• 대한약학회:학술대회논문집
• /
• 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.1
• /
• pp.134.1-134.1
• /
• 2003

Tempting to further understanding the biophysical mechanism of action of chlorhexidine, we examined effects of the antimicrobial agent(chlorhexidine digluconate) on rate of rotational mobility of liposomes of total lipids extracted from anaerobic bacterial outer membranes (Porphyromonas gingivalis outer membranes). (omitted)

• 대한임베디드공학회논문지
• /
• 제17권3호
• /
• pp.149-155
• /
• 2022

This paper proposes a method for estimating the road surface condition and tilt angle using an inertial measurement unit (IMU) to improve the safety in the use of mobility aids for the elderly. The measurements of the accelerometers of the IMU usually include the accelerations caused by not only the gravitational force but also linear and rotational motions. Thus, the gravitational accelerations are first extracted using several physical constraints and then incorporated into the Kalman filter to estimate the tilt angle. In addition, because the magnitudes of the accelerations produced by the rotational motions (roll and pitch motions) vary with the road surface condition, a criterion based on such accelerations is presented to classify the condition of the road surface. The obtained road surface condition and tilt angle are finally combined to provide the safety information (e.g., safe, warning, and danger) for the user to improve the walking safety. Experiments were carried out and the results showed that the proposed method can provide the condition of the road surface, the tilt of the road surface, and the safety information correctly.

• International Journal of Oral Biology
• /
• 제35권4호
• /
• pp.159-167
• /
• 2010

To provide a basis for studying the pharmacological actions of tetracaine HCl, we analyzed the membrane activities of this local anesthetic. The n-(9-anthroyloxy) stearic and palmitic acid (n-AS) probes (n = 2, 6, 9, 12 and 16) have been used previously to examine fluorescence polarization gradients. These probes can report the environment at a graded series of depths from the surface to the center of the membrane bilayer structure. In a dosedependent manner, tetracaine HCl decreased the anisotropies of 6-AS, 9-AS, 12-AS and 16-AP in the hydrocarbon interior of synaptosomal plasma membrane vesicles isolated from bovine cerebral cortex (SPMV), and liposomes derived from total lipids (SPMVTL) and phospholipids (SPMVPL) extracted from the SPMV. However, this compound increased the anisotropy of 2-AS at the membrane interface. The magnitude of the membrane rotational mobility reflects the carbon atom numbers of the phospholipids comprising SPMV, SPMVTL and SPMVPL and was in the order of the 16, 12, 9, 6, and 2 positions of the aliphatic chains. The sensitivity of the effects of tetracaine HCl on the rotational mobility of the hydrocarbon interior or surface region was dependent on the carbon atom numbers in the descending order 16-AP, 12-AS, 9-AS, 6-AS and 2-AS and on whether neuronal or model membranes were involved in the descending order SPMV, SPMVPL and SPMVTL.

• BMB Reports
• /
• 제33권3호
• /
• pp.279-284
• /
• 2000

Using fluorescence probes, 2-(9-anthroyloxy) stearic acid (2- AS) and 12-(9-anthroyloxy) stearic acid (12-AS), we determined the differential effects of local anesthetics (tetracaine-HCI, bupivacaine-HCI, lidocaine-HCI, prilocaine-HCI and procaine-HCI) on the differential rotational rate between the surface (in carbon number 2 and its surroundings including the head group) and the hydrocarbon interior (in carbon number 12 and its surroundings) of the outer monolayer of the total phospholipid fraction liposome that is extracted from synaptosomal plasma membrane vesicles. The anisotropy (r) values for the hydrocarbon interior and the surface region of the liposome outer monolayer were$0.051{\pm}0.001$ and $0.096{\pm}0.001,$ respectively. This means that the rate of rotational mobility in the hydrocarbon interior is faster than that of the surface region. Local anesthetics in a dosedependent manner decreased the anisotropy of 12-AS in the hydrocarbon interior of the liposome outer monolayer, but increased the anisotropy of 2-AS in the surface region of the monolayer. These results indicate that local anesthetics have significant disordering effects on the hydrocarbon interior, but have significant ordering effects on the surface region of the liposome outer monolayer.

• 한국소음진동공학회:학술대회논문집
• /
• 한국소음진동공학회 2002년도 추계학술대회논문집
• /
• pp.358-362
• /
• 2002

The HDD unbalance, with higher rotational speed, is directly influenced by the mechanical assembly allowance between clamping disk and platter disk. The low frequency structural vibration induced by the unbalance force finally gives rise to the structure borne noise of the personal computer. To meet the noise and vibration requirements, the absolute unbalance mass of HDD needs to be measured and adjusted in the disk assembling stage. This study introduces the measurement methods of the absolute magnitude and position of the unbalance mass of HDD based on the mobility and acceleration orbit. The absolute unbalance mass can be obtained by the acceleration responses and the mobility of the mechanical part, while the position of the unbalance mass ran be obtained by the rotation acceleration orbit.

• 제어로봇시스템학회논문지
• /
• 제8권3호
• /
• pp.243-248
• /
• 2002

In this paper, mobility of planar mobile robots is discussed. Firstly, simplified joint models for four typical wheels of the mobile robots are described including both rotational and translational friction parameters. Then, based on these joint models and through the inclusion of the additional imaginary joint particularly to the mobile robots which lack geometric generality, mobility analysis of various types of planar mobile robots is performed.

• The Korean Journal of Physiology and Pharmacology
• /
• 제16권6호
• /
• pp.413-422
• /
• 2012

The purpose of this study is to investigated the mechanism of pharmacological action of local anesthetic and provide the basic information about the development of new effective local anesthetics. Fluorescent probe techniques were used to evaluate the effect of lidocaine HCl on the physical properties (transbilayer asymmetric lateral and rotational mobility, annular lipid fluidity and protein distribution) of synaptosomal plasma membrane vesicles (SPMV) isolated from bovine cerebral cortex, and liposomes of total lipids (SPMVTL) and phospholipids (SPMVPL) extracted from the SPMV. An experimental procedure was used based on selective quenching of 1,3-di(1-pyrenyl)propane (Py-3-Py) and 1,6-diphenyl-1,3,5-hexatriene (DPH) by trinitrophenyl groups, and radiationless energy transfer from the tryptophans of membrane proteins to Py-3-Py. Lidocaine HCl increased the bulk lateral and rotational mobility of neuronal and model membrane lipid bilayes, and had a greater fluidizing effect on the inner monolayer than the outer monolayer. Lidocaine HCl increased annular lipid fluidity in SPMV lipid bilayers. It also caused membrane proteins to cluster. The most important finding of this study is that there is far greater increase in annular lipid fluidity than that in lateral and rotational mobilities by lidocaine HCl. Lidocaine HCl alters the stereo or dynamics of the proteins in the lipid bilayers by combining with lipids, especially with the annular lipids. In conclusion, the present data suggest that lidocaine, in addition to its direct interaction with proteins, concurrently interacts with membrane lipids, fluidizing the membrane, and thus inducing conformational changes of proteins known to be intimately associated with membrane lipid.

• 한국소음진동공학회:학술대회논문집
• /
• 한국소음진동공학회 2002년도 추계학술대회논문초록집
• /
• pp.340.1-340
• /
• 2002

The unbalance exciting force induced by HDD of lately getting higher speed is directly influenced by the rotational speed and the mechanical assembly allowance between disk and spindle motor, and which gives rise to the structure borne noise of the personal computer. The absolute unbalance mass of HDD needs to be measured and adjusted by the counter mass to control the unbalance exciting force effectively in the stage of assembling the disk and spindle motor. This study introduces the measurement methods of the magnitude of the absolute unbalance mass and the position of HDD by 2 accelerometers. The absolute unbalance mass can be obtained by the acceleration responses and the mobility of the mechanical part, while the position of the unbalance mass can e obtained by the rotation acceleration orbit.

• ETRI Journal
• /
• 제41권6호
• /
• pp.838-849
• /
• 2019

We present a permanent magnet-based spherical wheel motor that can be used in omnidirectional mobility applications. The proposed motor consists of a ball-shaped rotor with a magnetic dipole and a hemispherical shell with circumferential air-core coils attached to the outer surface acting as a stator. Based on the rotational symmetry of the rotor poles and stator coils, we are able to model the rotor poles and stator coils as dipoles. A simple physical model constructed based on a torque model enables fast numerical simulations of motor dynamics. Based on these numerical simulations, we test various control schemes that enable constant-speed rotation along arbitrary axes with small rotational attitude error. Torque analysis reveals that the back electromotive force induced in the coils can be used to construct a control scheme that achieves the desired results. Numerical simulations of trajectories confirm that even without explicit methods for correcting the rotational attitude error, it is possible to drive the motor with a low attitude error (<5°) using the proposed control scheme.

• 한국소음진동공학회:학술대회논문집
• /
• 한국소음진동공학회 2003년도 춘계학술대회논문집
• /
• pp.985-990
• /
• 2003

With the rotational speed of the hard disk drive (HDD) increased, the low frequency structural vibration induced by the unbalance force gives rise to the structure home noise of the personal computer, and finally degrades the noise quality. As the unbalance of the hard disk drive is decided by the mechanical assembly allowance between clamping and platter disk, there is limit to control this unbalance by the improved assembly method. To improve the noise and vibration performance of PC, basically the unbalance of HDD needs to be measured absolutely and reduced during the stage of the disk assembly. This study introduces the HDD unbalance measurement methods of the absolute magnitude based on the mobility concept, and the unbalance location information with the acceleration orbit.