• Title/Summary/Keyword: resources evaluation

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Development of New Antitumor Drugs from Natural Sources , with Guida (항종양활성 Screening을 지표로 한 천연물의약품의 개발연구와 그 생약소재의 품질평가에 대하여(抗腫瘍活性スクリ-ニングを指標とした天然物醫藥品の開發硏究とその生約素材の品質評價について))

  • Takeya, Koichi
    • Proceedings of the Plant Resources Society of Korea Conference
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    • 1993.08a
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    • pp.14-20
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    • 1993
  • We in anticancer drug development from natural resources have conceived and used a wide variety of experimental screening systems to support our efforts during the past 20 tears. Screens have been devided to address targets at the molecular, biochemical and cellular levels, both in vivo and in vitro. Screens have been essential for the experimental evaluation of the products from natural sources. In this congress, antitumor screening methods for deveol[ment of new drugs from natural sources and evaluation of their crude drugs are discussed.

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Chemical transformation and target preparation of saponins in stems and leaves of Panax notoginseng

  • Wang, Ru-Feng;Li, Juan;Hu, Hai-Jun;Li, Jia;Yang, Ying-Bo;Yang, Li;Wang, Zheng-Tao
    • Journal of Ginseng Research
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    • v.42 no.3
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    • pp.270-276
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    • 2018
  • Background: Notoginsenoside Ft1 is a promising potential candidate for cardiovascular and cancer disease therapy owing to its positive pharmacological activities. However, the yield of Ft1 is ultralow utilizing reported methods. Herein, an acid hydrolyzing strategy was implemented in the acquirement of rare notoginsenoside Ft1. Methods: Chemical profiles were identified by ultraperformance liquid chromatography coupled with quadruple-time-of-flight and electrospray ionization mass spectrometry (UPLC-Q/TOF-ESI-MS). The acid hydrolyzing dynamic changes of chemical compositions and the possible transformation pathways of saponins were monitored by ultrahigh-performance LC coupled with tandem MS (UHPLC-MS/ MS). Results and conclusion: Notoginsenoside Ft1 was epimerized from notoginsenoside ST4, which was generated through cleaving the carbohydrate side chains at C-20 of notoginsenosides Fa and Fc, and vinaginsenoside R7, and further converted to other compounds via hydroxylation at C-25 or hydrolysis of the carbohydrate side chains at C-3 under the acid conditions. High temperature contributed to the hydroxylation reaction at C-25 and 25% acetic acid concentration was conducive to the preparation of notoginsenoside Ft1. C-20 epimers of notoginsenoside Ft1 and ST4 were successfully separated utilizing solvent method of acetic acid solution. The theoretical preparation yield rate of notoginsenoside Ft1 was about 1.8%, which would be beneficial to further study on its bioactivities and clinical application.

Research on the Tasks Performed by Firm′s Consumer Department: Evaluation and Efficiency of those Tasks (기업 소비자 부서의 업무현황, 평가, 효율성에 대한 연구)

  • 허경옥
    • Journal of the Korean Home Economics Association
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    • v.42 no.6
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    • pp.137-149
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    • 2004
  • This research analyzed the tasks performed by firm's consumer department, evaluation, and efficiency of those tasks. In addition, regression analysis was employed to find what factors influence the level of evaluation and efficiency of tasks performed by firm's consumer department. Research results summarized as follows. First, two thirds of the appropriate amount of resources and systems for the consumer department were equipped and the score of evaluating for consumer counseling tasks was high. Second, the amounts of resources and systems being equipped by the firm's consumer department were greater in insurance companies and firms with more employees, firms with 70% to 100% female employees in the consumer department, firms that listed their stocks, and firms with the consumer department located higher than the second floor. Third, the score of evaluating the tasks performed by the firm's consumer department was greater in firms that listed their stocks, owned great resources and systems, and had a higher degree of work satisfaction. Finally, the task of consumer counseling performed by the consumer department turned out to be effective in firms that listed their stocks, were recently established, and owned necessary resources and systems.

Web Resources Based Collection Development for Digital Libraries (디지털 도서관의 웹자원 기반 장서개발)

  • Lee, Jee-Yeon;Kim, Sung-Un
    • Journal of Korean Society of Archives and Records Management
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    • v.3 no.1
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    • pp.111-127
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    • 2003
  • Web-based information resources should be managed and used methodically in the same manner as the paper-based resources are managed and used. It is necessitated by the prevalence of web-based delivery of a variety of information. To develop a web-based digital collection, it is critical to establish a set of standardized evaluation criteria for web-resources. The evaluation criteria needs to include authority, trustworthy, reliability, functionality, relatedness, accessibility, structure, design, user support, and security related matters. However, it is also necessary to have certain flexibility to either emphasize or include particular evaluation criteria to reflect varying characteristics of the web resources especially for the purpose of developing an effective digital collection. In addition, it is essential to review the evaluation criteria with respect to value, demand, duplication prevention, and intellectual property, which are relevant to the web-based digital collection development. Finally, various strategies were suggested as means to develop more effective web-based digital resource collection. These strategies include organizing a selection committee to ensure the objectivity and consistency in web-resource evaluation; developing a model for web-based digital resource collection; sharing new standards, protocols, markups, and metadata with other digital libraries; and developing user-centered digital resource collection.

Evaluation of Irrigation Canal Systems by the AHP(Analysis Hierarchy Process) Method (AHP기법에 의한 관개용수로 조직의 평가)

  • 박재흥;김선주;김필식
    • Magazine of the Korean Society of Agricultural Engineers
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    • v.45 no.6
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    • pp.96-108
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    • 2003
  • Agricultural water occupies the largest portion of total water use in Korea, and generally researches on the development of agricultural water have been stressed on the demand of agricultural water itself. But it is unavoidable to change a policy from the development of water resources to cope with the increase of water demand to the effective management of existing water resources. Evaluation of the decrepitude of irrigation facilities and their reasonable maintenance are important for the effective supply and use of agricultural water. Therefore it is necessary to develop evaluation technique that diagnoses the current condition of irrigation canals and suggest a countermeasure to improve the found problems. 25 items in 6 classes were selected for the evaluation of irrigation canal systems, and the weighted value between the items was calculated using AHP (Analysis Hierarchy Process) method. The current condition of the irrigation facilities was evaluated from the class evaluation marks, and ranking was decided from the total marks between the projects, and finally the priority of the project for the improvement was given.