• Biotechnology and Bioprocess Engineering:BBE
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• v.9 no.6
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• pp.476-481
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• 2004

The aim of this study was to formulate a sustained release system for indomethacin (IND) with rosin gum obtained from a pine tree. Rosin microparticles were prepared by a disper­sion and dialysis method without the addition of surfactant. In order to investigate the influence of solvents on the formation of colloidal microparitcles, various solvents like ethanol, DMF, DMAc, and acetone were used. The rosin microparticles containing IND were characterized by X­ray differactometry (XRD) and differential scanning calorimetry (DSC). The morphologies of rosin microparticles observed by scanning electron microscopy (SEM) were spherical. The solvents used to dissolve rosin significantly affected the drug content and drug release rate of IND. The release behaviors of IND from the rosin microparticles were dependent on the drug content and size of the particles. Rosin micorparticles with a higher drug content and of a larger particle size had a slower drug release rate. Also, the IND release rate from the rosin microparticles could be regulated by the rosin content in the microparticles. From these results, rosin microparticles have the potential of being used as a sustained release system of IND.

• Journal of the Korean Applied Science and Technology
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• v.27 no.4
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• pp.427-436
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• 2010

Much oyster shell is breeding by character and conduct of oyster-industry for a long time among them. An experimental study was carried out to investigate the recycling possibility of waste oyster shells, which induce environmental pollutions by piling up out at the open or the temporary reclamation. The purpose of this study is to develope eco-friendly binder using waste oyster shells, and to reinforce soils fur soft soil improvement. In this paper, a series of laboratory tests including compressive pot tests were performed to evaluate characteristics of soils treated by developed waste oyster shells with different water content of soils. Based on test results, eco-friendly Supporter manufactured from waste oyster shells were estimated as good resource materials for soft soil improvements. We got the conclusion by a series of experiment, It is verified that change of pH of soil is improved by mixing with oyster shells. The homogenization method for deducing apparent of oyster shells, which can consider micro-structure of mixed soil, is introduced. The improvement treatment leaded to enlarge fluctuation of soil moisture content. The effect of calcium concentration was good though improvement treatment of physical property. In addition, the crop yield in amelioration plots increased. It means that the increase of crop yield was caused by improvement of soil physical properties rather than improvement of calcium concentration.