• 한국발생생물학회지:발생과생식
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• 제20권2호
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• pp.91-99
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• 2016

Lipopolysaccharide (LPS), an endotoxin, elicits strong immune responses in mammals. Several lines of evidence demonstrate that LPS challenge profoundly affects female reproductive function. For example, LPS exposure affects steroidogenesis and folliculogenesis, resulting in delayed puberty onset. The present study was conducted to clarify the mechanism underlying the adverse effect of LPS on the delayed puberty in female rats. LPS was daily injected for 5 days ($50{\mu}g/kg$, PND 25-29) to treated animals and the date at VO was evaluated through daily visual examination. At PND 39, animals were sacrificed, and the tissues were immediately removed and weighed. Among the reproductive organs, the weights of the ovaries and oviduct from LPS-treated animals were significantly lower than those of control animals. There were no changes in the weights of uterus and vagina between the LPS-treated and their control animals. immunological challenge by LPS delayed VO. Multiple corpora lutea were found in the control ovaries, indicating ovulations were occurred. However, none of corpus luteum was present in the LPS-treated ovary. The transcription level of steroidogenic acute regulatory protein (StAR), CYP11A1, CYP17A1 and CYP19 were significantly increased by LPS treatment. On the other hand, the levels of $3{\beta}$-HSD, $17{\beta}$-HSD and LH receptor were not changed by LPS challenge. In conclusion, the present study demonstrated that the repeated LPS exposure during the prepubertal period could induce multiple alterations in the steroidogenic machinery in ovary, and in turn, delayed puberty onset. The prepubertal LPS challenge model used in our study is useful to understand the reciprocal regulation of immune (stress) - reproductive function in early life.

• Journal of Radiation Protection and Research
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• 제28권2호
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• pp.145-154
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• 2003

By optimizing the radiation protection the collective dose and individual dose could be reduced during YGN #4 $5^{th}$ outage in 2001. The collective doses for the two high radiation jobs decreased to 85% and 65% of expected doses. The proportion of workers with low dose (below 1mSv) exposure increased 4% while the proportion of workers with over 3mSv and 5mSv exposure are decreased to 2%, 1% respectively. But none is exposed over 8mSv for the annual dose. To aid decision of utilizing the robot, cost- benefit analysis was performed and reasonable point was proposed to use the robot. For the first time job, repeated ALARA meeting and mock up training were implemented to set up working procedure by identifying the trouble. To easily set up standard procedure, mockup process was videotaped and reviewed during ALARA meeting. Monitoring is a good approach to chase radiological working condition such as working time, dose rate. behavior of workers, especially for high radiation work. Those data were estimated and adjusted from the stage of work planning to mock up. At the stage of actual work the monitoring data were compared to the estimation and recorded to database. This database will not only be used as a powerful tool for dose optimization at the following outage but also as a guideline to dose constraint set up for optimization for each specific situation.

• 한국환경보건학회지
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• 제36권5호
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• pp.383-390
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• 2010

Exposure to fugitive dust can contribute to several respiratory health problems, and proper sampling of fugitive dust is necessary to assess exposure. However, field sampling of soil dust encounters problems from spatial and temporal differences in soil properties, field operations, and meteorological conditions. To minimize these problems, we designed a dust generator that simulates dust generation from soil. The dust generator consisted of a rotating chamber where soil samples were loaded and tumbled, and a settling chamber, where airborne soil dust samples were collected. As standard operating conditions, we decided on 2 g soil mass, 10 min sampling time, and 20 rpm rotating speed, with a flow rate of 30 l/min, based on three common soil textures of loam, sandy loam and silt loam. To evaluate optimal operating conditions, we used mixtures of Joomoonjin silica sand and clay. Although the average $PM_{10}$ concentration of Joomoonjin silica sand was low, dust concentrations were increased by an increased content of clay. The dust concentrations were consistent across repeated experiments, and showed similar concentration profiles during the sampling time with mixtures of clay and sand (coefficient of variation was $13.6{\pm}w;7.1%$). The results demonstrated that these standard operating conditions were suitable for the dust generator, which can be used to investigate variations in soil properties that affect dust production and potential potency of fugitive dust exposure.

• 한국지형학회지
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• 제19권1호
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• pp.83-97
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• 2012

무등산의 서석대~장불재 사면은 $70{\sim}90^{\circ}$의 단애와 $5^{\circ}$ 내외의 완경사지가 계단과 같은 형태로 반복적으로 나타나고 있다. 이들의 생성 발달 환경을 연구한 결과, 주빙하성 평활사면은 주로 남서쪽을 향하고 있으며, 이는 암괴의 수직 수평절리가 주빙하 기후환경 아래에서 동결융해의 반복에 의해 전도된 것으로 판단된다. 주상절리 하단의 평탄면은 구조벤치의 형태를 보인다. 평탄면 매트릭스의 이동영력은 솔리플럭션 또는 젤리플럭션이다. 장불재 일대의 사면의 연대측정결과 입석대 상부는 11만년 전부터 지표에 노출된 상태로 현재에 이르고 있다. 입석대 하부의 암괴는 약 1만년 전에, 장불재는 약 5만년에 지표면 부근에 노출되었으며, 노출이후 단애에서 떨어지고 현재 위치에 사면 이동하였을 것으로 추정된다. 이러한 암괴의 이동과정은 주빙하 기후의 영향으로 단애가 동결융해를 지속적으로 받아 평행후퇴하였고, 과거 1만년 가까운 시기에 현재 입석대에까지 영향을 주었던 것으로 예상된다.

• 한국방사선학회논문지
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• 제12권6호
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• pp.707-712
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• 2018

CT의 검사 건수는 크게 증가하고 있으며, 이에 따른 방사선 피폭도 늘어나고 있는 실정이다. 반복된 두부 CT검사는 수정체 및 갑상선에 영향을 줄 수 있다. 대부분의 병원에서는 두부 CT검사로 영상 정보 증가와 영상 질 향상에 대한 관심에 비해 주요장기 방사선 피폭에 대한 관심은 부족한 경향이 있다. 사용 프로토콜은 병원마다 다른 경향이 있고 업무과중으로 피폭선량을 고려할만한 여건은 부족한 편이다. 피폭감소를 고려한 저관전압 CT를 사용할 경우 임펄스 잡음이 발생한다. 본 연구에서는 잡음이 발생한 CT 영상에 대해 제안한 방법을 적용하여 화질 개선 정도를 분석하였다. 제안하는 영상개선 방법은 임펄스잡음후보 화소에 대해서만 총변량 최적화 방법을 적용하였다. 실험결과 에지 정보가 잘 보존되는 특징이 있었고 임펄스 잡음을 효과적으로 제거 할 수 있었다. 관전압과 회전시간에 따라 획득된 영상들에 대해서 매우 잘 작동하였다. 본 연구에서 제안하는 방법을 적용한다면 화질 걱정 없이 검사 프로토콜을 피폭 최저조건으로 설정하여 사용할 수 있고 CT에 적용시 도움이 될 것으로 판단한다.

• 한국산업보건학회지
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• 제32권2호
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• pp.137-145
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• 2022

Objectives: This study aimed to identify PM₁₀ mass concentration levels and conduct peak identification during five tasks in agricultural works. Methods: We investigated five agricultural tasks in 12 farms, which were harvesting, plowing, sowing, planting, and decapitation. All samples were measured by using the portable aerosol spectrometer(PAS 1.108) and the aerosol monitor(SidePak AM520). The collected data were compared with the national PM₁₀ concentrations. They were calculated to descriptive statistics, independent t-test, or ANOVA, and the peak identification on time series graph. Results: The ten investigated farms showed no significant difference with the national PM₁₀ concentrations, but the two greenhouses(AM, 143.31, 85.16 ㎍/m³) showed significant difference(p<0.05). As a result of the peak identification, the harvesting tasks showed repeated peak occurrence with the background concentration level of about 50 ㎍/m³. For plowing and sowing tasks, the peak occurred intermittently when the working was conducted near the sampling sites. Among the five tasks, the arithmetic mean of the harvesting task was 138.84±294.71 ㎍/m³, which was significantly higher than the other tasks(p<0.05). In addition, the case of using a tractor was higher than the case of not using the tractor(p<0.05), and the driver's seat showed the highest concentration(AM, 95.81 ㎍/m³). Conclusions: Works in greenhouses might have exposure to PM₁₀, while outdoor works is similar to general atmospheric PM₁₀ concentration levels. However, there is a possibility of intermittent exposure to high concentrations of PM₁₀ depending on the characteristics of agricultural tasks.

• 한국축산식품학회지
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• 제42권4호
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• pp.712-722
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• 2022

In this study, we investigated the residual properties of tebuconazole-treated pigs. Twenty pigs were treated with different concentrations (0.25, 1.25, 2.5, 12.5, and 25 mg/kg bw/d) of tebuconazole for 28 d. Blood biochemistry, histology, and residual levels were analyzed using the VetTest analyzer, Masson's trichrome staining kit, and liquid chromatography-mass spectrometry, respectively. The final body weights were not significantly different between the control and treatment groups. Alkaline phosphatase, blood urea nitrogen, cholesterol, and gamma-glutamyl transpeptidase levels were significantly different from those of the control after exposure for 14 d. However, alanine aminotransferase levels showed changes only after exposure to pesticides for 28 d. The biochemical parameters were separated during the experimental period (14 d versus 28 d) by principal component analysis. Based on variable importance plots, blood urea nitrogen/creatinine ratio, blood urea nitrogen, glucose, and gamma-glutamyl transpeptidase are candidate biomarkers for tebuconazole exposure. The residual levels were observed at T4 (12.5 mg/kg bw/d) and T5 (25 mg/kg bw/d) in the liver and fat tissues, respectively. Fibrosis increased in the liver, kidney, and fat tissues, depending on the tebuconazole concentration. In conclusion, the residue limits of tebuconazole and the physiological changes caused by dietary tebuconazole in pigs provide important information for establishing maximum residue limits of pork and pork products.

• 대한치과교정학회지
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• 제48권3호
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• pp.182-188
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• 2018

Objective: This study was performed to validate the autonomous maximal smile (AMS) as a new reference for evaluating dental and gingival exposure. Methods: Digital video clips of 100 volunteers showing posed smiles and AMS at different verbal directives were recorded for evaluation a total of three times at 1-week intervals. Lip-teeth relationship width (LTRW) and buccal corridor width (BCW) were measured. LTRW represented the vertical distance between the inferior border of the upper vermilion and the edge of the maxillary central incisors. Intraclass correlation coefficients (ICCs) for reproducibility, and the m-value (minimum number of repeated measurements required for an ICC level over 0.75), were calculated. Results: LTRW and BCW of the AMS were 1.41 and 2.04 mm, respectively, greater than those of the posed smile (p < 0.05), indicating significantly larger dental and gingival exposure in the AMS. The reproducibility of the AMS (0.74 to 0.77) was excellent, and higher than that of the posed smile (0.62 to 0.65), which had fair-to-good reproducibility. Moreover, the m-value of the AMS (0.88 to 1.05) was lower than that of the posed smile (1.59 to 1.85). Conclusions: Compared to the posed smile, the AMS shows significantly larger LTRW and BCW, with significantly higher reproducibility. The AMS might serve as an adjunctive reference, in addition to the posed smile, in orthodontic and other dentomaxillofacial treatments.

• 대한방사선기술학회지:방사선기술과학
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• 제21권1호
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• pp.52-58
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• 1998

We can and must improve the diagnostic images using available knowledge and technology. At the same time we must strive to reduce the patient's integral and entrance radiation dose. Reducing the integral dose to the patient during the radiologic procedure is a primary concern of the patient, especially the pediatric patient, the radiologist and the technologist. A 100cm focal film distance generally is used for most over-table radiography. The early x-ray tubes and screen film combinations required long exposures, which often resulted in motion artifacts. But nowaday, we have the generators and x-ray tubes that can deliver the energy necessary in a very short time and the receptors that can record the information just as rapidly. And, we performed this studies to evaluate the patient exposure dose and the image quality by increasing focal film distance in diagnostic radiography. There are many factors which affected to exposure factor, but we studied to verify of FFD increase, only. Effect of increasing the focal film distance to a 140 cm distance was tested as follows; 1. The focal film distances were set at 100, 120, and 140cm. 2. A 18cm acryl(tissue equivalent) phantom was placed on the table top. 3. An Capintec 192 electrometer with PM 05 ion chamber was placed at the entrance surface of the phantom, and exposure were made at each focal film distances. 4. The procedure was repeated in the same manner as above except the ion chamber was placed beneath the phantom at the film plane. 5. Exit exposure were normalize to 8mR for each portions of the experiment. Based on the success of the empirical measurements, a detailed mathematical analysis of the dose reduction was performed using the percent depth dose data. The results of this study can be summerized as followings ; 1) Increasing FFD from 100 cm to 140 cm, we would create a situation that would have a significant effect on the overall quality of radiograph and achive the 17.42% reduction of entrance dose and the 18.95% reduction of integral dose that the patient receives. 2) Thickness of Al step wedge for equal film density increased with the long distance. 3) Increasing FFD, Magnification of image was lowered. 4) Resolution of image also increased with the FFD. As the results described above, we strongly recommend using the long FFD to provide better information for our patients and profession in abdomen radiographic studies.

• Journal of Photoscience
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• 제9권2호
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• pp.194-196
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• 2002

While ultraviolet radiation alters various cutaneous cell functions, little is known about photo-immunological and photobiological effects of infrared radiation (IR) on the skin except its local thermal effects. The fIrst part of this study demonstrated that single exposure of mouse skin to near IR (0.7 - 1.3 $\mu$m) reversibly suppressed the proliferating activity of the epidermis, the density of Langerhans cells, and the ability of skin to induce contact hypersensitivity reaction. The second part demonstrated that the rate of wound closure was significantly accelerated by repeated exposures in animal models. The production of transforming growth factor-$\beta$l and matrix metalloproteinase-2, which are responsible for the wound healing processes, was significantly upregulated by irradiation, as shown by enzyme immunoassay, zymography, and reverse transcription polymerase chain reaction. Thermal controls were negative. The results suggest that near-IR irradiation can modulate the epidermal proliferation and part of the skin immune system, and stimulate the wound healing processes, presumably by non-thermal effects.