• Molecules and Cells
• /
• v.41 no.1
• /
• pp.11-17
• /
• 2018

Autophagy is critical for the maintenance of organelle function and intracellular nutrient environment. Autophagy is also involved in systemic metabolic homeostasis, and its dysregulation can lead to or accelerate the development of metabolic disorders. While the role of autophagy in the global metabolism of model organisms has been investigated mostly using site-specific genetic knockout technology, the impact of dysregulated autophagy on systemic metabolism has been unclear. Here, we review recent papers showing the role of autophagy in systemic metabolism and in the development of metabolic disorders. Also included are data suggesting the role of autophagy in human-type diabetes, which are different in several key aspects from murine models of diabetes. The results shown here support the view that autophagy modulation could be a new modality for the treatment of metabolic syndrome associated with lipid overload and human-type diabetes.

• Journal of Korean Academy of Nursing
• /
• v.25 no.4
• /
• pp.790-806
• /
• 1995

The present study examined the causal relationships among nurses' job environment /job characteristics(work overload, lack of autonomy, professional role conflict, interpersonal relationships), maturity, job stress, job satisfaction and turnover intention by constructing and testing a theoretial framework. Based on Katz and Kahn's (1978) theory of organizational open system and Kahn, Wolfe, Quinn, and Snoek's (1964) theory of stress, nurses' turnover intention, job satisfaction and job stress were conceived of as outcomes of the interplay between personal characteristics and work environment. Personal aspects associated with outcome variables included professional knowlege and skill, and maturity(challenge, commitment, control, responsibility). The work environment factors involved work overload, lack of autonomy, professional role conflict, and interpersonal relationships (social support). Three university hospitals located in Seoul were selected to participate. The total sample of 443 registered nurses represents a response rate of 96 percent. Linear structural relationships (LISREL) technique was used to test the fit of the proposed conceptual model to the data and to examine the causal relationships among variables. The result showed that both the proposed model and the modified model fit the data excellently, revealing considerable explanatinal power for job stress and job satisfaction. The explanatory power of turnover intention was relatively lower than those of stress and satisfaction. In predicting nurses' stress, satisfaction and turnover intention, the findings of this study clearly demonstrated that professional role conflict might be the most important variable of the all the environmental variables and personal characteristics. The results were dis-cussed, including directions for the future research and practical implications drawn from the research were suggested.

• Korean Journal of Social Welfare
• /
• v.56 no.4
• /
• pp.5-34
• /
• 2004

This study aims to find out the determinants of burnout in order to better understand the burnout process among social workers. For this purpose, a hypothetical model which explains the relationships among 8 job-related stressors (role ambiguity, role overload, difficulties in solving problems of clients, conflict with the clients, lack of support from the supervisor, closed communication pattern, bureaucracy, and lack of accountability), 4 mediators (job-stress, professional role performance, abiding by the agency policy and partiality in service delivery), and 4 dimensions of burnout (physical exhaustion, psychological exhaustion, depersonalization and personal accomplishment) was developed. Using the data collected from 207 social workers, the hypothetical model was tested. For data analysis, a path analysis was used, and the best-fitting model was found(df=66, $x^2$=63.250, GFI=0.962, CFI=1.00). As a result of this study, the following results were found. Burnout among social workers was increased by the 6 job-related stressors(role ambiguity, role overload, difficulties in solving problems of clients, conflict with the clients, lack of support from the supervisor, closed communication pattern). Job-stress, the mediating variable of the emotional path to burnout, increased professional role performance and the abiding by agency policy, and finally increased burnout. On the other hand, professional self-efficacy (which consists of professional role performance, abiding by agency policy and partiality in service delivery), the mediationg variable of the cognitive path to burnout, reduced burnout when the professional role performance was high, and abiding by agency policy and partiality in service delivery were low.

• The Korean Journal of Health Service Management
• /
• v.12 no.1
• /
• pp.23-34
• /
• 2018

Objectives : This study developed and validated the local clinic Medical Doctor Role Stress Scale(MDRS). Methods : The interviews were conducted with 12 local clinic medical doctors to develop final preliminary questions. The scale was developed using statistical item analysis, exploratory and confirmatory factor analysis surveys with local clinic medical doctors in Seoul, Busan, Daejeon, and Gyeonggi province. Results : The MDRS developed in this study consisted of 14 items and three factors. The factors were role conflict, role ambiguity and role overload. The three factors explained 56.71% of the total variance, and the internal consistency of this scale was .90. The internal consistency for each factor was .81 ~ .90. Confirmatory factor analysis through a separate sampling met the fit criteria (CFI = .941, TLI = .927, RMSEA = .079, SRMR = .069). Conclusions : The results indicate that this scale is a reliable instrument for assessing local clinic medical doctor role stress.

• Journal of the Korea Society of Computer and Information
• /
• v.26 no.2
• /
• pp.151-156
• /
• 2021

The purpose of this study is to examine the relationship between the role factors of local children's center life workers and turnover intentions, and propose a rational role in the work of life workers to suggest an intervention plan that can lower turnover intention. For analysis, data were collected and 221 cases were analyzed using dmfh google docs for life-service workers working at local children's centers. The analysis results are as follows. First, among the sub-variables of the role factors, role conflict was found to increase the turnover intention of life workers, and second, role overload increased the turnover intention of life workers. Based on these research results, policy and practical implications were proposed.

• Journal of Korean Society of Industrial and Systems Engineering
• /
• v.26 no.1
• /
• pp.40-46
• /
• 2003

The employees in information system organization are highly exposed to stress. However, there is little theoretical or empirical study on the effects of job stress on IS organizations. A major reason is because few researchers consider consequences of job stress. The major purpose of this study is to verify negative effects of job stress for IS organization. This study have three purposes : to investigate the relationship between job stressors and perceived job stress; to understand the effect of perceived job stress and job attitude - job satisfaction, job involvement; to examine the role of moderators such as social support and personality in the relationship between job stressors and perceived job stress in information system organizations. The results of this study suggest that job stressors such as role overload and role ambiguity are significantly related to perceived job stress, the higher the perceived job stress is the lower the job attitudes such as job satisfaction and job involvement, and the employees' personality has moderating effects between the job stressor and perceived job stress.

• Journal of Applied Reliability
• /
• v.6 no.4
• /
• pp.255-274
• /
• 2006

Recently firms become largely changed because of rapid technological innovation and serious global competition. It induces job stress of workers and finally leads to job burnout. This study aims to find the effects of job demands and job resources on job burnout. Job demands contains role ambiguity, role conflict, role overload and job characteristics. Job resources contains job control and feedback, involvement in decision making, learning opportunity and social support. The result reveals that job demands raises job burnout and job resources decreases job burnout. And it reveals that the effects of job demands and job resources on job burnout differs slightly according to job categories.

• Korean Journal of Social Welfare Studies
• /
• v.42 no.4
• /
• pp.187-216
• /
• 2011

This study examined the effects of elderly care facility social workers' work environment (role conflict, role ambiguity, role overload, and adequacy of the reward system) and personal tendency (emotional empathy, cognitive empathy, external attribution, and internal attribution) on their burnout (emotional burnout, low personal achievement, and depersonalization about clients) and suggested strategies for preventing burnout in social workers at elderly care facilities. For this purpose, we conducted a questionnaire survey of social workers working at institutions designated as elderly long-term care facilities and collected a total of 312 questionnaires. According to the results of analyzing the data using a structural equation model, among the sub-factors of work environment, role ambiguity had a significant positive effect on low personal achievement and depersonalization about clients, role conflict on emotional burnout, and role overload on depersonalization about clients. Among the sub-factors of personal tendency, cognitive empathy and internal attribution had a significant negative effect on low personal achievement, and external attribution had a significant positive effect on emotional burnout and depersonalization about clients. This study is meaningful in that it illuminated social workers' burnout not only from the aspect of work environment but also from that of personal tendency.

• Convergence Security Journal
• /
• v.21 no.3
• /
• pp.93-104
• /
• 2021

Today, due to the development of the 4th industrial revolution such as artificial intelligence, the security threat of the military organization is increasing. A study that can contribute to complying with military security is needed by studying the effects of influence factors occurring in this changing or newly emerging security environment on information security stress and security compliance behavior intention. In previous studies, task overload, task complexity, task uncertainty, and task conflict were extracted among environmental influencing factors that cause security stress. We empirically analyzed how these influencing factors affect security stress and whether they play a mediating role in security stress. As a result of the analysis, it was analyzed that the security stress was affected in the order of task overload, task conflict, and task uncertainty. Information security stress did not significantly affect security compliance behavior intention, but it was found to mediate the effect of task overload on security compliance behavior intention. This causes information security stress due to heavy security work in the military organization, which ultimately leads to lower security compliance behavior. Therefore, the security policy to manage this situation should be promoted first.

• Journal of Digital Convergence
• /
• v.10 no.5
• /
• pp.37-51
• /
• 2012

The purpose of this study is to approach information security from a more comprehensive perspective. Particularly, information countermeasures includes a technological tool for end users, thereby increasing the end users' technological stresses. Based on the technostress framework, we investigate a effect of security awareness training on technostress, and also examine a effect of technostress on the persistent security compliance. Results showed that security awareness training influenced on techno-overload and techno-uncertainty. We also found that techno-overload and techno-uncertainty have a significant effect on the persistent security compliance. Conclusion and implications are discussed.