• Journal of Korean Neurosurgical Society
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• v.63 no.6
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• pp.738-746
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• 2020

Objectives : The purpose of this study was to evaluate surgical outcomes and complications of spinal deformity associated with neurofibromatosis type-1 (NF-1). Methods : From 2012 to 2018, patients suffering from spinal deformity associated with NF-1 who underwent surgical correction were identified. Demographic data and radiographic measures were retrospectively reviewed. Pre- and postoperative whole spine radiograph images were used to determine both coronal and sagittal Cobb angles. All of patients underwent 3-dimentional computed tomographic scan and magnetic resonance imaging scan to confirm dystrophic features. For evaluation of clinical outcomes, we surveyed the pre- and postoperative scoliosis research society-22r (SRS-22r) score. Results : Seven patients with spinal deformity associated with NF-1 were enrolled in this study. The mean age of patients was 29.5±1.2 years old. The mean follow-up period was 2.8±1.4 years. The apex of the deformity was located in cervicothoracic (n=1), thoracic (n=4), and lumbar region (n=2). Most patients have poor bone quality and decreased bone mineral density with average T-score of -3.5±1.0. All patients underwent surgical correction via posterior approach. The pre- and postoperative mean coronal and sagittal Cobb angle was 61.6±22.6° and 34.6±38.1°, 56.8±18.5° and 40.2±9.1°, respectively. Mean correction rate of coronal and sagittal angle was 44.7% and 23.1%. Ultimate follow-up SRS-22r score (average score, 3.9±0.4) improved comparing to preoperative score (average score, 3.3±0.9). Only one patient received revision surgery due to rod fracture. No serious complication occurred, such as neurological deficit, and viscerovascular injury. Conclusion : The surgical correction of patients having spinal deformity associated with NF-1 is challenging, however the radiographic and clinical outcomes are satisfactory. The all posterior approach can be a safe and effective surgical option for patients having dystrophic curves associated with NF-1.

• Asian-Australasian Journal of Animal Sciences
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• v.30 no.11
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• pp.1633-1642
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• 2017

Objective: Evaluation of exercise effects in racehorses is important in horseracing industry and animal health care. In this study, we compared metabolic patterns between before and after exercise to screen metabolic biomarkers for exercise effects in thoroughbreds. Methods: The concentration of metabolites in muscle, plasma, and urine was measured by $^1H$ nuclear magnetic resonance (NMR) spectroscopy analysis and the relative metabolite levels in the three samples were compared between before and after exercise. Subsequently, multivariate data analysis based on the metabolic profiles was performed using orthogonal partial least square discriminant analysis (OPLS-DA) and variable important plots and t-test was used for basic statistical analysis. Results: From $^1H$ NMR spectroscopy analysis, 35, 25, and 34 metabolites were detected in the muscle, plasma, and urine. Aspartate, betaine, choline, cysteine, ethanol, and threonine were increased over 2-fold in the muscle; propionate and trimethylamine were increased over 2-fold in the plasma; and alanine, glycerol, inosine, lactate, and pyruvate were increased over 2-fold whereas acetoacetate, arginine, citrulline, creatine, glutamine, glutarate, hippurate, lysine, methionine, phenylacetylglycine, taurine, trigonelline, trimethylamine, and trimethylamine N-oxide were decreased below 0.5-fold in the urine. The OPLS-DA showed clear separation of the metabolic patterns before and after exercise in the muscle, plasma, and urine. Statistical analysis showed that after exercise, acetoacetate, arginine, glutamine, hippurate, phenylacetylglycine trimethylamine, trimethylamine N-oxide, and trigonelline were significantly decreased and alanine, glycerol, inosine, lactate, and pyruvate were significantly increased in the urine (p<0.05). Conclusion: In conclusion, we analyzed integrated metabolic patterns in the muscle, plasma, and urine before and after exercise in racehorses. We found changed patterns of metabolites in the muscle, plasma, and urine of racehorses before and after exercise.

• Journal of the Korean Arthroscopy Society
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• v.16 no.2
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• pp.140-146
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• 2012

Purpose: The objective of this study was to assess the clinical outcome of arthroscopic release of the extensor carpi radialis brevis (ECRB) tendon in chronic recalcitrant lateral epicondylitis and tried to determine any prognostic factors. Materials and Methods: A retrospective review of 24 patients with lateral epicondylitis treated by arthroscopic ECRB release was performed. Outcome measures included a patient self rating and visual analog scale (VAS). Functional evaluation was made with Quick-disabilities of the arm, shoulder and hand (DASH) score system to identify preoperative factors that might be associated with the outcomes. Results: Twenty one (88%) elbows received benefit from the procedure. A mean preoperative VAS pain score and the mean Quick-DASH were significantly improved at final follow up. Age, sex, dominant arm and duration of symptom, presence of capsular tear or calcification did not correlate significantly with the clinical outcome. Three of four patients without T2-weighted high signal focus of the ECRB origin on preoperative magnetic resonance imaging (MRI) showed higher Quick-DASH score. Conclusion: Arthroscopic release of the ECRB is an effective option for chronic recalcitrant lateral epicondylitis. Lack of high signal focus on preoperative MRI is significantly associated with a poor surgical outcome and a considerable factor for the proper surgical indication.

• Journal of Digital Convergence
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• v.15 no.5
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• pp.281-291
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• 2017

This study aimed to assess detection rate applying the mammographic imaging methods. The evaluation of the shape and margin of tumor was conducted by score oriented to 180 patients who had undergone FFDM, DBT and BMRI scans among breast cancer patients, and the number of calcification was classified by size. There was no significant difference between DBT and BMRI for tumors larger than 1 cm in low-density breasts and for tumors larger than 2 cm in high-density breasts. Moreover, as for the detection rate of number of fine calcification, the highest rate was observed in FFDM followed by DBT and BMRI in the order named regardless of size. In conclusion, DBT was able to be detected even without BMRI if the mass was larger than 1 cm in the low-density breast and larger than 2 cm in the high-density breast. The detection rate of calcification turned out to be the highest in FFDM followed by DBT regardless of size, and calcification was not observed by BMRI. The appropriate use of FFDM, DBT and BMRI with respect to mass tumor will contribute to serving as a guide to examination methods of reducing burden of patients.

• Journal of Veterinary Clinics
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• v.23 no.2
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• pp.96-101
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• 2006

Four dogs with neurologic dysfunction resulted from intracranial hemorrhage by head trauma were referred to Veterinary Medical Teaching Hospital, Chungnam National University. There were no remarkable findings in survey radiography in four cases. CT and MRI scans were diagnostic in these cases. Three dogs underwent CT scanning. On CT images, the lesion was hyperdense and was not enhanced after intravenous contrast administration in dog 1 and dog 2. On CT of dog 4, there was no significant finding. All of four dogs were verified by dorsal, sagittal, and transverse T1-weighted (T1W) and T2-weighted (T2W) images. Appearance of the lesions in dog 1 and dog 2 was isointense (dog 2) or isointense with hyperintense rim (dog 1) on T1W images and hyperintense on T2W images. In dog 3 and dog 4, there were hypointense and hyperintense lesions on T1Wand T2W images respectively. The lesions in four dogs were located in the left intracerebral region, intracerebral and cerebellovestibular region, subdural space, and right cerebral hemisphere, respectively.

• International Journal of Highway Engineering
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• v.10 no.3
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• pp.171-178
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• 2008

Compressive strength of concrete has been regarded as a very important parameter of the quality control both in new and existing concrete pavement. It has been used a lot as the concrete strength evaluation both in the various-mixture-using laboratory and construction field using the same mixture. An error usually occurs in the test experiments of the strength, even in the test experiments with evenly mixed and compacted specimens of the compressive strength. It is caused by the 'manually operated' compressing testing, or by the specimens preparation with eccentricity. When compressive strength of evenly mixed concrete is investigated by the curing ages at the construction field, there have to be lots of specimens. And it needs much labor and cost. To substitute the endlessly repeated test experiments of compressive strength, presumption of compressive strength, by nondestructive tests, is needed. In this study, elastic waves were used among various nondestructive tests. Compressive strength of concrete was presumed according to the curing ages, by using the shear wave velocity which is not affected by restricted conditions. In the result, shear wave velocity is very closely related to the compressive strength at the evenly mixed concrete.

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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• 2006.05a
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• pp.164-170
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• 2006

This paper proposes a RSM-based hybrid evolutionary algorithm (RHEA) which combines the merits of the popular programs such as genetic algorithm (GA), tabu search method, response surface methodology (RSM). This algorithm, for improving the convergent speed that is thought to be the demerit of genetic algorithm, uses response surface methodology and simplex method. The mutation of GA offers random variety to finding the optimum solution. In this study, however, systematic variety can be secured through the use of tabu list. Efficiency of this method has been proven by applying traditional test functions and comparing the results to GA. And it was also proved that the newly suggested algorithm is very effective to find the global optimum solution to minimize the weight for avoiding the resonance of fresh water tank that is placed in the rear of ship. According to the study, GA's convergent speed in initial stages is improved by using RSM method. An optimized solution is calculated without the evaluation of additional actual objective function. In a summary, it is concluded that RHEA is a very powerful global optimization algorithm from the view point of convergent speed and global search ability.

• Clinics in Shoulder and Elbow
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• v.16 no.2
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• pp.135-140
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• 2013

We report a case of recurrent shoulder dislocation and combined proximal humerus fracture in neurofibromatosis type I. A twenty-year-old male patient with known neurofibromatosis type I presented with right shoulder dislocation and proximal humerus fracture following a minor trauma. His injured arm also had large plexiform neurofibromas on the elbow, and the dislocation of the shoulder joint was proven to be recurrent. Bony deformation of the humerus and scapula were revealed on X-ray and computed tomography, as well as multiple neurofibromatic changes of the deltoid and periscapular muscles were noted on magnetic resonance imaging. Open reduction and capsular reconstruction were performed and humeral fracture was stabilized with a reconstruction plate. Satisfactory union and functional result were achieved and the dislocation did not recur until the 7-month followup after the procedure. Recurrent shoulder dislocation and combined proximal humerus fracture in neurofibromatosis type I are rare complications. However, it should still be considered in the orthopaedic evaluation process of the diseases.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.15 no.8
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• pp.5124-5130
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• 2014

Dilution of the contrast agent by analyzing the change in the signal intensity during MR angiography in accordance with the viscosity and osmotic pressure minimizes the side effects, and improves the image quality. The contrast agent molarity changes by the dilution of the contrast agent in the blood, as it is injected, which leads to a change in signal intensity. Based on this principle, a phantom was prepared and experiments were performed. After the phantom experiment, a clinical experiment was conducted using the results of the phantom experiment. From November 2013 to January 2014, a group of patients were classified into diluted contrast agent (30 persons) and undiluted (30 persons), and the signal intensity of the cerebral vessels was compared. The signal intensity of the phantom according to the molarity of the contrast agent increased sharply from 0.0125 mmol, reached a peak at 20 mmol, and achieved equilibrium from 200 mmol. Based on the study results, the signal intensity of the blood vessels in the brain through were compared in a clinical experiment. All the brain vessels in the imaging range with diluting a high content of the gadolinium contrast agent showed high signal intensity. This result supports the phantom experiment and means that using the 500mmol diluted contrast agent is better than using 1000mmol undiluted contrast agent because it is easier to approach the 20mmol level needed to achieve the highest signal intensity. This study has significance in that it can minimize the high viscosity and osmotic pressure, which can cause side effects and improve the image quality using the method of the dilution rate.

• Journal of Dental Rehabilitation and Applied Science
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• v.23 no.4
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• pp.327-336
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• 2007

Purpose This study was planned to compare and evaluate the stability of implant using $Osstell^{TM}$ and Osstell $Mentor^{TM}$. Material and methods Artificial bone and RBM(resorbable blasting media) surface blasted implants(Osstem US II, SS II implants - diameter: 4mm, length: 13mm) were used. To measure the stability of installed implants, $Osstell^{TM}$ and Osstell $Mentor^{TM}$ were used. In the first experiment, five implants were installed in D1(external type implants) and D3(internal type implants). In the second experiment, 4 internal type implants were divided in two groups and installed in D1 artificial bone with different depth. In the third experiment, two external implants were installed in D1 and D3 artificial bone each and two internal implants were installed in D1 and D3 artificial bone. In all groups, their stability were measured by $Osstell^{TM}$ and Osstell $Mentor^{TM}$. Results In all groups, $Osstell^{TM}$ and Osstell $Mentor^{TM}$ both showed reliable measurement values. The value difference between $Osstell^{TM}$ and Osstell $Mentor^{TM}$ was observed but the difference was small and clinically acceptable. Conclusion These results suggest that the use of Osstell $Mentor^{TM}$ has clinical relevance in the assessment of implant stability.