• 재활간호학회지
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• 제9권2호
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• pp.153-160
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• 2006

Purpose: This study was performed to examine present health condition on community clients and the degree of cognition on community oriental health promotion program. Method: Research design is cross-sectional descriptive study, 300 residents who live in S city were selected. The period of data collection was from October 2005 to April 2006. The research instruments used were the VAS of fatigue, headache, pain, Depression, anxiety to examine present physical and psychological health condition and questionnaire on the degree of cognition on Oriental Health Promotion Program. SPSS 10.0 was used for statistics. Results: The range of fatigue, headache, pain, depression, anxiety was 2.09-3.75. The degree of cognition on program was 2.67. As for the degree of cognition on oriental health promotion program according to general characteristics of subject, there was significant difference(F=3.79, p=.038) between below 65 years(2.88) and above 65 years(3.12). Conclusion: We are trying to develop oriental health promotion program fit to property of community, especially elderly.

• 가정과삶의질연구
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• 제19권6호
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• pp.95-112
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• 2001

The purpose of this study was to develop an Imaginary Audience Reduction Program and examine the effectiveness of using the program on improving female adolescents' self-esteem. Based on the results from the study, 10-session-Imaginary audience reduction program was developed. Then the researcher conducted the Imaginary Audience Reduction Program for 72 female adolescents from 4, May 2000 to 7, July 2000 at the girls'middle school in Daegu. For examining the effectiveness of using the program, the research instruments were Self-Esteem Inventory(SEI; Coopersmith, 1967) and New Imaginary Audience Scale(NIAS; Lapsley, FitzGerald, Rice & Jackson, 1989). The research instruments used for pre-post-follow up tests. The Data were analyzed by Repeated Measure ANOVA. There were statistically significant differences in self-esteem and Imaginary audience. Results revealed that adolescents who took the Imaginary Audience Reduction Program consistently reported the improvement of their self-esteem level and the reduction of their Imaginary audience level. The implication of study findings will be discussed.

• 의료ㆍ복지 건축 : 한국의료복지건축학회 논문집
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• 제14권4호
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• pp.3-10
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• 2008

Space program is not only meaning of area distribution on the planning of hospital architecture. The environment of health care such as medical examination, the level of service and construction on hospital. And also space program implies the composition of space and plan of size in which are activity, required manpower and rooms, and mutual relation between spaces in hospital by quantitative analysis of the requered rooms and unit area. Accordingly space program is the data at the beginning of plan which can understand the pursuing direction of hospital at the beginning of plan. This study analyze how to express the role and function of hospital in space program by research of it in korean general hospital. Through those research, the purpose of this study is to sight the position of present hospital and produce the basic data for precise space program.

• Translational and Clinical Pharmacology
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• 제25권2호
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• pp.67-73
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• 2017

Glimepiride, a third generation sulfonylurea, is an antihyperglycemic agent widely used to treat type 2 diabetes mellitus. In this study, an untargeted urinary metabolomic analysis was performed to identify endogenous metabolites affected by glimepiride administration. Urine samples of twelve healthy male volunteers were collected before and after administration of 2 mg glimepiride. These samples were analyzed by liquid chromatography-tandem mass spectrometry (LC-MS/MS), and then subjected to multivariate data analysis including principal component analysis and orthogonal partial least squares discriminant analysis. Through this metabolomic profiling, we identified several endogenous metabolites such as adenosine 3', 5'-cyclic monophosphate (cAMP), quercetin, tyramine, and urocanic acid, which exhibit significant metabolomic changes between pre- and posturine samples. Among these, cAMP, which is known to be related to insulin secretion, was the most significantly altered metabolite following glimepiride administration. In addition, the pathway analysis showed that purine, tyrosine, and histidine metabolism was affected by pharmacological responses to glimepiride. Together, the results suggest that the pharmacometabolomic approach, based on LC-MS/MS, is useful in understanding the alterations in biochemical pathways associated with glimepiride action.

• 한국산업보건학회지
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• 제31권1호
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• pp.1-12
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• 2021

Objective: The purpose of this study was to contribute to the prevention of occupational diseases through the development of an automatic analysis program for evaluating workers' exposure to hazardous chemical substances. Methods: The authors selected chemical substances that caused occupational disease in Korea and chemical substances that are frequently used in industrial sites as target substances for a GC-MS automatic analysis program. The target substances are organic compounds which can be measured by a passive sampler. The automatic analysis program was studied using various raw data obtained from GC-MS analysis for the target substances. Results: A total of 48 organic compounds that can be measured with a passive sampler were selected as target substances for the GC-MS automatic analysis program. The selected compounds included substances that caused occupational disease, substances related to C1 and D1 in special health examinations, and substances for which work environment measurements have been frequently conducted. The GC-MS automatic analysis program was developed by combining information mainly on retention time and mass spectrum. The GC-MS automatic analysis program is designed to analyze unknown samples by comparing the mass spectrum and retention time of the samples to those of reference materials. To evaluate the stability of the program, samples at about the 30-50% level of OELs were prepared and analyzed with the GC-MS automatic analysis program, resulting in stable results for all 48 organic compounds. Conclusion: An automatic analysis program for a total of 48 organic compounds was developed using a GC-MS system that can analyze organic compounds. Unknown samples that contain the 48 organic compounds can be automatically analyzed by the developed program. It is anticipated that it can contribute to the prevention of occupational diseases through an GC-MS automatic analysis program that can quickly provide workers with information on exposure to chemical substances.

• Industrial Engineering and Management Systems
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• 제10권3호
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• pp.232-237
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• 2011

Design for Six Sigma (DFSS) has been implemented in many companies to enhance their business performance and customer satisfaction. However, DFSS has not been widely applied to the aircraft industry which operates large, complex development programs. In this paper, the characteristics of an aeronautical product development program are analyzed to figure out the limitations of current DFSS methodology and the prerequisite to deployment of DFSS at the program level is suggested.

• 전력전자학회:학술대회논문집
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• 전력전자학회 1998년도 Proceedings ICPE 98 1998 International Conference on Power Electronics
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• pp.34-39
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• 1998

This paper describes the simulation approaches employed for a vector control system of induction motor drive using SIMNON for windows program. SIMNON program tool can solve differential and difference equations for nonlinear dynamical control system. One powerful feature is its ability of allowing integration of individual program modules after each individual module is programed and tested independently. This particular feature is exploited here for an SVPWM inverter drive by real-time modeling and simulation. The suggested programs are provided a simple and complete simulation for induction motor vector drive system.

• 한국환경교육학회지:환경교육
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• 제24권2호
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• pp.35-53
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• 2011

The purpose of this research is placed on the development and application of environmental play programs for elementary school students their utilizing the neighborhood learning gardens in their districts to find its effectiveness. The research questions drawn to attain the purpose of the research are as follows. Initially, analyze the contents related to the plant appearing in the textbooks of wise life, science and practical arts of the 7th elementary school curriculum. Secondly, develop a plant utilizing environmental play program targeted towards the 4th grade elementary school students with the results of the textbook analysis as the foundation. Third, apply the plant utilizing environmental play program into the classroom to verify its effectiveness. Based on the conclusion of this research, the following is to be proposed. First, the revitalization of regional environmental education utilizing the various surroundings of the region is essential. Also, the current method of education, which is focused on theoretical knowledge, and being operated in most of the schools need to be changed over to diverse environmental education programs that are linked with the region. For this, an internet based database, information sharing and exchange program centralized around the regional environmental education center needs to be prepared. Moreover, since this research had developed an environmental play program utilizing plants that focused on the 4th grade elementary school students to verify its effectiveness, the development for environmental play programs dealing with various themes for each grades is required. Lastly, although this research has verified the effectiveness in the variables of ecological knowledge, environmental susceptibility, environmental attitude, environmental concern, environmental function and responsible environmental behavior amongst the variables of environmental literacy but there requires a succeeding research considering the variables that haven't been included in this research.

• 한국환경교육학회지:환경교육
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• 제20권4호
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• pp.12-26
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• 2007

The purpose of this research is to develop a water environmental education (EE) program using streams, based on the core ideas of ENVISION and materializing elements that were extracted in this research. This research realized the elements and presented a model of the water EE program using a local stream. First, this research developed a basic model of a water EE program using streams by extracting 10 materializing elements and realizing the elements in 4 stage-procedural model. The 10 materializing elements were 1. experiencing the process of inquiry, 2. inquiring local environments, 3. self-directing learning and mutual interaction with colleagues, 4. collecting real data and interpreting, 5. utilizing the ICT(information and communication technology), 6. inquiring with the view point of the 'Environmental Studies for EE', 7. inquiring with the watershed concept, 8. inquiring with the integrating and the holistic view point, 9. pursuing the macroscopic understanding about environment, and 10. connecting the real world phenomena with the environmental concepts and theories. This research materialized these 10 elements in 4 stage model, following the previous ENVISION research, which are 1. preparing stage and visual assessment, 2. writing the report of the inquiry plan, 3. collecting the real data in the environment and performing the investigation, and 4. presenting the inquiry results. Second, with using this basic model, this research developed and presented a model of the specific water EE program using a case stream called 'Baig Cheon' stream, which is a local stream. This research is considered to have a considerable meaning in developing a EE program with ENVISION ideas for the watershed concept and inquiry with environmental science using local streams. The developed model can help the professional development of teachers and teacher education of water EE.

• Archives of Pharmacal Research
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• 제29권10호
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• pp.890-897
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• 2006

In inflammatory responses, induction of cytokines and other immune regulator genes in macrophages by pathogen-associated signal such as lipopolysaccharide (LPS) plays a crucial role. In this study, the gene expression profile changes by LPS treatment in the macrophage/monocyte lineage cell line RAW264.7 was investigated. A 60-mer oligonucleotide microarray of which probes target 32381 mouse genes was used. A reverse transcription-in vitro translation labeling protocol and a chemileuminescence detection system were employed. The mRNA expression levels in RAW264.7 cells treated for 6 h with LPS and the control vehicle were compared. 747 genes were up-regulated and 523 genes were down-regulated by more than 2 folds. 320 genes showing more than 4-fold change by LPS treatment were further classified for the biological process, molecular function, and signaling pathway. The biological process categories that showed high number of increased genes include the immunity and defense, the nucleic acid metabolism, the protein metabolism and modification, and the signal transduction process. The chemokine-cytokine signaling, interleukin signaling, Toll receptor signaling, and apoptosis signaling pathways involved high number of genes differentially expressed in response to LPS. These expression profile data provide more comprehensive information on LPS-target genes in RAW264.7 cells, which will be useful in comparing gene expression changes induced by extracts and compounds from anti-inflammatory medicinal herbs.