• Asian Pacific Journal of Cancer Prevention
• /
• v.15 no.20
• /
• pp.8595-8601
• /
• 2014

Background: miR-200a expression is frequently altered in numerous cancers. The aim of the present study was to determine the role of microRNA-200a in advanced ovarian carcinomas. Materials and Methods: We measured miR-200a expression in 72 matched normal ovarian tissues and advanced ovarian carcinomas, and also two ovarian carcinoma cell lines (SKOV3 and SKOV3.ip1 - the latter being more invasive and metastatic than the parental SKOV3) by stem-loop real-time RT-PCR based on TaqMan microRNA assay using U6 as a reference. Levels of miR-200a expression were compared by disease stage, tumor grade, histology, and lymph node involvement. To evaluate the role of microRNA-200a, cell proliferation and invasion of SKOV-3 and SKOV-3.ip1 were analyzed with miR-200a inhibitor/mimic transfected cells. Results: Of 72 paired samples, 65 cancer tissues overexpressed microRNA-200a greater than two fold in comparison with matched normal epithelium. Specifically, patients with lymph node metastasis showed significant elevation. The level correlated with clinicopathological features, including high tumor grade, late disease stage, most notably with lymph node metastasis, but not with tumor histology. In addition, SKOV-3.ip1 cells also overexpressed miR-200a compared with SKOV-3, and miR-200a inhibitor transfected SKOV-3.ip1 cells showed significant reduction in cellular proliferation and invasion, while a miR-200a mimic stimulated the opposite behavior. Conclusions: We provide definitive evidence that miR-200a is up-regulated in a significant proportion of advanced ovarian carcinomas, and that elevated miR-200a expression facilitates tumor progression. Our findings support the notion that miR-200a is an onco-microRNA for ovarian cancer, and elevation is a useful potential diagnostic indicator. This study also provides a solid basis for further functional analysis of miR-200a in advanced ovarian cancer.

• Korean Journal of Agricultural Science
• /
• v.39 no.4
• /
• pp.545-553
• /
• 2012

In Asia, including Japan and Korea, rice paddies occupy the largest cultivated area in agricultural land. Rice paddies provide the habitats for many organisms including endemic species, sustaining high biodiversity. Insect natural enemies inhabiting rice paddies have an important function for rice production as agents of 'ecosystem services' because they play a major role in suppressing rice pests. The diversity and abundance of natural enemies can be a good index reflecting the 'healthiness' of agro-ecosystem services in rice paddies. The present study investigates whether insect natural enemies could be good biological indicators for general arthropod biodiversity and agricultural practice. First, the concept of ideal bio-indicators was summarized. The strategy to explore and select such bio-indicators was then proposed. Lastly, field survey was made to evaluate the abundance and biodiversity of natural enemies in Japanese rice paddies where chemical inputs, i.e., insecticide use, were different. The results showed that reduction of chemical inputs led to an increase in species richness or diversity of natural enemies including parasitoids and predators. Then, the data were analyzed to examine suitable indicator species to assess environmental soundness of agricultural practice and biodiversity in rice paddies. The density of several species of natural enemies did respond both to pesticide use and to general arthropod biodiversity. The analyses thus have indicated that natural enemies can be suitable as bio-indicators. Usefulness of indicator species in rice paddies is discussed in the context of ecologically sound agriculture.

• Proceedings of the Korea Air Pollution Research Association Conference
• /
• 2003.05b
• /
• pp.261-264
• /
• 2003

We try to distribute air pollution sources at target area. The complex method is used to distribute air pollution sources. Most of people, However, want to simple indicator as standard for express air pollution source. In many area, air pollution is caused by different types of sources. The general type is point source, such as tall stack of power plants and oil refineries stacks. A second type is areal source, such as local industry and transportation. In this aspect, the ratio of sulfur dioxide to nitrogen oxides (RSN =SO$_2$/NOx)is an indicator of air pollution source. the role of this ratio is to show the characteristics at target area of the relationship the point and the areal source. (omitted)

• Journal of Families and Better Life
• /
• v.17 no.2
• /
• pp.31-42
• /
• 1999

This paper focuses on the concept of :"politicization of household labor" to the resolution of houework-related problems which are the products of household work and the women's status. the major discussions of this framework can be summarized as follows: First the policy problems of household labor is that the segregation of market labor and household labor public and private sphere and sex-role affects value of household labor and status of women. Second policy proposals on household labor is related to specific existing policy(family policy women's policy). Third Policy purposes are family welfare and women welfare a symmetry of family and work. Thus policy needs takes concrete shape and policy indicator of evaluing and and policy indicator of supporting. Ultimately it is direct to evaluate the quality of family living.

• Nuclear Engineering and Technology
• /
• v.51 no.3
• /
• pp.904-907
• /
• 2019

Nuclear energy remains one of the world's major energy sources, making up over 10% of global electricity generation in 2017. Public acceptance of nuclear energy is essential for its adoption. From a practical perspective, it is beneficial to have a simple indicator that can predict the actual adoption of nuclear energy. Based on practical experience, the authors suggest tolerance and self-sufficiency as potential indicators that may predict the adoption of nuclear energy. By evaluating the cross-sectional data of 18 countries in 2013, this research assesses the actual impact of tolerance and self-sufficiency on public acceptance in order to identify the validity of the two variables. The results indicate that the two variables are statistically significant, while public acceptance is insignificant in explaining national adoption of nuclear energy. This may be because tolerance reflects national willingness to accept potential risk, while self-sufficiency explains a government's likelihood of developing non-carbon energy sources.

• Journal of the Korean Society for information Management
• /
• v.36 no.4
• /
• pp.53-81
• /
• 2019

The 3rd Library Comprehensive Development Plan (2019-2023) of the Committee on Library and Information Policy under IFLA-UN 2030 Agenda emphasize the role of libraries in practicing social inclusion. At home and abroad, this is shedding new light on libraries as the public service institutions aimed at resolving information inequality. This study thus developed the information inequality measurement indicator optimized for libraries. For this purpose, FGI and Delphi technique were implemented as the verification stage of the expert group. As a result, the final indicators were derived in three evaluation areas, twelve evaluation items, and 30 evaluation indicators. Specifically, first, 3 evaluation items and 8 evaluation indicators were derived in the access evaluation area; second, 5 evaluation items and 12 evaluation indicators were derived in the competency evaluation area; and third, 4 evaluation items and 10 evaluation indicators were derived in the utilization evaluation area. This study is considered to be of great significance in that the information inequality measurement indicators optimized for libraries were developed, the first of its kind.

• Journal of Digital Convergence
• /
• v.19 no.11
• /
• pp.499-509
• /
• 2021

The purpose of this study was to examine the mediating effect of flourishing on the relationship between role conflict and burnout as perceived by school counselors. A total of 242 school counselors participated in this study. The collected data were analyzed using the SPSS and PROCESS macro programs. The study results showed a significant positive correlation between role conflict and burnout and a significant negative correlation between flourishing and role conflict and burnout. In addition, depending on the three subtypes of role conflict (i.e., role-expectation conflict, individual-role conflict, and role ambiguity conflict), the effects on various sub-signs of burnout differed. It was found that flourishing mediated all of these variables of role conflict influencing burnout. These results suggest that flourishing can be considered an indicator for professionalism management of school counselors and a result showing that a positive psychological approach at the school level can be helpful in improving the effectiveness of school counseling by contributing positively not only to students but also to school counselors.

• Research in Community and Public Health Nursing
• /
• v.13 no.3
• /
• pp.556-565
• /
• 2002

Due to the fact that nurses may deal with diverse populations in the work place, it is very important for then to maintain appropriate interpersonal relationships with clients. Nurses should maintain diverse types of relationships appropriately with patients with special needs and their families during crisis, other nursing colleagues and staff on the same team, clients in the school or work place as well as the community. In particular, a hospital is a society with a system and hierarchy, and the importance of interpersonal relationships is much more emphasized. In interpersonal relationships, it is very important for a person to communicate with others in an accurate manner, and when the communication is not achieved appropriately, the person may have troubles and experience distress and conflicts because of the inaccurate communication of thoughts. According to the findings of previous studies, nurses actually experience much distress in the work place because of the miscommunication that they have with others. The purpose of this study was to observe a correlation between Myers-Briggs Type Indicator and assertiveness behavior, and to exam the effects of assertiveness training on the assertiveness behavior and conflict management mode. The subjects of this study included 20 persons in the experimental group and 20 persons the in control group. Myers-Briggs Type Indicator was applied before the study. The assertiveness training group received six, 120 minutes sessions over a 3 week period. Pre-test on assertiveness behavior, Communication Conflict Inventory-General, Role Conflict Inventory- General, Conflict Management Mode was achieved for all the subjects prior to the training. Post-test was administered to all the subjects one week following the last session. The data were analyzed using SPSS PC program to obtain findings on mean. standard distribution, t-test, and Pearson correlation. The results are as follows: (1) Myers-Briggs Type Indicator Introvert/Extrovert was correlated to assertive behavior and avoid- response type conflict management mode. (2) The assertiveness training was correlated to assertiveness behavior, communication conflict degree, and avoid- response type conflict management mode. (3) The post-test scores between the training group and the control group were significantly different in assertiveness behavior and avoid-response type conflict management mode. It is suggested that more studies need to be done to differentiate the effects of Myers-Briggs Type Indicator and assertiveness training on assertiveness behavior and avoid-response type conflict management mode.

• Journal of the Korea Academia-Industrial cooperation Society
• /
• v.17 no.12
• /
• pp.128-137
• /
• 2016

This study aimed to investigate the effect of kangaroo care on physical development adaptation of external environment of prematurity, and maternal role confidence of those who delivered preterm infants. The subjects were 38 preterm infants and mothers with cesarean section delivery in the hospital, located at B city. Eighteen premature infants were assigned to the kangaroo care (KC) group or the control group (CG). Data were collected between June 2013 and June 2015. KC was given 3 times a day (60 min at a time) and performed a total of 10 times. The physical development indicator (weight, height, and head circumference) as well as the adaptation of external environment (temperature, heart rate, oxygenation) of preterm infants were checked before the start of the program. Following the initial measurement, the program was performed, and measurements were taken again at the end of the program. For measurement of maternal role confidence, structured self-reported questionnaires were performed. The results showed that the KC group had a lower oxygenation compared with the CG (t=2.27, p=.02); however, the physical development indicator (weight t=-0.83, p=.21, height t=-0.34, p=.37, head circumference t=1.29, p=.10) and maternal role confidence (t=-0.41, p=.34) were not significantly compared with the CG. The results of this study suggest that the practice of KC helps the adaptation of external environment of preterm infants

• Journal of the Korean Society for information Management
• /
• v.28 no.3
• /
• pp.65-82
• /
• 2011

Statement of responsibility in bibliographical records plays a key role in clarifying intellectual responsibility of the work, and it also plays a role in making up access points. However, cataloging rules for the statement of responsibility mostly deal with the distinction between the principal role and minor roles. This becomes a problem because the responsibility type itself is more important than the order of the types. For this reason, in this paper I will explore improvements of the description methods of statement of responsibility by organizing the role indicators. Namely, using the role indicators more effectively than the current description methods do, we can collocate the dispersed statements of responsibilities. The role indicators can also be used for an author facet in information retrieval and can provide additional information for authority control.