• Journal of Korean Biological Nursing Science
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• 제18권1호
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• pp.36-42
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• 2016

Purpose: Stress activates the sympathetic nervous system and hypothalamic-pituitary-adrenal (HPA) axis and induces the release of glucocorticoids. Saccharin is 300 times sweeter than sucrose, but does not increase blood insulin levels. Thus, this study was designed to evaluate the effect of saccharin intake in restraint-induced stress response reduction in rats. Methods: Adult male Sprague-Dawley (SD) rats had stress induced by restraint for 2 hours/day for 1 week. Saccharin was provided in sufficient amounts to allow them to intake it voluntarily at 0.1% diluted in water. The Y-maze test and forced swim test (FST) were performed to evaluate cognitive function and the depressive behavior of the rats. The protein expression of the glucocorticoid receptor (GR) in hippocampal cornu ammonis (CA) 1 was investigated by using immunohistochemistry. Results: It was found that, the percentage of alternation in the Y-maze test was significantly (p<.01) higher in the Stress + saccharin group than in the Stress group. Immobility time in the FST was significantly (p<.01) lower in the Stress + saccharin group than in the Stress group. Also, the positive cells of GR in hippocampus CA1 were significantly (p<.05) lower in the Stress + saccharin group than in the Stress group. Conclusion: This study showed that there was an effect of saccharin intake in restraint-induced stress response reduction in rats.

• 한국광물학회지
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• 제15권3호
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• pp.183-194
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• 2002

안동화강암에 발달한 풍화단면에서 발견되는 흑운모 및 그 풍화산물을 대상으로 X-선회절분석, 화학분석, 전자현미경 관찰 등의 광물학적 분석을 실시하였다. 그 결과, 이 지역의 흑운모는 풍화과정에서 별개의 질석이나 흑운모-질석 규칙혼합층 구조로 변질되지 않고 10$\AA$의 회절선을 보이는 산화흑운모로 풍화되었다. Fe의 산화로 발생하는 과잉 양전하는 사면체 자리의 양이온 점유율의 변화는 없이 팔면체자리로부터 16%의 Fe와 12%의 Mg, 그리고 층간에서 13%의 K가 제거되는 방식으로 해소되었다. 동시에 흑운모의 5%는 산화흑운모와 불규칙혼합층을 이루는 질석으로 변환되었다. 흑운모 풍화초기에 Fe의 산화로 야기된 약간의 화학조성 및 구조적 변화의 결과로 생성된 산화흑운모는 대부분의 풍화 구간에서 더 이상 질석으로 풍화되지 않고 안정한 상태를 유지하다가 상부에서 부분적으로 캐올리나이트로 분해된다. 흑운모가 풍부한 기반암의 지표환경에서 원소거동을 이해하기 위해서는 신선한 흑운모가 아닌 풍화저항도가 매우 큰 산화흑운모에 대한 생성원인과 용해실험이 요청된다.

• Carbon letters
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• 제12권1호
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• pp.31-38
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• 2011

This study experimentally investigated dicyclohexylammonium 2-cyanoacrylate (CA) as a potential comonomer for polyacrylonitrile (PAN) based carbon fiber precursors. The P(AN-CA) copolymers with different CA contents (0.19-0.78 mol% in the feed) were polymerized using solution polymerization with 2,2-azobis(isobutyronitrile) as an initiator. The chemical structure and composition of P(AN-CA) copolymers were determined by proton nuclear magnetic resonance and elemental analysis, and the copolymer composition was similar to the feeding ratio of the monomers. The effects of CA comonomer on the thermal properties of its copolymers were characterized differential scanning calorimetry (DSC) in nitrogen and air atmospheres. The DSC curves of P(AN-CA) under nitrogen atmosphere indicated that the initiation temperature for cyclization of nitrile groups was reduced to around $235^{\circ}C$. The heat release and the activation energy for cyclization reactions were decreased in comparison with those of PAN homopolymers. On the other hand, under air atmosphere, the P(AN-CA) with 0.78 mol% CA content showed that the initiation temperature of cyclization was significantly lowered to $160.1^{\circ}C$. The activation energy value showed 116 kJ/mol, that was smaller than that of the copolymers with 0.82 mol% of itaconic acids. The thermal stability of P(AN-CA), evidenced by thermogravimetric analyses in air atmosphere, was found higher than PAN homopolymer and similar to P(AN-IA) copolymers. Therefore, this study successfully demonstrated the great potential of P(AN-CA) copolymers as carbon fiber precursors, taking advantages of the temperature-lowering effects of CA comonomers and higher thermal stability of the CA copolymers for the stabilizing processes.

• 시스템엔지니어링학술지
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• 제13권1호
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• pp.33-39
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• 2017

This paper describes the system engineering approach for the heat transfer analysis of plus7 fuel rod for APR1400 using, a commercial software, ANSYS. The fuel rod is composed of fuel pellets, fill gas, end caps, plenum spring and cladding. The heat is transferred from the pellet outward by conduction through the pellet, fill gas and cladding and further by convection from the cladding surface to the coolant in the flow channel. The goal of this paper is to demonstrate the temperature and heat flux change from the fuel centerline to the cladding surface when having maximum fuel centerline temperature at 100% power. This phenomenon is modelled using the ANSYS FEM code and analyzed for steady state temperature distribution across the fuel pellet and clad and the results were compared to the standard values given in APR1400 SSAR. Specifically the applicability of commercial software in the evaluation of nuclear fuel temperature distribution has been accounted. It is note that special codes have been used for fuel rod mechanical analysis which calculates interrelated effects of temperature, pressure, cladding elastic and plastic behavior, fission gas release, and fuel densification and swelling under the time-varying irradiation conditions. To satisfactorily meet this objective we apply system engineering methodologies to formulate the process and allow for verification and validation of the results acquired. The close proximity of the results obtained validated the accuracy of the FEM analysis of the 2D axisymmetric model and 3D model. This result demonstrated the validity of commercial software instead of proprietary in-house code that is more costly to develop and maintain.

• Clinical and Experimental Pediatrics
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• 제61권2호
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• pp.64-67
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• 2018

We report the case of a 12-year-old girl who had mild encephalopathy with a reversible splenial lesion (MERS) associated with acutepyelonephritis caused by Escherichia coli. The patient was admitted with a high fever, and she was diagnosed with acute pyelonephritis based on pyuria and the results of urine culture, which detected cefotaxime-sensitive E. coli. Although intravenous cefotaxime and tobramycin were administered, her fever persisted and her C-reactive protein level increased to 307 mg/L. On day 3 of admission, she demonstrated abnormal neuropsychiatric symptoms, such as delirium, ataxia, and word salad. Magnetic resonance imaging (MRI) of the brain performed on day 4 showed marked hyperintensities in the bilateral corpus callosum and deep white matter on diffusion-weighted images, with corresponding diffusion restriction on apparent diffusion coefficient mapping. No abnormalities or pathogens were detected in the cerebrospinal fluid; however, lipopolysaccharides (LPS, endotoxin) were detected in plasma (41.6 pg/mL), associated with acute neurological deterioration. Her clinical condition gradually improved, and no neurological abnormalities were observed on day 6. Follow-up brain MRI performed 2 weeks later showed near-disappearance of the previously noted hyperintense lesions. In this patient, we first proved endotoxemia in a setting of MERS. The release of LPS following antibiotic administration might be related to the development of MERS in this patient. The possibility of MERS should be considered in patients who present with acute pyelonephritis and demonstrate delirious behavior.

• Asian Journal of Atmospheric Environment
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• 제10권3호
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• pp.125-136
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• 2016

In this study, the effects of the mesh barrier on the free dispersion of ammonia were numerically investigated under different atmospheric conditions. This study presents the detail and flow feature of the dispersion of ammonia through the mesh barrier on various free stream conditions to decline and limit the toxic danger of the ammonia. It is assumed that the dispersion of the ammonia occurred through the leakage in the pipeline. Parametric studies were conducted on the performance of the mesh barrier by using the Reynolds-averaged Navier-Stokes equations with realizable k-${\varepsilon}$ turbulence model. Numerical simulations of ammonia dispersion in the presence of mesh barrier revealed significant results in a fully turbulent free stream condition. The results clearly show that the flow behavior was found to be a direct result of mesh size and ammonia dispersion is highly influenced by these changes in flow patterns in downstream. In fact, the flow regime becomes laminar as flow passes through mesh barrier. According to the results, the mesh barrier decreased the maximum concentration of the ammonia gas and limited the risk zone (more than 500 ppm) lower than 2 m height. Furthermore, a significant reduction occurs in the slope of the upper boundary of $NH_3$ risk zone distribution at downstream when a mesh barrier is presented. Thus, this device highly restricts the leak distribution of ammonia in the industrial plan.

• The Korean Journal of Physiology and Pharmacology
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• 제22권2호
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• pp.183-192
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• 2018

Post-traumatic stress disorder (PTSD) is a trauma-induced psychiatric disorder characterized by impaired fear extermination, hyperarousal, anxiety, depression, and amnesic symptoms that may involve the release of monoamines in the fear circuit. The present study measured several anxiety-related behavioral responses to examine the effects of berberine (BER) on symptoms of anxiety in rats after single prolonged stress (SPS) exposure, and to determine if BER reversed the dopamine (DA) dysfunction. Rats received BER (10, 20, or 30 mg/kg, intraperitoneally, once daily) for 14 days after SPS exposure. BER administration significantly increased the time spent in the open arms and reduced grooming behavior during the elevated plus maze test, and increased the time spent in the central zone and the number of central zone crossings in the open field test. BER restored neurochemical abnormalities and the SPS-induced decrease in DA tissue levels in the hippocampus and striatum. The increased DA concentration during BER treatment may partly be attributed to mRNA expression of tyrosine hydroxylase and the DA transporter in the hippocampus, while BER exerted no significant effects on vesicular monoamine transporter mRNA expression in the hippocampus of rats with PTSD. These results suggest that BER had anxiolytic-like effects on behavioral and biochemical measures associated with anxiety. These findings support a role for reduced anxiety altered DAergic transmission and reduced anxiety in rats with PTSD. Thus, BER may be a useful agent to treat or alleviate psychiatric disorders like those observed in patients with PTSD.

• 한국통신학회논문지
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• 제32권1B호
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• pp.1-10
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• 2007

논문에서는 인터넷 트래픽 환경에서 예측하기 어려운 동적 트래픽은 물론 양방향 비대칭적 트래픽을 광 네트워킹 기술을 이용하여, WDM(Wavelength Division Multiplexing) Mesh 네트워크로 수용하는 방안을 제안한다. 제안된 방안에서는 중간 노드(intermediate node)에서 변동하는 인터넷 트래픽에 대한 IP 라우터의 스위칭 통계정보를 기반으로 새로운 광경로를 결정하도록 함으로써, 네트워크의 동적인 그리고 분산적인 트래픽 제어가 이루어지도록 하였다. 이로써 인터넷 트래픽의 실시간적 변동에 따른 RWA(Routing and Wavelength Assignment)의 효율성 열화 효과를 줄이면서 네트워크의 확장성과 유연성이 개선되도록 하였다. 본 논문에서는 노드에서의 트래픽 형상 분석방법과 광경로 설정/절체 과정에 대해 설명하고, 컴퓨터 시뮬레이션을 통해 제안한 개념의 성능을 분석하였다.

• 콘크리트학회논문집
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• 제21권6호
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• pp.773-780
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• 2009

강-콘크리트 계면거동의 성질을 정의하는 계면변수를 파악하고, 구성모델의 성격을 정의하는 구성변수의 물리적 특성 파악과 값의 크기를 결정하기 위해 강-콘크리트 계면에 대한 거동실험을 수행하였다. 구성변수는 포괄적인 적용을 목적으로 부착계면 뿐만 아니라 비부착계면의 거동까지 포함하기 위해 최근에 Mohr-Coulomb 파괴규준에 근거하여 제안된 구성모델을 기준하여 결정하였으며, 구속압을 받는 계면의 취성으로부터 연성까지의 파괴거동 성질을 고려하기 위해 낮은 구속압 및 중간크기의 구속압을 포함하는 네 종류의 구속압을 고려하였다. 실험 결과에 대한 분석을 통해 최대평균전단응력과 잔류응력 및 모드 II 파괴에너지 방출률과 구속압 간의 관계는 각 경우가 선형적 관계에 있음을 확인하였다. 이 논문에서 얻어진 실험 결과에 근거하여 이어지는 후속 논문에서는 해석적 방법에 의한 계면상수 값의 결정과 결정된 계면상수 값을 이용한 계면유한요소해석을 수행하여 계면상수 값의 적절성을 검증하였다.

• 한국전기전자재료학회:학술대회논문집
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• 한국전기전자재료학회 2008년도 추계학술대회 논문집 Vol.21
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• pp.414-414
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• 2008

Vertically well-aligned Ga-doped ZnO nanorods with different Ga contents were grown by thermal evaporation on a ZnO template. The Ga-doped ZnO nanorods synthesized with 50 wt % Ga with respect to the Zn content showed maximum compressive stress relative to the ZnO template, which led to a rapid growth rate along the c-axis due to the rapid release of stored strain energy. A further increase in the Ga content improved the conductivity of the nanorods due to the substitutional incorporation of Ga atoms in the Zn sites based on a decrease in lattice spacing. The p-n diode structure with Ga-doped ZnO nanorods, as a n-type, displayed a distinct white light luminescence from the side-view of the device, showing weak ultraviolet and various deep-level emissions.