• 한국의류학회지
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• 제23권3호
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• pp.483-494
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• 1999

This study investigated the relation between seasonal variation of clothing weight and its resting metabolic rate to determine the relation between proper living temperature and cold/heat tolerance. Thirty six subjects(18 males and females twenties) were composed to obtain the clothing weight(Total clothing weight) and resting metabolic rate for a year and grouped four seasons : spring (Mar-May) Summer(Jun-Aug) Fall(Sep-Nov) and Winter(Dec-Feb). The data of males and females were respectively divided into three groups by cluster analysis with clothing weight. 1. The resting metabolic rate of male(41.1kcal/m2/hr) was higher than that of female(33.2kcal/m2/hr). It is suggested there is gender difference in the resting metabolic rate(p<.001) 2. The resting metabolic rate of male and female was the highest in Winter. It is suggested there is seasonal variation in the resting metabolic rate(p<.001) 3. It was found that there was relation between clothing weight and resting metabolic rate. The difference of resting metabolic rate between Summer and Winter which is profitable to adaptation to living temperature was significant in light clothing weight in male as well as in female. 4. In comfortable sensation most subjects responded that he/she felt 'comfortable' except Winter. However the heavy clothing weight group felt 'a little uncomfortable' throughout all seasons. l In thermal sensation most subjects responded that he/she felt 'neutral' And then the heavy clothing weight group responded warmer in summer and cooler in winter than light clothing weight group. From the results it was confirmed that male and female showed seasonal variations in clothing weight and resting metabolic rate. Also the resting metabolic rate of male and female was influenced by the clothing weight. In short seasonal variation of resting metabolic rate was larger in light clothing weight group than in heavy clothing weight group. Therefore light clothing weight group is advantgeous in living temperature to improve cold/heat tolerance and it also shows that living with the light clothing weight may enhance the degree of adaptation to change of living environment

• 대한의생명과학회지
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• 제23권2호
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• pp.118-127
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• 2017

Elevated serum uric acid and resting heart rate are risk factors and predictors of metabolic syndrome. However, few studies have examined the optimal cutoff value for serum uric acid and resting heart rate to predict metabolic syndrome in Korean adults. Subjects for this study were 22,302 adults (average age 45 years old), who underwent health screening examination from January 2010 to December 2012 at the Health Promotion Center of one hospital in Gyeonggi-do for general health check-up. The uric acid and resting heart rate cutoff values were calculated by ROC analysis for metabolic syndrome. Elevated serum uric acid and resting heart rate were associated with an increased prevalence of metabolic syndrome in Korean adults. The optimal cutoff value for uric acid level to predict metabolic syndrome in adults was 4.95 mg/dL (male 6.35, female 4.55) and optimal cutoff value for resting heart rate to predict metabolic syndrome was 68 beats per minute (male 66, female 68). However, serum uric acid and resting heart rate were found to have limitations for the diagnosis of metabolic syndrome.

• 한방비만학회지
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• 제3권1호
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• pp.95-105
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• 2003

The obesity is the matter of the energy balance in essential. The energy balance in human body is energy expenditure subtracted from energy intake. The energy intake is mainly supplied by carbohydrates, proteins and lipids in food, and the energy expenditure is composed of basal metabolic rate or resting energy expenditure, physical activity and thermogenesis including diet-induced thermogenesis. The resting energy expenditure is measured by direct calorimetry and indirect calorimetry. Generally we can simply use predictive equation with the variables of weight, height, age and fat-free mass to yield metabolic rate. But there is discrepancy between the estimate and real metabolic rate because the equations can not reflect individuality and environments. The resting energy expenditure is influenced by many factors but the fundamental factor is fat-free mass. We briefly reviewed the concept and evaluation of the energy balance, intake and expenditure, which are important parts in the study of obesity. Finally, we surveyed the correlation between metabolic rate and obesity and suggested applicable herb medication to increase metabolic rate.

• 생명과학회지
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• 제20권8호
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• pp.1261-1267
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• 2010

본 연구는 체지방을 감소시키는데 효과적이라는 diacylglycerol (DG) 섭취와 유산소운동이 체구성비의 변화 및 혈중지질 개선에 미치는 영향을 규명하고 안정 시 대사량 변화를 관찰함으로써 임상적 및 대사적 측면에서 비만 개선 효과를 규명하는데 그 목적이 있었다. 본 연구의 대상은 의학적으로 다른 질병을 동반하지 않은 비만 남자 대학생으로서 연구의 의의를 충분히 이해하고 자발적으로 참여 의사를 밝힌 사람으로 선정하였으며, 체지방 측정 후 25%미만인 자와 흡연자는 대상에서 제외하였다. 모든 피험자들은 기본검사와 사전검사가 끝난 후 세가지(D, E, DE) 집단에 6명씩 무선 배정하였다. 첫 번째 실험군(D)은 diacylglycerol 섭취 조건으로 12주 동안 diacylglycerol을 섭취하였고, 두 번째 실험군(E)은 12주 동안 러닝 트레이닝을 실시하였다. 마지막 세번째 실험군(DE)은 12주 동안 diacylglycerol 섭취와 유산소 트레이닝을 실시하였으며, 본 연구결과 모든 그룹에서 12주 동안의 그룹별 처치가 진행됨에 따라 체지방이 감소하는 경향을 보였다. 안정 시 대사량은 D그룹을 제외하고 모든 그룹에서 증가하는 경향을 보였으며 운동과 다이아실글리세롤 섭취에 따라 콜레스테롤의 감소가 일어났다. 추후 카테콜라민, CAMP, HSL, Insulin 등과 같은 지방대사와 관련된 항목들에 대한 추가적인 분석이 이루어짐으로써, DG섭취와 트레이닝의 비만개선효과를 보다 신뢰성 높게 예측할 수 있으리라 본다.

• 운동영양학회지
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• 제16권2호
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• pp.113-122
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• 2012

This study assessed the amount of energy consumed and fat deposition after endurance training in order to review the effect of 4-week endurance exercise on resting metabolic rate of a mouse during and after exercise and the effect of exercise. A total of 19 seven-week-old ICR male mice were used as the study subject. Those mice were divided into sedentary group (Sed) and trained group (Tr) after a week of environment adaption. The Tr group was trained with endurance exercise five times a week for four weeks. Weight and the amount of food intake were daily weighed and resting metabolic rate and metabolic rate after exercise were assessed before starting exercise and on the fourth week after training. Metabolic rate during exercise were measured four weeks after training. At the end of breeding period, statistically significant difference was shown in weights of trained and sedentary groups (p < 0.05). During a resting period, no significant difference was shown in oxygen intake, respiratory exchange ratio, and the amount of carbohydrate and fat oxidized. Moreover, no significant difference was shown in excess post-exercise oxygen consumption (EPOC) of an hour period after training. In contrast, the maximal oxygen uptake (VO₂ max) was approximately 11.1% higher in trained group after training compare to before. However, there was no significant difference in respiratory exchange ratio and carbohydrate and fat oxidization. During exercise, oxygen uptake, carbon dioxide production, and respiratory exchange ratio in energy metabolism during exercise showed no significant difference. However, significant difference was exhibited in the amount of fat oxidized in both groups. Summing up those results, endurance exercise could be concluded to be effective in weight control. However, weight loss is thought to be resulted from increase in fat oxidization during exercise unlike the conclusion made from previous studies where weight loss is prominently influenced by energy metabolism during a resting period and increased fat oxidation during post-exercise recovery. All experimental procedures were carried out at the Animal Experiment Research Center of Konkuk University. This study was conducted in accordance with the ethical guidelines of the Konkuk University Institutional Animal Care and Use Committee.

• Genomics & Informatics
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• 제11권4호
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• pp.263-271
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• 2013

We investigated the contribution of genetic variations of KLF5 to basal metabolic rate (BMR) and resting metabolic rate (RMR) and the inhibition of obesity in Korean children. A variation of KLF5 (rs3782933) was genotyped in 62 Korean children. Using multiple linear regression analysis, we developed a model to predict BMR in children. We divided them into several groups; normal versus overweight by body mass index (BMI) and low BMR versus high BMR by BMR. There were no differences in the distributions of alleles and genotypes between each group. The genetic variation of KLF5 gene showed a significant correlation with several clinical factors, such as BMR, muscle, low-density lipoprotein cholesterol, and insulin. Children with the TT had significantly higher BMR than those with CC (p=0.030). The highest muscle was observed in the children with TT compared with CC (p=0.032). The insulin and C-peptide values were higher in children with TT than those with CC (p=0.029 vs. p=0.004, respectively). In linear regression analysis, BMI and muscle mass were correlated with BMR, whereas insulin and C-peptide were not associated with BMR. In the high-BMR group, we observed that higher muscle, fat mass, and C-peptide affect the increase of BMR in children with TT (p < 0.001, p < 0.001, and p=0.018, respectively), while Rohrer's index could explain the usual decrease in BMR (adjust $r^2$=1.000, p < 0.001, respectively). We identified a novel association between TT of KLF5 rs3782933 and BMR in Korean children. We could make better use of the variation within KLF5 in a future clinical intervention study of obesity.

• 운동과학
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• 제28권1호
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• pp.82-90
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• 2019

PURPOSE: The purpose of this study was to examine the association of waist to height ratio (WHtR) and resting heart rate (RHR) with cardio-metabolic risk factors among Korean postmenopausal women. METHODS: A cross-sectional analysis was performed using the 2015 Korea National Health and Nutrition Examination Survey. The analysis included a total of 1,540 postmenopausal women. RESULTS: Individuals with higher WHtR (>0.56) showed significantly higher glucose, triglyceride, insulin, Homeostatic Model Assessment for Insulin resistance (HOMA-IR), total cholesterol, systolic and diastolic blood pressure compared with ones with lower WHtR (≤0.51). Similar findings were found in those with higher RHR (≥90 bpm) compared with ones with lower RHR (<60 bpm) for glucose and HOMA-IR. When determining the combined effects of WHtR and RHR on the prevalence of metabolic syndrome, individual with WHtR above 0.5 and RHR above 80 bpm showed 10.39 times higher prevalence of metabolic syndrome compared with those with WHtR below 0.5 and RHR below 70 bpm. We further performed multiple linear regression analysis to understand how WHtR and RHR contribute to fasting glucose, and found that both WHtR and RHR contribute to fasting glucose levels independent of age, education level, marital status and income level. CONCLUSIONS: The current study showed that the WHtR and RHR are associated with cardio-metabolic risk factor and prevalence of metabolic syndrome in Korean postmenopausal women.

• 대한의생명과학회지
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• 제17권4호
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• pp.305-311
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• 2011

Heart rate recovery (HRR) immediately after a treadmill exercise test is a function of vagal reactivation. A delayed heart rate recovery is associated with an increased risk for overall cardiovascular mortality. The purpose of this study is to find out if metabolic syndrome is associated with autonomic nerve function and exercise capacity in healthy adults. We measured the treadmill exercise capacity (METs) and heart rate recovery in 119 subjects through a medical checkup at $J$ General Hospital. The metabolic syndrome was defined according to the National Cholesterol Education Program Adult Treatment Panel III (NCEP-ATP III) criteria. The value for the HRR was defined as the difference between the heart rate obtained during the peak exercise and the heart rate obtained at first minute during the recovery period. The subjects with the metabolic syndrome had significantly lower exercise duration ($9.6{\pm}1.5$ vs $8.7{\pm}1.4$), METs ($11.6{\pm}1.7$ vs $10.4{\pm}2.5$), and HRR ($37.5{\pm}14.3$ vs $27.1{\pm}8.9$). The waist circumference in subjects with the metabolic syndrome was more strongly correlated with HRR ($r$=-.517, $P$ <.001) than in normal subjects. Furthermore, delayed HRR was associated with high resting heart rate and increased waist circumference ($P$=.032, $P$ <.001, respectively). In conclusion, delayed HRR during the first minute after a treadmill exercise test was associated with the metabolic syndrome risk factors. Delayed HRR was also associated with high resting heart rate and increased waist circumference.

• 한국의류학회지
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• 제25권2호
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• pp.339-349
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• 2001

This study was investigated the effects of ambient temperatures and menstrual cycle on Resting Metabolic Rate(RMR), Rectal Temperature(Tre), Skin(forehead, chest, abdomen, forearm, hand, thigh, leg, foot) Temperatures, and subjective thermal sensations in 8 young Korean females(ages 22-25, voluntarily). The Tre and the Skin Temperatures were measured in once every five minute for one hour. RMR was measured three times at 30 minutes intervals by indirect calorimetry. All measurements were gathered during Luteal Phase(LP), Menstruation(M), and Follicular Phase(FP) at two levels of ambient temperatures; low(17~21$^{\circ}C$) and middle(21.1~$25^{\circ}C$). LP were the highest values during FP and M in RMR, Tre, forehead temperature, chest temperature and abdomen temperature, while the leg(leg and foot) and arm(forearm and hand) temperatures were higher during FP rather than during LP at each ambient temperature. The downward curve of Tre in the experiment was larger during FP than LP. The values in subjective thermal sensations were most comfortable during LP than M and FP at each ambient temperature. The LP-FP differences in core and mean skin temperatures, and resting metabolic rate, were more significant at middle ambient temperatures than at low ambient temperatures.

• 대한한의학회지
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• 제26권3호
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• pp.249-262
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• 2005

Backgrounds : As obesity prevails as an epidemic. diet programs including low-calorie diets are developed continuously. It is generally believed that a low-calorie diet is commonly followed by resting metabolic rate decrease and ultimate weight regain. Ephedra and Evodia are known to have sympathomimetic and anti-obesity effect. Objectives : This study was a prospective, double-blinded, randomized md placebo-controlled clinical trial to evaluate the effects of Ephedra sinica and Evodia rutaecarpa on resting metabolic rate (RMR), weight, body composition, and short-term safety in obese women on low-calorie diet. Methods : 125 otherwise healthy obese women (body mass Index ${\geq}\;25kg/m^2$) were recruited and randomly assigned to three groups: Ephedra group (n=41), Evodia group (n =45), and placebo group (n=39). Subjects were administered Ephedra extract in capsules (pseudo-ephedrine 31.52mg) or Evodia extract in capsules (evodiamine 6.75mg, rutaecarpine 0.66mg) or placebo capsules as well as participating in a low-calorie diet for 8 weeks, Resting metabolic rate and body composition were measured at baseline,4 and 8 weeks. Basic serum exams were performed to evaluate the short-term safety of the herbs and changes of lipid variables. Results : All three groups showed significant BMI decreases probably due to low-calorie diet. Among them, the Ephedra group manifested most prominent BMI-reducing effect and towered total cholesterol and triglycerides significantly. The RMR was not changed during the 8-week diet in all groups. No significant difference among the groups was found in RMR, either. Stbject with higher RMR than the mean at the baseline showed a tendency to keep their RMR more stable during the diet program. Conclusions : Ephedra with a low-calorie diet was effective in reducing BMI. RMR change was not compensated by herbal medicines. RMR change seemed to be affected rather by constitution and body composition than medicine. Ephedra and Evodia were proven to be safe for sort-term use in herbal form. Especially, Ephedra was effective in lowering total cholesterol and triglycerides during the 8 weeks.