• Journal of Society of Preventive Korean Medicine
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• v.20 no.1
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• pp.145-159
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• 2016

Objectives : The aim was to investigate the characteristics of low dose effect and non monotonic dose responses(NMDRs) and to predict the influence it might have on the health and medicine, traditional Korean medicine. Methods : By investigating recently published major literatures related to low dose effect and NMDRs, the definition, mechanism, major related fields, and the influence on public health and medicine has been categorized and summarized. Results : Although there are still heated debates about the definition of low dose, it implies the biological responses in environmental exposure level and the NDMDRs means the nonlinear relationship between the dose-response in the slope sign change. Also, it implies the new form of the curve showing a U, reverse U shape, and the slop sign constantly changing showing various forms. This mechanism is because the two acceptor shows opposing effects to toxic materials and the affinity is different along with the numerical value that increase and decrease being different. These characteristics generally appear in endocrine disrupters such as bisphenol A, agricultural pesticides, metal, and radiation. The research field in the public health and medical treatment is obesity, problems in metabolism, growth hormone treatment, climacteric treatment, breast cancer, intake of Korean traditional medicine for pregnancy, menopause and phytoestrogen. Conclusions : As a result of discussing implications, NMDRs is a particular effect in low dose and heated debates surround this response, research is being conducted surrounding the field of obesity, problems in metabolism, growth hormone treatment, climacteric treatment, breast cancer, intake of Korean traditional medicine for pregnancy, menopause, and phytoestrogen. More research and interest in needed as it can have a massive influence in the public health and medicine.

• Korean Journal of Construction Engineering and Management
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• v.15 no.1
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• pp.28-38
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• 2014

Construction value engineering(VE) is often performed in the form of a short term review of designs, rather than during a regular workshop with a standardized work plan, and its application method is limited. Thus, tasks are performed by applying the method in reverse depending on the VE results, and function analysis, a key VE method, is omitted or only applied for the sake of formality. In addition, it is hard to expect great results from VE because of insufficient time and budget allowed to perform VE and a lack of understanding of VE procedures and methods. In particular, the methods used to store and reuse the tremendous amount of ideas and information created during the process of VE implementation is not systematic. Even the Korea Expressway Corporation, which has produced relatively systematic VE performance compared to other institutions, has had the above-mentioned problems. Therefore, this study aims to improve existing VE processes and suggest a method to efficiently store and retrieve VE information by analyzing the limitations of construction VE practice and the characteristics of VE for highway facilities as part of improving design VE performance.

• IMMUNE NETWORK
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• v.9 no.6
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• pp.236-242
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• 2009

Background: Melanoma is the most fatal form of skin cancer due to its rapid metastasis. Recently, several studies reported that selenium can induce apoptosis in melanoma cells. However, the precise mechanism remains to be elucidated. In this study, we investigated the effect of selenium on cell proliferation in murine melanoma and on tumor growth and metastasis in C57BL/6 mice. Methods: Cell proliferation was measured by MTT assay in selenium-treated melanoma cells. Cell cycle distribution was analysized by staining DNA with propidum iodide (PI). mRNA and protein expression related to cell cycle arrest was measured by reverse transcription PCR and western blot. Tumor growth and metastasis was measured by in vivo model. Results: Selenium was suppressed the proliferation of melanoma cells in a dose dependent manner. The growth inhibition of melanoma by selenium was associated with an arrest of cell cycle distribution at G0/G1 stage. The mRNA and protein level of CDK2/CDK4 was suppressed by treatment with selenium in a time-dependent manner. In vivo, tumor growth was not suppressed by selenium; however tumor metastasis was suppressed by selenium in mouse model. Conclusion: These results suggest that selenium might be a potent agent to inhibit proliferative activity of melanoma cells.

• Journal of Digital Convergence
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• v.10 no.10
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• pp.529-538
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• 2012

This study analyzed a variety of different kinds of usage patterns of four-digit personal identification numbers(PINs) based on the data collected from students attending at A-university in 2011. According to the analysis, the 4 digit PINs '1234' was being used most frequently which is similar to the findings of the study by the Daniel Amitay research. In addition, almost 50 percent of the students were using the four-digit PINs closely related to their personal information, and more than 10 percent of them were using it only by the reason of easiness to remember or convenience to use. Number '0' was the most frequently used, and girl students used it more than boys did. According to the result of analysis of four-digit PINs, it was found that number '1' was the most frequently used in the first and the third position. It was also found that number '2' and number '4' were the most frequently used in the second and the forth position respectively. Among students who had used number 3 in third position, around 63.6 percent of those students were using number 4 in the forth position in their PINs which showed highest frequency from analysis of double-digits connected together in each position. The analysis of PINs were represented by the polygonal (type) graph with that X-axis showed from first to forth position and Y-axis showed number had been used at each position. Among many polygonal graphs, the form showed an N-type which was called in type 1 took the first place by 35 percent.

• Journal of the Korean Society of Food Science and Nutrition
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• v.35 no.5
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• pp.606-612
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• 2006

Obtaining powder form of seaweed is essential for the use of seaweed as a food additive. The deterioration of seaweed caused by high temperatures during homogenization and powder processing is a serious problem and limits the use of seaweed as a food or pharmaceutical ingredient. Furthermore, many powder particles are not fluidized very well because of the interaction between particles. In order to solve this problem, sea tangle was hydrolyzed to a level of single cell detritus (SCD) by Vibrio sp., isolated from Batillus cornutus. with strong hydrolytic activity. The crude protein and amino acid contents of sea tangle SCD were higher than those of the powder, whereas the reverse was true for ash content. Sea tangle powder contained more mineral than its SCD, whereas total amino acid content was 5 times more in SCD than in power. The anticancer activities of sea tangle SCD and powder were 31.20 and 29.07%, respectively, with no significant difference (p<0.05), but about 15% higher than that of the control. The ACE inhibitory activity of the sea tangle powder, 39.31%, was higher than the 26.07% of the SCD. The antithrombin activity of the sea tangle powder, 55.3 seconds, was higher than the 34.5 seconds of the SCD. Moreover, there was no antioxidative and ischemic activities in both tile sea tangle powder and SCD.

• Analytical Science and Technology
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• v.10 no.2
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• pp.91-104
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• 1997

Scutellariae radix has been used on the control of body fever as oriental medicine for thousand years. Analytical aspect for the main components of Scutellariae radix was set up improving sensitivity and resolution. The analysis of 3 different flavonoids present in Scutellariae radix-baicalin, baicalein, wogonin-was conducted by means of high performance liquid chromatography with ODS reverse phase column in conjunction with a Photo Diode Array UV detector(280nm) at $40^{\circ}C$. Mobile phase was carried out at 1mL/min, composed of acetonitrile and 0.1M phosphoric acid in the form of a gradient method. Under these circumstances the retention time for baicalin, baicalein, wogonin was 7.65, 11.65 and 14.12 minutes respectively. As a result for the efficiency on extraction of active ingredients with proposed analytical process according to it's growing districts, Sunchang in Junbuk for baicalin and Bulkyo in, Junnam for bicalein and wogonin have shown the best results. Even the extraction at room temperature was satisfactory. Among acids, 0.1M acetic acid revealed the best achievements. The mixture of acetonitrile and 0.2M phosphoric acid(75:25) has been shown the best efficiency as well as stability for the extraction of active ingredients.

• Journal of Broadcast Engineering
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• v.18 no.1
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• pp.66-76
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• 2013

Although there has been much advance in the development of 3D displays of various purpose, 3D contents are not yet so used as expected in those displays. One well-known obstacle in the enjoyment of 3D contents is visual fatigue, but another major issue is image distortion of 3D contents. In the previous research, Shin, Li, & Kim (2012) reported systematic linear relationship between screen disparity and size perception of a simple object whose retinal size was constant across different disparities. In this research, we intended to generalize the previous finding by using various 3D stimuli in the test of the relationship between screen disparity and size perception of those stimuli. Consistent with previous findings, our data indicated that size perception linearly changes as a function of screen disparity and the linearity was observed in all stimuli types we used in this research. We described the empirical relationship between screen disparity and size perception in the form of prediction function for size perception in which visual angle is the predictor. This function will be very useful in the creation of 3D contents as one can make reasonable predictions on the to-be-perceived size of an object being filmed using screen disparity of their camera setting.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.19 no.7
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• pp.1-8
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• 2018

This paper describes new communication methods for transmitting torque commands between the vehicle controller that determines the amount of power generation in a range-extended electric vehicle and the engine controller that performs it. Generally, vehicles use CAN communication, but in this case, the hardware and software of the existing engine controller must be modified. For this reason, it is not easy to apply CAN communication to small and medium sized automotive reorganize companies. Therefore, this research presents a pin-pin communication method for applying the existing mass produced engine controller to range-extended electric vehicles. The pin-pin communication method converts the driver's demand torque control map inside an mass produced engine controller into a virtual accelerator opening position according to the target speed and target torque of the engine, and converts this to a voltage signal for the existing mass produced engine controller to recognize it. The virtual accelerator opening positions are mounted in the form of a control map in the vehicle controller through the reverse conversion process in an offline environment and are determined by the engine generating power requirements and engine optimal operating point algorithm. These algorithms and signal conversion circuits for engine torque transmission have been mounted on the vehicle controller to conduct the virtual accelerator opening position conversion process according to the engine target torque and to establish the virtual accelerator voltage signal using the signal converter.

• Journal of Pharmaceutical Investigation
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• v.37 no.4
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• pp.237-242
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• 2007

The chemical formula of indapamide is 3-(aminosulfonyl)-4-chloro-N-(2,3-dihydro-2-methyl-1H-indol-l-yl)-benzamide, Indapamide is an oral antipertensive diuretic agent indicated for the treatment of hypertensive and edema. Indapamide inhibits carbonic anhydrase enzyme. Transdermal drug delivery systems, as compared to their corresponding classical oral or injectable dosage form counterparts, offer many advantages. The most important advantages are improved systemic bioavailability of the pharmaceutical active ingredients (PAI), because the first-pass metabolism by the liver and digestive system are avoided; and the controlled, constant drug delivery profile (that is, controlled zero-order absorption). Also of importance is the reduced dose frequency compared to the conventional oral dosage forms (that is, once-a-day, twice-a-week or once-a-week). Other benefits include longer duration of therapeutic action from a single application, and reversible action. For example, patches can be removed to reverse any adverse effects that may be caused by overdosing. In order to evaluate the effects of vehicles and penetration enhancers on skin permeation of Indapamide, the skin permeation rates of Indapamide from vehicles of different composition were determined using Franz cells fitted with excised hairless skins. Solubility of Indapamide in various solvents was investigated to select a vehicle suitable for the percutaneous absorption of Indapamide, The solvents used were Tween80, Tween20, Labrasol, Lauroglycol90 (LG90) and Peceol. Lauroglycol90 increase the permeability of indapamide approximately 3.75-fold compared with the control. Tween80, Tween20, Labrasol, Lauroglycol90 (LG90) and Peceol showed flux of $0.06ug/cm^2/hr,\;0.4ug/cm^2/hr,\;0.21ug/cm^2/hr,\;0.72ug/cm^2/hr,\;0.29ug/cm^2/hr$, respectively.

• Journal of Korea Water Resources Association
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• v.53 no.4
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• pp.303-312
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• 2020

An underground deep tunnel system is a facility in form of a reverse siphon for an under flood defense structure. In this study, the 'Shinwol rainwater storage and drainage system', which is under construction for the first time in South Korea, in order to confirm the effects of undular bore and pressurized air on the hydraulic stability of the facility in various flood scenarios a hydraulic model experiment was performed. As a result of this study, it was analyzed that the undular bore generated downstream pushed the pressurized air collected in the facility while moving upstream, and the pressure inside the pipe increased at this time. It was analyzed that the pressure during the passage of the undular bore was greater than the sum of the static pressure and dynamic pressure at the time and overflow occurred when the cross-sectional size of the pressurized air was more than 40% of the cross sectional area of the tunnel. It is determined that this is correlated with the volume of pressurized air collected in the facility, and it is determined that it is necessary to study the relationship between velocity of undular bore and the volume of pressurized air in the future.