• Title/Summary/Keyword: relative type

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Statistical Assessment of Biosimilarity based on the Relative Distance between Follow-on Biologics in the (k + 1)-Arm Parallel Design

  • Kang, Seung-Ho;Shin, Wooyoung
    • Communications for Statistical Applications and Methods
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    • v.22 no.6
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    • pp.605-613
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    • 2015
  • A three-arm parallel design has been proposed to assess the biosimilarity between a biological product and a reference product using relative distance (Kang and Chow, 2013). The three-arm parallel design consists of two arms for the reference product and one arm for the biosimilar product. This paper extended the three-arm parallel design to a (k + 1)-arm parallel design composed of k (${\geq}3$) arms for the reference product and one arm for the biosimilar product. A new relative distance was defined based on Euclidean distance; consequently, a corresponding test procedure was developed based on asymptotic distribution. Type I error rates and powers were investigated both theoretically and empirically.

Preliminary Development of Pinwheel Model Created by Convergent Truss Structure with Biological DNA Structure (생물학적 DNA 구조와 트러스구조의 융합으로 개발한 바람개비형 모델 선행연구)

  • Choi, Jeongho
    • Journal of the Korea Convergence Society
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    • v.7 no.4
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    • pp.181-190
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    • 2016
  • The objective of this study is to find the effective stiffness and compressive strengths of a unit-cell pinwheel truss and double pinwheel truss model designed following a double helical geometry similar to that of the DNA (deoxyribonucleic acid) structure in biology. The ideal solution for their derived relative density is correlated with a ratio of the truss thickness and length. To validate the relative stiffness or relative strength, ABAQUS software is used for the computational model analysis on five models having a different size of truss diameter from 1mm to 5mm. Applied material properties are stainless steel type 304. The boundary conditions applied were fixed bottom and 5 mm downward displacement. It was assumed that the width, length, and height are all equal. Consequently, it is found that the truss model has a lower effective stiffness and a lower effective yielding strength.

Interface shear between different oil-contaminated sand and construction materials

  • Mohammadi, Amirhossein;Ebadi, Taghi;Boroomand, Mohammad Reza
    • Geomechanics and Engineering
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    • v.20 no.4
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    • pp.299-312
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    • 2020
  • The aim of this paper was to investigating the effects of soil relative density, construction materials roughness, oil type (gasoil, crude oil, and used motor oil), and oil content on the internal and interface shear behavior of sand with different construction materials by means of a modified large direct shear test apparatus. Tests conducted on the soil-soil (S-S), soil-rough concrete (S-RC), soil-smooth concrete (S-SC), and soil-steel (S-ST) interfaces and results showed that the shear strength of S-S interface is always higher than the soil-material interfaces. Internal and interface friction angles of sand beds increased by increase in relative density and decreased by increasing oil content. The oil properties (especially viscosity) played a major role in interface friction behavior. Despite the friction angles of contaminated sands with viscous fluids drastically decreased, it compensated by the apparent cohesion and adhesion developed between the soil grains and construction materials.

Electrical Properties of Plasma Polymerized Hexamethyldisiloxane Thin Film (플라즈마 중합법에 의한 헥사메틸디실록산 박막의 전기적 특성)

  • 이상희;이덕출
    • Journal of the Korean Institute of Electrical and Electronic Material Engineers
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    • v.14 no.1
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    • pp.43-47
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    • 2001
  • Plasma polymerized hexamethyldisiloxane thin film was fabricated by employing an inter-electrode capacitively coupled type apparatus under the following conditions : carrier gas flow rate of 11 sccm, reaction pressure of 0.1 torr, discharge frequency of 13.56 MHz and discharge power of 30∼90 W. Polymerization rate of thin film fabricated at the discharge power of 90W is 32.5nm/min. Relative dielectric constant and dielectric loss tangent of thin film shows 3.2∼3.8 and 2.6x10$\^$-3/∼4.51x10$\^$-3/ respectively in the frequency range of 1 kHz∼1 MHz. As the annealing temperature is increased, the relative dielectric constant gradually decreases while the dielectric loss tangent increases. The current density increase gradually with increasing annealing temperature and electric field. The electric conduction of the heaxamethyldisiloxane thin film shows Schottky effect.

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SOME POINT ESTIMATES FOR THE SHAPE PARAMETERS OF EXPONENTIATED-WEIBULL FAMILY

  • Singh Umesh;Gupta Pramod K.;Upadhyay S.K.
    • Journal of the Korean Statistical Society
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    • v.35 no.1
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    • pp.63-77
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    • 2006
  • Maximum product of spacings estimator is proposed in this paper as a competent alternative of maximum likelihood estimator for the parameters of exponentiated-Weibull distribution, which does work even when the maximum likelihood estimator does not exist. In addition, a Bayes type estimator known as generalized maximum likelihood estimator is also obtained for both of the shape parameters of the aforesaid distribution. Though, the closed form solutions for these proposed estimators do not exist yet these can be obtained by simple appropriate numerical techniques. The relative performances of estimators are compared on the basis of their relative risk efficiencies obtained under symmetric and asymmetric losses. An example based on simulated data is considered for illustration.

A Design of Stable Continuous-time Model Reference Adaptive Controllers by a Hyperstability Method (초안정도 방법에 의한 안정한 시연속 기준모델 적응제어기의 설계)

  • 이호진;정종대;최계근
    • Journal of the Korean Institute of Telematics and Electronics
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    • v.26 no.10
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    • pp.1488-1497
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    • 1989
  • In this paper, a new adaptive control scheme is proposed that uses a special form of rational function-type linear operator in the parameter adaptation and that removes the augmenting signal terms of the control input components. This adaptation scheme is applied to the MRAC of continuous-time, linear time-invariant, minimum-phase plants whose relative degrees are arbitrary. This scheme can be applied without any change of the controller structure to the adaptive systems regardless of the relative degree if it is greater than 1. And this scheme does not require any signal augmentation for arbitrary relative-degree plants if the reference model has no zeros. The asymptotic stability of the adaptive systems controlled by this scheme is shown by a hyper-stability method.

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Radiochromic film dosimetry for linac-based stereotactic radiosurgery

  • Han, Seung-Hee;Park, Suk-Won;Oh, Do-Hoon
    • Proceedings of the Korean Society of Medical Physics Conference
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    • 2002.09a
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    • pp.302-304
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    • 2002
  • In linac-based stereotactic radiosurgery, assuring the quality of the planning and delivery of external photon beam requires accurate evaluation of beam parameters, usually including output factors, tissue-phantom ratio and off-axis ratios, and measurement of actual dose distributions from simulated treatment. We're going to test the use of calibrated radio chromic film (Gafchromic film; type MD-55, Nuclear associate) using a Lumiscan 75 digitizer to measure absolute dose and relative dose distributions for linac-based radiosurgery unit Relative dose distribution of a human-style spherical acryl phantom were measured using radiochromic film and calculated by treatment planning system. The absolute dose at the sphere center was measured by radiochromic film and micro chamber (Exradin A-14, 0.009cc). What we want to demonstrate in this work, the 'well selected' radiochromic films when external photon beam are used in linac-based stereotactic radiosurgery are very accurate detector for dosimetry.

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Research on Disaster and Fire Response Capability and Hazard Analysis Using Basic Mapping Method (Mapping을 이용한 소방방재력 및 재해취약성의 연구)

  • Wang, Soon-Joo;Baek, Min-Ho
    • Journal of the Society of Disaster Information
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    • v.3 no.1
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    • pp.69-86
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    • 2007
  • The fire department has one of the most important role as public resources of response to disasters in the aspect of supply and the adequate distribution of resources of response is essential, but the distribution of the response capability to disaster of fire department does not reflect the regional hazard vulnerability and hazard risks. Researchers performed database process with simple mapping based on the regional fire disaster response capability and the regional hazard vulnerability and hazard risks. The cities and towns are divided to four types each, total eight types and relative threat ratios are extracted from every type. The fire disaster response capability was extracted from number of firemen and fire vehicles in defined region. The distribution of the fire disaster response capability was inadequate and not matching to relative threat especially in small cities and some types of towns. The regional relative threat and resources should be analyzed by more delicate mapping and software development in the future.

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A Computational Study of the Mach Disk in Under-Expanded Moist Air Jet (부족팽창 습공기 제트의 마하디스크 거동에 관한 수치적 연구)

  • Baek, Seung-Cheol;Kwon, Soon-Bum;Kim, Heuy-Dong
    • Proceedings of the KSME Conference
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    • 2003.11a
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    • pp.514-519
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    • 2003
  • A computational study is performed to clarify the characteristics of supersonic moist air jet issuing from a simple sonic nozzle. The effects of the initial supersaturation on the Mach disk diameter and location, the barrel shock wave and jet boundary structures are investigated in details. The axisymmetric, compressible, Navier-Stokes equations, coupled with droplet growth equation, are solved using a third-order MUSCL type TVD finite-difference scheme. It is found that the Mach disk diameter increases with an increase in relative humidity of moist air. while its location is not significantly dependent on the relative humidity. As the relative humidity increases, the barrel shock wave and jet boundary are more expanded due to the local static pressure rise of nonequilibrium condensation.

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A Computational Study of the Mach Disk in Under-Expanded Moist Air Jet (부족팽창 습공기 제트의 마하디스크 거동에 관한 수치적 연구)

  • Baek, Seung-Cheol;Kwon, Soon-Bum;Kim, Heuy-Dong
    • Proceedings of the KSME Conference
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    • 2003.11a
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    • pp.562-567
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    • 2003
  • A computational study is performed to clarify the characteristics of supersonic moist air jet issuing from a simple sonic nozzle. The effects of the initial supersaturation on the Mach disk diameter and location, the barrel shock wave and jet boundary structures are investigated in details. The axisymmetric, compressible, Navier-Stokes equations, coupled with droplet growth equation, are solved using a third-order MUSCL type TVD finite-difference scheme. It is found that the Mach disk diameter increases with an increase in relative humidity of moist air. while its location is not significantly dependent on the relative humidity. As the relative humidity increases, the barrel shock wave and jet boundary are more expanded due to the local static pressure rise of nonequilibrium condensation.

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