• Biomedical Science Letters
• /
• v.28 no.2
• /
• pp.67-82
• /
• 2022

The prevalence of SARS-CoV-2 led to inconsistent public health policies that resulted in COVID-19 containment failure. These factors resulted in increased hospitalization and death. To prevent viral spread and achieve herd immunity, the only safe and effective measure is to provide to vaccinates. Ever since the release of the SARS-CoV-2 nucleotide sequence in January of 2020, research centers and pharmaceutical companies from many countries have developed different types of vaccines including mRNA, recombinant protein, and viral vector vaccines. Prior to initiating vaccinations, phase 3 clinical trials are necessary. However, no vaccine has yet to complete a phase 3 clinical trial. Many products obtained "emergency use authorization" from governmental agencies such as WHO, FDA etc. The Korean government authorized the use of five different vaccines. The viral vector vaccine of Oxford/AstraZeneca and the Janssen showed effectiveness of 76% and 66.9%, respectively. The mRNA vaccine of Pfizer-BioNTech and Moderna showed effectiveness of 95% and 94.1%, respectively. The protein recombinant vaccine of Novavax showed an effectiveness of 90.4%. In this review, we compared the characteristics, production platform, synthesis principles, authorization, protective effects, immune responses, clinical trials and adverse effects of five different vaccines currently used in Korea. Through this review, we conceptualize the importance of selecting the optimal vaccine to prevent the COVID-19 pandemic.

• Journal of Marine Bioscience and Biotechnology
• /
• v.14 no.2
• /
• pp.69-75
• /
• 2022

The micro-Kjeldahl method, a common technique for analyzing crude proteins, is time-consuming and dangerous due to the employment of reagents such as sulfuric acid and sodium hydroxide. However, a Fourier transform near-infrared (FT-NIR) spectrophotometer analysis can be completed in under a minute after simple pre-processing if data has been gathered using sufficient reference material in advance. Furthermore, the use of safe reagents in this technique ensures the safety of the experimenter and the environment. In addition, a portable FT-NIR spectrophotometer enables real-time measurement at processing or distribution sites and has recently gained popularity. The standard errors of calibration and regression (r²) for the calibration result for estimating the crude protein content of dried laver were 0.9775 and 1.2526, respectively. The standard error of prediction was 1.1814, and the r² was 0.9303 in the validation results, which was a good level. In the present study, a method for predicting the crude protein content of dried laver using an FT-NIR spectrophotometer in the range of 29%-40% crude protein content has been reported.

• International Journal of Advanced Culture Technology
• /
• v.10 no.4
• /
• pp.547-554
• /
• 2022

Due to the expansion of non-face-to-face services, the demand for user identification for mobile devices is increasing. Recently, mobile resident registration cards, mobile driver's licenses, etc. are installed in mobile phones and used for user identification and authentication services. In order to identify a user online, unique identification information of the online user is required. In particular, in order to provide information only to online users, it is necessary to accurately deliver information to a mobile device owned by the user. To make this service possible, it was realized with the advent of mobile electronic notice service. However, the identification of online service users and information on mobile devices owned or subscribed by the relevant users require safe management as personal information, and it is also necessary to increase the convenience of online service users. In this paper, we propose an operating standard for providing a mobile electronic notice service that sends electronic notice using a mobile device owned by the user. The mobile electronic notice service is a service that provides notices expressed in electronic information to the recipient's cell phone, mobile app, e-mail, etc. Therefore, as the use of mobile electronic notification service increases and the provision and use of connecting information to identify users increases, it is necessary to expand the mobile electronic notification service while safely protecting users' personal information.

• Journal of Oral Medicine and Pain
• /
• v.48 no.1
• /
• pp.3-10
• /
• 2023

This review aimed to update our knowledge of the classification, pathophysiology, prognosis, and treatment of trigeminal neuralgia (TN), with the intention of establishing better treatment protocols. The latest version of the International Classification of Headache Disorders uses an etiology-based approach to characterize TN patients, potentially contributing to the development of targeted treatment measures. Noticeable changes in the recent European Academy of Neurology guidelines for the management of TN include the use of magnetic resonance imaging for exclusion of secondary TN and differentiation of idiopathic and classical TN. Additionally, the use of botulinum toxin type A as an addon therapy for mid-term treatment of TN has also been included. Though there has been limited recent progress in the treatment of TN, previous studies emphasize the importance of customized, multidisciplinary management protocols that include drug therapy optimization; provision of continuous education and support; and timely referral of medically refractory patients for surgery in order to achieve favorable prognosis. Furthermore, slow but growing evidence on gene mutations will help elucidate the pathophysiology of TN and contribute to the development of targeted drugs that are effective and safe.

• KSII Transactions on Internet and Information Systems (TIIS)
• /
• v.16 no.5
• /
• pp.1634-1652
• /
• 2022

Due to the increasing need for data sharing in the age of big data, how to achieve data access control and implement user permission revocation in the blockchain environment becomes an urgent problem. To solve the above problems, we propose a novel blockchain-based data sharing scheme (BDSS) with fine-grained access control and permission revocation in this paper, which regards the medical environment as the application scenario. In this scheme, we separate the public part and private part of the electronic medical record (EMR). Then, we use symmetric searchable encryption (SSE) technology to encrypt these two parts separately, and use attribute-based encryption (ABE) technology to encrypt symmetric keys which used in SSE technology separately. This guarantees better fine-grained access control and makes patients to share data at ease. In addition, we design a mechanism for EMR permission grant and revocation so that hospital can verify attribute set to determine whether to grant and revoke access permission through blockchain, so it is no longer necessary for ciphertext re-encryption and key update. Finally, security analysis, security proof and performance evaluation demonstrate that the proposed scheme is safe and effective in practical applications.

• Advances in concrete construction
• /
• v.15 no.1
• /
• pp.41-46
• /
• 2023

Sport has no age limit and can be done anywhere and in any condition with minimal equipment. The existence of sports spaces in all parts of the world is considered a citizen's right. One of the activities carried out in this field is installing sports equipment and structures in parks and encouraging citizens to use this equipment for physical health with the least cost and facilities. Installing sports structures in open spaces such as parks is a practical step for developing citizens' sports. Although using devices in parks is acceptable, it is more critical to meet scientific and technical standards. The components of these structures must have high strength and endurance against changes in environmental conditions such as humidity, temperature difference, and corrosion. Among the various causes of material degradation, corrosion has always been one of several fundamental causes of metal equipment failure. Sports structures in open spaces are not safe from corrosion. Uniform corrosion is the most common type of corrosion. This corrosion usually occurs uniformly through a chemical or electrochemical reaction across the surface exposed to the corrosive environment. Rust and corrosion of outdoor sports structures are examples of this corrosion. For this reason, in this research, with the green synthesis of silica nanoparticles and its application in outdoor sports structures, the life span of these structures can be increased for the use of physical exercises as well as their quality.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
• /
• 2022.10a
• /
• pp.328-330
• /
• 2022

Currently, the Metaverse is introduced in various fields, and a virtual convergence economy that uses NFTs for content or item transactions is expected to develop into a 'metaverse environment'. The 'metaverse environment' will lead the changes in our society in the future and it will be fused with AI, big data, cloud, IoT, block chain, and next-generation network technology. However, personal information, device information, and behavior information provided by Metaverse users to use the service are subject to major attacks. Therefore, in order to provide a safe environment for users to use and to expand the business base of related companies, building a public-private cooperation system and developing a security guide are the leading tasks. Therefore, in this study, we compare and analyze metaverse features and technologies, and examine possible security threats and countermeasures.

• Journal of Digestive Cancer Research
• /
• v.4 no.2
• /
• pp.99-106
• /
• 2016

Minimally invasive surgery for gastric cancer has increased in popularity during the last two decades mainly in the Asia for patients with early-stage cancer. Nevertheless, the development of laparoscopic surgery for gastric cancers in the Western world has been slow because of the advanced stage at diagnosis for which LG is not yet considered an acceptable alternative to standard open surgery. RAG has been reported as a safe alternative to conventional surgery for treating of early gastric carcinoma. We assess the current status of robotic surgery in the treatment of gastric cancer focusing on the technical details, postoperative outcome, oncological considerations and future perspectives. In gastrectomy the biggest advantage of the robotic approach is the ease and reproducibility of lymphadenectomy. Reports also show that even the intra corporeal digestive restoration is facilitated by use of the robotic approach, particularly following TG. Additionally, the accuracy of robotic dissection is confirmed by decreased blood loss in comparison to conventional laparoscopy. The learning curve and technical reproducibility also appear to be shorter with robotic surgery and, consequently, robotics can help to standardize and diffuse minimally invasive surgery in the treatment of gastric cancer. While published reports have shown no significant differences in surgical morbidity, mortality, or oncological adequacy between robot-assisted and conventional gastrectomy. There are some advantages in terms of postoperative recovery of patients after robotic surgery. More studies are needed to assess the true indications and oncological effectiveness of robotic use in the treatment of gastric carcinoma.

• Nuclear Engineering and Technology
• /
• v.56 no.6
• /
• pp.2428-2435
• /
• 2024

Training for radiation protection and control requires a visual understanding of radiation, which cannot be perceived by the human senses. Trainees must also master the effective use of measuring instruments. Traditionally, such training has exposed trainees to radiation sources. Here, we present a novel e-training strategy that enables safe, exposure-free handling of a radiation measuring tool called a survey meter. Our mixed reality radiation-training system merges the physical world with a digital one. Collaborating with a mixed reality headset (HoloLens 2), this system constructs a mock-up of a survey meter in real-world space. The HoloLens 2 employs a browser-based application to visualize radiation and to simulate/share the use of the survey meter, including its physical movements. To provide a dynamic learning experience, the system adjusts the survey-meter mock-up readings according to the operator's movements, distance from the radiation source, the response time of survey meter, and shielding levels. Through this approach, we expect that trainees will acquire practical skills in interpreting survey-meter readings and gain a visual understanding of radiation in real-world situations.

• Journal of the Korean Society of Safety
• /
• v.39 no.3
• /
• pp.14-19
• /
• 2024

Hydrogen is one of the most popular eco-friendly energy sources for reducing global warming. To use hydrogen as a conventional fuel, liquid hydrogen plants should introduce waste hydrogen treatment processes. A major safety issue of liquid hydrogen plants is choosing the most suitable purge gas to use in case of an accident. A purge gas prevents the formation of explosive mixed gases in the vent header. In general, nitrogen is the main purge gas used in chemical plants. Nitrogen has a freezing point of -210℃, which is higher than the boiling point of hydrogen. Helium, with a freezing point lower than hydrogen, is instead recommended as a purge gas of the vent header during hydrogen liquefaction. However, helium is roughly 100 times more expensive than nitrogen. To address this issue, this study uses simulations to investigate safe conditions for introducing nitrogen as the purge gas during hydrogen liquefaction. The temperature change from the safety valve to the vent header is evaluated when the external temperature of the safety valve discharge pipe is at 5℃, 10℃, and 20℃. Additionally, the most optimal length for a discharge pipe according to pipe diameter is investigated.