• Coupled systems mechanics
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• 제11권3호
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• pp.217-231
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• 2022

The present paper is concerned with a delamination analysis of a multilayered frame structure that exhibits non-linear creep behavior. A solution to the strain energy release rate is obtained by considering the time-dependent complementary strain energy in the frame. The mechanical behavior of the frame is treated by using a non-linear stress-strain-time relationship. The time-dependent solution to the strain energy release rate obtained in the present paper holds for a multilayered frame made of arbitrary number of adhesively bonded layers of different thicknesses and material properties. Besides, the dealamination is located arbitrary along the thickness. The solution to the strain energy release rate is verifiedby applying the J-integral approach. A parametric study of the strain energy release rate is carried-out. Two three-layered frame configurations are analyzed in order to evaluate the influence of the delamination crack location along the thickness on the strain energy release rate. The strain energy release is analyzed also for the case when a notch is cut-out in the inner delamination crack arm. The results obtained are compared with these for a frame without a notch.

• 한국고분자학회:학술대회논문집
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• 한국고분자학회 2006년도 IUPAC International Symposium on Advanced Polymers for Emerging Technologies
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• pp.258-258
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• 2006

Electrospun fibers of poly(vinyl alcohol) (PVA) were successfully prepared and applied as drug carriers for transdermal drug delivery system. Sodium Salicylate (SS) was the model drug and it was incorporated in the PVA fibers by adding 20 % of SS in a PVA solution prior to electrospinning. Electrospinning of SS-containing PVA solution resulted in the formation of beaded fibers. In order to control the rate of SS release and decrease water solubility of PVA, the SS-loaded electrospun PVA mat was cross-linked by either glutaraldehyde or glyoxal vapor. The morphology, thermal behavior, swelling behavior, release characteristic, kinetics of drug release and also toxicity of the cross-linked sample were investigated.

• Structural Engineering and Mechanics
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• 제71권2호
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• pp.153-163
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• 2019

Longitudinal fracture behavior of non-linear elastic beam configurations is studied in terms of the strain energy release rate. It is assumed that the beams exhibit continuous material inhomogeneity along the width as well as along the height of the crosssection. The Ramberg-Osgood stress-strain relation is used for describing the non-linear mechanical behavior of the inhomogeneous material. A solution to strain energy release rate is derived that holds for inhomogeneous beams of arbitrary cross-section under combination of axial force and bending moments. Besides, the solution may be applied at any law of continuous distribution of the modulus of elasticity in the beam cross-section. The longitudinal crack may be located arbitrary along the beam height. The solution is used to investigate a longitudinal crack in a beam configuration of rectangular cross-section under four-point bending. The crack is located symmetrically with respect to the beam mid-span. It is assumed that the modulus of elasticity varies continuously according a cosine law in the beam cross-section. The longitudinal fracture behavior of the inhomogeneous beam is studied also by applying the J-integral approach for verification of the non-linear solution to the strain energy release rate derived in the present paper. Effects of material inhomogeneity, crack location along the beam height and non-linear mechanical behavior of the material on the longitudinal fracture behavior are evaluated. Thus, the solution derived in the present paper can be used in engineering design of inhomogeneous non-linear elastic structural members to assess the influence of various material and geometrical parameters on longitudinal fracture.

• 약학회지
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• 제28권3호
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• pp.169-177
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• 1984

Release characteristics of salicylic acid from ethylcellulose(EC) films containing varying ratio of dieththylphthalate (DEP) were studied. Mathematical analysis of the release data showed that the release behavior actually conforms with the Higuchi's diffusion-controlled model. The release rate constants(k) were independent from the film thickness and the pH of release medium, but were proportional to the concentration of salicylic acid itself. The logarithm of the release rate constant (log k) increased as the concentration of DEP was increased. In conclusion, hydrophobic plastisizer DEP seemed to be very useful in controlling release rate constant of slightly soluble drugs as like salicylic acid without changing it's release characteristics.

• 대한치과기공학회지
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• 제36권3호
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• pp.179-184
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• 2014

Purpose: This study was performed to investigate the release behavior of bioactive materials as a BMP-2 embedding on the porous titanium implant. Methods: Porous Ti implant samples were fabricated by sintering of spherical Ti powders in a high vacuum furnace. Specimens diameter and height were 4mm and 10mm. Embedding materials were used to stamp ink. Sectional images, porosity and release behavior of porous Ti implants were evaluated by scanning electron microscope(SEM), mercury porosimeter and UV-Vis-NIR spectrophotometer. Results: Internal pore structure was formed fully open pore. Average pore size and porosity were $8.993{\mu}m$ and 8.918%. Embedding materials were released continually and slowly. Conclusion: Porous Ti implant was fabricated successfully by sintering method. Particles are necking strongly each other and others portions were vacancy. Therefore bioactive materials will be able to embedding to porous Ti implants. If the development of the fusion implant of the bioactive material will be able to have the chance to several patients.

• Advances in materials Research
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• 제5권4호
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• pp.299-318
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• 2016

Analytical investigations were performed of a longitudinal crack representing a cylindrical surface in circular shafts loaded in torsion with taking into account the non-linear material behavior. Both functionally graded and multilayered shafts were analyzed. It was assumed that the material is functionally graded in radial direction. The mechanical behavior of shafts was modeled by using non-linear constitutive relations between the shear stresses and shear strains. The fracture was studied in terms of the strain energy release rate. Within the framework of small strain approach, the strain energy release rate was derived in a function of the torsion moments in the cross-sections ahead and behind the crack front. The analytical approach developed was applied to study the fracture in a clamped circular shaft. In order to verify the solution derived, the strain energy release rate was determined also by considering the shaft complimentary strain energy. The effects were evaluated of material properties, crack location and material non-linearity on the fracture behavior. The results obtained can be applied for optimization of the shafts structure with respect to the fracture performance. It was shown that the approach developed in the present paper is very useful for studying the longitudinal fracture in circular shafts in torsion with considering the material non-linearity.

• 폴리머
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• 제37권3호
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• pp.294-301
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• 2013

Polymersomes made of biodegradable triblock copolymers based on poly(fumaric acid-co-sebacoyl chloride)/PEG (PEG-co-P(FA/SC)-co-PEG) were prepared and studied in aqueous solutions. TEM confirmed the formation of vesicles in aqueous media. Aggregation behavior of the copolymers was studied by fluorescence spectroscopy of 8-anilino-1-naphthalenesulfonic acid, and the critical aggregation concentration (c.a.c.) of the copolymer was found to be ${\sim}26.2{\mu}M$ indicating desirable stability of the vesicles. Dynamic light scattering revealed that the size of the vesicles was distributed within the range of 170-270 nm. Turbidity measurements confirmed the relative short-term stability of the polymersomes. Carboxyfluorescein, a hydrophilic compound, was simply encapsulated in the vesicles during polymersome preparation. The release of encapsulant from the polymersomes at 25 and $37^{\circ}C$ lasted about 3 weeks, and the rate of release followed a first-order kinetics. The release is speculated to be primarily carried out through diffusion. These results confirm that these polymersomes are promising as controlled-release carriers of various drugs.

• Archives of Pharmacal Research
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• 제9권2호
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• pp.87-91
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• 1986

In attempt to develop a drug delivery system using serum albumin microspheres, bovine serum albumin microspheres containing antitumar agent. Cytarabine, were prepared. The shape, surface characteristics, size distribution, behavior of in vivo distribution, drug release behavior, and degradation of albumin microsphers in animal liver issue homogenate and proteolytic enzyme were investigated. The shape of albumin microspheres was spherical and the surface was smooth and compact. The size distribution of the albumin microspheres was effected by dispertion forces during emulsification and albumin concentration. Distribution of albumin microspheres after imtravenous administration in rabbit was achieved immediately. In vitro, albumin microsphere matrix was so hard that it retained most of cytarabine except initial burst during the first 10 minutes, and the level of drug release during the initial burst was affected by heating temperature, drug/albumin microsphere matrix was so hard that it retained most of cytarabine except initial burst during the first 10 minutes, and the level of drug release during the initial burst was affected by heating temperature, drug/albumin concentration ratio and size distribution. After drug release test, the morphology of albumin microspheres was not changed. Albumin microsphere matrix was degraded by the animal liver issue homogenate and proteolytic enzyme. The degree of degradation was affected by heating temperature.

• 한국화재소방학회논문지
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• 제25권2호
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• pp.88-94
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• 2011

건축물 적재가연물의 연소성상 및 발열특성은 건물 내부의 화재전파속도와 화재규모 등을 크게 좌우하는 중요한 요인이다. 그러나 대형 서점의 적재가연물은 다른 건축용도에 비해 다량 적재되어 있기 때문에 화재시 건물 전체의 화재피해가 대형화할 가능성이 있지만 연소발열성상이 화재실험 등으로 파악되어 있지 않다. 따라서 본 연구는 대형서점의 적재가연물인 목재 서가 등을 재현한 시험체를 대상으로 연소실험을 실행하여 연소발열성상을 파악하였다. 또한 이 결과를 바탕으로 대형서점의 화재시 화재안전성을 검토하고 대형 서점의 화재안전설계에 필요한 적재가연물의 연소표면적당 최대열방출률과 화재성장률 등을 제시하였다.

• 한국지반환경공학회 논문집
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• 제14권10호
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• pp.17-27
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• 2013

This paper explores stress release induced by unloading in dry sand. A series of model tests were carried out to measure stresses developed in testing sand during loading and those released during unloading for different boundary conditions. It was found that stress in the sand increased linearly with applied load. At the onset of unloading, almost no stress release was observed. Significant stress release took place when the shear stress in the sand induced by unloading exceeded the frictional resistance and caused movement of sand particles. The initiation and the magnitude of stress release depend on the stress condition prior to unloading, the decrease of external load, and also the frictional resistance in sand. A new conceptual stress-release model was next developed based on the model test results by considering the fundamental frictional behavior of granular materials.