• 수면정신생리
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• 제19권1호
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• pp.5-10
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• 2012

The release of hormones and the metabolism of human body are controlled by the circadian rhythm related to sleep-wake cycle. Growth hormone, prolactin, thyroid stimulating hormone, cortisol, glucose, and insulin-secretion rates fluctuate according to the sleep-wake cycle. In addition, sleep is related to the appetite regulation and carbohydrate and other energy metabolism. Hypocretin (orexin), an excitatory neuropeptide, regulates waking and diet intake, and the poor sleep increases diet intake. The short sleep duration increases one's body mass index and impairs the function of the endocrine and metabolism, causing increases in the risk of glucose intolerance and diabetes. The poor sleep quality and sleep disorders have similar impact on the metabolic function. In short, the sleep loss and the poor quality of sleep have a detrimental effect on the endocrine and energy metabolism. The improvement of sleep quality by the future research and appropriate clinical treatment would contribute to the decrease of the metabolic diseases such as diabetes.

• 기본간호학회지
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• 제21권2호
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• pp.123-130
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• 2014

Purpose: The purpose of this study was to identify quality of sleep and health-promoting behaviors in rotating-shift nurses and to explore the influence of health promoting behaviors on quality of sleep. Method: Participants were 161 staff nurses working in an irregular three shift system in one of three general hospitals located in Kyungpook province. Data were collected using the Pittsburgh Sleep Quality Index and the Health Promoting Lifestyle Profile-IIand were analyzed using hierarchical multiple regression analysis. Results: The majority of the participants had very poor quality of sleep and performed a low level of health promoting behaviors. In terms of health promoting behaviors, nutrition and stress management significantly influenced quality of sleep of these nurses. Conclusion: Results indicate the importance of encouraging rotating-shift nurses to enhance their health promoting behaviors in order to improve quality of sleep.

• 한국임상수의학회지
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• 제40권2호
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• pp.130-134
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• 2023

A 12-year-old Standard Poodle presented with intermittent weakness and occasional dyspnea at the Veterinary Medicine Teaching Hospital of Kangwon National University. A grade of 4 out of 6 systolic murmur with an irregular tachycardic rhythm was auscultated on both sides of the chest. Systolic blood pressure was 140 mmHg. Panting was noticed in the hospital, but there was no crackle sound. Blood analysis revealed mild increases in liver panel levels (alanine aminotransferase 149 [reference interval, 19-70] U/L; and alkaline phosphatase, 185 [reference interval, 15-127] U/L) and severe increases in cardiac biomarker levels (n-terminal pro-brain natriuretic peptide, 4169 [reference interval, 50-900] pmol/L; and cardiac troponin I, 0.22 [reference interval, 0.03-0.12] ng/mL). On electrocardiography, irregularly irregular supraventricular tachycardic rhythm with an f-wave and no distinct p-wave was observed. Generalized cardiomegaly with an enlarged right atrium and left ventricle was confirmed on thoracic radiography. Moreover, hepatomegaly and an enlarged caudal vena cava were observed. Echocardiographic evaluation revealed a fibromuscular diaphragm in the right ventricle. Because of the obstructive lesion in the right ventricle, the right atrium and ventricle were enlarged (right atrial area index, 38.82 cm²/m² [reference interval, 4.2-10.2 cm²/m²]; right ventricle end-diastolic area index, 14.152 cm²/m² [reference interval, 4.9-10.92 cm²/m²]). Accordingly, the patient was diagnosed with double-chambered right ventricle (DCRV). Pimobendan, furosemide, enalapril, diltiazem, and S-adenosylmethionine (SAMe) were prescribed, and all symptoms were relieved. DCRV is a right-sided congenital heart defect resembling pulmonic valve stenosis. If symptoms are not severe, medical therapy can be facilitated without surgery or the balloon dilation.

• Clinical and Experimental Pediatrics
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• 제52권7호
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• pp.752-755
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• 2009

It is well known that hemodynamic load is one of the most important determinants of cardiac structure and function. Circadian variations in blood pressure (BP) are usually accompanied by consensual changes in peripheral resistance and/or cardiac output. In recent years, reduction in circadian variations in BP and, in particular, loss of nocturnal decline of BP were observed in hypertensive patients with left ventricular hypertrophy (LVH). The patients with only a slight or no loss of nocturnal decline of BP were considered "non-dippers". Regression of LVH was observed after prolonged antihypertensive therapy. Restoration of the circadian rhythm of BP was also observed. However, the classification of patients into "dippers" and "non-dippers" is arbitrary and poorly standardized and repeatable, and in the recent studies, most hypertensive patients with LVH were "dippers". Therefore, we should be particularly cautious about the conclusions drawn using this index. On the other hand, reduced activity of low-pressure cardiopulmonary baroreceptors and impaired day-to-night modulation of autonomic nervous system activity were observed in patients with only LVH. Therefore, alterations in cardiac structure may impair BP modulation. On the other hand, the reverse can also be trueprimary alterations in BP modulation, through a persistently elevated afterload, can increase cardiac mass. Thus, the interrelationship between cardiac structure and BP modulation is complex. Hence, new and more specific methods of evaluating circadian changes in BP are needed to better clarify the abovementioned reciprocal influences.

• 말소리와 음성과학
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• 제7권3호
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• pp.3-11
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• 2015

This study compared English and Korean speakers with regard to the nasalization of the English stops /b, d, g, p, t, k/before a nasal within and across a word boundary. Nine English and thirty Korean speakers participated in the experiment. We used 37 speech items with different grammatical structures. Overall the English informants rarely nasalized the stops while the Korean informants generally greatly nasalized them though widely varying from no nasalization to almost complete nasalization. In general, voiced stops were more likely to be nasalized than voiceless stops. Also, the alveolar stops /d, t/tended to be nasalized the most, the bilabial stops /b, p/ the second most, and the velar stops /g, k/ the least. Besides, the closer the grammatical relationship between neighboring words, the more likely the stop nasalization occurred. In contrast, the Korean syllabification - the addition of the vowel /i/ to the final stops - worked against the stop nasalization. On the other hand, different stress (accent) or rhythm effects of the two languages are assumed to contribute to the significantly different nasalization between English and Korean speakers. The spectrum of stop nasalization obtained from this study can be used as an index to measure how close a certain Korean speaker's stop nasalization is to English speakers'.

• Clinical Nutrition Research
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• 제12권1호
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• pp.7-20
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• 2023

Creating a complex balance between dietary composition, circadian rhythm, and the hemostasis control of energy is important for managing diseases. Therefore, we aimed to determine the interaction between cryptochrome circadian clocks 1 polymorphism and energy-adjusted dietary inflammatory index (E-DII) on high-sensitivity C-reactive protein in women with central obesity. This cross-sectional study recruited 220 Iranian women aged 18-45 with central obesity. The 147-item semi-quantitative food frequency questionnaire was used to assess the dietary intakes, and the E-DII score was calculated. Anthropometric and biochemical measurements were determined. By polymerase chain response-restricted length polymorphism method, cryptochrome circadian clocks 1 polymorphism was assigned. Participants were categorized into three groups based on the E-DII score, then categorized according to cryptochrome circadian clocks 1 genotypes. The mean and standard deviation of age, BMI, and high-sensitivity C-reactive protein (hs-CRP) were 35.61 ± 9.57 years, 30.97 ± 4.16 kg/m², and 4.82 ± 5.16 mg/dL, respectively. The interaction of the CG genotype and E-DII score had a significant association with higher hs-CRP level compared to GG genotype as the reference group (β, 1.19; 95% CI, 0.11-2.27; p value, 0.03). There was a marginally significant association between the interaction of the CC genotype and the E-DII score with higher hs-CRP level compared to the GG genotype as the reference group (β, 0.85; 95% CI, -0.15 to 1.86; p value, 0.05). There is probably positive interaction between CG, CC genotypes of cryptochrome circadian clocks 1, and E-DII score on the high-sensitivity C-reactive protein level in women with central obesity.

• 디지털융복합연구
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• 제11권4호
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• pp.331-338
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• 2013

본 연구는 엉치엉덩관절 통증을 동반한 만성 요통환자 52명을 대상으로 6주 간 골반운동프로그램 및 전통적 물리치료를 병행한 실험군 27명과 전통적 물리치료만을 중재한 대조군 25명을 무작위 임상 표본 추출 하였다. 두 군 모두 통증의 정도를 알아보는 오스웨스트리-요통장애지수검사와 보행 시 엉덩관절의 각도분석을 한 후, 집단별 실험 전과 실험 후의 오스웨스트리-요통장애지수검사와 보행 시 엉덩관절의 각도분석을 비교하여 골반안정화 운동프로그램이 엉치엉덩관절 통증을 동반한 만성요통환자의 통증과 엉덩관절에 미치는 영향을 알아보고자 하였다. 요통의 변화는 집단 내와 집단 간에서 모두 유의하게 감소되었음을 알 수 있었고, 엉덩관절 각도비교에서는 실험군내 좌측 엉덩관절에서 중간디딤기, 말기디딤기, 유각전기, 초기흔들기와 우측 엉덩관절의 중간디딤기, 말기디딤기, 유각전기, 초기흔들기에서 차이가 있었다. 대조군 내 좌측 엉덩관절에서는 중간디딤기, 말기디딤기, 초기흔들기와 우측 엉덩관절의 체중전달기, 중간디딤기, 말기흔들기, 유각전기에서 유의한 차이가 있었다. 따라서 골반안정화 운동프로그램이 통증을 포함한 요통기능장애수준에 효과적이고 보행 시 입각기와 유각기 동안 엉덩관절의 굽힘과 폄이 리듬 있게 이동하여 보행이 대칭적으로 자연스럽게 이동되는데 도움이 되는 것으로 나타났다.

• 수면정신생리
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• 제19권2호
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• pp.77-83
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• 2012

목 적: 저녁형일수록 우울해지기 쉽다는 경향성이 일반 인구집단이 아닌 폐쇄성 수면무호흡증 환자들에서도 동일하게 나타나는지를 알아보고, 수면다원검사를 통해 획득한 데이터와 상황별 졸음 평가지 등을 통해 얻은 자료 중 저녁형일수록 증가되는 항목과 우울할수록 증가되는 항목을 알아보고자 하였다. 방 법: 2008년 1월 1일부터 2011년 2월 18일까지 을지병원 수면장애 클리닉에 내원한 환자들 중 수면다원검사를 통해 OSA로 진단받은 환자 211명을 대상으로 인구학적 자료와 신체 계측 자료를 얻었으며, 상황별 졸음 평가지(ESS). 아침형-저녁형 설문지(HOQ), 한국판 기분상태척도(K-POMS), 수면다원검사를 통해 얻은 자료를 분석하였다. 일원배치 분산분석을 통해 아침형군과 저녁형군, 중간형군 별로 인구학적 자료 및 신체계측자료, 수면다원검사 자료에 대한 평균값 비교를 시행하였다. 이후 연령과 체중을 보정하여 인구학적 자료 및 신체계측자료, 수면다원검사 자료들간의 편상관분석을 시행하였다. 또한 연령과 체중을 보정한 공분산분석을 통해 아침형군과 저녁형군, 중간형군 별로 각각의 인구학적 자료 및 신체계측자료, 수면다원검사 자료에 대한 평균값 비교를 시행하였다. 결 과: 나이와 체중을 보정한 편상관분석에서 HOQ점수에 따라 저녁형일수록 K-POMS, POMS-T, POMS-D, POMS-A, POMS-F, POMS-C 점수가 상승되는 경향이 나타났다. 반대로 아침형일수록 POMS-V, AHI, respiratory arousal index, snore time(%)이 증가되는 경향이 나타났다. 또한 우울할수록 POMS 총점과 POMS-T, POMS-A, POMS-F, POMS-C, sleep latency, stage 2 sleep(%)가 증가되는 경향성이 나타나고, 우울할수록 HOQ점수가 낮아지므로 저녁형이며, 우울할수록 stage 1 sleep(%), AHI, TAI, respiratory arousal index, 목 둘레가 감소된다고 생각할 수 있다. 공분산 분석을 통해 나이와 체중을 보정한 뒤 아침형, 중간형, 저녁형 사이에 유의한 차이가 있는 항목은 K-POMS, POMS-T, POMS-D, POMS-F, POMS-C, spontaneous arousal index이다. 결 론: 폐쇄성 수면무호흡증 환자에서도 일반인구집단에서처럼 저녁형일수록 우울한 경향성이 나타난다. 이러한 경향성은 주간 졸음 등과는 무관하며, 무호흡의 심각도와도 관련성이 적은 것으로 생각할 수 있다. 그러므로 폐쇄성 수면무호흡증 환자를 평가할 때 무호흡의 심각도를 평가하는 것과는 별도로 아침형-저녁형의 일주기리듬을 확인하고 저녁형인 경우 환자의 우울감에 대한 추가적인 접근을 하는 것이 의미가 있을 것으로 생각된다.

• 한국산학기술학회논문지
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• 제21권2호
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• pp.124-132
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• 2020

본 연구는 노년기 Alpha 리듬의 진폭, 비대칭 및 평균 주파수가 뇌건강 상태를 반영할 수 있는 뇌파 지표로써 임상적 활용 가능성이 있는지 알아보고자 하였다. 이를 위하여 평균 나이 73세 남녀 노인 72명을 대상으로 폐안 시 전전두엽의 뇌파를 4분간 측정하였다. 집단 구분은 Alpha 진폭, 비대칭 및 평균주파수의 평균값을 각각 기준으로 높은집단과 낮은집단으로 분류하였다. 뇌파 지표들 간 상관관계와 t-검정을 실시한 결과는 다음과 같다. 첫 번째, Alpha 진폭이 높아지면 육체적·정신적 스트레스 저항도와 좌·우뇌 소통수준도 높아졌으며, Alpha 평균주파수 위치는 낮아졌다. 또한 Alpha 비대칭이 높아지면 좌·우뇌의 소통수준은 낮아지는 상관관계를 보였다. 두 번째, 좌뇌에 비해 우뇌의 Alpha 파워가 높아지면 Alpha 진폭과 정신적 스트레스 저항도, 좌·우뇌 소통수준도 높아졌다. 세 번째, Alpha 평균주파수 위치가 높아지면 Alpha 진폭과 정신적 항스트레스 지표는 낮아지고 각성 수준은 높아졌다. 이상과 같이 정량화 뇌파 지표들은 서로 간 관련성이 높고, 보완적 의미가 있어 노년기 뇌건강 상태를 반영하는 생체 표지자로써의 가능성을 보여주었다.

• Annals of Occupational and Environmental Medicine
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• 제35권
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• pp.30.1-30.13
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• 2023

Background: Dysmenorrhea and menstrual cycle changes occur in women working shifts. Circadian rhythm disruption and sleep disturbances associated with shift work leads to health problems. We identified chronotypes and the occurrence of insomnia among newly employed university hospital nurses and investigated the association of these factors with menstrual problems. Methods: We conducted pre-placement health examinations for shift workers using self-reported questionnaires between 2018 and 2020. A total of 463 nurses were included in the study. Sociodemographic data, shift work experience, and information on insomnia were collected from health examination data. In addition, details regarding chronotype, dysmenorrhea, irregular and abnormal menstrual cycles, amenorrhea, and contraceptive use were obtained from the questionnaire. Multiple logistic regression analysis was performed to study the association between chronotype, insomnia, and menstrual problems after controlling for age, body mass index, contraceptive use, amenorrhea, and prior shift work. Results: The prevalence rates of dysmenorrhea, irregular menstrual cycles, and longer menstrual cycles were 23.8%, 14.9%, and 4.1%, respectively. The risk of dysmenorrhea increased in the evening-type (odds ratio [OR]: 3.209; 95% confidence interval [CI]: 1.685-6.113) and those with insomnia (OR: 1.871; 95% CI: 1.074-3.261). Additionally, the risk of an irregular menstrual cycle (OR: 2.698; 95% CI: 1.167-6.237) increased in the evening-type, and the risk of a longer menstrual cycle (OR: 4.008; 95% CI: 1.354-11.864) increased in individuals with insomnia. Conclusions: Our findings suggest that dysmenorrhea is promoted in the evening-type and insomnia individuals. There may be an increased risk of irregular menstrual cycles among evening-type nurses and an increased risk of longer menstrual cycles among those with insomnia. Therefore, factors such as evening-type and insomnia should be considered for the prevention of menstrual problems in women performing shift work.