• Allergy, Asthma & Respiratory Disease
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• v.6 no.6
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• pp.279-283
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• 2018

Asthma is considered a chronic inflammatory airway disease. Mounting evidence reports that patients with asthma are at significantly higher risk of developing communicable diseases such as invasive pneumococcal disease, Haemophilus influenza, varicella, measles, pertussis and tetanus. While impaired innate immunity may play a role in increased risk of developing these infections, suboptimal adaptive immune responses have also been reported to play a role in asthmatic subjects with regard to increased risk of infections. This review discusses the currently underrecognized immunological effect of asthma on antibody to vaccines and recommends that clinicians be aware of less optimal antibody production in response to vaccines in subjects with asthma.

• ETRI Journal
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• v.38 no.4
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• pp.757-766
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• 2016

This study was conducted to examine the usage effects of an augmented reality head-up display (AR-HUD) system on the risk perception and psychological changes of drivers. To do so, we conducted an experiment to collect the driver response times for vehicles and pedestrians as their risk perception behavior, and used a driving behavior determinants questionnaire consisting of Problem Evading, Benefits/Sensation Seeking, Anti-Personal Anxiety, Anti-Personal Angry, and Aggression factors for collecting the psychological characteristics of the drivers. Thirty drivers were randomly assigned into an in-vehicle AR-HUD using group and a control group. As a result, the Anti-Personal Anxiety and Anti-Personal Angry factors were negatively correlated with the response time for the control group. In contrast, these results were not shown for the in-vehicle AR-HUD system using group. These results indicate that the in-vehicle AR-HUD system may partially induce a relaxation of tension or stress for drivers with a high level of interpersonal anxiety. Therefore, the in-vehicle AR-HUD system might contribute to not only the visual safety driving behaviors of drivers, but also to their psychological driving safety with specific characteristics.

• Clinical and Experimental Reproductive Medicine
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• v.43 no.3
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• pp.139-145
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• 2016

Measurements of ovarian reserve play an important role in predicting the clinical results of assisted reproductive technology (ART). The ideal markers of ovarian reserve for clinical applications should have high specificity in order to determine genuine poor responders. Basal follicle-stimulating hormone levels, antral follicle count, and serum anti-$M{\ddot{u}}llerian$ hormone (AMH) levels have been suggested as ovarian reserve tests that may fulfill this requirement, with serum AMH levels being the most promising parameter. Serum AMH levels have been suggested to be a predictor of clinical pregnancy in ART for older women, who are at a high risk for decreased ovarian response. We reviewed the prognostic significance of ovarian reserve tests for patients undergoing ART treatment, with a particular focus on the significance of serum AMH levels in patients at a high risk of poor ovarian response.

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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• 2014.10a
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• pp.347-349
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• 2014

Model verification and validation (V&V) is a current research topic to build computational models with high predictive capability by addressing the general concepts, processes and statistical techniques. The hypothesis test for validity check is one of the model validation techniques and gives a guideline to evaluate the validity of a computational model when limited experimental data only exist due to restricted test resources (e.g., time and budget). The hypothesis test for validity check mainly employ Type I error, the risk of rejecting the valid computational model, for the validity evaluation since quantification of Type II error is not feasible for model validation. However, Type II error, the risk of accepting invalid computational model, should be importantly considered for an engineered products having high risk on predicted results. This paper proposes a technique named as the response-adaptive experimental design to reduce Type II error by adaptively designing experimental conditions for the validation experiment. A tire tread block problem and a numerical example are employed to show the effectiveness of the response-adaptive experimental design for the validity evaluation.

• Korean Journal of Clinical Laboratory Science
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• v.43 no.4
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• pp.138-144
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• 2011

Exaggerated blood pressure response during exercise has been found to increase the risk of future hypertension, left ventricular hypertrophy, cerebrovascular stroke, and CVD (cardiovascular disease) death. The aim of this study was to evaluate exercise capacity, cardiovascular factors in exaggerated blood pressure response during treadmill exercise testing. For research subjects, 72 subjects (normal blood response: 49 subjects, exaggerated blood response: 23 subjects) who received treadmill exercise test at J General Hospital were selected in this study. Exaggerated SBP (systolic blood pressure) response was defined as an SBP of 210 mmHg or greater during a maximal treadmill exercise test. The group with an exaggerated SBP response showed significantly higher values for RPP (rate pressure product) compared with the group with a normal SBP response. Subjects with METs (metabolic equivalents) had lower exaggerated SBP response than normal SBP response group. Subjects with recovery SBP had delayed exaggerated SBP response than normal SBP response group. Exaggerated SBP response to exercise is negative correlation with METs.

• Environmental Analysis Health and Toxicology
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• v.25 no.2
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• pp.169-177
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• 2010

Ecological risk assessment (ERA) has been used to establish environmental quality standards or evaluate ecological risk in site-specific areas. The scope of ERA was expanded based on regions, and the concept of regional-scale ecological risk assessment was recently introduced in developed countries. In the present study, regional ERA approaches of relative risk model (RRM), contaminants in aquatic and terrestrial ecosystems (CATS) model, and procedure for ecological tired assessment of risks (PETAR) in advanced countries were extensively investigated. Regional ERA was compared with traditional ERA process. Stressors, receptor and response in traditional ERA were replaced with sources of stressors, habitats, and ecological impacts, respectively in regional ERA. This study introduces the concept and assessment process of regional ERA, and provides a wide perspective how the relative ERA could be applied in Korean ecosystem.

• Journal of the Korea Society of Computer and Information
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• v.24 no.9
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• pp.69-75
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• 2019

We propose a method to analyze user requirements to design a virtual reality-based risk management system. This paper presents surveys, interviews, prototype evaluation methods, and implementation process. Architectural heritage is easily exposed to natural and artificial dangers caused by various material combinations and structural features. So, risk management of cultural heritage plays a key role in preserving and managing cultural heritage. However, risk management has been carried out through empirical methods using distributed data. This study analyzes user requirements for designing functions and interfaces of VR-based risk management system and evaluates prototypes to overcome the above problems. As a result, most heritage managers wanted a system function to support risk analysis and response. They also found that they prefer 2D information such as existing drawings and photos rather than 3D information. The results of the user requirements analysis derived from this study will be used to create risk management applications.

• Journal of the Society of Naval Architects of Korea
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• v.40 no.5
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• pp.60-67
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• 2003

For risk or reliability assessment of ship structures against particular hazardous situations such as total loss or sinking due to hull girder collapse, the short-term based response analysis rather than the long-term response analysis is required to determine wave-induced bending moments when the ship encounters a storm of specific duration and with a specified small encounter probability. In the present study, the effects of operational condition and sea states on wave-induced bending moments of large merchant vessels are investigated. A series of the short-term response analyses for a hypothetical VLCC and a Capesize bulk carrier (CSBC) are carried out with varying operational condition and sea states which include ship speed, significant wave height and wave persistence time, using the linear-strip theory based program ABS/SHIPMOTION and the MIT sea-keeping tables. The computed results are also compared with the IACS design formula predictions. The results and insights developed from the present study are summarized.

• Journal of Preventive Medicine and Public Health
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• v.49 no.6
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• pp.367-375
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• 2016

Objectives: The established theory that breast density is an independent predictor of breast cancer risk is based on studies targeting white women in the West. More Asian women than Western women have dense breasts, but the incidence of breast cancer is lower among Asian women. This meta-analysis investigated the association between breast density in mammography and breast cancer risk in Asian women. Methods: PubMed and Scopus were searched, and the final date of publication was set as December 31, 2015. The effect size in each article was calculated using the interval-collapse method. Summary effect sizes (sESs) and 95% confidence intervals (CIs) were calculated by conducting a meta-analysis applying a random effect model. To investigate the dose-response relationship, random effect dose-response meta-regression (RE-DRMR) was conducted. Results: Six analytical epidemiology studies in total were selected, including one cohort study and five case-control studies. A total of 17 datasets were constructed by type of breast density index and menopausal status. In analyzing the subgroups of premenopausal vs. postmenopausal women, the percent density (PD) index was confirmed to be associated with a significantly elevated risk for breast cancer (sES, 2.21; 95% CI, 1.52 to 3.21; $I^2=50.0%$). The RE-DRMR results showed that the risk of breast cancer increased 1.73 times for each 25% increase in PD in postmenopausal women (95% CI, 1.20 to 2.47). Conclusions: In Asian women, breast cancer risk increased with breast density measured using the PD index, regardless of menopausal status. We propose the further development of a breast cancer risk prediction model based on the application of PD in Asian women.

• Journal of Korean Society of Industrial and Systems Engineering
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• v.39 no.1
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• pp.9-16
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• 2016

The project schedule risk in the engineering and facility construction industry is increasingly considered as important management factor because the risks in terms of schedule or deadline may significantly affect the project cost. Especially, the project-based operating companies attempt to find the best estimate of the project completion time for use at their proposals, and therefore, usually have much interest in accurate estimation of the duration of the projects. In general, the management of projects schedule risk is achieved by modeling project schedule with PERT/CPM techniques, and then performing risk assessment with simulation such as Monte-Carlo simulation method. However, since these approaches require the accumulated executional data, which are not usually available in project-based operating company, and, further, they cannot reflect various schedule constraints, which usually are met during the project execution, the project managers have difficulty in preparing for the project risks in advance of their occurrence in the project execution. As these constraints may affect time and cost which role as the crucial evaluation factors to the quality of the project result, they must be identified and described in advance of their occurrence in the project management. This paper proposes a Bayesian Net based methodology for estimating project schedule risk by identifying and enforcing the project risks and its response plan which may occur in storage tank engineering and construction project environment. First, we translated the schedule network with the project risks and its response plan into Bayesian Net. Second, we analyzed the integrated Bayesian Net and suggested an estimate of project schedule risk with simulation approach. Finally, we applied our approach to a storage tank construction project to validate its feasibility.