• 제목/요약/키워드: ruthenium

검색결과 323건 처리시간 0.023초

Novel Mononuclear Ruthenium(II) Compounds in Cancer Therapy

  • Anchuri, Shyam Sunder;Thota, Sreekanth;Yerra, Rajeshwar;Devarakonda, Krishna Prasad;Dhulipala, Satyavati
    • Asian Pacific Journal of Cancer Prevention
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    • 제13권7호
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    • pp.3293-3298
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    • 2012

  • The present study was conducted to evaluate in vivo anticancer activity of two novel mononuclear ruthenium(II) compounds, namely Ru(1,10-phenanthroline)$_2$(2-nitro phenyl thiosemicarbazone)$Cl_2$(Compound $R_1$) and Ru (1,10-phenanthroline)$_2$(2-hydroxy phenyl thiosemicarbazone)$Cl_2$(Compound $R_2$) against Ehrlich ascites carcinoma (EAC) mice and in vitro cytotoxic activity against IEC-6 (small intestine) cell lines and Artemia salina nauplii using MTT [(3-(4,5-dimethylthiazol-2yl)-2,5-diphenyltetrazolium bromide)] and BLT [brine shrimp lethality] assays respectively. The tested ruthenium compounds at the doses 2 and 4 mg/kg body weight showed promising biological activity especially in decreasing the tumor volume, viable ascites cell counts and body weights. These compounds prolonged the life span (% ILS), mean survival time (MST) of mice bearing-EAC tumor. The results for in vitro cytotoxicity against IEC-6 cells showed the ruthenium compound $R_2$ to have significant cytotoxic activity with a $IC_{50}$ value of $20.0{\mu}g/mL$ than $R_1$ ($IC_{50}=78.8{\mu}g/mL$) in the MTT assay and the $LC_{50}$ values of $R_1$ and $R_2$ compounds were found to be 38.3 and $43.8{\mu}g/mL$ respectively in the BLT assay. The biochemical and histopathological results revealed that there was no significant hepatotoxicity and nephrotoxicity associated with the ruthenium administration to mice.

  • https://doi.org/10.7314/APJCP.2012.13.7.3293 인용 PDF KSCI

Brachytherapy of Uveal Melanomas with Ruthenium-106 Plaques

  • Belaid, Asma;Nasr, Chiraz;Jmour, Omar;Cherif, Aziz;Kochbati, Lotfi;Bouguila, Hedi;Besbes, Mounir;Benna, Farouk
    • Asian Pacific Journal of Cancer Prevention
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    • 제17권12호
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    • pp.5281-5285
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    • 2016

  • Background: Brachytherapy is the most commonly used conservative treatment for the uveal melanoma. The aim of this study was to evaluate therapeutic results of Ruthenium-106 plaque brachytherapy in the management of localized uveal melanoma cases. Methods: We reviewed retrospectively the clinical records of all patients treated in our department for an uveal melanoma, undergoing Ruthenium-106 plaque brachytherapy, from January 1996 to December 2015. We focused on clinical features, therapeutic characteristics, local and distant tumor control and side effects. Results: Nineteen patients were enrolled in our study. Mean age was 56.2 years (28-79) and the sex ratio was 1.37:1 males to females. Diagnosis was made on the basis of ophthalmological clinical examination, angiography, ultrasound and/or magnetic resonance. Median tumor diameter was 9.7 mm (6-13) and median thickness 4.4 mm (2.5-8). The dose of Ruthenium-106 plaque brachytherapy prescribed to the apex of each tumor was 70 Gy in all cases. The median radiation dose to the sclera surface was 226.4 Gy (range: 179.6-342.3) and the median total application time 115.2 hours (range: 27 to 237). After a median follow-up of 61.5 months, local control was achieved in 17 patients (89%): 16 demonstrated a partial tumor response and 1 tumor stabilization. Two patients suffered local progression leading to enucleation, one dying of hepatic metastasis. Radiation-induced complications were cataracts in 3 cases and vitreal hemorrhage in 2. Conclusion: Ruthenium-106 plaque brachytherapy is an efficient treatment for localized uveal melanoma, offering good local control with low toxicity.

  • https://doi.org/10.22034/APJCP.2016.17.12.5281 인용 KSCI

루테늄이 도입된 티타네이트 나노시트의 합성 및 산화 촉매 활성 연구 (Synthesis and Oxidative Catalytic Property of Ruthenium-doped Titanate Nanosheets)

  • 이윤희;권기영
    • 공업화학
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    • 제28권5호
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    • pp.593-596
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    • 2017

  • 본 연구에서는 염기조건에서 수열합성법으로 소듐 티타네이트 나노시트를 합성하였다. 합성한 소듐 티타네이트 나노시트를 $RuCl_3$ 수용액에서 자외선을 조사하여 루테늄을 소듐 티타네이트 나노시트의 표면에 도입하였다. X-선 회절분석과 투과전자현미경 및 에너지 분산형 분광기 실험을 통하여 샘플의 결정성과 형태를 분석하였고, 그 결과 루테늄원자가 소듐 티타네이트 표면에 균일하게 흡착되어 있는 것을 확인할 수 있었다. 또한 유도결합플라즈마 발광분광분석법을 통하여 소듐 티타네이트 나노시트에 도입된 루테늄을 정량하였다. 루테늄이 도입된 소듐 티타네이트 나노시트의 경우 산소를 산화제로 이용한 알코올 산화반응에 응용하였으며, 특히 루테늄이 7% 도입된 소듐 티타네이트 나노시트는 $105^{\circ}C$, 1기압 상에서 벤질 알코올을 다른 부산물 없이 벤즈알데하이드로 산화시키는 데 있어서 turnover frequency가 $2.1h^{-1}$인 촉매활성을 보였다.

  • https://doi.org/10.14478/ace.2017.1056 인용 PDF KSCI