• Nuclear Engineering and Technology
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• 제54권1호
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• pp.374-385
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• 2022

In order to investigate the application of 3D base-seismic isolation system in nuclear power plants (NPPs), comprehensive analysis of constitution and design theory for 3-dimensional combined isolation bearing (3D-CIB) was presented and derived. Four different vertical stiffness of 3D-CIB was designed to isolate the nuclear island (NI) building. This paper aimed at investigating the isolation effectiveness of 3D-CIB through modal analysis and dynamic time-history analysis. Numerical results in terms of dynamic response of 3D-CIB, relative displacement response, acceleration and floor response spectra (FRS) of the superstructure were compared to validate the reliability of 3D-CIB in mitigating seismic response. The results showed that 3D-CIB can significantly attenuate the horizontal acceleration response, and a fair amount of the vertical acceleration response reduction of the upper structure was still observed. 3D-CIB plays a significant role in reducing the horizontal and vertical FRS, the vertical FRS basically do not vary with the floor height. The smaller the vertical stiffness of 3D-CIB is, the better the vertical isolation effectiveness is, whereas, it will increase the displacement and the rocking effect of superstructure. Although the advantage of 3D-CIB is that the vertical stiffness can be flexibly adjusted, it should be designed by properly accounting for the balance between the isolation effectiveness and displacement control including rocking effect. The results of this study can provide the technical basis and guidance for the application of 3D-CIB to engineering structure.

• 대한안전경영과학회지
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• 제16권4호
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• pp.133-145
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• 2014

Aging of the fire organizations, typical disaster response agencies also will be in serious problems with aging society. It is expected that the ratio of more than fifties will reach 31~40% after 10~15 years in Seoul fire organization. This Aging of firefighters can bring about a serious problem in disaster and safety management, since firefighters require robust fitness and healthy bodies in disaster situations. In this study, after the analysis of aging status and trend of firefighters in Seoul, I have an empirical analysis about the impact this aging has on organization effectiveness and QA. As a result, the increase of the elderly reduced organization effectiveness and QA. In addition, in the group consisting of less than 50, it is expected to increase the organization's effectiveness and QA activities through field activity to improve the professional skills with age, but could not be confirmed. In the group consisting of more than fifties, it was found that aging had a significant negative impact on organizational effectiveness and QA activities as factors, including physical deterioration by aging.

• Ocean Systems Engineering
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• 제5권3호
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• pp.161-179
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• 2015

An emergency response system (ERS) for vessel oil spills is a complex and dynamic system comprising a number of subsystems and activities. Failures may occur during the emergency response operations, this has negative impacts on the effectiveness of the ERS. Of the classes of problems in analyzing failures, the lack of quantitative data is fundamental. In fact, most of the empirical data collected via questionnaire survey is subjective in nature and is inevitably associated with uncertainties caused by the human being's inability to provide complete judgement. In addition, incomplete information and/or vagueness of the meaning about the failures add difficulties in evaluating the effectiveness of the system. Therefore this paper proposes a framework to evaluate the ERS effectiveness by using the combination of fuzzy reasoning and evidential synthesis approaches. Based on analyzing the procedure of ERS for oil spills, the failures in the system could be identified, using Analytic Hierarchy Process(AHP)to determine the relative weight of identified failures. Fuzzy reasoning combined with evidential synthesis is applied to evaluate the effectiveness of ERS for oil spills under uncertainties last. The proposed method is capable of dealing with uncertainties in data including ignorance and vagueness which traditional methods cannot effectively handle. A case study is used to illustrate the application of the proposed method.

• 한국임상약학회지
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• 제18권2호
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• pp.75-83
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• 2008

Purpose: Currently lung cancer ranks second in cancer for incidence rate and is a disease that ranks first for a death rate by cancerous growth because it is already advanced at the time of diagnosis. The purpose of this paper was to analyze the factors that affect the effectiveness of and rash occurrence by Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor (EGFR TKI) in patients with non-small cell lung cancer. Methods: A retrospective chart review of 100 patients, who took EGFR TKI (erlotinib, gefitinib) among patients who were diagnosed with non-small cell lung cancer in a Hospital in Korea between May 2005 and February 2008, was conducted. The drug effectiveness was evaluated by Response Evaluation Criteria In Solid Tumor. Results: EGFR mutation was the only factor associated with drug response (complete response and partial response). When stable disease was added to drug response as the evaluation parameter, ECOG and rash as well as EGFR mutation were found to be important factors. Survival, however, was not affected by EGFR mutation. The factors influenced on survival were older age (${\geq}65$), low ECOG ($1{\sim}2$), adenocarcinoma and rash. In the case of rash, group with EGFR mutation or low ECOG showed significantly higher chance of occurrence. There was no significant difference in rash occurrence between gefitinib and erlotinib groups. Conclusions: Based on the results, EGFR mutation positive and low ECOG ($1{\sim}2$) were significantly important factors for both effectiveness of EGFR TKI and rash occurrence. Also, rash itself was found to be an independently significant factor for the disease control and survival. Therefore, while administering EGFR TKI, patients who have the factors associated with rash occurrence should be closely monitored for effective and safe drug therapy.

• Earthquakes and Structures
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• 제24권3호
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• pp.165-181
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• 2023

The effectiveness of fluid viscous dampers (FVDs) on dynamic response mitigation of coupled two adjacent structures was investigated, considering soil-structure interaction (SSI) effects under earthquake excitation. A numerical procedure was employed to evaluate system response. The finite elements were used for the numerical treatment of the adjacent buildings and soil region. Viscous boundary conditions were used as special non-reflecting boundaries on the edges of finite soil region. According to the results, the FVDs were found to be very effective for dynamic response mitigation of the adjacent buildings, even if considering the soil medium. The results showed that the most affecting parameter on the system response was found to be soil type. It was also concluded that when adjacent structures coupled by FVDs, the maximum values of the roof displacements, the base shear forces, and the base bending moments could decrease up to around 50%. Changing in lateral stiffness of the one building has minor effects on the effectiveness of viscous dampers.

• 한국의류학회지
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• 제23권7호
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• pp.953-964
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• 1999

The purpose of this study was to analyze the effectiveness of negative appeal ads taking social problems as their themes. Two social problem ad themes concerning abortion and drug addiction were selected as stimulus. Questionnaires consisted of questions about affective response cognitive evaluation consumer's characteristics(sex, clothing involvement social problem involvement) and the ad and brand attitudes They were distributed to 200 high school students in Seoul. Results were : 1 The affective response consisted of 4 dimensions(negative inactivating activating positive) and the cognitive evaluation had 3 dimensions(utility·persuasive power creativity awareness) 2. Creativity and awareness dimensions and the ad attitude had positive influence on the brand attitude for the abortion theme ad,. Creativity dimension and consumer's clothing involvement had positive influence on the brand attitude for the drug addiction theme ad . Especially the affective response had no significant influence on the brand attitude. This result suggests that in case of negative appeal ads the affective response does not necessarily degrade the brand attitude while positive cognitive evaluation on creativity and awareness of the could influence the brand attitude favorably through raising attention to the brand resulting in high effectiveness of the ad.

• 전기학회논문지
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• 제66권1호
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• pp.23-26
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• 2017

Social Welfare is useful concept for evaluating the effectiveness of an economic policy in micro economics. This paper focuses on Social Welfare(SW) of electricity market incorporating demand response(DR). Competition between DR and generation company is modeled as a simple bid function. DR function can be considered as an negative generation(called Negawatt) and as an element of modified demand function. These two approaches result in the same demand reduction, generation power, and the market price. However, SW in the modified demand function approach is not identical to SW in the Negawatt approach. It makes the numerical index of DR effectiveness less persuasive. This paper proposes modified definition of SW in the demand function approach. The proposed definition of SW leads the DR effectiveness index to be identical to that in the Negawatt approach.

• Structural Engineering and Mechanics
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• 제24권3호
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• pp.375-393
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• 2006

Under high velocity, pulse type near source earthquakes semi-active control systems are very effective in reducing seismic response base isolated structures. Semi-active control systems can be classified as: 1) independently variable stiffness, 2) independently variable damping, and 3) combined variable stiffness and damping systems. Several researchers have studied the effectiveness of independently varying damping systems for seismic response reduction of base isolated structures. In this study effectiveness of a combined system consisting of a semi-active independently variable stiffness (SAIVS) device and a magnetorheological (MR) damper in reducing seismic response of base isolated structures is analytically investigated. The SAIVS device can vary the stiffness, and hence the period, of the isolation system; whereas, the MR damper enhances the energy dissipation characteristics of the isolation system. Two separate control algorithms, i.e., a nonlinear tangential stiffness moving average control algorithm for smooth switching of the SAIVS device and a Lyapunov based control algorithm for damping variation of MR damper, are developed. Single and multi degree of freedom systems consisting of sliding base isolation system and both the SAIVS device and MR damper are considered. Results are presented in the form of nonlinear response spectra, and effectiveness of combined variable stiffness and variable damping system in reducing seismic response of sliding base isolated structures is evaluated. It is shown that the combined variable stiffness and variable damping system leads to significant response reduction over cases with variable stiffness or variable damping systems acting independently, over a broad period range.

• Structural Engineering and Mechanics
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• 제3권5호
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• pp.497-509
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• 1995

Effectiveness of multiple tuned mass dampers (MTMD) in suppressing the dynamic response of base excited structure for first mode vibration is investigated. The effectiveness of the MTMD is expressed by the ratio of the root mean square (RMS) displacement of the structure with MTMD to corresponding displacement without MTMD. The frequency content of base excitation is modelled as a broad-band stationary random process. The MTMD's with uniformly distributed natural frequencies are considered for this purpose. A parametric study is conducted to investigate the fundamental characteristics of the MTMD's and the effect of important parameters on the effectiveness of the MTMD's. The parameters include: the fundamental characteristics of the MTMD system such as damping, mass ratio, total number of MTMD, tuning frequency ratio, frequency spacing of the dampers and frequency content of the base excitation. It has been shown that MTMD can be more effective and more robust than a single TMD with equal mass and damping ratio.

• IMMUNE NETWORK
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• 제4권1호
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• pp.38-43
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• 2004

Backgroud: Immunotherapy using dendritic cells (DC) loaded with tumor antigens may represent a potentially effective method for inducing antitumor immunity. We evaluated the effectiveness of DC-based antitumor immune response in various conditions. Methods: DC were cultured from peripheral blood mononuclear cells (PBMNC) in myelogenous leukemia (ML) and lysates of autologous leukemic cells are used as tumor antigen. The effectiveness of interleukin-12 (IL-12) and CD40L (CD154) on the antigen presenting function of lysates-loaded DC was analyzed by proliferation, cytokine production, and cytotoxicity tests with activated PBMNC (mainly lymphocytes). For generating antigen-loaded DC, direct fusion of DC with ML was studied. Results: Antigen loaded DC induced significantly effective antitumor immune response against autologous leukemic cells. Administration of IL-12 on the DC based antitumor immune response showed higher proliferation activity, IFN-$\gamma$ production, and cytotoxic activity of PBMNC. Also, fused cell has a potent antitumor immune response. Conclusion: We conclude that lysates-loaded DC with IL-12 may be effectively utilized as inducer of antitumor immune reaction in ML and in vivo application with DC-based antitumor immunotherapy or tumor vaccination seems to be feasible.