• 한국약용작물학회지
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• 제16권6호
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• pp.409-415
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• 2008

Moutan cortex, the root bark of Paeonia suffruticosa Andrews (Paeoniaceae), has pharmacological effects such as anti-inflammatory, antiallergic, analgesic and antioxidant activities. We investigated a methanol extract of Moutan cortex for neuroprotective effects on neurotoxicity induced by amyloid ${\beta}$ protein ($A{\beta}$) (25-35) in cultured rat cortical neurons. Exposure of cultured cortical neurons to $10\;{\mu}M\;A{\beta}$ (25-35) for 24 h induced neuronal apoptotic death. Moutan cortex inhibited $10\;{\mu}M\;A{\beta}$ (25-35)-induced neuronal cell death at 30 and $50\;{\mu}g/m{\ell}$, which was measured by a 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyl-tetrazolium bromide (MTT) assay and Hoechst 33342 staining. Moutan cortex inhibited $10\;{\mu}M\;A{\beta}$ (25-35)-induced elevation of intracellular calcium concentration ($[Ca^{2+}]_i$), and generation of reactive oxygen species (ROS) which were measured by fluorescent dyes. Moutan cortex also inhibited glutamate release into medium induced by $10\;{\mu}M\;A{\beta}$ (25-35), which was measured by HPLC. These results suggest that Moutan cortex prevents $A{\beta}$ (25-35)-induced neuronal cell damage by interfering with the increase of $[Ca^{2+}]_i$, and then inhibiting glutamate release and ROS generation. Moutan cortex may have a therapeutic role in preventing the progression of Alzheimer's disease.

• 대한조선학회논문집
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• 제47권2호
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• pp.132-140
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• 2010

The very erosive cavitation is simulated by an inclined propeller dynamometer in the medium-size cavitation tunnel of MOERI. The inclined shaft for propeller makes strong cavitaion, which occurs around the root of a propeller blade. The cavitation begins at the leading edge of the propeller and contracted toward the trailing edge through the reentrant jet action. The cavity focused on the region near the trailing edge collapsed over the blade surface. As the impact pressure by the cavitation collapsing is too strong, it can damage the blade surface in the form of pit. This cavitation impacts created by the collapsing process are similar to the full-scale ones and are different from those by other erosion test methods. The newly developed cavitation erosion test method can be applied to evaluate the materials such as metals, ceramics and coatings in terms of cavitation resistance.

• 한국응용곤충학회지
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• 제24권4호
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• pp.179-182
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• 1986

$1983{\sim}1984$ 제(第)에 걸쳐 한국인삼연초연구소 수원경작시험장 인삼포(人蔘圃) 및 그 주변에서 궁뱅이를 채집(採集)하여 외부형태상(外部形態上)의 특징, 종구성(種構成) 및 인삼가해여부(人蔘加害如否)를 조사(調査)하여 다음과 같은 결과를 얻었다. 1. 채집(採集)된 굼뱅이는 항문공(肛門孔)의 모양과 여상부에 있는 융기선(隆起線)의 유무(有無)에 따라 검정풍뎅이 아과(亞科), 줄풍뎅이 아과(亞科), 우단풍뎅이 아과(亞科)로 나뉘어지고, 이들은 다시 두부(頭部)나 제10복절(第10腹節) 복면(腹面)의 자모(刺毛) 배열(配列), 두개(頭蓋)의 광택 정도에 띠라 8종(種)으로 분류(分類)되었다. 2. 인삼포(人蔘圃) 주변의 포장(圃場)이나 휴한지(休閑地)에서 주로 다색풍뎅이 애풍뎅이 다색줄풍뎅이 참검정풍뎅이 큰검정풍뎅이 등이 채집(採集)되었으나, 인삼포(人蔘圃)에서는 참검정풍뎅이와 큰검정풍뎅이만이 발견되었으며 이들의 인삼(人蔘) 가해(加害)가 확인되었다.

• Maxillofacial Plastic and Reconstructive Surgery
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• 제39권
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• pp.29.1-29.5
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• 2017

Background: The surgical extraction of the third molar is the most frequently encountered procedure in oral and maxillofacial surgery and is related with a variety of complications. This study examined the efficacy of intentional partial odontectomy (IPO) in the third molars which have no periapical lesions and are located near important anatomical structures such as inferior alveolar nerve. Methods: Seven patients (four males, three females, $39.1{\pm}11.6years$), who received IPO to reduce the risk of inferior alveolar nerve injury (IANI), were followed long-term. The treated teeth were horizontally impacted third molars in the mandibular left (n = 5) or mandibular right (n = 4) areas and were all ankylosed with the surrounding alveolar bone. During the IPO, the bone around the crown was removed to expose the crown, and then the tooth was resected at cement-enamel junction (CEJ). Any secondary trauma to the healthy root was minimized and remained intact after primary suture. Results: The mean follow-up time was $63.2{\pm}29.8months$, and all sites showed good bone healing after the crown removal. Also, sensory abnormality was not found in any patients after IPO. In one patient, the bone fragments erupted 4 months after IPO. In other patient, an implant placed on second molar site adjacent to the third molar that received IPO was explanted about 2 years after the patient's persistent discomfort. Conclusions: In case where high risk of IANI exists, IPO may be chosen alternatively to surgical extraction to reduce the risk of nerve damage.

• Journal of Ginseng Research
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• 제4권1호
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• pp.104-120
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• 1980

The effects of temperature on transpiration, chlorophyll content, frequency and aperture of stomata, and leaf temperature of Panax ginseng were reviewed. Temperature changes of soil and air under spade roof were also reviewed. Growth responses of responses of ginseng plant at various temperature were assessed in relation to suseptibillity of ginseng plants. Reasonable management of ginseng fields was suggested based on the response of ginseng to various temperatures. Stomata frequency may be increased under high temperature during leaf$.$growing stage. Stomata aperture increased by high temperature but the increase of both frequency and aperture appears not enough for transpiration to overcome high temperature encountered during summer in most fields. Serial high temperature disorder, i.e high leaf temperature, chlorophyll loss, inhibition of photosynthesis, increased respiration and wilting might be alleviated by high humidity and abundant water supply to leaf. High air temperature which limits light transmission rate inside the shade roof, induces high soil temperature(optimum soil temperature 16∼18$^{\circ}C$) and both(especially the latter) are the principal factors to increase alternaria blight, anthracnose, early leaf fall, root rot and high missing rate of plant resulting in poor yield. High temperature disorder was lessen by abundant soil water(optimum 17∼21%) and could be decreased by lowering the content of availability of phosphorus and nitrogen in soil consequently resulting in less activity of microorganisms. Repeated plowing of fields during preparation seems to be effective for sterilization of pathogenic microoganisms by high soil temperature only on surface of soils. Low temperature damage appeared at thowing of soils and emergence stage of ginseng but reports were limited. Most limiting factor of yield appeared as physiological disorder and high pathogen activity due to high temperature during summer(about three months).

• Journal of Ginseng Research
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• 제35권2호
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• pp.243-249
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• 2011

Korean red ginseng (KRG), the steamed root of Panax ginseng Meyer, has a variety of biological properties, including anti-inflammatory, antioxidant and anticancer effects. Aflatoxin $B_1$ ($AFB_1$) produced by the Aspergillus spp. causes acute hepatotoxicity by lipid peroxidation and oxidative DNA damage, and induces liver carcinoma in humans and laboratory animals. This study was performed to examine the protective effects of KRG against hepatotoxicity induced by $AFB_1$ using liver-specific serum marker analysis, histopathology, and terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling. In addition, to elucidate the possible mechanism of hepatoprotective effects, superoxide dismutase, catalase, glutathione peroxidase, and malondialdehyde were analyzed. Rats were treated with 250 mg/kg of KRG (KRG group) or saline ($AFB_1$ group) for 4 weeks and then received 150 ${\mu}g/kg$ of $AFB_1$ intraperitoneally for 3 days. Rats were sacrificed at 12 h, 24 h, 48 h, 72 h, or 1 wk after $AFB_1$ treatment. In the KRG pre-treatment group, serum alanine aminotransferase, aspartate aminotransferase, and malondialdehyde levels were low, but superoxide dismutase, catalase, and glutathione peroxidase activities were high as compared to the $AFB_1$ alone group. Histopathologically, $AFB_1$ treatment induced necrosis and apoptosis in hepatocytes, and led to inflammatory cells infiltration in the liver. KRG pre-treatment ameliorated these changes. These results indicate that KRG may have protective effects against hepatotoxicity induced by $AFB_1$ that involve the antioxidant properties of KRG.

• Journal of Communications and Networks
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• 제18권3호
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• pp.327-332
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• 2016

The routing protocol for low-power and lossy networks (RPL) is an internet protocol based routing protocol developed and standardized by IETF in 2012 to support a wide range of applications for low-power and lossy-networks (LLNs). In LLNs consisting of resource-constrained devices, the energy consumption of battery powered sensing devices during network operations can greatly impact network lifetime. In the case of inefficient route selection, the energy depletion from even a few nodes in the network can damage network integrity and reliability by creating holes in the network. In this paper, a composite energy-aware node metric ($RER_{BDI}$) is proposed for RPL; this metric uses both the residual energy ratio (RER) of the nodes and their battery discharge index. This composite metric helps avoid overburdening power depleted network nodes during packet routing from the source towards the destination oriented directed acyclic graph root node. Additionally, an objective function is defined for RPL, which combines the node metric $RER_{BDI}$ and the expected transmission count (ETX) link quality metric; this helps to improve the overall network packet delivery ratio. The COOJA simulator is used to evaluate the performance of the proposed scheme. The simulations show encouraging results for the proposed scheme in terms of network lifetime, packet delivery ratio and energy consumption, when compared to the most popular schemes for RPL like ETX, hop-count and RER.

• 정보보호학회논문지
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• 제24권3호
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• pp.523-533
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• 2014

컴퓨터 침해사고 대응 시 침입경로를 파악하는데 많은 시간을 소비하므로 피해 범위가 확대되거나 침해사고 발생의 원인을 밝힐 주요 증거를 유실하게 된다. 이로 인해 동일한 원인의 침해사고가 재발하고 있다. 이 논문에서는 침입자를 신속하고 정확하게 찾아낼 수 있도록 침해사고 발생 전, 디지털증거지도 작성을 제안한다. 디지털증거지도는 다양한 IT장비와 소프트웨어가 만들어 내는 머신 데이터간의 연결 고리가 그물 형태로 만들어진다. 연결 고리는 다양한 외부요인에 민감하기 때문에 지속적인 관리가 필요하다. 침해사고 발생 전, 유효한 디지털증거지도를 숙지함으로써 침해사고 발생 시 신속히 대응하여 피해 범위를 축소하며 침입경로를 제거하여 침해사고 재발을 방지한다. 디지털증거지도는 로그뿐만 아니라 컴퓨터에서 발생하는 다양한 아티팩트들을 채용함으로써 고도화된 APT 공격과 안티-포렌식 기법에 효과적으로 대응한다.

• Restorative Dentistry and Endodontics
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• 제42권2호
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• pp.111-117
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• 2017

Objectives: Periapical lesions, including periapical cyst (PC), periapical granuloma (PG), and periapical abscess (PA), are frequently affected by chemical/physical damage during root canal treatment or severe bacterial infection, and thus, the differential diagnosis of periapical lesions may be difficult due to the presence of severe inflammatory reaction. The aim of this study was to make differential diagnosis among PC, PG, and PA under polarizing microscope. Materials and Methods: The collagen birefringence patterns of 319 cases of PC (n = 122), PG (n = 158), and PA (n = 39) obtained using a polarizing microscope were compared. In addition, 6 cases of periodontal fibroma (PF) were used as positive controls. Results: Collagen birefringence was condensed with a thick, linear band-like pattern in PC, but was short and irregularly scattered in PG, and scarce or absent in PA. PF showed intense collagen birefringence with a short, palisading pattern but no continuous band-like pattern. The linear band-like birefringence in PC was ascribed to pre-existing expansile tensile stress of the cyst wall. Conclusions: In this study all PCs (n = 122) were distinguishable from PGs and PAs by their characteristic birefringence, despite the absence of lining epithelium (n = 20). Therefore, the authors suggest that the presence of linear band-like collagen birefringence of the cyst wall aids the diagnostic differentiation of PC from PG and PA.

• 동의생리병리학회지
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• 제20권6호
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• pp.1658-1663
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• 2006

Panax notoginseng (Buck) F.H chen. root (PNS) is used as a therapeutic agent to stop haemorrhages and a tonic to promote health in Korean and Chinses medicine. The pharmacokinetic profiles of the main PNS are still not accurately investigated. Our preliminary aim is to elucidate the pharmacokinetics features of the PNS in rats. Objective of this study is to determine whether PNS affects hepatic microvascular dysfunction elicited by gut ischemia and reperfusion (I/R), since gut I/R causes hepatic microvascular dysfunction, and to investigate the role of nitric oxide (NO). No has been found to be a modulator of the adhesive interactions between platelet and endothelial cells. Male Wistar rats were exposed to 30 min of gut ischemia followed by 60 min of reperfusion. Intravital microscopy was used to monitor the number of non-perfused sinusoids (NPS). In another set of experiments, PNS (1 g/kg pre day intragastrically) was administered to rats for 7 days. In some experiments, dexamethasone (ST) (2 mg/kg per day intravenously) was administered. In control rats, gut I/R elicited increases in the number of NPS, and plasma TNF-${\alpha}$ and ALT activities, and these changes were mitigated by the pretreatment with PNS. Pretreatment with an No synthase inhibitor diminished the protective effects of PNS on the increase in NPS and plasma TNF-${\alpha}$ levels, but not its effect on the increase in plasma ALT activities. Pretreatment with PNS increased plasma nitrite/nitrate levels. The responses caused by gut I/R were attenuated by the pretreatment with ST. Pretreatment with an NO synthase inhibitor did not affect the effect of ST. These results suggest that PNS attenuates the gut I/R-induced hepatic microvascular dysfunction and inflammatory responses such as TNF-${\alpha}$ production in the early phase via enhancement of NO production, and sequential hepatocellular damage via its anti-inflammatory effect like corticosteroid effect.