• Journal of Pharmaceutical Investigation
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• 제26권2호
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• pp.119-124
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• 1996

To develop oral controlled release dosage forms, ionic interactions between polymers and drugs were evaluated. Hydroxypropylmethyl cellulose and carboxymethylene were used as model nonionic and ionic polymers, respectively. 5-fluorouracil, propranolol-HCl and sodium salicylate were selected as model nonionic, cationic and anionic, respectively. Polymer-drug mixtures were compressed into tablets and drug release kinetics from these tablets were determined. Drug release from the tablets made of the nonionic polymer was not affected by the charge of drugs, rather, was regulated by the solubility of drugs in different pH releasing media. However, drug release kinetics were significantly affected when drug-polymer ionic interactions exist. Enhanced drug release was observed from anionic drug-anionic polymer tablets due to ionic repulsion, whereas drug release was retarded in cationic drug-anionic polymer tablets owing to ionic attractive force. Therefore, the results suggested that the polymer-drug interactions are important factors in designing controlled release dosage forms.

• Journal of Photoscience
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• 제5권4호
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• pp.149-152
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• 1998

Expression of light-harvesting chlorophyll a/b-binding protein gene(cab) is repressed in the dark and activited by light. However, the detail of its regulatory mechanism is not characterized so far. To identify the interactions of cis-acting elements and trans-acting factors involvedin this regulation, nuclear extracts from the light-grown and dark-adapted Arabidopsis thaliana leaves were anlayzed for mobility shift assay against 134bp fragments had two retarded bands and one retardation band, respectively, both in light-grown and dark-adapted bands in the dark-adapted tissues. A new retardation the cab 3 expression in the dark. Several light regulatory motifs are scattered in the 146 bp region of cab 3 promoter. One of the light-regulatory motifs could be the binding site for the negative regulatory factor.

• Applied Biological Chemistry
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• 제25권4호
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• pp.252-256
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• 1982

Tribolium castaneum은 건전미입(健全米粒)에서 완전한 생활환(生活環)을 완성(完成)하여 쌀에 가해가능성(加害可能性)을 보였으며 그 활동(活動)은 1.3%의 수분함량의 경우는 증가를 초래하였으나 곰팡이의 증식은 오히려 저해하는 경향을 보였다. T. castaneum의 생육은 Asp. repens에 의해 안정화(安定化)되었으나 Asp. niger에 의해서는 지체되었다.

• KSBB Journal
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• 제20권3호
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• pp.133-141
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• 2005

This review presents the preparation, transport mechanism and application of molecularly imprinted membranes (MIM). Molecular imprinting has now been established as a technique which allows the creation of tailor-made binding sites for many classes of compounds. MIM have some advantages; a high capacity due to a large surface area, faster transport of substrate molecules and faster equilibrium of binding cavities compared to molecularly imprinted particles. MIM were prepared by covalent and non-covalent chemical bonding systems, by interactions between functional monomer and template. MIM can be prepared by in-situ polymerization, wet phase inversion, dry phase inversion, and surface imprinting method. MIM can continuously separate mixtures based on facilitated or retarded diffusion of the template. MIM can change their permeability in the presence of templates. MIM have a potential to be used to separate chiral compounds and materials with similar structures. However the application of MIM by the chemical industries is still in its infancy stages.

• 한국초전도ㆍ저온공학회논문지
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• 제22권4호
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• pp.6-9
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• 2020

Since the discovery of superconductivity, the unique and mysterious phenomenon has been observed in various metallic material systems. Now days, the superconductivity becomes ubiquitous because almost every metallic material system shows the superconductivity when it is cooled down enough. This ubiquity of the superconductivity is associated with the fermionic nature and itinerancy of electrons in metallic materials. Because fermions are governed by the Pauli's exclusion principle the total energy of fermions is much larger than that of bosons. Therefore, fermionic itinerant electrons are fundamentally instable. Itinerant electrons are able to find "a way" to lead them to their lowest possible energy state through an available bosonization (or pairing) process and Bose-Einstein condensation. Therefore, the lowest possible energy state of itinerant electrons will be a superconducting state, which is "their ultimate destination". This may explain the reason why the superconductivity is ubiquitous.

• 대한용접접합학회:학술대회논문집
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• 대한용접접합학회 2006년도 춘계 학술대회 개요집
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• pp.33-35
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• 2006

The interactions between Cu/Sn-Ag-(Cu) and Sn-Ag-(Cu)/Ni interfacial reactions were studied during isothermal aging at $150^{\circ}C$ for up to 1000h using Cu(ENIG)/Sn-3.5Ag-(0.7Cu)/Cu(ENIG) sandwich solder joints. A typical scallop-type Cu-Sn intermetallic compound (IMC) layer formed at the upper Sn-Ag/Cu interface after reflowing, whereas a $(Cu,Ni)_6Sn_5$ IMC layer was observed at the Sn-Ag/ENIG interface. The Cu in the $(Cu,Ni)_6Sn_5$ IMC layer formed on the Ni side was sourced from the dissolution of the opposite Cu metal pad or Cu-Sn IMC layer. When the dissolved Cu arrived at the interface of the Ni pad, the $(Cu,Ni)_6Sn_5$ IMC layer formed on the Ni interface, preventing the Ni pad from reacting with the solder. Although a long isothermal aging treatment was performed at $150^{\circ}C$, no Ni was detected in the Cu-Sn IMC layer formed on the Cu side. Compared to the single Sn-Ag/ENIG solder joint, the formation of the $(Cu,Ni)_6Sn_5$ IMC layer of the Cu/sn-Ag/ENIG sandwich joint effectively retarded the Ni consumption from the electroless Ni-P layer.

• Bulletin of the Korean Chemical Society
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• 제31권1호
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• pp.104-111
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• 2010

The heterogeneous electron transfer at $SiMo_{12}O_{40}^{4-}$ monolayers on GC, HOPG, and Au electrode surfaces are investigated using cyclic voltammetric and electrochemical impedance spectroscopic (EIS) methods. The electron transfer of negatively charged $Fe(CN)_6^{3-}$ species is retarded at $SiMo_{12}O_{40}^{4-}$-modified electrode surfaces, while that of positively charged $Ru(NH_3)_6^{3+}$species is accelerated at the modified surfaces. This is due to the electrostatic interactions between $SiMo_{12}O_{40}^{4-}$ layers on surfaces and charged redox species. The electron transfer kinetics of a neutral redox species, 1,1‘-ferrocenedimethanol (FDM), is not affected by the modification of electrode surfaces with $SiMo_{12}O_{40}^{4-}$, indicating the $SiMo_{12}O_{40}^{4-}$ monolayers do not impart barriers to electron transfer of neutral redox species. This is different from the case of thiolate SAMs which always add barriers to electron transfer. The effect of $SiMo_{12}O_{40}^{4-}$ layers on the electron transfer of charged redox species is dependent on the kind of electrodes, where HOPG surfaces exhibit marked effects. Possible mechanisms responsible for different electron transfer behaviors at $SiMo_{12}O_{40}^{4-}$ layers are proposed.

• 인간행동과 음악연구
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• 제2권1호
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• pp.17-33
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• 2005

음악은 가장 오래되고 자연스러운 자기 표현의 수단으로 인간의 역사 속에서 현재까지 내려와 인간과 관계 맺고 있다. 이는 음악이 개인의 감정을 자유롭게 표현할 수 있는 통로의 역할을 하면서도 그 내용에 대해 직접적인 판단을 받지 않은 음악이라는 매체의 특성 때문인데, 이는 클라이언트에게 자유롭고 비위협적인 안전한 환경을 조성해 주기 때문이다. 이러한 음악의 특성들은 사회적 위축감과 무기력감으로 인해 수동적이거나 공격적인 부적절한 감정 표현의 양상을 보이는 정신지체인들에게 긍정적인 도구가 될 것이다. 본 연구에서는 정신지체를 가진 성인들에게 기존의 감정 표현 훈련에 음악을 활용할 경우 정신지체를 가진 성인들의 자기 감정 표현 및 사회생활기술에 음악이 긍정적인 영향성을 미치는지 알아 보기 위함이다. 각 3명의 실험집단과 통제집단으로 나누어 실시하였으며, 실시한 프로그램의 효과를 분석하기 위해, 자기 표현 평정 척도 및 사회 생활 기술 척도 도구를 사용하여 사전 사후 검사를 실시하였다. 연구 결과 기존의 감정 표현 훈련보다 음악을 활용한 감정 표현 훈련이 성인정신지체인들의 말할 때의 내용표현, 음성 표현, 신체 및 비언어적 표현력을 모두 포함한 자기 감정 표현력에서 긍정적인 영향을 미치는 것으로 나타났고, 이는 전반적인 정신지체인들의 사회생활기술의 향상에도 긍정적인 영향을 주었다고 해석할 수 있다. 이는 전반적인 사회생활기술의 향상과 자기 감정 표현의 불가분의 관계를 보여주는 것과 동시에 음악을 활용한 감정 표현 훈련이 정신지체를 가진 성인들의 효과적인 감정 표현 훈련의 방법으로 사용될 수 있다는 것을 제시했다고 볼 수 있다.

• The Plant Pathology Journal
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• 제29권1호
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• pp.17-30
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• 2013

Barley stripe mosaic virus (BSMV) induces massive actin filament thickening at the infection front of infected Nicotiana benthamiana leaves. To determine the mechanisms leading to actin remodeling, fluorescent protein fusions of the BSMV triple gene block (TGB) proteins were coexpressed in cells with the actin marker DsRed: Talin. TGB ectopic expression experiments revealed that TGB3 is a major elicitor of filament thickening, that TGB2 resulted in formation of intermediate DsRed:Talin filaments, and that TGB1 alone had no obvious effects on actin filament structure. Latrunculin B (LatB) treat-ments retarded BSMV cell-to-cell movement, disrupted actin filament organization, and dramatically decreased the proportion of paired TGB3 foci appearing at the cell wall (CW). BSMV infection of transgenic plants tagged with GFP-KDEL exhibited membrane proliferation and vesicle formation that were especially evident around the nucleus. Similar membrane proliferation occurred in plants expressing TGB2 and/or TGB3, and DsRed: Talin fluorescence in these plants colocalized with the ER vesicles. TGB3 also associated with the Golgi apparatus and overlapped with cortical vesicles appearing at the cell periphery. Brefeldin A treatments disrupted Golgi and also altered vesicles at the CW, but failed to interfere with TGB CW localization. Our results indicate that actin cytoskeleton interactions are important in BSMV cell-to-cell movement and for CW localization of TGB3.

• 한국수산과학회지
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• 제19권2호
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• pp.100-108
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• 1986

This study was carried out in order to investigate protein cross-linking in freeze-dried meat of flounder (Limanda herzensteini). Changes in solubility or extractability of proteins and electrophoretic patterns of the extracted proteins were determined to monitor the cross-linking during the storage of freeze-dried meat. Development of nonenzymatic browning and the loss of in vitro protein digestibilily were also measured to assess their influences on the changes of functional and nutritional properties of proteins. In addition, the effects of lysine added, and removal of fat and water extractives were also mentioned. The extractability of protein decreased upon storage time and temperature, and the loss of solubility of myosin was evident. In case of the samples stored at $5^{\circ}C$ for 150 days, the extractability of protein decreased $26.4\%$, while that of the samples stored at $20^{\circ}C$ for 60 days decreased about $39.7\%$. And it was noted that the loss of solubility of myosin was $68.3\%$ and $98.1%$ for the same storage conditions, respectively. It was noteworthy that the samples treated with $L-lysine{\cdot}HCl$ seemed to prevent more or less the loss of protein solubility, in that, even stored at $20^{\circ}C$ for 120 days, revealed only $57.03\%$ decrease. The nonenzymatic browning was proceeded with the increase of storage temperature, especially, in the samples treated with glucose. This suggests that the decrease in extractibility of myosin was accompanied by the extent of browning. But the browning was retarded in defatted samples. The in vitro apparent protein digestibility was also higher in the samples defatted or water extracted. It was suggested from these results that changes in properties of proteins in freeze dried fish meat were led by the protein cross-linking which was attributed to Maillard type of reactions and protein-lipid interactions.