• Nutrition Research and Practice
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• 제4권6호
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• pp.477-485
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• 2010

The purpose of this study was to evaluate the effects of repeated fasting and refeeding on lipid metabolism. Thirty male ICR mice, aged 6 weeks, were fed an AIN-93 control diet during the experimental period. The mice were divided into 5 groups: Non fasting group (ad libitum-fed, NF), fasting for 3 days (F), fasting for 3 days and then refeeding for 4 days repeated once (FRF1), fasting for 3 days and then refeeding for 4 days repeated twice (FRF2), and fasting for 3 days and then refeeding for 4 days repeated three times (FRF3). Rates of body weight gain, epididymal fat weight, and serum TG were significantly decreased in the F, FRF1, FRF2, and FRF3 groups, compared to the NF group. LDL-cholesterol was significantly higher in the FRF3 group than the NF and F groups, but HDL-cholesterol and HDL/TC were significantly lower in the FRF3 group than in the NF and F groups. Serum total carnitine was significantly lower in the FRF1, FRF2, FRF3 groups than the NF and F groups. However, rates of serum and hepatic acyl-carnitine concentration were significantly lower in FRF1, FRF2, and FRF3 than in NF and F. Repeated tasting-refeeding resulted in visible reductions of body weight and fat mass, but it caused ill-effects with lipid and carnitine metabolism in the body.

• Journal of Nutrition and Health
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• 제45권1호
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• pp.5-11
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• 2012

We investigated the effects of short-term food restriction and repeated fasting and refeeding on appetite regulating hormones and adiponectin activity in rats. To investigate the acute and chronic effects of food restriction in vivo, Sprague-Dawley rats were divided into a control group (CON), a 1 day fasting group, a 2 days fasting gruop, a 3 days fasting gruop, a fasting and refeeding for 1 week gruoup and a fasting and refeeding for 2 weeks group. Blood glucose, triglyceride and total cholesterol decreased in all fasting groups compared to those in the CON group. Free fatty acid of all fasting groups was higher than those in the CON, and were lowest in the three cycle fasting and refeeding group. Blood insulin following short-term food restriction was lower than that in the CON. blood ghrelin increased significantly (p < 0.01) following the short-term food restriction, However, blood ghrelin in the repeated fasting and refeeding groups decreased significantly decreased (p < 0.01) compared to that in the CON and short-term food restriction group. In contrast, blood leptin decreased significantly (p < 0.01) in the short term food restriction group and the three cycle of fasting and refeeding group but increased in the six cycle of fasting and refeeding group. No significant differences in adiponectin contents were observed in the short-term food restriction group. But, adiponectin increased significantly (p < 0.01) following the fasting and refeeding cycles. Blood adiponectin and blood leptin levels were showed positively correlated ($r^2$ = 0.469) when all samples were analysed together.