• Proceedings of the KSR Conference
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• 2007.11a
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• pp.623-628
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• 2007

Metro Subway System is widely known as the leader of public transportation in a metropolitan area. The signal interlocking is one of the most important organs that plays a major role in the system. By improving the quality of signal interlocking on of the traffic system and keeping its maintenance on a high level will not only repair the current state, but it will also let the PLC(Programmable Logic Controller). The Non-Vital relay of No. 3, 4 Line are the most one of the unstable system, device, which underwent a process of fine manufacture establishment and a close examination, obtained as a new device. Utilizing the equipment with cautious preservation on the system will enhance the current state of the signal device. Especially, the test for improvement and development based upon the technique that decreases the frequency of defect produced will further precipitate its efficiency. With authorization of imposing the newly made equipment will bring improvement to the signal technology and to the industry at largest extent.

• 대한공업교육학회지
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• v.33 no.2
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• pp.325-339
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• 2008

In this paper, we developed a module that can execute the data acquisition of the real-time measured radiant rays in the specific part of the nuclear power station. This module that includes the RF communication function, paces around the power station, being loaded on robot and can obtain the generated radiant rays in the various places through the detecting devices. It is considered that this new developed radiant rays acquisition method will have the higher degree of efficiency as compared with the existing method and reduce the expenses of the maintenance and repair work.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.13
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• pp.5191-5197
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• 2015

A partial response or resistance to chemotherapeutic agents is considered as a main obstacle in treatment of patients with cancer, including breast cancer. Refining taxane-based treatment procedures using adjuvant or combination treatment is a novel strategy to increase the efficiency of chemotherapy. PPM1D is a molecule activated by reactive oxygen species. whose expression is reported to modulate the recruitment of DNA repair molecules. In this study we examined the impact of arsenic trioxide on efficacy of paclitaxel-induced apoptosis in paclitaxel-resistant MCF-7 cells. We also investigated the expression of PPM1D and TP53 genes in response to this combination treatment. Resistant cells were developed from the parent MCF-7 cell line by applying increasing concentrations of paclitaxel. MTT assays were applied to determine the rate of cell survival. DAPI staining using fluorescent microscopy was employed to study apoptotic bodies. Real-time RT-PCR analysis was also applied to determine PPM1D mRNA levels. Our results revealed that combination of arsenic trioxide and paclitaxel elevates the efficacy of the latter in induction of apoptosis in MCF-7/PAC resistant cells. Applying arsenic trioxide also caused significant decreases in PPM1D mRNA levels (p<0.05). Our findings suggest that arsenic trioxide increases paclitaxel-induced apoptosis by down regulation of PPM1D expression. PPM1D dependent signaling can be considered as a novel target to improve the efficacy of chemotherapeutic agents in resistant breast cancer cells.

• Asian Pacific Journal of Cancer Prevention
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• v.13 no.10
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• pp.4983-4988
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• 2012

The xeroderma pigmentosum complementation group C gene (XPC) has been identified as important for repairing UV-related DNA damage. Some subtle changes in this gene may impair repair efficiency and influence susceptibility to human cancers, including skin cancer. Two polymorphisms in XPC, 939A>C (rs2228001) and 499C>T (rs2228000), are considered to have possible associations with the risk of skin cancer, but the reported results have been inconsistent. Here we performed a meta-analysis of the available evidence regarding the relationship between these two polymorphisms and the risk of skin cancer. All relevant studies were searched using PubMed, Embase and Web of Science before February 2012. A total of 8 case-control studies were included in this analysis, and no convincing associations between the two polymorphisms and risk of skin cancer were observed in any of the genetic models. Stratified analyses by skin cancer type also did not detect significant associations in any subgroup. This meta-analysis suggested that the XPC 939A>C and 499C>T polymorphisms may have little involvement in susceptibility to skin cancer.

• Journal of IKEEE
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• v.24 no.3
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• pp.691-698
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• 2020

The installation cost or the magnitude of the fault current varies depending on the grid connection method of the offshore wind farm. Therefore, there is a need for an efficient power grid connection method considering the capacity and location of the complex. In particular, most power cables in offshore wind farms use 3-core considering cost and efficiency. In the event of a failure such as a short circuit, the entire cable must be replaced, which can lead to significant losses in terms of cost, considering repair costs and turbine downtime. Therefore, in this paper, a radial, ring, and molding method is introduced into a 100 MW wind farm to be installed at Jeju offshore, and a three-phase short circuit failure is performed using a PSCAD/EMTDC program to perform computer analysis. I would like to propose a suitable power grid connection method.

• Journal of Korean Society of Steel Construction
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• v.15 no.5 s.66
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• pp.489-497
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• 2003

Bridge has to be long-spanned and of simple structure, considering the social environment. As a result of this trend in bridge construction, it is important for the sake of economical efficiency to improve the structural system and increase the life cycle of a bridge. To attain these goals in constructing a steel bridge, the detail analyses based on real structure must be performed. In the steel structure bridge, the parts that are a main focus of interest are the diaphragm and the vertical bracing of the steel box girder support. This study observed the behavior of the diaphragms on the bearings of a closed section steel box girder bridge support, as dead load was increased. Stress variation of the support diaphragms in a steel box girder was considered, and both experimental test and structural analyses were performed to verify the behavior of a composite steel box girder bridge under repair or maintenance.

• Journal of the Korean Society of Surveying, Geodesy, Photogrammetry and Cartography
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• v.24 no.5
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• pp.399-408
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• 2006

Railroads have been developed as public transportation and made a great contribution to national economic growth. But after the mid-20th century, its qualities have been getting low because of focusing on the investment and development of cars and airplanes. Its role which is getting the excellent merits on the mass transportation, rapid transit, safety, state period, energy efficiency, and prevention of environmental pollution has been reconsidered. Elements of horizontal alignment are needed in the case where the existing railroad lines should be improved or moved. If its design drawing was lost or damaged, it is impossible to recover. It is not easy to repair for it as disasters. We must understand an existing railroad line to bring a function included a basic geography situation. In this study, we acquire, analyze, and process the digital images of the railroad and then reappear shape of three dimension. And we expect to be utilized to construct the facility information by extracting the alignment elements of existing railroad lines reversely.

• Biomolecules & Therapeutics
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• v.20 no.6
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• pp.544-549
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• 2012

To examine the neuroprotective effects of ginsenoside R0, we investigated the effects of ginsenoside R0 in PC12 cells under an anoxic or oxidative environment with Edaravone as a control. PC12 neuroendocrine cells were used as a model target. Anoxic damage or oxidative damage in PC12 cells were induced by adding sodium dithionite or hydrogen peroxide respectively in cultured medium. Survival ratios of different groups were detected by an AlamarBlue assay. At the same time, the apoptosis of PC12 cells were determined with flow cytometry. The putative neuroprotective effects of ginsenoside R0 is thought to be exerted through enhancing the activity of antioxidant enzymes Superoxide dismutases (SOD). The activity of SOD and the level of malondialdehyde (MDA) and intracellular reactive oxygen species (ROS), were measured to evaluate the protective and therapeutic effects of ginsenoside R0. Ginsenoside R0 treated cells had a higher SOD activity, lower MDA level and lower ROS, and their survival ratio was higher with a lower apoptosis rate. It is suggested that ginsenoside R0 has a protective effect in the cultured PC12 cells, and the protection efficiency is higher than Edaravone. The protective mechanisms of these two are different. The prevent ability of ginsenoside R0 is higher than its repair ability in neuroprotection in vitro.

• Korean Journal of Construction Engineering and Management
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• v.10 no.3
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• pp.53-61
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• 2009

With the Government's policy of increasing the supply of residential houses in 1970s, the number of apartments have increased dramatically, and as the result, the number of old aged apartment are increasing too. Therefore remodeling is being executed to improve the residential environment. The rate of remodeling is increasing instead of rebuilding because rebuilding takes more resource and because of the realestate issue. There are many uncertainties in construction progress of remodeling such as communication between personnel, demolition and repair work. There are no standard for remodeling construction so such problems have been causing more problems. It has been found that BIM (Building Information Modeling) may be effective for resolving issues of standardization of remodeling construction. Therefore this study wishes to develop a standard process for remodeling work through BIM to estimate the possibility of its use at remodeling sites. Based on this, I wish to contribute to the issue of achieving construction efficiency pursued by BIM.

• Smart Structures and Systems
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• v.6 no.9
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• pp.1057-1077
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• 2010

An early detection of structural damages is critical for the decision making of repair and replacement maintenance in order to guarantee a specified structural reliability. Consequently, the structural damage detection, based on vibration data measured from the structural health monitoring (SHM) system, has received considerable attention recently. The traditional time-domain analysis techniques, such as the least square estimation (LSE) method and the extended Kalman filter (EKF) approach, require that all the external excitations (inputs) be available, which may not be the case for some SHM systems. Recently, these two approaches have been extended to cover the general case where some of the external excitations (inputs) are not measured, referred to as the adaptive LSE with unknown inputs (ALSE-UI) and the adaptive EKF with unknown inputs (AEKF-UI). Also, new analysis methods, referred to as the adaptive sequential non-linear least-square estimation with unknown inputs and unknown outputs (ASNLSE-UI-UO) and the adaptive quadratic sum-squares error with unknown inputs (AQSSE-UI), have been proposed for the damage tracking of structures when some of the acceleration responses are not measured and the external excitations are not available. In this paper, these newly proposed analysis methods will be compared in terms of accuracy, convergence and efficiency, for damage identification of structures based on experimental data obtained through a series of laboratory tests using a scaled 3-story building model with white noise excitations. The capability of the ALSE-UI, AEKF-UI, ASNLSE-UI-UO and AQSSE-UI approaches in tracking the structural damages will be demonstrated and compared.