• 무역상무연구
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• 제69권
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• pp.85-105
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• 2016

The fact that one of the parties to the sale contract has had to pay demurrage to the shipowner under LD clauses in the charterparty does not of itself mean that he can recover that loss from his sale counter party under the sale contract: the route to such recovery is through express clauses in the sale contract itself. LD clauses in a sale contract stand free and independent of their counterparts in the relevant charterparty. LD clauses in a sale contract should be construed and applied as clauses in sale contracts, not as adjuncts to charterparties. Their interpretation should therefore be coloured not by decisions on laytime and demurrage in charterparties, but by their relationship to the contractual duties of CIF and FOB sellers and buyers. The results discussed here have implications for the drafting of LD clauses in sale contracts. If unwelcome surprises are to be avoided, it seems to advisable to start from the principle: what exactly do traders want or need in LD clauses. They need a clause which covers them against charterparty losses where those losses are the result of dealy caused by the counterparty to the sale contract. The parties to the sale contracts are well advised to prepare LD clauses concentrating on that purpose and bearing in mind the followiing questions. First, should the loading and discharge code in the sale contract appear in traders' or trade associations' standard terms and conditions or should they be left to ad hoc negotiation in contract sheets? Second, should that code be as complete as possible, covering loading or discharge periods or rates, demurrage and despatch, or is it enough for only some of those matters to be covered explicitly, leaving other matters to be governed" as per charterparty"? Third, does the introduction or incorporation of a stipulation for the giving of a notice of readiness make the start of laytime more or less predictable as between seller and buyer? Finally should a loading and discharge code in a sale contract actully be called a "laytime and demmurrage clauses"?

• 센서학회지
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• 제24권1호
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• pp.41-46
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• 2015

In this work, pure hierarchical ZnO structure was prepared using a simple hydrothermal method, and Ag nanoparticles doped hierarchical ZnO structure was synthesized uniformly through photochemical route. The reduced graphene oxide (rGO) has been synthesized by typical Hummer's method and reduced by hydrazine. Prepared Ag/ZnO nanostructures are uniformly dispersed on the surface of rGO sheets using ultrasonication process. The synthesized samples were characterized by SEM, TEM, EDS, XRD and PL spectra. The average size of prepared ZnO microspheres was around $2{\sim}3{\mu}m$ and showed highly uniform. The average size of doped-Ag nanoparticles was 50 nm and decorated into ZnO/rGO network. The $C_2H_2$ gas sensing properties of as-prepared products were investigated using resistivity-type gas sensor. Ag/ZnO-rGO based sensors exhibited good performances for $C_2H_2$ gas in comparison with the Ag/ZnO. The $C_2H_2$ sensor based on Ag/ZnO-rGO had linear response property from 3~1000 ppm of $C_2H_2$ concentration at working temperature of $200^{\circ}C$. The response values with 100 ppm $C_2H_2$ at $200^{\circ}C$ were 22% and 78% for Ag/ZnO and Ag/ZnO-rGO, respectively. In additions, the sensor still shows high sensitivity and quick response/recovery to $C_2H_2$ under high relative humidity conditions. Moreover, the device shows excellent selectivity towards to $C_2H_2$ gas at optimal working temperature of $200^{\circ}C$.

• 한국동물위생학회지
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• 제19권1호
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• pp.1-29
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• 1996

This study was conducted to elucidate the pathogenesis of Aujeszky's disease virus(ADV) by histopathologic examination. The first Korean ADV Isolate, which was isolated from piglets with clinical signs of Aujeszky's disease in Yangsan(YS) county, Kyungnam province, was inoculated into 32 days old piglets with a dose of $10^{5.9}$$TCID_{50}/ml$ through intranasal or intramuscular route. These piglets were sacrificed at intervals of every 24hrs for 8 days. The virulence of YS strain was determined by the observation of clinical signs, gross findings, and histopathologic changes in tissues. The virus recovery test was performed from brain, spleen, lung and tonsil in cell culture. The pathogenesis of YS strain was determined by the observation of histopathologlc lesions in CNS and neuronal tracts. The major clinical signs were fever, anorexia, dyspnea, constipation, tremor, ataxia, circling movement, hindleg paralysis and salivation. The clinical signs were more severe in piglets of the group inoculated intranasally than those of the intramuscularly inoculated gorup. Lymphocytopenia was detected on day 5 to day 6 postinoculation (PI). The ADV was recovered from the tissue homogenates of tonsil, lung, spleen and cerebrum in cell culture. The highest virus titer was detected from tonsil between day 6 and day 7 PI. Reddish sublobar consolidation foci were scattered in the apical and cardiac lobes of lung. Although yellowish necrotic foci were detected in tonsil and liver, hemorrhagic lesions were mainly observed in heart, kidney and lymph nodes. Histopathologically, degeneration and necrosis of nerve cells, nonsuppurative meningoe-ncephalitis, nodular gliosis and perivascular cuffings were observed in CNS. Multifocal fibronecrotic foci were observed in lung, liver, lymph nodes and spleen. The major pathologic changes were detected in the midbrain, pons and medulla oblongata. Eosinophilic intranuclear inclusion bodies were mainly observed in epithelia and /or macrophages of tonsil, liver, lung, spleen and submandibular lymph nodes, and neurons of brain, respectively. Observation of viral particles at various stages of replication were possible from the endothelial cells of the alveolar capillaries and tonsillar crypt epithelia by transmission electron microscope.

• The Korean Journal of Pain
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• 제27권3호
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• pp.219-228
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• 2014

Background: A lipo-prostaglandin E1 agonist is effective for the treatment of neurological symptoms of spinal stenosis when administered by an oral or intravenous route. we would like to reveal the therapeutic effect of an epidural injection of lipo-prostaglandin E1 on hyperalgesia in foraminal stenosis. Methods: A total of 40 male Sprague-Dawley rats were included. A small stainless steel rod was inserted into the L5/L6 intervertebral foramen to produce intervertebral foraminal stenosis and chronic compression of the dorsal root ganglia (DRG). The rats were divided into three groups: epidural PGE1 (EP) (n = 15), saline (n = 15), and control (n = 10). In the EP group, $0.15{\mu}g{\cdot}kg-1$ of a lipo-PGE1 agonist was injected daily via an epidural catheter for 10 days from postoperative day 3. In the saline group, saline was injected. Behavioral tests for mechanical hyperalgesia were performed for 3 weeks. Then, the target DRG was analyzed for the degree of chromatolysis, chronic inflammation, and fibrosis in light microscopic images. Results: From the fifth day after lipo-PGE1 agonist injection, the EP group showed significant recovery from mechanical hyperalgesia, which was maintained for 3 weeks (P < 0.05). Microscopic analysis showed much less chromatolysis in the EP group than in the saline or control groups. Conclusions: An epidurally administered lipo-PGE1 agonist relieved neuropathic pain, such as mechanical hyperalgesia, in a rat foraminal stenosis model, with decreasing chromatolysis in target DRG. We suggest that epidurally administered lipo-PGE1 may be a useful therapeutic candidate for patients with spinal stenosis.

• 한국멀티미디어학회논문지
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• 제10권9호
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• pp.1165-1174
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• 2007

본 논문에서는 방향성 안테나를 이용하는 애드 혹 네트워크에 있어서 노드의 고장이나 이동에 따라 라우팅 경로가 이용 불가능하게 되는 경우 해당 노드의 braid라 명명된 이웃 노드로 우회하도록 함으로서 신속하게 경로를 복구하도록 하는 다중 경로 라우팅 기법을 제안 한다. $1,000m{\times}1,000M$의 영역에 50개의 노드가 균등하게 분포되며 10m/s 이하의 노드 이동 환경에서 전방향 안테나를 사용하는 경우(사용 안테나 요소수 K=1)와 비교하여 방향성 안테나를 사용하는 경우(K>1), 제안 방식은 패킷 전송률과 라우팅 홉 수 등의 측정 항목에 있어 우수하였다. 개선점으로 경로 설정 시 수반되는 지연시간을 단축하는 것이 필요하다.

• 대한금속재료학회지
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• 제49권6호
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• pp.474-487
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• 2011

Bars of OFHC Cu with the diameter of 45 mm were processed by equal channel angular pressing up to 16 passes via route $B_c$, and homogeneity of their microstructures and mechanical properties was examined at every four passes which develop the equiaxed ultrafine grains. In general, overall hardness, yield strength and tensile strength increased by 3, 7, and 2 times respectively compared with those of unECAPed sample. Cross-sectional hardness exhibited a concentric distribution. Hardness was the highest at the center of bar and it decreased gradually from center to surface. After 16 passes, overall hardness decreased due to recovery and partial recrystallization. Regardless of the number of passage, yield strength and tensile strength were quite uniform at all positions, but elongation showed some degree of scattering. At 4 passes, coarse and ultrafine grains coexisted at all positions. After 4 passes, uniform equiaxed ultrafine grains were obtained at the center, while uniform elongated ultrafine grains were manifested at the upper half position. At the lower half position, grains were equiaxed but its size were inhomogeneous. It was found that inhomogeneity of grain morphology and grain size distribution at different positions are to be attributed to scattering in elongation but they did not affect strength. The present results reveal the high potential of practical application of equal channel angular pressing on fabrication of large-sized ultrafine grained bars with quite homogeneous mechanical properties.

• 대한임상독성학회지
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• 제18권2호
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• pp.123-129
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• 2020

Purpose: Atropine is an antidote used to relieve muscarinic symptoms in patients with organophosphate and carbamate poisoning. Nutritional support via the enteral nutrition (EN) route might be associated with improved clinical outcomes in critically ill patients. This study examined the administration of nutritional support in patients undergoing atropinization, including methods of supply, outcomes, and complications. Methods: A retrospective observational study was conducted in a tertiary care teaching hospital from 2010 to 2018. Forty-five patients, who were administered with atropine and on mechanical ventilation (MV) due to organophosphate or carbamate poisoning, were enrolled. Results: Nutritional support was initiated on the third day of hospitalization. Thirty-three patients (73.3%) were initially supported using parenteral nutrition (PN). During atropinization, 32 patients (71.1%) received nutritional support via EN (9) or PN (23). There was no obvious reason for not starting EN during atropinization (61.1%). Pneumonia was observed in both patient groups on EN and PN (p=0.049). Patients without nutritional support had a shorter MV duration (p=0.034) than patients with nutritional support. The methods of nutritional support during atropinization did not show differences in the number of hospital days (p=0.711), MV duration (p=0.933), duration of ICU stay (p=0.850), or recovery at discharge (p=0.197). Conclusion: Most patients undergoing atropinization were administered PN without obvious reasons to preclude EN. Nutritional support was not correlated with the treatment outcomes or pneumonia. From these results, it might be possible to choose EN in patients undergoing atropinization, but further studies will be necessary.

• 아태비즈니스연구
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• 제12권1호
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• pp.151-163
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• 2021

Purpose - The break-even point refers to the point where total profit and total cost coincide, and from this point on, the entrepreneur's decision-making takes a different route. Strategic decisions can be made for more efficient operation and eventually for more likelihood for growth and sustainability if a startup figures out when it recoups the investment and switches to a net profit. Design/methodology/approach - 748 creativity and skill-based sole proprietors in manufacturing industry were examined to demonstrate the effect of the entrepreneur's entrepreneurial experience and education level, the business launch preparation time, or the self-financing on the achievement of break-even point. Findings - While the business launch preparation time lowered the likelihood of reaching a break-even point, self-financing increased the likelihood. As a result of further analysis by subdividing into subgroups according to skill level, only the business launch preparation time was statistically significant in the highly skilled industries. In the low skilled industries, in addition to the business launch preparation time, the CEO's education level and the self-financing were statistically significant. Research implications or Originality - The longer the business launch preparation time, the higher the start-up cost, which increases the burden of initial cost recovery, and the agile response to market changes is thereby delayed, resulting in the business idea losing its appeal. Self-financing not only provides stability and strong motivation for the business operation but also promotes careful spending which contributes to the achievement of break-even point. In particular, it is found that practical experience is more useful than theoretical knowledge in low skilled industries. Due to the limitation of secondary data based on the recollection, the time required to reach a break-even point, percentage of financing sources, etc. may include cognitive errors. In addition, variables are not included that explain the characteristics of creativity and skill-based sole proprietorship, so it is necessary to exercise caution with the actual application.

• 대한소아치과학회지
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• 제32권3호
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• pp.416-426
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• 2005

소아환자는 치과치료시 다양한 방법의 진정요법이 요구된다. 정맥내 투여방법은 약효의 발현이 빠르고, 진정의 심도 및 시간을 술자의 의도대로 조절할 수 있다는 장점이 있다. Midazolam은 현재 의과 및 치과영역에서 성인의 진정요법에 가장 널리 쓰이며, 심혈관계와 호흡계에 대한 영향이 적은 진정 약제이다. 그러나 midazolam을 이용한 정맥내 진정요법의 소아치과에서의 사용에 대한 연구와 보고는 적은 편으로, 이에 본 연구에서는 소아환자에서의 midazolam을 이용한 정맥내 투여시 효과적이고 안전한 초기 투여용량에 관한 연구를 하고자 한다. 진정요법으로 2회 이상의 구치부 치료가 필요한 건강하고 비협조적인 행동을 보이는 16명의 환자를 대상으로 하였으며 평균연령은 $54.7{\pm}10.7$개월, 평균 몸무게는 $18.1{\pm}3.0kg$이었다. 술전 투약으로 0.3mg/kg, 최대 5mg의 midazolam을 근육내 투여 후 30~50%의 $N_2O-O_2$를 병용투여한다. 이중 맹검법에 의해 모든 환자는 두 번의 내원 중 임의로 한번은 0.1mg/kg(I군)을, 다른 한번은 0.2mg/kg(II군)의 초기 용량의 midazolam을 정맥내 투여하여 치료하였고, 추가투여시에는 초기용량의 1/2을 투여하였다. 치료시 환자의 생징후를 측정하였고, 행동양상은 Ohio State University Behavioral Rating Scale과 Automated Counting System을 사용하여 평가하였다. 술자는 Houpt가 제시한 기준을 응용하여 임상적 치료의 성공과 실패를 평가하였다. 몸무게에 대한 총 투여용량은 I군에서 0.16mg/kg, 2군에서 0.24 mg/kg 이었다. 생징후의 경우 두 군 모두 정상범위 내에서 안정된 상태를 보였고, 통계적으로 유의한 차이를 보이지 않았다(p>0.05). 행동양상평가에서 II군에서 바람직한 행동양상(Quiet)의 비율이 높았고, 임상적 성공률은 II군에서 높았으나, 두 군간 통계학적 유의차는 보이지 않았다(p>0.05). 작용 발현시간은 II군에서, 회복시간은 I군에서 빨랐고, 약물 투여 횟수는 I군에서 많았으나, 두 군간 통계학적으로 유의한 차이를 보이지 않았다(p>0.05).

• 지능정보연구
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• 제29권2호
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• pp.101-114
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• 2023

유사시 종심 깊숙한 곳에서 적을 타격하는 임무를 수행하는 항공기의 경우 격추될 위험에 항시 노출되어 있다. 현대전의 핵심 전투력으로써 최첨단의 무기체계를 운용하는 공중근무 요원은 양성하는데 많은 시간과 노력, 국가 예산이 소요되며 그들이 가진 작전 능력과 군사기밀이 매우 중요하기에 공중근무 요원의 생환은 매우 중요한 문제이다. 따라서, 본 연구에서는 적지에서 비상탈출한 조난자가 장애물을 피해 목표지점까지 도피·탈출을 시행할 경로를 예측하는 경로 문제를 연구하였으며 이를 통해 비상탈출한 조난자의 무사 생환 가능성을 높이고자 하였다. 본 연구 주제와 관련된 기존 연구들은 경로 문제를 네트워크 기반 문제로 접근하여 TSP, VRP, Dijkstra 알고리즘 등으로 문제를 변형하여 최적화 기법으로 접근한 연구가 있었다. 본 연구에서는 동적 환경을 모델링 하기에 적합한 MDP(마코프 의사결정과정)를 적용하여 연구하였다. 또한 GIS를 이용하여 지형정보 데이터를 추출하여 활용함으로써 모형의 객관성을 높였으며, MDP의 보상구조를 설계하는 과정에서 기존 연구 대비 모형이 좀 더 현실성을 가질 수 있도록 보다 상세히 지형정보를 반영하였다. 본 연구에서는 조난자가 지형적 이점을 최대한 이용함과 동시에 최단거리로 이동할 수 있는 경로를 도출하기 위하여 가치 반복법 알고리즘, 결정론적 방법론을 사용하였으며 실제 지형정보와 조난자가 도피·탈출 과정에서 만날 수 있는 장애요소들을 추가하여 모형의 현실성을 더하고자 하였다. 이를 통해 조난자가 조난 상황에서 어떠한 경로를 통해 도피·탈출을 수행할지 예측해 볼 수 있었다. 본 연구에서 제시한 모형은 보상구조의 재설계를 통해 여러 가지 다양한 작전 상황에 응용이 가능하며 실제 상황에서 조난자의 도피·탈출 경로를 예측하고 전투 탐색구조 작전을 진행시키는 데 있어 다양한 요소가 반영된 과학적인 기법에 근거한 의사결정 지원이 가능할 것이다.