• IMMUNE NETWORK
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• v.22 no.1
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• pp.3.1-3.21
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• 2022

Cancer is one of the leading causes of death worldwide and the number of cancer patients is expected to continuously increase in the future. Traditional cancer therapies focus on inhibiting cancer growth while largely ignoring the contribution of the immune system in eliminating cancer cells. Recently, better understanding of immunological mechanisms pertaining to cancer progress has led to development of several immunotherapies, which revolutionized cancer treatment. Nonetheless, only a small proportion of cancer patients respond to immunotherapy and maintain a durable response. Among multiple factors contributing to the variability of immunotherapy response rates, commensal microbiota inhabiting patients have been identified as one of the most critical factors determining the success of immunotherapy. The functional diversity of microbiota differentially affects the host immune system and controls the efficacy of immunotherapy in individual cancer patients. Moreover, clinical studies have demonstrated that changing the gut microbiota composition by fecal microbiota transplantation in patients who failed a previous immunotherapy converts them to responders of the same therapy. Consequently, both academic and industrial researchers are putting extensive efforts to identify and develop specific bacteria or bacteria mixtures for cancer immunotherapy. In this review, we will summarize the immunological roles of commensal microbiota in cancer treatment and give specific examples of bacteria that show anticancer effect when administered as a monotherapy or as an adjuvant agent for immunotherapy. We will also list ongoing clinical trials testing the anticancer effect of commensal bacteria.

• Journal of Environmental Impact Assessment
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• v.4 no.3
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• pp.73-86
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• 1995

This paper demonstrates Environmental Impact Assessment (EIA) has to be applied for development projects with regard to the ecological, economical and social aspects before any decisions made in the project. Korea has confronted various environmental problems during the last fifteen years, even though EIA has been enacted since 1981. The role of impact assessment in planning and policy processes should be emphasized to investigate the magnitude and intensity of the adverse influences of economic development. In the Seoul Metropolitan Region, it is necessary to apply EIA all urban projects to reduce the adverse effects of urbanization. Special attention should be given to the climatological effects throughout the urbanization process in Korea to keep the urban area energy-efficient. This study intends not only to establish basic data for national-and regional-based land-use policy in the environmental aspects, but also to provide the basic data for the possible climate model (scenarios) that may provide spatial and temporal variability by analyzing the actual climatic record. There is a noticeable impact of urbanization on the atmospheric environment in the Seoul Metropolitan Region. In this sense, the climatic aspect must be taken into consideration in the process of EIA to mitigate the well-known climatic alterations of urbanization. Moreover, the techniques of assessment should be improved by developing geo-reference data sets to build models of the global climate in response to the man-made environmental change.

• Maxillofacial Plastic and Reconstructive Surgery
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• v.21 no.3
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• pp.284-287
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• 1999

The nose, a striking features of the human face, is regarded by many clinicians as the keystone of facial esthetics. Clinically, as the treatment of a dentofacial deformity, the soft tissue changes that occurred normally with movement of the skeletal bases. Changes of the soft tissue in the maxillary orthognathic surgery are widening of alar base, elevated nasal tip and flattening of upper lip. In addition, soft tissue change is difficult to predict, it has considerable variability in the response of soft tissue. We reviewed patients who received Le Fort I advancement osteotomy in our department and analysed preoperative and postoperative alar base width, nasal height in clinical measurement and cephalometry and patient's satisfaction of postoperative nasal appearance.

• Journal of Biomedical Engineering Research
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• v.22 no.3
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• pp.275-283
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• 2001

This study was performed to extract and analyze the biosignals to find the relationship between the level of anesthesia and the variations of physiological parameters during epidural anesthesia. Seven male and twenty female patients(ages from 45 to 70 years old) were participated for the experiment, and ECGs, PPGs, SKTs, SCRs were obtained during anesthesia. As results, the HF/LF ratios of HRV were decreased after the injection anesthetics. For skin temperatures, values measured from the palm was reduced and the temperatures from four channels, measured from armpit through the right side of the body, were increased. SCRs were decreased for all channels after the injection of anesthetics. However the heart rate and PPGs showed no significant changes. It was concluded that the injection of anesthetics result the changes in biosignals, and it could be explained by the degree of the sympathetic and/or parasympathetic nerve activities. Results of this study could provide the valuable information for the estimation of level for the spinal and general anesthesia, and could be extended to the development of a system which could quantify the level of anesthesia.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 2005.06a
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• pp.1958-1962
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• 2005

A driver's emotion is a very important factor of safe driving. This paper classified a driver's emotion into 3 major emotions, can be occur when driving a car: Surprise, Joy, Tired. And It evaluated the classifier using Hidden Markov Models, which have observation sequence as bio-signals. It used the 2-D emotional plane to classfiy a human's general emotion state. The 2-D emotional plane has 2 axes of pleasure-displeasure and arsual-relaxztion. The used bio-signals are Galvanic Skin Response(GSR) and Heart Rate Variability(HRV), which are easy to acquire and reliable. We classified several moving pictures into 3 major emotions to evaluate our HMM system. As a result of driving simulations for each emotional situations, we can get recognition rates of 67% for surprise, 58% for joy and 52% for tired.

• The Korean Journal of Applied Statistics
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• v.8 no.2
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• pp.147-161
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• 1995

The primary objective of this paper is to review parametric models and test statistics related to overdspersion of count data. Poisson or binomial assumption often fails to explain overdispersion. We reviewed real examples of overdispersion in count data that occurred in toxicological or teratological experiments. We also reviewed several models that were suggested for implementing experiments. We also reviewed several models that were suggested for implementing the extra-binomial variation or hyper-Poisson variability, and we noted how these models were generalized and further developed. The approaches that have been suggested for the overdispersion fall into two broad categories. The one is to develop a parametric model for it, and the other is to assume a particular relationship between the variance and the mean of the response variable and to derive a score test staistics for detecting the overdispersion. Recently, Dean(1992) derived a general score test statistics for detecting overdispersion from the exponential family.

• Korean Journal of Veterinary Research
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• v.32 no.3
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• pp.377-380
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• 1992

The value of the cell enzyme-linked immunosorbent assay as a possible replacement for the indirect immunofluorescence antibody test for the estimation of antibodies against BD virus was assessed in four animal models. The serum antibody response was measured by both assay systems;the variability of both tests was less than one diluent step, and correlation of the two tests was assessed using regression analysis. The study showed that the all four animal models gave satisfactory correlation of CELISA and IFA. There, CELISA is acceptable for use in mouse, rabbit, chicken and rat models.

• Journal of Environmental Policy
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• v.1 no.1
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• pp.1-24
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• 2002

Due to the recent increase in greenhouse gases in atmosphere, world climate is rapidly changing and in turn, the earth ecosystem responds upon the climate changes. Comparing the ecosystem in the past, the present shapes of ecosystem is the result of the serious modification. Fishery resources in marine ecosystem, which usually occupy the upper trophic level, are also inevitable from such changes, because they always react to the natural environmental conditions. The northwestern Pacific is the most productive ocean in the world producing about 30% of world catch. From time to time, however, it has been notified that abundance, distribution and species composition of major fish species were altered by climate events. Furthermore, primary productivity of the ocean is not stable under the changing environments, so that carrying capacity of the ocean varies from one climate regime to another. Major climate events such as global warming, atmospheric circulation pattern, climate regime shift in the North Pacific, and El Nino event in the Pacific tropical waters were introduced in relation to fisheries aspects. The current status and future projection of fishery production was investigated, especially in the North Pacific including Korean waters. This new paradigm, ecosystem response to environmental variability, has become the main theme in marine ecology and fishery science, and the GLOBEC-type researches might provide a solution far cause-effect mechanism as well as prediction capability. Ecosystem management principles for multi-species should be adopted for better understanding and management of ecosystem.

• Atmosphere
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• v.26 no.4
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• pp.665-672
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• 2016

In this study, we examine future changes in the Hadley cell (HC) strength using CMIP5 climate change simulations. The current study is an extension of a previous study by Seo et al. that used all 30 available models. Here, we select 18-23 well-performing models based on their significant internal sensitivity of the interannual HC strength variation to the latitudinal temperature gradient variation. The model projections along with simple scaling analysis show that the inter-model variability in the HC strength change is a result of the inter-model spread in the meridional temperature gradient across the subtropics for both DJF and JJA, not by the tropopause height or gross static stability change. The HC strength is expected to weaken significantly during DJF, while little change is expected in the JJA HC strength. Compared to the calculations with all model members, selected model statistics increase the linear correlation between the changes in HC strength and meridional temperature gradient by 13~23%, confirming the robust sensitivity of the HC strength to the meridional temperature gradient. Two scaling equations for the selected models predict changes in HC strength better than all-member predictions. In particular, the prediction improvement in DJF is as high as 30%. The simple scaling relations successfully predict both the ensemble-mean changes and model-to-model variations in the HC strength for both seasons.

• Biomedical Science Letters
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• v.23 no.4
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• pp.416-420
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• 2017

Endoplasmic reticulum (ER) stress induces unfolded protein response (UPR) via inositol-requiring enzyme 1 (IRE1) activation, which sends a molecular signal for X box-binding protein 1 (XBP1) mRNA splicing in the cytosol. IRE1 endoribonuclease activity induces cleavage of XBP1 mRNA. The XBP1 mRNA is then ligated by an uncharacterized RNA ligase and translated to produce spliced XBP1 by 23 nt removed in which contains the PstI restriction enzyme site. The splicing of XBP1 mRNA can be detected by semiquantitative RT-PCR, and then splicing of XBP1 is a useful tool to measure the genetic variability in ER stress. In this study, we have estimated IRE1-dependent splicing of XBP1 mRNA under conditions of various hypothermia. The results indicated that hypothermia regulated ER stress. This study demonstrated that hypothermia is closely related to ER stress and may be useful for early diagnosis of ER-associated disease.