• 한국물환경학회지
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• 제26권1호
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• pp.156-159
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• 2010

Peroxide is used frequently to provide electron acceptors to aerobes for the purpose of in situ bioremediation of contaminated soil/sediment. In this study, oxygen release rate of peroxides and factors affecting on dissolution and diffusion of oxygen into pore water were evaluated. Peroxides studied in this study were magnesium peroxide ($MgO_2$), calcium peroxide ($CaO_2$), and sodium percarbonate ($Na_2CO_3{\cdot}1.5H_2O_2$). $Na_2CO_3{\cdot}1.5H_2O_2$ showed the highest oxygen release rate per unit mass and the shortest release duration time among three peroxides. A simple first-order decay model for predicting the release rate of oxygen from peroxide into pore water was presented and used to fit the experimental data. The first order oxygen release rate constants k for $MgO_2$, $CaO_2$ and $Na_2CO_3{\cdot}1.5H_2O_2$ were 0.45 /hr, 3.22 /hr and 134 /hr, respectively. If $MgO_2$ was mixed with clay, oxygen release rate was lowered significantly mainly due to limitation of contact area and diffusion, implying that oxygen can be provided to the indigenous aerobes for the extended period of time.

• 국제물리치료학회지
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• 제10권1호
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• pp.1739-1745
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• 2019

Background: There have been many studies on self-myofascial release (SMR) stretching, but there are few comparative studies on the effects of massages using a release ball, which is a type of the SMR method. Objective: To investigate the immediate effects of release ball massage and self-stretching on proprioceptive sensory, hamstring's temperature, range of motion (ROM) muscle strength,. Design: Crossover study. Methods: Thirty women in 20's at S University in Busan voluntarily participated in the study. Participants were random to release ball group (n=15) or self-stretching group (n=15). Both groups performed 3 sets of exercises, stretching for 30 seconds and resting for 15 seconds in each position. The proprioceptive sensory, temperature of the hamstring muscle, ROM, and strength were measured before exercise, 5 minutes after exercise, and 30 minutes after exercise. Results: Release ball group showed significant differences in muscle length and temperature over time (p<.05). The comparison between two group over time showed significant differences in muscle length, temperature, and muscle strength (p<.05). Conclusions: These results demonstrate that release ball massage and self-stretching are beneficial for improving hamstring's temperature, ROM and muscle strength.

• Journal of Pharmaceutical Investigation
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• 제23권3호spc1호
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• pp.9-18
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• 1993

Sugar spheres loaded with melatonin (MT) were coated with $Aquacoat^{\circledR}$ to control the release rate of MT over 8 hours. A zero-order release pattern over 8 hours was obtained with 20% coating on 8-10 mesh beads in USP basket dissolution studies. MT in 20% coated beads was quite stable at room temperature with less than 5% MT degraded during 6 months' storage. Dissolution profiles were also unchanged after 6 months. An oral preparation containing MT-loaded uncoated beads for immediate release and 20% coated beads with $Aquacoat^{\circledR}$ for controlled release over 8 hours was evaluated in six human subjects. When total 0.5 mg MT as low dose (immediate release portion of MT, 0.1 mg) was administered to four subjects, average peak plasma MT concentration was reached at about 600 pg/ml and maintained at about 10 pg/ml over 8 hours. Plasma MT concentration-time profiles were similar in shape to computer-simulated profiles. However, maximal plasma MT concentrations were three times greater compared to computer simulated curve. These results suggest that MT dose, ratio of immediate and controlled release MT, and pharmacokinetic parameters selected are adjusted to mimic endogenous MT concentration-time curve. In another study, 0.2 mg MT having 10% of immediate release portion and 80% controlled release portion produced plasma MT concentration-time curve which is more similar to endogenous profiles. A low bioavailability (<20%) may result from extensive first pass metabolism and remaining amounts of MT from controlled beads. A good correlation between plasma MT concentration and urinary excretion rate of 6-sulphatoxymelatonin (6-STMT), a major metabolite of MT was observed. As plasma MT concentration increased, urinary excretion rate of 6-STMT increased concomitantly. The linear relation between plasma MT and urinary excretion rate of 6-STMT was statistically significant. This result suggests that urinary 6-STMT may be used as an index of circadian rhythms of MT in humans.

• 한국시뮬레이션학회논문지
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• 제8권4호
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• pp.73-87
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• 1999

Order Review/Release (ORR) System is the linkage between planning system and actual production. Reduction of the waiting time on the machines, work in process and lead time variation may be achieved by adopting ORR strategies. But researchers on the ORR do not agree on the effectiveness of ORR. Some say that the overall system flow time may be increased if ORR is adopted, but others say that ORR can reduce work in process, flow time and variation of flow time. The objective of this research is to clarify under what environments order release strategy is effective. Simulation study was conducted in a hypothetical job shop. The experimental results show that dispatching rule is much more important than ORR is in controlling the shop floor. But the results indicate that ORR can reduce mean shop flow time, average work in process and variation of shop flow time under such environments where utilization level is high and planned order is weekly released to the order pool. And the results also show that the effect of plan smoothing on the ORR is insignificant, which is inconsistent with the results of the previous researches.

• 대한산업공학회지
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• 제25권2호
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• pp.192-203
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• 1999

This paper deals with the order release problem for minimizing weighted earliness and tardiness as well as Work In Process (WIP) in dynamic job shop environments. A newly designed hierarchical order release mechanism is developed for efficient real-time control of the earliness/tardiness and WIP. The hierarchical order release mechanism consists of the order release plan and the order release control which is composed of two procedures. The experimental results show that the proposed order release mechanism is superior to other four order release mechanisms under overall simulation conditions of utilization rate, due-date allowances, and earliness/tardiness cost structures. In addition, the difference of total cost among the four dispatching rules is much more reduced in the proposed order release mechanism than in other release mechanisms.

• 한국산학기술학회논문지
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• 제11권4호
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• pp.1239-1247
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• 2010

본 연구에서는 소프트웨어 제품을 개발하여 테스팅을 거친 후 사용자에게 인도하는 시기를 결정하는 방출문제에 대하여 연구되었다. 인도시기에 관한 모형은 무한 고장수에 의존하는 비동질적인 포아송 과정을 적용하였다. 이러한 포아송 과정은 소프트웨어의 결함을 제거하거나 수정 작업 중에도 새로운 결함이 발생될 가능성을 반영하는 모형이다. 강도함수는 여러 수명 분포들을 적합시키는데 효율적인 특성을 가진 콤페르쯔, 파레토, 로그-로지스틱 패턴을 이용하였다. 따라서 소프트웨어 요구 신뢰도를 만족시키고 소프트웨어 개발 및 유지 총비용을 최소화 시키는 방출시간이 최적 소프트웨어 방출 정책이 된다. 본 논문의 수치적인 예에서는 고장 간격 시간 자료를 적용하고 모수추정 방법은 최우추정법과 추세분석을 통하여 자료의 효율성을 입증한 후 최적 방출시기를 추정하였다.

• The Korean Journal of Physiology and Pharmacology
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• 제13권1호
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• pp.23-26
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• 2009

During operations, neurosurgeons usually perform multiple temporary occlusions of parental artery, possibly resulting in the neuronal damage. It is generally thought that neuronal damage by cerebral ischemia is associated with extracellular concentrations of the excitatory amino acids. In this study, we measured the dynamics of extracellular glutamate release in 11 vessel occlusion(VO) model to compare between single occlusion and repeated transient occlusions within short interval. Changes in cerebral blood flow were monitored by laser-Doppler flowmetry simultaneously with cortical glutamate level measured by amperometric biosensor. From real time monitoring of glutamate release in 11 VO model, the change of extracellular glutamate level in repeated transient occlusion group was smaller than that of single occlusion group, and the onset time of glutamate release in the second ischemic episode of repeated occlusion group was delayed compared to the first ischemic episode which was similar to that of single 10 min ischemic episode. These results suggested that repeated transient occlusion induces less glutamate release from neuronal cell than single occlusion, and the delayed onset time of glutamate release is attributed to endogeneous protective mechanism of ischemic tolerance.

• 한국컴퓨터정보학회논문지
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• 제15권5호
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• pp.125-132
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• 2010

본 연구에서는 소프트웨어 제품을 개발하여 테스팅을 거친 후 사용자에게 인도하는 시기를 결정하는 방출문제에 대하여 연구 하였다. 방출문제의 분포는 소프트웨어의 결함을 제거하거나 수정 작업 중에도 새로운 결함이 발생될 가능성이 있는 무한고장수를 가진 비동질적인 포아송 과정에 기초하였다. 수명분포는 지수 족 분포와 비지수족 분포를 이용한 최적 방출시기에 관한 문제를 비교 제시하였다. 이러한 지수 및 비지수분포에 근거하여 소프트웨어 요구 신뢰도를 만족시키고 소프트웨어 개발 및 유지 총비용을 최소화 시키는 최적 소프트웨어 방출 정책에 대하여 논의 되었다. 본 논문의 수치적인 예에서는 고장 간격 시간 자료를 적용하고 모수추정 방법은 최우추정법을 이용하고 추세분석을 통하여 자료의 효율성을 입증한 후 최적 방출시기를 추정하였다.

• 한국산학기술학회논문지
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• 제10권8호
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• pp.1903-1910
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• 2009

본 연구에서는 소프트웨어 제품을 개발하여 테스팅을 거친 후 사용자에게 인도하는 시기를 결정하는 방출문제에 대하여 연구하였다. 인도시기에 관한 모형은 무한 고장수에 의존하는 비동질적인 포아송 과정을 적용하였다. 이러한 포아송 과정은 소프트웨어의 결함을 제거하거나 수정 작업 중에도 새로운 결함이 발생될 가능성을 반영하는 모형이다. 고장발생 수명분포는 여러 분포들을 적합시키는데 효율적인 특성을 가진 와이블분포를 이용하였다. 따라서 소프트웨어 요구 신뢰도를 만족시키고 소프트웨어 개발 및 유지 총비용을 최소화시키는 방출시간이 최적 소프트웨어 방출 정책이 된다. 본 논문의 수치적인 예에서는 고장 간격 시간 자료를 적용하고 모수추정 방법은 최우추정법과 추세분석을 통하여 자료의 효율성을 입증한 후 최적 방출시기를 추정하였다.

• KSBB Journal
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• 제5권4호
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• pp.377-382
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• 1990

The characteristics controlled drug release have been studied for biodegradable polymer matrix. Polymer matrix was prepared from glycerine, prednisolone and dextran. Mathematical analysis of the data showed that the release behavior actually conformed to the Higuchi's diffusion controlled model. The release time was increased as drug loading doses increased, whereas decreased as glycerine concentration increased. The release rate did not change by varying molecular weight of dextran.