The purpose of this study is to explore types of postpartum depression and to understand the nature and structure of the postpartum depression by using Q-methodological approach. As a way of research, 55 statements concerning postpartum depression were selected through individual interviews with postpartum mothers and literature review. 30 women were chosen as a subject group for the study, with opinions shown in 55 statements divided into 9 scales by forced distribution. PC QUANL Program was used for analysis and Q-factors were analyzed by using principal component analysis. As a result, postpartum depression experience was classified into 5 types. There are "Role-Strain Type", "Unattributional Depression Type", "Psychosomatic Symptoms Type", "Self-Compassion Type", and "Role-Crisis Type". Type I was named "Role-Strain Type", referring to the strain generally experienced by mothers with regard to the new role as a mother and as a social member. Type II was named "Unattributional Depression Type", referring to the symptom experienced by people who were in a state of vanity and a sense of loss. They often break into tears for no specific reasons. In case of Type III, people in a state of "Psychosomatic Symptoms Type" develop physical symptoms after suffering from inherent emotional conflict. Type IV was named "Self-Compassion Type" refers to the symptom shown by those who feel pity for their children and for themselves. And they show inability to cope with the reality properly. Type V was named "Role -Crisis Type", which is experienced by people who have a burden and a severe fear of their own job and their children in their mind, also showing serious conflict with maternal role. Futhermore, it was carried out to examine structure of postpartum depression in terms of degree of depression and adjustment ability. Type I showed mild degree of depression and relatively good adjustment ability. Type II showed broad range of degree in depression and moderate adjustment ability. Type III showed moderate depression and relatively low adjustment ability. Type IV revealed relatively serious degree of depression and the lowest adjustment ability. Type V revealed very serious degree of depression and the lowest adjustment ability. As a result, considering the structure of postpartum depression. Type I is considered to be a normal depression sympton which most mothers generally experience, followed by Type II, Type III, Type IV and Type V, each of which show increasingly worse degree of depression and lower adjustment ability. In conclusion, it seems to be it is necessary to understand distinct symptoms of postpartum depression and to examine the characteristics and structure of those types, so that it could lead to more individual nursing approach.cteristics and structure of those types, so that it could lead to more individual nursing approach.
It is widely accepted that the pressure variation of interstitial fluid is one of the most important factors in bone physiology. In order to understand the role of interstitial fluid on porous bony structure, a consideration for the biomechanical interactions between fluid and solid constituents within bone is required. In this study, a poroelastic theory was applied to investigate the elastic behavior of calf vertebral trabecular bone composed of the porous solid trabeculae and the viscous bone marrow. The poroelastic behavior of trabecular bone in a uniaxial stress condition was simulated using a commercial finite difference analysis software (FLAC, Itasca Consulting Group, USA), and tested for 5 different strain rates, i.e., 0.001, 0.01, 0.1, and 10 per second. The material properties of the calf vertebral trabecular bone were utilized from the previous experimental study. Two asymptotic poroelastic responses, the drained and undrained deformations, were predicted. From the predicted results for the simulated five strain rates, it was found that the pore pressure generation has a linearly increasing behavior when the strain rate is the highest at 10 per second, otherwise it showed a nonlinear behavior. The pore pressure generation with respect to the strain was found to be increased as the strain rate increased. The elastic moduli predicted at each strain were 208.3, 212.2, 337.6, 593.1, and 602.2 MPa, respectively. Based on the results of the present study, it was suggested that the calf vertebral trabecular bone could be modeled as a poroelastic material and its strain rate dependent material behavior could be predicted.
Important role of chemical interaction in flame extinction was numerically investigated in downstream interaction among lean(rich) and lean(rich) premixed as well as partially premixed $H_2$-air and CO-air flames. The strain rate varied from 30 to $5917s^{-1}$ until interacting flame could not be sustained anymore. Flame stability diagrams mapping lower and upper limit fuel concentrations for flame extinction as a function of strain rate are presented. Highly stretched interacting flames were survived only within two islands in the flame stability map where partially premixed mixture consisted of rich $H_2$-air flame, extremely lean CO-air flame, and a diffusion flame. Further increase in strain rate finally converges to two points. Appreciable amount of hydrogen in the side of lean $H_2$-air flame also oxidized the CO penetrated from CO-air flame, and this reduced flame speed of the $H_2$-air flame, leading to flame extinction. At extremely high strain rates, interacting flames were survived only by a partially premixed flame such that it consisted of a very rich $H_2$-air flame, an extremely lean CO-air flame, and a diffusion flame. In such a situation, both the weaker $H_2$-air and CO-air flames were parasite on the stronger diffusion flame such that it could lead to flame extinction in the situation of weakening the stronger diffusion flame. Particular concerns are focused on important role of chemical interaction in flame extinction was also discussed in detail.
The role of glyoxylate bypass in lysine production by Corynebacterium glutamicum ssp. lactofermentum ATCC21799 was analyzed by using cloned aceA and aceB genes which encode enzymes catalyzing the bypass. Introduction of a plasmid carrying aceA and aceB to the strain increased enzyme activities of the bypass to approximately 5 fold on acetate minimal medium. The strain with amplified glyoxylate bypass excreted 25% more lysine to the growth medium than the parental strain, apparently due to the increased availability of intracellular oxaloacetate. The final cell yield was lower in the strain with amplified glyoxylate bypass. These changes were specific to the lysine-producing C. glutamicum ssp. lactofermentum ATCC21799, since the lysine-nonproducing wild type Corynebacterium glutamicum strain grew faster and achieved higher cell yield when the glyoxylate bypass was amplified. These findings suggest that the lysine producing C. glutamicum ssp. lactofermentum ATCC21799 has the ability to efficiently channel oxaloacetate, the TCA cycle intermediate, to the lysine biosynthesis pathway whereas lysine-nonproducing strains do not. Our results show that amplification of the glyoxylate bypass efficiently increases the intracellular oxaloacetate in lysine producing Corynebacterium species and thus results in increased lysine production.
Kolasangiani, K.;Farhangdoost, K.;Shariati, M.;Varvani-Farahani, A.
Steel and Composite Structures
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제28권1호
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pp.1-11
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2018
In this paper, local ratcheting behavior of 1045 steel plates with circular cutout was investigated. Experimental tests were carried out by a Zwick/Roell HB 100 servo hydraulic machine. In order to measure the local strain at notch root, a data acquisition system with strain gauge was used. Various notch diameters and distances of strain gauges mounted from the notch root were found influential in the magnitude of local ratcheting strain. It was found that the local maximum principal stress plays a crucial role in increasing the local plastic deformation. Numerical simulation was done by ABAQUS software using nonlinear isotropic/kinematic hardening model. Material parameters of hardening model were attained from several stabilized cycles of flat specimens subjected to symmetric strain cycles. The nonlinear kinematic hardening model along with the Neuber's rule was employed to assess local ratcheting at the notch root of steel plates. The results of the numerical simulations agreed closely with those measured values in this study. Both ratcheting progress and mean stress relaxation occurred simultaneously at the notch root.
Creep tests were conducted under a condition of constant stress on two aluminum-based alloys containing particles: Al-5% Mg-0.25% Fe and Al-5% Zn-0.22% Fe. The role of grain boundary sliding was examined in the plane of the surface using a square grid printed on the surface by carbon deposition and perpendicular to the surface using two-beam interferometry. Estimates of the contribution of grain boundary sliding to the total strain, $\varepsilon_{gbs}/\varepsilon_t$ reveal two trends; (i) the sliding contribution is consistently higher in the Al-Mg-Fe alloy, and (ii) the sliding contribution is essentially independent of strain in the Al-Mg-Fe alloy, but it shows a significant decrease with increasing strain in the Al-Zn-Fe alloy. Sliding is inhibited by the presence of particles and its contributions to the total strain are low. This inhibition is attributed to the interaction between the grain boundary dislocations responsible for sliding and particles in the boundaries.
This work employed density functional theory to investigate the structural and ferroelectric properties of the Ruddlesden-Popper (RP) phase of lead titanate, $Pb_2TiO_4$, as well as its phase transitions with epitaxial strain. A wealth of novel structural instabilities, which are absent in the host $PbTiO_3$ material, were identified in the RP phase through phonon soft-mode analysis. Our calculations showed that the ground state of $Pb_2TiO_4$ is antiferroelectric, distinct from the dominant ferroelectric phase in the corresponding host material. In addition, applied epitaxial strain was found to play a key role in the interactions among the instabilities. The induction of a sequence of antiferroelectric and antiferrodistortive (AFD) phase transitions by epitaxial strain was demonstrated, in which the ferroic instability and AFD distortion were cooperative rather than competitive, as is the case in the host $PbTiO_3$. The RP phase in conjunction with strain engineering thus represents a new approach to creating ferroic orders and modifying the interplay among structural instabilities in the same constituent materials, enabling us to tailor the functionality of perovskite oxides for novel device applications.
Buckling of longitudinal bars is a brittle failure mechanism, often recorded in reinforced concrete (RC) structures after an earthquake. Studies in the literature highlights that it often occurs when steel is in the post elastic range, by inducing a modification of the engineered stress-strain law of steel in compression. A proper evaluation of this effect is of fundamental importance for correctly evaluating capacity and ductility of structures. Significant errors can be obtained in terms of ultimate bending moment and curvature ductility of an RC section if these effects are not accounted, as well as incorrect evaluations are achieved by non-linear static analyses. This paper presents a numerical investigation aiming to evaluate the engineered stress-strain law of reinforcing steel in compression, including second order effects. Non-linear FE analyses are performed under the assumption of local buckling. A role of key parameters is evaluated, making difference between steel with strain hardening or with perfectly plastic behaviour. Comparisons with experimental data available in the literature confirm the accuracy of the achieved results and make it possible to formulate recommendations for design purposes. Finally, comparisons are made with analytical formulations available in the literature and based on obtained results, a modification of the stress-strain law model of Dhakal and Maekawa (2002) is proposed for fitting the numerical predictions.
Lee, Ji Young;Jun, Do Youn;Park, Ju Eun;Kwon, Gi Hyun;Kim, Jong-Sik;Kim, Young Ho
Journal of Microbiology and Biotechnology
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제27권3호
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pp.633-643
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2017
To examine the pro-apoptotic role of the human ortholog (YPEL5) of the Drosophila Yippee protein, the cell viability of Saccharomyces cerevisiae mutant strain with deleted MOH1, the yeast ortholog, was compared with that of the wild-type (WT)-MOH1 strain after exposure to different apoptogenic stimulants, including UV irradiation, methyl methanesulfonate (MMS), camptothecin (CPT), heat shock, and hyperosmotic shock. The $moh1{\Delta}$ mutant exhibited enhanced cell viability compared with the WT-MOH1 strain when treated with lethal UV irradiation, 1.8 mM MMS, $100{\mu}M$ CPT, heat shock at $50^{\circ}C$, or 1.2 M KCl. At the same time, the level of Moh1 protein was commonly up-regulated in the WT-MOH1 strain as was that of Ynk1 protein, which is known as a marker for DNA damage. Although the enhanced UV resistance of the $moh1{\Delta}$ mutant largely disappeared following transformation with the yeast MOH1 gene or one of the human YPEL1-YPEL5 genes, the transformant bearing pYES2-YPEL5 was more sensitive to lethal UV irradiation and its UV sensitivity was similar to that of the WT-MOH1 strain. Under these conditions, the UV irradiation-induced apoptotic events, such as FITC-Annexin V stainability, mitochondrial membrane potential (${\Delta}{\psi}m$) loss, and metacaspase activation, occurred to a much lesser extent in the $moh1{\Delta}$ mutant compared with the WT-MOH1 strain and the mutant strain bearing pYES2-MOH1 or pYES2-YPEL5. These results demonstrate the functional conservation between yeast Moh1 and human YPEL5, and their involvement in mitochondria-dependent apoptosis induced by DNA damage.
The effects of strain rate and preferential diffusion of $H_2$ on flame extinction are numerically studied in interacting premixed syngas-air flames with fuel compositions of 50% $H_2$ + 50% CO and 30% $H_2$ + 70% CO. Flame stability diagrams mapping lower and upper limit fuel concentrations at flame extinction as a function of strain rate are examined. Increasing strain rate reduces the boundaries of both flammable lean and rich fuel concentrations and produces a flammable island and subsequently even a point, implying that there exists a limit strain rate over which interacting flame cannot be sustained anymore. Even if effective Lewis numbers are slightly larger than unity on extinction boundaries, the shape of the lean extinction boundary is slanted even at low strain rate, i.e. $a_g=30s^{-1}$ and is more slanted in further increase of strain rate, implying that flame interaction on lean extinction boundary is strong and thus hydrogen (as a deficient reactant) Lewis number much less than unity plays an important role of flame interaction. It is also shown that effects of preferential diffusion of $H_2$ cause flame interaction to be stronger on lean extinction boundaries and weaker on rich extinction boundaries. Detailed analyses are made through the comparison between flame structures with and without the restriction of the diffusivities of $H_2$ and H in symmetric and asymmetric fuel compositions. The reduction of flammable fuel compositions in increase of strain rate suggests that the mechanism of flame extinction is significant conductive heat loss from the stronger flame to ambience.
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