• The Transactions of The Korean Institute of Electrical Engineers
• /
• v.66 no.1
• /
• pp.144-152
• /
• 2017

A motor model and off-line diagnosis method of the induction motor having an interturn fault(ITF) is studied. The proposed method is based on the magnitude comparison of the six impedance in the d-q plane. To prove the impedance unbalance, the induction motor model is presented with an ITF circuit loop with a fault resistance. Then, six impedance components in the stationary d-q plane are defined depending on the connected phase windings. Finding the maximum and minimum magnitude of the six impedance, the ITF and the faulty phase can be founded. To verify the proposed method, the experimental results with an induction motor having an ITF are shown.

• Tuberculosis and Respiratory Diseases
• /
• v.55 no.1
• /
• pp.41-58
• /
• 2003

Background : The resurgence of tuberculosis and the widespread emergence of multidrug-resistant M. tuberculosis have emphasized the importance of rapid and accurate diagnostic procedures. Recently, the oligonucleotide chip has proven to be a useful tool in the rapid diagnosis of infectious diseases. The purpose of this study was to rapidly and accurately detect specific mutations in the rpoB, katG and rpsL genes associated with rifampin, isoniazid and streptomycin resistance in M. tuberculosis, respectively, using a single oligonucleotide chip. Method : For detection of drug-resistance, 7 wild-type and 13 mutant-type probes for rifampin, 2 wild-type and 3 mutant-type probes for isoniazid, and 2 wild-type and 2 mutant-type probes for streptomycin were designed and spotted onto glass slides. Fifty-five cultured samples of M. tuberculosis were amplified by PCR, and then underwent hybridization and scanning. Direct sequencing was done to verify the results from the oligonucleotide chip and to analyze the types of mutations. Result : Thirty-five cases out of 40 rifampin-resistant strains(~88%) had mutations in the rpoB gene. One case had a new mutation(D516F, GAC R TTC) and another known mutation together. Twenty cases out of 42 isoniazid-resistant strains(~50%) had mutations in the katG gene, while 7 cases out of 9 streptomycin-resistant strains(~78%) had mutations in the rpsL gene. From these results, the oligonucleotide chip was confirmed to be able to detect the most frequent mutations from the genes associated with rifampin, isoniazid and streptomycin resistance. The results proved that the drug-resistance detection probes were specific. When the results from the oligonucleotide chip and DNA sequencing were compared, the types of mutations were exactly matched. Conclusion : The diagnostic oligonucleotide chip with mutation specific probes for drug resistance is a very reliable and useful tool for the rapid and accurate diagnosis of drug resistance against rifampin, isoniazid and streptomycin in M. tuberculosis infections.

• Tuberculosis and Respiratory Diseases
• /
• v.49 no.5
• /
• pp.546-557
• /
• 2000

Background : Oligonucleotide chip technology has proven to be a very useful tool in the rapid diagnosis of infectious disease. Rifampin resistance is considered as a useful marker of multidrug-resistance in tuberculosis. Mutations in the rpoB gene coding $\beta$ subunit of RNA polymerase represent the main mechanism of rifampin resistance. The purpose of this study was to develop a diagnosis kit using oligonucleotide chip for the rapid and accurate detection of rifampin-resistance in Mycobacterium tuberculosis. Method : The sequence specific probes for mutations in the rpoB gene were designed and spotted onto the glass slide, oligonucleotide chip. 38 clinical isolates of Mycobacterium were tested. A part of rpoB was amplified, labelled, and hybridized on the oligonucleotide chip with probes. Results were analyzed with a laser scanner. Direct sequencing was done to verify the results. Result : The low-density oligonucleotide chip design어 to determine the specific mutations in the rpoB gene of M. tuberculosis accurately detected rifampin resistance associated with mutations in 28 clinical isolates. Mutations at codons 531, 526, and 513 were confirmed by direct sequencing analysis. Conclusion : Mutant detection using oligonucleotide chip technology is a reliable and useful diagnostic tool for the detection of multidrug-resistance in M. tuberculosis.

• Tuberculosis and Respiratory Diseases
• /
• v.77 no.4
• /
• pp.161-166
• /
• 2014

Since tuberculosis (TB) remains a major global health concern and the incidence of multi-drug resistant (MDR)-TB is increasing globally, new modalities for the detection of TB and drug resistant TB are needed to improve TB control. The Xpert MTB/RIF test can be a valuable new tool for early detection of TB and rifampicin resistance, with a high sensitivity and specificity. Late-generation fluoroquinolones, levofloxacin, and moxifloxacin, which are the principal drugs for the treatment of MDR-TB, show equally high efficacy and safety. Systemic steroids may reduce the overall TB mortality attributable to all forms of TB across all organ systems, although inhaled corticosteroids can increase the risk of TB development. Although fixed dose combinations were expected to reduce the risk of drug resistance and increase drug compliance, a recent meta-analysis found that they might actually increase the risk of relapse and treatment failure. Regarding treatment duration, patients with cavitation and culture positivity at 2 months of TB treatment may require more than 6 months of standard treatment. New anti-TB drugs, such as linezolid, bedaquiline, and delamanid, could improve the outcomes in drug-resistant TB. Nontuberculous mycobacterial lung disease has typical clinical and immunological phenotypes. Mycobacterial genotyping may predict disease progression, and whole genome sequencing may reveal the transmission of Mycobacterium abscessus. In refractory Mycobacterium avium complex lung disease, a moxifloxacin-containing regimen was expected to improve the treatment outcome.

• Journal of Chest Surgery
• /
• v.23 no.1
• /
• pp.32-40
• /
• 1990

Surgical correction of congenital cardiac defects in infants and children with an elevated pulmonary arterial pressure or pulmonary vascular resistance carries a significant early postoperative mortality. And accurate assessments of cardiac output is critically important in these patients. From April 1988 through September 1989, serial measurements of cardiac index, ratio of pulmonary-systemic systolic pressure, ratio of pulmonary-systemic resistance, central venous pressure, left atrial pressure, and urine output during the first 48 hours after the cardiac operation were made in 30 congenital cardiac defects associated with pulmonary hypertension. Cardiac index showed significant increase only after 24 hour postoperatively and this low cardiac performance in the early postoperative period should be considered when postoperative management is being planned in the risky patients. There were no variables which showed any significant correlation with cardiac index. In 12 cases[40%], pulmonary hypertensive crisis developed during the 48 hours postoperatively, and they were treated with full sedation, hyperventilation with 100 % 0y and pulmonary vasodilator infusion. In all patient with preoperative pulmonary hypertension, surgical placement of a pulmonary artery catheter is desirable to allow prompt diagnosis of pulmonary hypertensive crisis and to monitor subsequent therapy.

• Journal of the Korean Institute of Illuminating and Electrical Installation Engineers
• /
• v.16 no.5
• /
• pp.97-103
• /
• 2002

The assessment of the condition of a transformer winding which is suspected of having suffered short circuit damage can be difficult. Conventional test such as winding resistance, magnetic current or insulation resistance will only detect damage if a permanent electrical fault exists. Visual inspection of windings necessitates the removal of oil and in many cases only a very small proportion of the winding can be seen. We describe the characteristic of LVI test system and methods to detect the deformation of windings in the power transformers. As the front rise time of recurrent-surge generator pulse less than 1000 ㎱ and the peak value of pulse is about 500 V, we have the good results of detecting winding deformation in the LVI test of transformers.

• Biomedical Science Letters
• /
• v.23 no.4
• /
• pp.348-354
• /
• 2017

TyG (triglyceride and glucose) index using triglyceride and fasting blood glucose is recommended as a useful marker for insulin resistance. The present study evaluated the usefulness of TyG index in diagnosing metabolic syndrome and suggested an optimal cut-off value. The subjects of this study were adult 4,415 adults aged 20 to 80 years who underwent health screening at J General Hospital from January 2016 to January 2017. Metabolic syndrome was based on AHA/NHLBI (American Heart Association/National Heart, Lung, and Blood Institute) criteria. TyG index correlated with metabolic syndrome risk factors including HOMA-IR. Compared with the participants in the lowest quartile of TyG index, odds ratios and 95% confidence intervals for metabolic syndrome were 8.5 (3.005~23.903), 20.0 (17.190~23.407) for those in the third, and the fourth quartile of TyG index. The optimal cut-off value of the metabolic syndrome was 8.81 for TyG index (sensitivity 86.7%, specificity 80.1%) and area under the ROC curve (AUC) was 0.894. In conclusion, TyG index is effective to identify individuals at risk for metabolic syndrome.

• Asia-Pacific Journal of Business Venturing and Entrepreneurship
• /
• v.9 no.6
• /
• pp.145-152
• /
• 2014

This Study was done to estimate the availability of biological resistance analysis method in medical equipment companies in Korea, and if it is usefull in predicting risk of obesity and cardiovascular disease and managing of it, by means of comparing it with blood tests. Especially, we analyzed the correlation between circumference length and fat thickness of each site of body area, which are ones of among measurement values of the BIA. This study has the purpose to propose the use of BIA as basement of diagnosis for efficient management and assessment in the medical device industry in our country.

• The Transactions of The Korean Institute of Electrical Engineers
• /
• v.59 no.6
• /
• pp.1087-1094
• /
• 2010

We have developed a cylindrical multi-terminal capacitive-conductive sensor that could be attached to the internal surface of cooling system pipe to evaluate capacitance and conductivity of heat transfer fluid. It was used as measuring system to diagnose insulating condition, by which was kept a insulating resistance of inner stack and at the same time was cooled electrochemical heat of reaction of FCEV(fuel cell electric vehicle) stack that used a compressed hydrogen gas reacting with oxygen in accordance with variation on thermal degradation of nonconductive heat transfer fluid. Also to assess diagnosis characteristics of heat transfer fluid, i.e. coolant, we have performed accelerated aging test using developed sensor attached to cooling system. Consequently, it was measured dielectric and electric resistance of coolant to estimate and analyse for dielectric properties by degradation condition.

• Korean Journal of Human Ecology
• /
• v.12 no.5
• /
• pp.747-754
• /
• 2003

The actual clothing conditions were surveyed to diagnose clothing condition of Korean female in the view point of the adaptation to the thermal environment according to seasonal changes. Then, clothing microclimate, physiological responses, and subjective sensation were investigated through wearing trials on human body in climatic chamber based on the results from the survey. Factors to evaluate validity of clothing condition were clothing weight, clothing microclimate, physiological response of human body, and subjective sensation. The results were as follows: 1. Clothing weight per body surface area of the season was $856g/m^{2}$, $439g/m^{2}$ in summer, $630g/m^{2}$ in fall, and $1184g/m^{2}$ in winter. Cold - resistance of Korean female in office was superior to Japanese, inferior to residents of rural areas of Korea, and similar to male in office. However, in heat - resistance, female in office was inferior to residents of rural areas of Korea. 2. In spring, fall, winter, clothing microclimate temperature was a little higher than that in summer. Therefore, it was not a desirable wearing condition even though the clothing microclimate was comfortable zone. 3. Mean skin temperature of female in office was including within the range of Winslow's comfortable zone, but the range of comfortable zone in mean skin temperature of female was more narrow than Winslow's. Thus, it has problem for female to adaptation to thermal environment.