with continuous Korean medicine care in convalescence. Diagnoses and treatment adhered to the telemedicine guidelines of the Association of Korean Medicine, with varied Cheongpebaedok-tang prescriptions based on symptom severity. Symptom evaluation involved a detailed assessment using a 15-item tool at initial and final sessions. Results: The study included 27 patients, with a mean age of 48.7 ± 2.3 years (mean ± standard error). Patients began self-administering oral Cheongpebaedok-tang for an average of 19.4 ± 1.8 days after the date of COVID-19 diagnosis confirmation and continued the medication for 15.8 ± 1.2 days. The reported side effects of the Cheongpebaedok-tang included palpitations (11.1%), insomnia (7.4%), dizziness (3.7%), and diarrhea (3.7%). All side effects disappeared after adjusting the prescription according to standard treatment guidelines. The occurrence of all COVID-19-related adverse symptoms, except fatigue and myalgia, decreased. Fatigue was the most common chronic symptom persisting after 6 months (51.9%), followed by ocular symptoms (37.0%) and sore throat (22.2%). Conclusions: This study implies Cheongpebaedok-tang may offer a potentially safe, symptom-alleviating approach for managing mild COVID-19 cases via telemedicine, although further comprehensive research is warranted.

• Journal of Applied Biological Chemistry
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• v.66
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• pp.114-121
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• 2023

Selective cyclooxygenase (COX)-2 inhibition is a novel strategy to reduce the risk of gastrointestinal side effects caused by conventional nonsteroidal anti-inflammatory drugs. However, some selective COX-2 inhibitors have become apparent to increase the risk of severe cardiovascular disease. The aim of this study was to examine the anti-inflammatory effect of rosemary extract (RE) and confirm the safety of cardiovascular side effects. Inhibition of COX enzyme activity was assessed, and the levels of COX-2 and prostaglandin E₂ (PGE₂) and COX-1 and thromboxane B₂ (TXB₂) were evaluated in lipopolysaccharide (LPS)-induced RAW 264.7 cells. The 40% RE group showed increased COX-2 inhibition activity in a dose-dependent manner, whereas the 50% RE group only exhibited at 100 ㎍/mL. In a cell-based study, COX-2 mRNA expression was similar in both RE groups and PGE₂ levels tended to decrease in the 40% RE group compared to the LPS group in the LPS pretreatment condition. In the LPS posttreatment condition, the COX-2 mRNA expression decreased in the 40% RE group, and PGE₂ levels were increased in the 40 and 50% RE groups. In both conditions, there was no significant difference in COX-1 and TXB₂ levels. In conclusion, 40 and 50% RE showed significant COX-2 inhibition, similar to the positive control group. It was confirmed that the inhibition of the COX-2 expression, but the effect did not affect the balance between prostacyclin and TXB₂. These results indicate that rosemary showed COX-2 inhibition activity with a low risk of cardiovascular diseases.

• Nuclear Engineering and Technology
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• v.55 no.12
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• pp.4447-4464
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• 2023

This paper focuses on the development of a new computational model of the CNESTEN's TRIGA Mark II research reactor using the 3D continuous energy Monte-Carlo code TRIPOLI-4 (T4). This new model was developed to assess neutronic simulations and determine quantities of interest such as kinetic parameters of the reactor, control rods worth, power peaking factors and neutron flux distributions. This model is also a key tool used to accurately design new experiments in the TRIGA reactor, to analyze these experiments and to carry out sensitivity and uncertainty studies. The geometry and materials data, as part of the MCNP reference model, were used to build the T4 model. In this regard, the differences between the two models are mainly due to mathematical approaches of both codes. Indeed, the study presented in this article is divided into two parts: the first part deals with the development and the validation of the T4 model. The results obtained with the T4 model were compared to the existing MCNP reference model and to the experimental results from the Final Safety Analysis Report (FSAR). Different core configurations were investigated via simulations to test the computational model reliability in predicting the physical parameters of the reactor. As a fairly good agreement among the results was deduced, it seems reasonable to assume that the T4 model can accurately reproduce the MCNP calculated values. The second part of this study is devoted to the sensitivity and uncertainty (S/U) studies that were carried out to quantify the nuclear data uncertainty in the multiplication factor k_eff. For that purpose, the T4 model was used to calculate the sensitivity profiles of the k_eff to the nuclear data. The integrated-sensitivities were compared to the results obtained from the previous works that were carried out with MCNP and SCALE-6.2 simulation tools and differences of less than 5% were obtained for most of these quantities except for the C-graphite sensitivities. Moreover, the nuclear data uncertainties in the k_eff were derived using the COMAC-V2.1 covariance matrices library and the calculated sensitivities. The results have shown that the total nuclear data uncertainty in the k_eff is around 585 pcm using the COMAC-V2.1. This study also demonstrates that the contribution of zirconium isotopes to the nuclear data uncertainty in the k_eff is not negligible and should be taken into account when performing S/U analysis.

• Therapeutic Science for Rehabilitation
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• v.13 no.2
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• pp.85-94
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• 2024

Objective : This study aimed to determine the impact of an instrumental daily living activity program for adults with developmental disabilities on their daily living activities and quality of life (QOL). Methods : This study used a single-group pre-test-post-test experimental design. Participants comprised 17 adults with developmental disabilities from the Welfare Center for the Disabled. This program consisted of 10 sessions, including pre- and post-assessments, pertaining to training and education on grocery shopping, meal preparation and cleaning, home management, safety, and emergency management. The evaluation tools used in this study were the Quality of Life Questionnaire, Korean version of the Life Space Assessment (K-LSA), and Korean version of the Instrumental Activities of Daily Living (K-IADL). Results : There was a statistically significant difference in the QOL and K-IADL scores before and after the instrumental activities of daily living occupational therapy program, and there was no statistically significant difference in the K-LSA scores. Conclusion : This study confirmed that implementing an IADL program for adults with developmental disabilities had a positive impact on performance and QOL. For adults with developmental disabilities to participate in daily life and society, interventions for work participation, including training in activities of daily living, must be expanded.

• The Journal of The Korea Institute of Intelligent Transport Systems
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• v.23 no.3
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• pp.48-66
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• 2024

According to the three amended Laws of the Data Economy and the Data Industry Act of Korea, systems for pseudonymous data integration and Data Safe Zones have been operated separately by selected agencies, eventually causing a burden of use in SMEs, startups, and general users because of complicated and ineffective procedures. An over-stringent pseudonymization policy to prevent data breaches has also compromised data quality. Such trials should be improved to ensure the convenience of use and data quality. This paper proposes a prototype system of the Integrated Data Safe Zone based on redesigned and optimized pseudonymization workflows. Conventional workflows of pseudonymization were redesigned by applying the amended guidelines and selectively revising existing guidelines for business process redesign. The proposed prototype has been shown quantitatively to outperform the conventional one: 6-fold increase in time efficiency, 1.28-fold in cost reduction, and 1.3-fold improvement in data quality.

• Applied Chemistry for Engineering
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• v.35 no.3
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• pp.200-208
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• 2024

Chung's equations-IX and Chung's equation-XII were utilized to predict the fire risk and evaluate fire risk ratings for four types of wood: camphor, cherry, rubber, and elm trees. The combustion tests were conducted using a cone calorimeter test method by ISO 5660-1 standards. The fire risk and fire risk rating (FRR) were compared for Fire Risk Index-IX (FRI-IX) and Fire Risk Index-XII (FRI-XII). The results yielded Fire Performance Index-XI (FPI-XI) ranging from 0.08 to 11.48 and Fire Growth Index-XI (FGI-XI) ranging from 0.67 to 111.89. The Fire Risk Index-XII (FRI-XII), indicating fire risk rating, exhibited an increasing order of cherry (0.45): Grade A (Ranking 5) < PMMA (1): Grade A (Ranking 4) < elm (1.23): Grade A (Ranking 3) < rubber (1.56): Grade A (Ranking 2) << camphor (148.23): Grade G (Ranking 1). Additionally, the fire risk index-IX (FRI-IX) was cherry (0): Grade A (Ranking 3) ≈ rubber (0): Grade A (Ranking 3) ≈ elm tree (0): Grade A (Ranking 3) < PMMA (1): Grade A (Ranking 2) << camphor tree (66.67): Grade G (Ranking 1). In general, camphor was found to have the highest fire risk. In conclusion, although the expression of the index is different as shown based on the standards of FRI-IX and FRI-XII, predictions based on fire risk assessment of combustible materials showed similar trends.