• International Journal of Advanced Culture Technology
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• v.12 no.2
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• pp.360-367
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• 2024

The purpose of this study was to examine the role of parental support in mitigating the impact of discrimination experiences on depression among children and adolescents. This focus was based on the premise that experiences of discrimination can negatively affect peer relationships as well as behavioral and emotional development in youths who spend a significant amount of time with their peers at school. We aimed to explore the mediating role of parental support and to present policy and practical recommendations from a social welfare perspective. For this purpose, data from the "2020 Survey on the Human Rights of Children and Adolescents" was utilized, involving 9,000 students ranging from 4th to 6th grade in elementary school, grade in middle school, and grade in high school from across the country. The study was conducted targeting these groups. For research analysis, frequency analysis using SPSS 26.0 was employed to calculate the general characteristics of the study subjects and the reliability coefficient of the testing tool. And regression analysis was conducted to verify the mediating effect of parental support on the impact of discrimination experiences on depression. The analysis revealed that there were 4,473 males (51.9%) and 4,150 females (48.1%), and that experiences of discrimination had a negative effect on depression (B=311, P<0.001). It was found that the more frequent the experiences of discrimination, the higher the level of depression, and the more a youth experienced discrimination, the greater the psychological depression they endured.

• Korean Journal of Veterinary Service
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• v.41 no.3
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• pp.197-202
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• 2018

Helicobacter suis is a gram negative bacterium and colonizes in porcine stomach. It causes gastric diseases in the stomach and plays a significant role in daily weight gains in pigs. Recent studies about one of potential sources of human gastric diseases. Therefore, this study was conducted to compare histopathological lesions and molecular detection of Helicobacter suis in the pyloric mucosa of porcine stomachs transferred from slaughterhouses, based on gross and histological examinations and a PCR assay. A total 90 stomach samples were investigated to record gastric lesion scores by characteristic gastric lesions, followed by routine H & E and Warthin-Starry silver staining to detect Helicobacter-like organisms. For PCR assay, H. suis specific primers and conditions are used. Sixty-one samples (67.8%) showed gross gastric lesions, of which 38 samples (40.2%) presented grade 1, 12 samples (13.3%) presented grade 2, and 11 samples (12.2%) presented grade 3, respectively. In Warthin-Starry silver stain, Helicobacter-like organisms were detected from 11 samples (12.2%) with 4 samples (4.4%) for grade 0, 5 samples (5.6%) for grade 1, 1 sample (1.1%) for grade 2 and 1 sample (1.1%) for grade 3, respectively. The PCR resulted positive in 37 samples (41.1%) with 14 samples (15.6%) for grade 0, 14 samples (15.6%) for grade 1, 3 samples (3.3%) for grade 2 and 6 samples (6.7%) for grade 3, respectively. Positive samples for both examinations were 5 samples (5.6%). The result suggested that it should be considered as one of factors causing a gastric disease in pigs. Also, it could be acknowledged to research fundamental aspects of Helicobacter-induced gastritis in human as an animal model.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.22
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• pp.9603-9606
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• 2014

Background: Endometrial cancer is the fourth most common cancer among women in developed countries. Patients with endometrial cancer may benefit from systemic chemotherapy alone or in combination with targeted therapies if the disease is clinically diagnosed prior to spread and metastasis to other organs. The aim of this study was to evaluate the prognostic role of p53 polymorphism and its correlation with tumor grade in human uterine endometrial carcinomas. Materials and Methods: A total of 75 patients with endometrial carcinomas were studied for possible mutations in exon 4 of the p53 gene using polymerase chain reaction and restricting fragment length polymorphism techniques and sequencing. Results: In recent study, The rate of homozygote genotype of pro/pro or Arg/Arg in high grade group was higher than in comparison with low grade one. In addition samples that were undigested in RFLP, showed mutation in exone 4. Conclusions: Our findings showed that high grade endometrial carcinomas are highly associated with TP53 polymorphisms in comparison with low grades.

• The Korean Journal of Cytopathology
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• v.6 no.2
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• pp.148-155
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• 1995

Urinary cytology has become an essential element in the diagnosis and management of transitional ceil carcinoma(TCC) of the urinary tract. It has the advantage of being noninvasive, inexpensive, and easily accessible. Besides that it can even detect malignancy when unsuspected at cystoscopy. We report a retrospective review of urine cytology un the diagnosis of 83 TCC cases that underwent 295 cytologic evaluation. All patients had biopsy-proven TCC of the bladder, ureter and renal pelvis, The overall incidence of the positive cytology cases was 66.2%. To define the cytologic features of tumor cells, we tried to use three cytologic gradings such as "grade 1", "grade 2", and "grade 3" according to the cytologic degree of anaplastic neoplastic cells. These cytologic gades of TCC were relatively well correlated with the histologic grade and tumor invasiveness. This result suggests that the recognition of characteristic cellular features of TCC can suspect the histologic grade and tumor stage. The false negative TCC cases were 78.9%. They showed severe inflammatory or bloody background and a few neoplastic cells. Therefore, a cautious approach for accurate interpretation, personal experience, and proper fixation and processing could expand the role of urinary cytology.

• Journal of Family Resource Management and Policy Review
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• v.20 no.4
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• pp.35-47
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• 2016

This research aimed to observe adolescent children's use of time and to discover the parent-related factors that affect adolescent children's use of time. The subjects included 2,092 fourth-grade elementary school students and 2,108 first-grade middle school students. We used data from the Korean Children and Youth Panel Survey. We tested sociodemographic factors, parents characteristics, and time usage, and we studied these factors using SPSS version 23.0; the results are as follows. Firstly, in the subordinate scope of the child-rearing attitude of parents, affection fourth-grade elementary school students(M = 1.83) and first-grade middle school students(M = 2.02). Inconsistency had an effect on fourth-grade elementary school students(M = 1.99), and first-grade middle school students(M = 2.12). Excessive expectations had an effect on fourth-grade elementary school students(M = 2.40) and first-grade middle school students(M = 2.55). Over-involvement had an effect on fourth-grade elementary school students(M = 2.68)and first-grade middle school students(M = 2.80). Finally, giving reasonable explanations had an effect on fourth-grade elementary school students(M = 1.51)and first-grade middle school students(M = 1.68). Secondly, in fourth-grade elementary school students(M = 463.35) and first-grade middle school students(M = 378.75). Further, studying hours during weekdays had an effect on fourth-grade elementary school students(M = 456.15) and first-grade middle school students(M = 460.86). Free activity hours during had an effect on fourth-grade elementary school students(M = 390.54) and first-grade middle school students(M = 387.11). Sleeping hours during holidays had an effect on fourth-grade elementary school students(M = 544.85) and first-grade middle school students (M = 511.74). Studying hours during holidays had an effect on fourth-grade elementary school students (M = 484.86) and first-grade middle school students (M = 511.74). Free activity hours during holidays had an effect on fourth-grade elementary school students(M = 518.68) and first-grade middle school students(M = 509.73). Thirdly, by observing the relative influence of related factors on adolescent children's use of time, grade(${\beta}$ = -.284), gender(${\beta}$ = -.208), over-involvement(${\beta}$ = -.380), supervising(${\beta}$ = -.217), and (${\beta}$ = .243) in terms of the child-rearing attitudes of parents was found to affect study hours($F=2.595^{**}$). The education level of fathers(${\beta}$ = -.144) results in(${\beta}$ = 1.991) and longer free activity hours for children($F= 4.116^{***}$). This research can be used to study the influence of parents'child-rearing attitudes on adolescent children's use of time and to suggest the role of parents in adolescents' ability to manage time effectively using practical.

• Journal of Families and Better Life
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• v.13 no.4
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• pp.181-198
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• 1995

The purpose of this was to identify the level of adolescent consumers' knowledge consumer attitudes and consumer needs toward market opening and to investigate the influencing variables Data have been collected through questonnaires with 929 middle school high school university students residents of Seoul The major findings are : 1) The average score of consumer knowledge about market opening was 5.26 on the scale of 1-10 2) Consumer attitudes toward market opening were some positive and differed significantly according to grade sex foreign travel experience economic status comsumer knowledge about market opening. 3) The level of consumer education needs was so high and consumer education needs differed significantly according to grade sex consumer knowledge and consumer attitudes toward market opening. 4) Adolescent consumer needs for government consumer business role were so high and the business role was considered most important.

• Proceedings of the Korean Society of Applied Pharmacology
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• 1996.04a
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• pp.193-193
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• 1996

Endothelin-1, which is a peptide originally isolated from cultured porcine aortic cell, has been found to play a crucial role in potentiating the vasoconstriction mitogenesis, and chemotaxis. In the present study, we examined the level of endothelin-1 in the brain, spinal cord and blood from rat with experimental allergic encephalomyelitis(EAE). At the peak stage of EAE(grade 3), endothelin-1 level in the spinal cord of rat with EAE increased two folds as compared with that of sham-treated rats, and subsequently decreased to the level of control at the recovery stage. In the endothelin-1 immunocytochemistry, endothelin-1 immunopositive cells and ED-1, macrophage marker immunopositive cells observed in the spinal cord of peak stage(grade 3). These Findings suggest that endothelin-1 play the important role in progression of EAE.

• Korean Journal of Child Studies
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• v.27 no.3
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• pp.189-205
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• 2006

Gender role flexibility in social and non-social situations across 4 areas of gender-role concepts(appearance, activities, occupations, and personality traits) were studied in 74 1st, 3rd, and 5th grade children. They were interviewed with 16 pictures depicting cross-gender characteristics. Children showed higher flexibility in social than in non-social situations. In social situations, children justified cross-gender characteristics in all 4 areas of gender-role concept. In non-social situations, children showed (a) highest flexibility in occupations and lowest in appearance, (b) lower flexibility toward male than female target children, (c) peak flexibility at age 8, then remaining the same except for appearance, and (d) higher flexibility in girls than in boys. In social and non-social situations children gave variable justifications for flexibility.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• v.27 no.1
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• pp.62-70
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• 2024

Purpose: Choledochal cysts are congenital anomalies that occur as localized cystic or fusiform dilatations of the biliary tree. Reflux and stasis of pancreatic enzymes in the biliary duct may relate to the development of intestinal metaplasia which might be an important factor related to the carcinogenesis of choledochal cyst, thus the expression of beta-catenin in the metaplastic epithelium might be associated with malignant transformation of choledochal cyst epithelium. Methods: This study was conducted at a tertiary care pediatric center between October 2014 and March 2017. Forty patients were evaluated for epithelial lining, mural ulceration, fibrosis, inflammation, and metaplasia. Results: Out of 40, 12 cases (30.0%) were the infantile age group and 28 cases (70.0%) were in the classic pediatric group. Ulceration was classified as grade 0 (14 cases, 35.0%), grade 1 (17 cases, 42.5%), or grade 2 (nine cases, 22.5%). Inflammation was classified as grade 0 (2 cases, 5.0%), grade 1 (26 cases, 65.0%), or grade 2 (12 cases, 30.0%). Fibrosis was classified as grade 0 (five cases, 12.5%), grade 1 (11 cases, 27.5%), grade 2 (17 cases, 42.5%), or grade 3 (seven cases, 17.5%). Metaplasia was noted in five (12.5%) out of 40 cases. All choledochal cysts with metaplasia showed beta-catenin nuclear positivity on immunohistochemistry and were followed up. Conclusion: This study emphasizes the importance of detailed histopathological examination and documentation of metaplastic changes. Metaplasia was associated with beta-catenin nuclear positivity. These findings suggest a potential role for beta-catenin as a marker of metaplastic changes in choledochal cysts.

• Asian Pacific Journal of Cancer Prevention
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• v.13 no.2
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• pp.521-525
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• 2012

Microsomal epoxide hydrolase (mEH) plays a significant role in the metabolism of numerous xenobiotics and is associated with several forms of cancer. Here, we investigated the role of mEH expression in bladder carcinogenesis, subsequent progression and recurrence. The expression of mEH was analyzed by Western blot in 50 bladder urothelial carcinoma and 20 normal epithelial tissues. There was a significantly higher mEH expression in the normal epithelium (P<0.05) and mEH expression was lower in high stage than in low stage tumors (P<0.05). Further, immunohistochmistry in 106 bladder urothelial carcinoma demonstrated mEH expression to be negatively correlated with histological grade, pT stage and recurrence (P<0.05). These findings suggest the important role of mEH in bladder carcinogenesis, cancer development and recurrence, providing support for efforts to develop mEH-based gene therapy.