• Title/Summary/Keyword: risk assessment

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Factors Associated with Early Death in Patients with Community-Acquired Pneumonia (지역사회획득폐렴에서 조기 사망과 관련된 인자)

  • Park, Hun-Pyo;Seo, Yong-Woo;Lee, Jeong-Eun;Kim, Young-Ho;Jang, Young-Yun;Park, Soon-Hyo;Seo, Chang-Kyun;Jeon, Young-June;Lee, Mi-Young;Choi, Won-Il
    • Tuberculosis and Respiratory Diseases
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    • v.58 no.6
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    • pp.607-613
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    • 2005
  • Background : Early death is an important problem associated with the management of community-acquired pneumonia. However, there is little information on the risk factors associated with it. The aim of this study was to identify the factors associated with early death in community-acquired pneumonia patients. Methods : From January 1999 to July 2004, 1,487 adult patients with community-acquired pneumonia who were admitted to the pulmonary department via emergency center were examined. Early death was defined as those who died within 2 days of hospitalization. The clinical and laboratory aspects of the patients who died early (n = 30) were compared with those of an age and gender matched control population (n = 60). Results : In the early death group, respiratory rate, heart rate, and blood urea nitrogen (BUN) were significant higher (p < 0.05 for all), while the arterial pH, systolic pressure, and $PaO_2$ were significant lower (p < 0.05 for all) than the control. The independent factor significantly associated with early death was tachypnea (OR, 7.049). Conclusion : The importance of an early clinical assessment in emergency center with community-acquired pneumonia needs to be emphasized in order to recognize patients at risk of early death.

GEOTECHNICAL DESIGNS OF THE SHIP IMPACT PROTECTION SYSTEM FOR INCHEON BRIDGE

  • Choi, Sung-Min;Oh, Seung-Tak;Park, Sang-Il;Kim, Sung-Hwan
    • Proceedings of the Korean Geotechical Society Conference
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    • 2010.09c
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    • pp.72-77
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    • 2010
  • The Incheon Bridge, which was opened to the traffic in October 2009, is an 18.4 km long sea-crossing bridge connecting the Incheon International Airport with the expressway networks around the Seoul metropolitan area by way of Songdo District of Incheon City. This bridge is an integration of several special featured bridges and the major part of the bridge consists of cable-stayed spans. This marine cable-stayed bridge has a main span of 800 m wide to cross the vessel navigation channel in and out of the Incheon Port. In waterways where ship collision is anticipated, bridges shall be designed to resist ship impact forces, and/or, adequately protected by ship impact protection (SIP) systems. For the Incheon Bridge, large diameter circular dolphins as SIP were made at 44 locations of the both side of the main span around the piers of the cable-stayed bridge span. This world's largest dolphin-type SIP system protects the bridge against the collision with 100,000 DWT tanker navigating the channel with speed of 10 knots. Diameter of the dolphin is up to 25 m. Vessel collision risk was assessed by probability based analysis with AASHTO Method-II. The annual frequency of bridge collapse through the risk analysis for 71,370 cases of the impact scenario was less than $0.5{\times}10^{-4}$ and satisfies design requirements. The dolphin is the circular sheet pile structure filled with crushed rock and closed at the top with a robust concrete cap. The structural design was performed with numerical analyses of which constitutional model was verified by the physical model experiment using the geo-centrifugal testing equipment. 3D non-linear finite element models were used to analyze the structural response and energy-dissipating capability of dolphins which were deeply embedded in the seabed. The dolphin structure secures external stability and internal stability for ordinary loads such as wave and current pressure. Considering failure mechanism, stability assessment was performed for the strength limit state and service limit state of the dolphins. The friction angle of the crushed stone as a filling material was reduced to $38^{\circ}$ considering the possibility of contracting behavior as the impact.

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Analysis of Drug Interaction Information (국내의약품의 약물상호작용 정보 분석)

  • Lee, Young-Sook;Lee, Ji-Seon;Lee, Suk-Hyang
    • Korean Journal of Clinical Pharmacy
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    • v.19 no.1
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    • pp.1-17
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    • 2009
  • Adverse drug reactions (ADR) caused by inappropriate prescription are responsible for major socioeconomic loss. Drug-drug interactions (DDI) has been recognized as a major part of ADRs and, therefore, healthcare professionals should prevent possible DDIs to minimize preventable ADRs. This study aimed to examine DDI information in drug information references and Korea Food & Drug Administration (KFDA) drug labeling information. Drug ingredients from the formulary of Health Insurance Review and Assessment Service in Korea (HIRA) were included for the study. DDI information source used for the study were Micromedex Drugdex and Drug Information Facts (DIF) with the DDI severity level of "moderate" or more. The DDI information in KFDA drug labeling were collected and compared. Drug ingredients were classified with KFDA Drug Classification and ATC Classification of WHO for the analysis. Among the total 1,355 drug ingredients satisfying inclusion criteria, 738 ingredients involved at least one DDI, which was described in Micromedex and/or DIF. Drug Ingredients of 176 involved DDI only described in KFDA drug labeling, but not Micromedex nor DIF. Drug ingredients of 35 which DDIs were described in Micromedex or DIF did not have DDI based on KFDA drug labeling. Micromedex and DIF retrieved 7,582 and 3,071 DDIs, respectively 57.6% and 58.5% of DDIs were also described in KFDA drug labeling. Central nervous system (CNS) drugs, cardiovascular system (CVS) drugs and the antiinfectives appeared to have higher frequency of DDIs among all drug classes. The highest number of DDIs with high severity level ("contraindicated" or "major") were the DDIs of CNS drugs. The antiinfectives are the second drug group having serious DDIs. The DDI pairs of the CNS drug and the antiinfective had the highest contraindication risk (13.6%). DDI information from Micromedex and DIF were not consistent with the result that only 465 ingredients' DDIs are common in both literature (total DDI numbers were 715 vs 488, respectively). And 1,652 DDI information are common in both references among 7,582 vs 3,071 DDIs, respectively. Only 55.2% of DDI information in the database contained in the KFDA drug labeling. Prescribers and pharmacists should pay attention to the drugs for CV system, CNS and infections because of higher risk of possible DDIs compared to other drug classes. KFDA drug labeling is not likely to be recommended as a good information source for DDI due to significant inconsistency of information. Drug information providers should be aware that DDI information from different sources are not consistent and therefore multiple references should be used.

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Hazard Evaluation of Gas Processes Using a Multi-distinction Equipment Screening Algorithm (다중판별 장치 스크리닝 기법을 이용한 가스공정의 위험성 평가)

  • Yoon En Sup;Park Jeong Su;Ahn Sung Joon;Han Kyounghoon;Yoon Jong Phil;Kim Ku Hwoi;Shin Dongil
    • Journal of the Korean Institute of Gas
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    • v.7 no.1 s.18
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    • pp.1-9
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    • 2003
  • A Multi-distinction Equipment Screening Algorithm (MESA) is proposed. It selectively integrates Dow's F&EI as its process hazard index technique and ESA (Equipment Screening Algorithm) as qualitative hazard classification technique, and retrieves a detailed list of hazardous equipments with the total hazard indices of those equipments. The inherent expert system, which includes the accident scenarios of the equipments and processes and experts' views of them, narrows further down the list of hazardous equipments and recommends only the most notable candidates. Through the case study of distinguishing the hazardous ranking of the equipments of the LPG underground storage process, using the expert system or not, the applicability of MESA has been validated. Taking the characteristics of the process equipments with hazardous ranking in the point of process intrinsic safety, this proposed algorithm would contribute to providing engineers or managers with information on constructing safely devices and mitigation devices and on scheduling emergency response planning.

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Risk assessment on cytotoxicity for benzimidazole fungicides (Benzimidazole계 살균제의 세포독성 평가)

  • Lee, Je-Bong;Sung, Pil-Nam;Jeong, Mi-Hye;Shin, Jin-Sup;Kang, Kyu-Young
    • The Korean Journal of Pesticide Science
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    • v.7 no.3
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    • pp.198-206
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    • 2003
  • To assess potential risk of the benzimidazole fungicides, their cytotoxicities were evaluated. Activities of LDH(Lactic dehydrogenase) in the culture fluid of CHL(chinese hamster lung) fiberoblast cell treated with 4.0, 16.0 or $32.0{\mu}g/mL$ of carbendazim for 24 hours were elevated 2.16, 2.94 and 2.64 folds compared to the control, respectively. DNA synthesis was inhibited by 45% at $2.0{\mu}g/mL$ of carbendazim. Benzimidazole fungicides showed high toxicity to cell and mitochondria of CHL cell by Giemsa and MTT (3-(4,5-dimethylthiazole-2-yl)-2,5-diphenyltetrazolium bromide) assay. $IC_{50}$ by the Giemsa assay of thiophanate-methyl, benomyl, carbendazim and captafol were over 125, 1.2, 30.0 and $0.3{\mu}g/mL$, respectively. $IC_{50}$ by the MTT assay of thiophanate-methyl, benomyl, carbendazim and captafol were over 125, 18.7, 20.4 and $2.6{\mu}g/mL$, respectively. Inhibitory concentration of cell median proliferation by SRB (sulforhodamin B) assay for thiophanate-methyl, carbendazim, benomyl, and captafol were 17.4, 5.3, 1.5 and $0.5{\mu}g/mL$, respectively. Accordingly, benzimidazole fungicides inhibited DNA synthesis, mitochondrial function, cell proliferation and induced cell necrosis.

Hydrological Assessment of Different Phase of ENSO through Estimation of Integrated Risk Index: A Case Study of the Han River basin (통합위험지수 산정을 통한 서로 다른 ENSO의 수문학적 영향 평가: 한강유역을 중심으로)

  • Yoon, Sun-Kwon;Kim, Jong-Suk;Lee, Joo-Heon;Moon, Young-Il
    • Proceedings of the Korea Water Resources Association Conference
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    • 2012.05a
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    • pp.982-982
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    • 2012
  • 본 연구에서는 우리나라의 중 소규모 유역의 수문학적 위험도 분석을 위하여 한강유역을 대상으로 통합위험지수(IRI: Integrated Risk Index)를 산정하였으며, El Ni$\tilde{n}$o-Southern Oscillation (ENSO)에 의한 대규모 대기순환 패턴의 변화가 한강 유역의 통합위험지수 변화에 미치는 영향을 평가하였다. ENSO자료는 전통적인 El Ni$\tilde{n}$o에 해당하는 Cold-tongue (CT) El Ni$\tilde{n}$o와 중앙태평양 부근의 이상적인 해수면 온도 상승에 의한 Warm-pool (WP) El Ni$\tilde{n}$o, 그리고 해수면 온도가 이상적으로 낮게 관측되는 La Ni$\tilde{n}$a 기간으로 구분하였으며, 각 기간 중 가장 강한 ENSO가 발생한 해(CT El Ni$\tilde{n}$o, 1998; WP El Ni$\tilde{n}$o, 2005; La Ni$\tilde{n}$a, 2000)를 대상으로 통합위험지수를 산정하였다. 통합위험지수는 수문학적 요인(Hydrologic Components), 사회 경제적 요인(Socio-Economic Components)과 생태적 요인(Ecological Components)으로 구분하였고, 엔트로피(entropy) 기법을 통하여 각 인자와 요인별 가중치를 적용하였다. 중권역별 통합위험지수의 평가는 5개의 계급구간(Very High, High, Medium, Low, Very Low)으로 구분하였다. 분석결과, CT El Ni$\tilde{n}$o해의 유역평균 IRI 값은 0.58, WP El Ni$\tilde{n}$o해의 IRI 값은 0.57로 비슷한 결과를 보였으나, La Ni$\tilde{n}$a해에는 IRI 값이 0.41로 낮게 나타났다. CT와 WP El Ni$\tilde{n}$o해에는 한강 서쪽일부 중권역에서 통합위험지수가 높게 나타났으며, La Ni$\tilde{n}$a해에는 한강 중 동부 대부분 유역에서 낮게 분석되었다. 향후 유역별 통합위험지수 산정과 더불어 서로 다른 형태의 ENSO에 따른 수자원 변동 예측이 이루어진다면, 수자원의 효율적인 관리와 안정적인 용수공급에 도움을 줄 것으로 사료되며, 이는 유역별 수자원의 취약성 평가 및 위험도 분석을 위한 기초자료로 활용이 가능하리라 사료된다.

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Analysis of Glyphosate and Glufosinate in Animal Feeds using LC-MS/MS (LC-MS/MS를 이용한 동물 사료 내 글라이포세이트 및 글루포시네이트 분석)

  • Lee, Ji-Su;Kim, Wanseo;Yang, Heedeuk;Park, Na-Youn;Jung, Woong;Kim, Junghoan;Kho, Younglim
    • Journal of the Korean Chemical Society
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    • v.63 no.5
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    • pp.342-345
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    • 2019
  • The standards for the contents of glyphosate and glufosinate in foods are specific and well categorized. However, the standard of content in animal feeds is relatively inadequate and the classification is insufficient. There is also constant debate about the risk of glyphosate and glufosinate to human health, but the risk to animals has not been well studied. In this study, we established an analytical method in feeds that is estimated to be the path for animals to ingest glyphosate. The solvent extraction was carried out using 25% methanol. After centrifugation, samples were purified using solid phase extraction (SPE) and quantitatively analysed using LC-MS/MS after concentrated. Assessment of validation was conducted through detection limits, accuracy, and precision tests. The detection limits for the established method were 1.8 of ${\mu}g/kg$ of glufosinate and $2.4{\mu}g/kg$ of glyphosate. Accuracy was ranged from 94.4% to 103.4% and precision was range from 1.5% to 7.2%. Glufosinate was detected in one sample ($ND{\sim}8.8{\mu}g/kg$) and glyphosate was detected in all but one sample ($ND{\sim}337.0{\mu}g/kg$) by applying the analytical method to animal feeds (n=13).

A Survey on Heavy Metal Contents and Transfer Rate in Animal Medicines (동물성 생약의 중금속 함량 및 이행률 조사)

  • Lee, Sung-Deuk;Lee, Jeong-Sook;Hwang, Kwang-Ho;Kim, Hee-Soon;Yoo, In-Sil;Han, Ki-Young;Chae, Young-Zoo
    • YAKHAK HOEJI
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    • v.57 no.1
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    • pp.8-17
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    • 2013
  • The objective of this study is investigation of contamination levels and transfer rate of heavy metals and assessment of health risk effects in animal medicines. A total of sixteen items with 148 samples were obtained for this investigation from major herbal medicine producing areas and herbal markets from 2011 to 2012. Inductively coupled plasma mass spectrometer method was conducted for the quantitative analysis of Pb, Cd and As. In addition, the mercury analyzer system was conducted for that of Hg without sample digestion. The average contents of heavy metals in animal medicines were as follows : 1.55 mg/kg for Pb, 0.28 mg/kg for Cd, 0.70 mg/kg for As and 0.047 mg/kg for Hg respectively. The average contents of heavy metals in decoctions were as follows : 0.03 mg/kg for Pb, 0.01 mg/kg for Cd, 0.17 mg/kg for As and 0.003 mg/kg for Hg respectively. The average transfer rates of heavy metals from animal medicines to decoctions were 1.9% for Pb, 3.6% for Cd, 24.2% for As and 6.0% for Hg respectively. Cancer risks of animal medicines and decoctions through slope factor by ministry of environment republic korea and environmental protection agency was $1.36{\times}10^{-6}$ and $2.50{\times}10^{-8}$ for Pb and $7.46{\times}10^{-5}$ and $1.98{\times}10^{-5}$ for As (assuming that the total arsenic content was equal to the inorganic arsenic) respectively. The hazard index of heavy metals in animal medicines and decoctions was below recommended hazard index as 0.52 and 0.05 respectively. Taken together, cancer risks about Pb and hazard indexes of animal medicines and decoctions indicate that the majority of samples except for some samples with relative high contents of heavy metals were safe. But cancer risks about As of animal medicines indicate that the majority of samples were not relatively safe.

The Relationship between Possibility of Bipolar Disorder and Suicidal Attempt in Emergency Room (자살시도로 응급실에 내원한 환자의 자살 위험성과 양극성 장애 가능성의 연관성)

  • Huh, Lyang;Kim, Kun Hyung;Chun, Jin Ho;Park, Young Min;Kim, Young Hoon;Lee, Bong Ju
    • Korean Journal of Psychosomatic Medicine
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    • v.23 no.2
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    • pp.107-113
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    • 2015
  • Objectives : The aim of this study was to investigate the factors including possibility of bipolar disorder that are related to intensity of suicidal idea. Methods : The study subjects consisted of 50 patients who did suicidal attempt and treated at the Inje University Haeundae Paik Hospital Emergency Room. All participants underwent psychiatric interview and underwent Columbia Suicide Severity Rating Scale(C-SSRS), Beck Depression Inventory(BDI), Korean Version of Mood Disorder Questionnaire(MDQ) and Bipolar Spectrum Diagnostic Scale(BSDS) to evaluate patient's suicide attempt, severity of depression and possibility of bipolar disorder. Results : Compared to non-high risk group, suicide high risk group showed significantly higher BDI(p<0.001) and intensity of ideation(IOI) in C-SSRS(p<0.001). Also intensity of ideation(IOI) was correlated with Mood Disorder Questionnaire(MDQ) bipolarity positive(p=0.033). Conclusions : The present study indicated that possibility of bipolar disorder plays a significant role in suicide attempters. Assessment of suicide ideation severity and possibility of bipolar disorder should be considered when suicide attempters come to emergency room.

The Effect of 4-Week Health Promotion Summer Camp on the Metabolic Syndrome and Insulin Resistance among Obese Elementary Students (비만 초등학생의 4주 여름 건강증진캠프 참여가 대사증후군 및 인슐린저항성에 미치는 효과)

  • Kim, Hee-Jung;Jekal, Yoonsuk
    • Journal of the Korean Applied Science and Technology
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    • v.38 no.4
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    • pp.1117-1128
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    • 2021
  • The purpose of the current study was to investigate the effects of 4-week health promotion intervention program consisting of high-intensity aerobic exercise to improve energy consumption and cardiorespiratory capacity, circuit training to strengthen muscular strength and endurance and education for lifestyle changes on the obesity level, physical fitness, insulin resistance and metabolic syndrome among overweight or obese elementary school students. Twenty three overweight or obese children as obese group and 15 normal body weight children as normal group were recruited. The health promotion program consisted of two exercise sessions and one education session, 3days/week in 4-week. Obesity level(body mass index, waist circumference, %body fat), physical fitness(muscular strength, muscular endurance, flexibility, cardiopulmonary fitness), insulin resistance(homeostasis model assessment of insulin resistance) and metabolic syndrome risk factors(blood pressure, fasting glucose, triglycerides, high density lipoprotein cholesterol) were measured. There was not significant decrease in obesity level; however, there were significant improvement in physical fitness, insulin resistance and metabolic syndrome risk factors after program participation among obese children. As a result, through participation in the summer camp consisting mainly of exercise, the improvement of the physical fitness level and the decrease of insulin resistance had an effect on the reduction of the metabolic syndrome frequency.