• Title/Summary/Keyword: research unit

Search Result 8,338, Processing Time 0.04 seconds

Risk of Recrudescence of Lymphatic Filariasis after Post-MDA Surveillance in Brugia malayi Endemic Belitung District, Indonesia

  • Santoso, Santoso;Yahya, Yahya;Supranelfy, Yanelza;Suryaningtyas, Nungki Hapsari;Taviv, Yulian;Yenni, Aprioza;Arisanti, Maya;Mayasari, Rika;Mahdalena, Vivin;Nurmaliani, Rizki;Marini, Marini;Krishnamoorthy, K.;Pangaribuan, Helena Ullyartha
    • Parasites, Hosts and Diseases
    • /
    • v.58 no.6
    • /
    • pp.627-634
    • /
    • 2020
  • Belitung district in Bangka-Belitung Province, Indonesia with a population of 0.27 million is endemic for Brugia malayi and 5 rounds of mass drug administration (MDA) were completed by 2010. Based on the results of 3 transmission assessment surveys (TAS), the district is declared as achieving elimination of lymphatic filariasis (LF) in 2017. The findings of an independent survey conducted by the National Institute of Health Research and Development (NIHRD) in the same year showed microfilaria (Mf) prevalence of 1.3% in this district. In 2019, NIHRD conducted microfilaria survey in 2 villages in Belitung district. Screening of 311 and 360 individuals in Lasar and Suak Gual villages showed Mf prevalence of 5.1% and 2.2% with mean Mf density of 120 and 354 mf/ml in the respective villages. Mf prevalence was significantly higher among farmers and fishermen compared to others and the gender specific difference was not significant. The results of a questionnaire based interview showed that 62.4% of the respondents reported to have participated in MDA in Lasar while it was 57.7% in Suak Gual village. About 42% of the Mf positive cases did not participate in MDA. Environmental surveys identified many swampy areas supporting the breeding of Mansonia vector species. Persistence of infection is evident and in the event of successful TAS3 it is necessary to monitor the situation and plan for focal MDA. Appropriate surveillance strategies including xenomonitoring in post-MDA situations need to be developed to prevent resurgence of infection. Possible role of animal reservoirs is discussed.

Chaetoglobosin A, an Inhibitor of Bleb Formation on K562 Cells Induced by Phorbol 12, 13-Dibutyrate

  • Ko, Hack-Ryong;Kim , Bo-Yeon;Ahn , Soon-Cheol;Oh, Won-Keun;Kim, Jin-Hee;Lee, Hyun-Sun;Kim, Hwan-Mook;Han, Sang-Bae;Mheen, Tae-Ick;Ahn, Jong-Seog
    • Journal of Microbiology and Biotechnology
    • /
    • v.8 no.6
    • /
    • pp.705-709
    • /
    • 1998
  • In the course of screening for the substances suppressing bleb formation of K562 cell induced by phorbol 12, 13-dibutyrate (PDBu), an inhibitor, chaetoglobosin A (CgA) was isolated from a cultured broth of unidentified fungus. CgA showed a strong inhibitory activity with the $IC_{50}$ value of 60 pM against bleb formation on K562 cells induced by PDBu, but it did not inhibit the activity of protein kinase C (PKC) in vitro. The inhibitory activity of CgA might be due to the modulation of actin filaments on the cell membrane. CgA exhibited strong cytotoxicity against various human cancer cell lines.

  • PDF

Study of Improved Transporting Methods on Unit Module (유닛모듈 운송 방법의 개선방향 연구)

  • Park, Su-Yeul;Kim, Kyoon-Tai;Park, Nam-Cheon;Jung, In-Su
    • Proceedings of the Korean Institute of Building Construction Conference
    • /
    • 2012.11a
    • /
    • pp.243-244
    • /
    • 2012
  • Recently, research has been actively conducted for getting interested in unit module housing. However, the domestic unit modular housing research in the early stages yet, so the major process for research is lacking. Explore all these reasons fit with domestic unit housing development this paper, focusing on the process of shipping cargo by truck, transport unit module was studied. The purpose of this paper is to present new ideas and derive the direction of the development of the equipment safely and effectively fixed to the unit module of the transport unit module that will be helpful in the development of the equipment required for the transport process of the next unit module.

  • PDF

lsolation of Bacillus Strains Secreting Fibrinolytic Enzymes from Doen-Jang (된장으로부터 혈전용해능을 가진 Bacillus sp.의 분리 및 동정)

  • Kim, Seung-Ho;Choi, Nack-Shick;Lee, Woo-Yiel;Lee, Jong-Woo;Kim, Dong-Ho
    • Korean Journal of Microbiology
    • /
    • v.34 no.3
    • /
    • pp.87-90
    • /
    • 1998
  • Various bacterial strains that secret extracellular fibrinolytic enzyme were screened from Doen-Jang, a traditional soybean fermented food in Korea. Five microbes of them were identified to be Bacillus sp. strains according to Bergey's manual of systematic bacteriology. The culture filtrates of B. amyloliquefaciens (2.46 plasmin unit/ml) and B. pantothenticus (3.82 plasmin unit/ml) showed a level of fibrinolytic activity that was about three times higher than that of plasmin 1.0 unit and Bacillus subtilis showed the highest fibrinolytic activity (4.94 plasmin unit/ml). All of the extracellular proteases showing the fibrinolytic activity are confirmed by SDS-PAGE followed by reverse fibrin zymogram activity assay and we proposed that some of the fibrinolytic enzymes from this work are novel enzymes.

  • PDF

Evaluation of Effective Rainfall Ratio Method for Estimating Unit Load from Paddy Fields (비우량 방법에 의한 논 오염부하 원단위 산정시 적용성 평가)

  • Jung, Jae-Woon;Yoon, Kwang-Sik;Yoon, Suk-Gun;Choi, Woo-Jung;Choi, Woo-Young;Huh, Yu-Jeong;Cho, Kyeong-Min;Hong, Jung-Jin
    • Journal of Korean Society on Water Environment
    • /
    • v.25 no.6
    • /
    • pp.849-854
    • /
    • 2009
  • Pollutant unit load (unit-load) reported by Ministry of Environment (MOE) in 1995 has been a useful method for watershed management and environmental policy decision. The unit-load has been estimated using effective rainfall ratio method. However, reliability of unit-load determined by the method has been criticized especially for paddy field and upland conditions. In this paper the unit-load of paddy field estimated by effective rainfall ratio method was compared with continuous monitoring data. Annual loads was simulated by the method choosing 5~6 storm events randomly from whole events collected. Probability distribution of difference between results by the method and measured data was investigated. The results showed that unit-load derived by the method was generally lesser than measured unit-load and showed wide variations. Therefore, unit-load estimation of paddy fields by effective rainfall ratio method need caution.