• Title/Summary/Keyword: research and development

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Design and Synthesis of Oxime Ethers of β-Oxo-γ-phenylbutanoic Acids as PPAR α and -γ Dual Agonists

  • Han, Hee-Oon;Koh, Jong-Sung;Kim, Seung-Hae;Park, Ok-Ku;Kim, Kyoung-Hee;Jeon, Sang-Kweon;Hur, Gwong-Cheung;Yim, Hyeon-Joo;Kim, Geun-Tae
    • Bulletin of the Korean Chemical Society
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    • v.33 no.6
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    • pp.1979-1982
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    • 2012
  • Oxime ethers of ${\beta}$-oxo-${\gamma}$-phenylbutanoic acids were prepared to develop more effective PPAR ${\alpha}$ and ${\gamma}$ dual agonists. Among them, compound 11k exhibited potent $in$ $vitro$ activities with $EC_{50}$ of 2.5 nM and 3.3 nM in PPAR ${\alpha}$ and ${\gamma}$, respectively. It showed better glucose lowering effects than rosiglitazone 1 and improved the lipid profile like plasma triglyceride in db/db mice model.

Total Mercury Contents of Antarctic Toothfish Dissostichus mawsoni Caught in the Antarctic Sea

  • Son, Kwang-Tae;Kwon, Ji-Young;Jo, Mi-Ra;Yoon, Minchul;Song, Ki-Cheol;Choi, Woo-Seok;Yeon, In-Ja;Kim, Ji-Hoe;Lee, Tae Seek
    • Fisheries and Aquatic Sciences
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    • v.17 no.4
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    • pp.427-431
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    • 2014
  • Mercury is an element of special concern for human health. Measurements of total mercury levels in fish have been taken into consideration to assess risk. In this study, the Antarctic toothfish Dissostichus mawsoni was evaluated as a potential safe food source through measurement of total mercury contents. Total mercury concentrations in Antarctic toothfish ranged from $0.101{\pm}0.047mg/kg$ to $0.139{\pm}0.075mg/kg$. The total mercury concentration was significantly correlated with macroscopic values including total fish length, weight, gonadosomatic index, and maturity (P < 0.01 or 0.05). Furthermore, according to the risk assessment, the total mercury body exposure rate from Antarctic toothfish ranged from 2.125% to 2.847% of the Provisional Tolerable Weekly Intake. Therefore, the Antarctic toothfish could be used as a potential safe seafood source.

New Records of Two Penaeoid Shrimps (Crustacea: Decapoda) from Korean Waters

  • Kim, Jung-Nyun;Choi, Jung-Hwa;Oh, Taeg-Yun;Hwang, Kang-Seok;Kim, Jong-Bin;Choi, Kwang-Ho;Lee, Dong-Woo
    • Fisheries and Aquatic Sciences
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    • v.13 no.4
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    • pp.320-323
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    • 2010
  • Two penaeoid shrimps, Hadropenaeus lucasii (Bate, 1881) and Sicyonia truncata (Kubo, 1949), were collected from the northeastern waters of Jeju Island, Korea. These represent the only Korean reports of a member of the genus Hadropenaeus, family Solenoceridae and of a member of family Sicyonidae, respectively. Morphological descriptions and illustrations with a color photograph of each species are given. Korean Penaeoidea presently includes 27 species in three families.

Development of Radar Environmental Signals Simulator for Simulating Sub-array Receiving Signals of Active Phased Array Multi-function Radar (능동위상배열 다기능레이다의 부배열 수신신호 모의를 위한 레이다환경신호모의장비 개발)

  • Kim, Gukhyun;Yoo, Kyungjoo;Lee, Kyungmin;Gil, Sungjun;Yang, Eunho;Lee, Kwangchul;Lee, Heeyoung
    • Journal of the Korea Institute of Military Science and Technology
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    • v.23 no.5
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    • pp.452-458
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    • 2020
  • In this paper, the contents of the development of RESS(Radar Environmental Signals Simulator) for the test of active phased array multi-function radar are described. The developed RESS can simulate multiple target environments, such as target/jamming/missile response/cluster signals, by using received radar operational information and simulated scenario. It can also modulate frequency, phase, gain, timing on all waveforms operated by multi-function radar and simulated two targets and one jamming in the beam. The RESS can be used to perform functional and performance verification of the active phased array multi-function radar with sub-array receiving structures.

Breeding and Production Research Direction for Soybean Self-Sufficiency Improvement in Korea

  • Jee-Yeon Ko;Beom-Kyu Kang;Jeong-Hyun Seo;Jun-Hoi Kim;Su-Vin Heo;Man-Soo Choi;Jae-Bok Hwang ;Choon-Song Kim;Myeong-Gyu Oh
    • Proceedings of the Korean Society of Crop Science Conference
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    • 2022.10a
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    • pp.23-23
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    • 2022
  • Recently, soybean production and market price are unstable, even if demand of soybean is maintained. Diverse conditions such as climate change, a decrease in rural population, and consuming affect food industry. In this situation, food security is soaring as important key-word again, and MAFRA is promoting policies for improving soybean self-sufficiency with the goal of 40% until 2030. The point of policy is to extend a production and stabilize a demand for soybean with supporting large-scale soybean paddy-field complex. According to the background, soybean breeding and production research in NICS are proceeded with three parts. First, production improvement with soybean cultivation land enlargement and high-yield cultivar development. Various growth period soybean cultivars for double cropping, irrigation management technologies in paddy field, and hyper-yield and specific-region adaptable cultivar development. Second, reduction of production expense with mechanized cultivation and digital-based field management technologies. Third, consumer-friendly and high quality soybeans with high protein cultivar for alternative protein usage and high food process-ability for soy milk, tofu, soybean sprouts, and grain usage. Each part need to be combined and advanced to improve soybean industry and soybean self-sufficiency.

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