• Journal of Pharmaceutical Investigation
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• v.34 no.6
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• pp.521-527
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• 2004

Cimetidine is a histamine $H_2-receptor$ antagonist, used for the treatment of endoscopically or radiographically comfirmed duodenal ulcer, pathologic GI hypersecretory conditions, and active, benign and gastric ulcer. Simple method for determining cimetidine in human plasma has been developed and validated. The analytical procedure for cimetidine showed a linear relationship in the concentration ranges from $0.05\;to\;5\;{\mu}g/ml$. Coefficient of variance (CV, %) for intraday and interday validation and relative error (RE, %) were less than ${\pm}15%$. Based on this analytical method, the bioequivalence of two cimetidine 400 mg tablets, reference (Tagamet 400 mg) and test drug (Sinil CIMETIDINE 400 mg) was evaluated according to the guidelines set by the Korea Food and Drug Administration (KFDA). Release of cimetidine from the tablets in vitro was tested using KP VIII Apparatus II with various dissolution media (pH 1.2, 4.0, 6.8 buffer solutions and water). Twenty-four healthy volunteers, $21.38{\pm}1.86$ years in age and $68.71{\pm}8.68\;kg$ in body weight, were divided into two groups and a randomized $2{\times}2$ cross-over study was performed. After oral administration of a tablet containing 400 mg of cimetidine, blood samples were taken at predetermined time intervals and concentrations of cimetidine in plasma were determined using HPLC equipped with UV detector. The dissolution profiles of the two tablet formulations were very similar at all dissolution media. In addition, pharmacokinetic parameters such as $AUC_t$ and $C_{max}$ were calculated and ANOVA was employed for the statistical analysis of parameters. The results were revealed that the differences in $AUC_t$ and $C_{max}$ between the two tablets were 4.17 % and 0.97% respectively. At 90% confidence intervals, the differences in these parameters were also within ${\pm}20%$. All of the above mentioned parameters have met the criteria of KFDA guidelines for bioequivalence, indicating that the test drug tablet (Sinil CIMETIDINE tablet) is bioequivalent to Tagamet 400 mg tablet.

• Journal of KIISE
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• v.42 no.5
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• pp.642-651
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• 2015

A vanishing point is a point where parallel lines converge, and they become evident when a camera's lenses are used to project 3D space onto a 2D image plane. Vanishing point detection is the use of the information contained within an image to detect the vanishing point, and can be utilized to infer the relative distance between certain points in the image or for understanding the geometry of a 3D scene. Since parallel lines generally exist for the artificial structures within images, line-detection-based vanishing point-detection techniques aim to find the point where the parallel lines of artificial structures converge. To detect parallel lines in an image, we detect edge pixels through edge detection and then find the lines by using the Hough transform. However, the various textures and noise in an image can hamper the line-detection process so that not all of the lines converging toward the vanishing point are obvious. To overcome this difficulty, it is necessary to assign a different weight to each line according to the degree of possibility that the line passes through the vanishing point. While previous research studies assigned equal weight or adopted a simple weighting calculation, in this paper, we are proposing a new method of assigning weights to lines after noticing that the lines that pass through vanishing points typically belong to artificial structures. Experimental results show that our proposed method reduces the vanishing point-estimation error rate by 65% when compared to existing methods.

• Journal of Korea Water Resources Association
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• v.46 no.5
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• pp.531-545
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• 2013

This paper was considered on the applicability of EFDC KUNSAN_SEDTRAN MODEL (2012) to calculate Gunsan Port sediment deposition height efficiently and to use for grasping its aspects quantitatively and providing its prevention measures reasonably based on well-known 3-dimensional EFDC sediment transport module. This model was calibrated and verified with various measured field data of A Report of Hydrological Variation on Kum River Estuary (2004). Due to the model calibration and relevant literature investigation for cohesive sediment parameters, settling velocity (WS), critical deposition stress (TD), reference surface erosion rate (RSE), critical erosion stress (TE) were identified as 2.2E-04m/s, 0.20 $N/m^2$, 0.003 $g/s{\cdot}m^2$, 0.40 $N/m^2$ respectivly on this model. In order to examine the applicability and precision of the model computation, the calculated model data of sediment deposition height at 13 stations for 71 days and suspended-sediment concentration at 2 stations, inner port and outer port for 15 days were compared and analyzed with the measured field data. As a result, the model applicability for sediment deposition height simulation was evaluated as NSE coefficient 0.86 and the precision for suspended-sediment concentration computation was evaluated as time averaged relative error (RE) 23%.

• Journal of Veterinary Clinics
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• v.33 no.2
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• pp.107-112
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• 2016

The objective of this study was to determine potential contributing factors associated with biosecurity level of farrow-to-finish pig farms and to develop a classification tree model to explore how these factors related to each other based on prediction model. To this end, the author analyzed data (n = 193) extracted from a cross-sectional study of 344 farrow-to-finish farms which was conducted between March and September 2014 aimed to explore swine disease status at farm level. Standardized questionnaires with information about basic demographical data and management practices were collected in each farm by on-site visit of trained veterinarians. For the classification of the data sets regarding biosecurity level as a dependent variable and predictor variables, Chi-squared Automatic Interaction Detection (CHAID) algorithm was applied for modeling classification tree. The statistics of misclassification risk was used to evaluate the fitness of the model in terms of prediction results. Categorical multivariate input data (40 variables) was used to construct a classification tree, and the target variable was biosecurity level dichotomized into low versus high. In general, the level of biosecurity was lower in the majority of farms studied, mainly due to the limited implementation of on-farm basic biosecurity measures aimed at controlling the potential introduction and transmission of swine diseases. The CHAID model illustrated the relative importance of significant predictors in explaining the level of biosecurity; maintenance of medical records of treatment and vaccination, use of dedicated clothing to enter the farm, installing fence surrounding the farm perimeter, and periodic monitoring of the herd using written biosecurity plan in place. The misclassification risk estimate of the prediction model was 0.145 with the standard error of 0.025, indicating that 85.5% of the cases could be classified correctly by using the decision rule based on the current tree. Although CHAID approach could provide detailed information and insight about interactions among factors associated with biosecurity level, further evaluation of potential bias intervened in the course of data collection should be included in future studies. In addition, there is still need to validate findings through the external dataset with larger sample size to improve the external validity of the current model.

• Journal of the Korean Institute of Gas
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• v.2 no.1
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• pp.28-39
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• 1998

This study investigated the natural convection and radiation in a rectangular enclosure with ceiling vent experimentally and numerically. A heat source is located on the center of the bottom surface. The analysis was peformed a pure convection and is combination of natural convection and radiation. The shape of the considered two dimensional model is a square whose center of ceiling($30\%$) is opened. The numerical simulations are carried out for the pure natural convection case and the combined heat transfer case by using the SIMPLE algorithm. For the turbulent flow, Reynolds stresses are closed by the standard $k-{\epsilon}$ model and the wall function is used to determine the wall boundary conditions. The experiment was performed on the same geometrical shape as the computations. The radiative heat transfer is analized by the S-N discrete ordinates method. The results of pure natural convection are compared with those of combined heat transfer by the velocity vectors, stream lines, isothermal lines. The results obtained are as follows 1. Comparing the results of pure convection with those of the combined convection-radiation through the shape of stream lines, isothermal lines are similar to each other. 2. The temperature fields obtained by numerical method are compared to those obtained by experimental one, and it is found that they are showed mean relative error $8.5\%$. 3. Visualization bt smoke is similar to computational results.

• Journal of agriculture & life science
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• v.46 no.1
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• pp.189-194
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• 2012

Measurement of compositions and somatic cells in raw milk by chemical methods usually requires a lot of time, skilled labor and expensive analytical equipments. Recently, near-infrared reflectance spectroscopy (NIRS), which is a rapid, cost-effective and non-destructive technique, has been extensively used for safety and quality evaluation in the field of dairy products. However, less study has been performed to evaluate the effect of transmitted light on milk quality during NIRS analysis. Therefore, the objective of this study was to analyze the changes in milk quality using transmitted light. Raw milk samples collected from dairy farm from Siga prefecture in Japan were analyzed for fat, protein, lactose, solids not fat, total solids, milk urea and citric acid using the Milko scan 4000. Somatic cells in raw milk samples were counted by the Fossomatic 5000. Transmittance spectra of 50 ml raw milk samples were obtained by the Lax-Cute lighter in the 400 nm or less, 689 nm, 773 nm, 900 nm and 979 nm. As a result, milk fat as well as somatic cell count was increased by 2.6% and 9.0%, respectively. The other compositions were, however, changed within the relative error of the measurement. Further studies are needed to apply raw milk quality evaluation using the UV band by accumulating more samples and more data.

• Nuclear Engineering and Technology
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• v.53 no.6
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• pp.1834-1845
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• 2021

Liquid lead-bismuth cooled fast reactor is one of the most promising reactor types among the fourth-generation nuclear energy systems. The flow and heat transfer characteristics of lead-bismuth eutectic (LBE) are completely different from ordinary fluids due to its special thermal properties, causing that the traditional Reynolds analogy is no longer recommended and appropriate. More accurate turbulence flow and heat transfer model for the liquid metal lead-bismuth should be developed and applied in CFD simulation. In this paper, a specific CFD solver for simulating the flow and heat transfer of liquid lead-bismuth based on the k - 𝜀 - k_𝜃 - 𝜀_𝜃 model was developed based on the open source platform OpenFOAM. Then the advantage of proposed model was demonstrated and validated against a set of experimental data. Finally, the simulation of LBE turbulent flow and heat transfer in a 7-pin wire-wrapped rod bundle with the k - 𝜀 - k_𝜃 - 𝜀_𝜃 model was carried out. The influence of wire on the flow and heat transfer characteristics and the three-dimensional distribution of key thermal hydraulic parameters such as temperature, cross-flow velocity and Nusselt number were studied and presented. Compared with the traditional SED model with a constant Pr_t = 1.5 or 2.0, the k - 𝜀 - k_𝜃 - 𝜀_𝜃 model is more accurate on predicting the turbulence flow and heat transfer of liquid lead-bismuth. The average relative error of the k - 𝜀 - k_𝜃 - 𝜀_𝜃 model is reduced by 11.1% at most under the simulation conditions in this paper. This work is meaningful for the thermal hydraulic analysis and structure design of fuel assembly in the liquid lead-bismuth cooled fast reactor.

• Journal of the Korean Society of Radiology
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• v.12 no.7
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• pp.801-806
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• 2018

Germanium crystals have a dead layer that causes efficiency deterioration because the layer is not useful for detection but strongly weakens the photons. Thus, when the data provided by the manufacturer is used in the detector simulation model, there is a slight difference between the calculated efficiency and the measured efficiency.The shape and dimensions of the high purity germanium (HPGe) detector were determined by CT scans to accurately characterize the shape for the Monte Carlo roll simulation. It is found that the adjustment of the dead layer is a good match with the relative deviation of ${\pm}3%$ between the measurement efficiency and the simulation efficiency at the energy range of 50 - 1500 keV. Simulation data were compared by varying the thickness of the dead layer. The new Monte Carlo simulations were compared with the experimental results to obtain new blank layer thicknesses. The difference in dead layer results for the 1.5 mm thick end cap simulation model in 1.4 and 1.6 mm thick End Cap simulation models was a systematic error due to the accuracy of the end cap dimensions. After considering all errors including statistical errors and systematic errors, the thickness of the detector was calculated as $1.02{\pm}0.14mm$. Therefore, it was confirmed that the increase in the thickness of the dead layer causes the effect to be effected on the efficiency reduction.

• Journal of Korean Tunnelling and Underground Space Association
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• v.21 no.4
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• pp.501-518
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• 2019

The rock properties measured under in-situ geological condition can be used to increase the reliability in numerical simulations with regard to the long-term performance of a high-level waste repository. In this study, the change in mechanical properties of KURT (Korea atomic energy research institute Underground Research Tunnel) granite was evaluated under the simulated THM (Thermo-Hydro-Mechanical) coupled condition due to a deep geological formation in the disposal repository. The rock properties such as uniaxial compression strength, indirect tensile strength, elastic modulus and Poisson's ratio were measured under the coupled test conditions (M, HM, TM, THM). It was found that the mechanical properties of KURT granite is more susceptible to the change in saturation rather than temperature within the test condition of this study. The changes in uniaxial compression strength and indirect tensile strength from the rock samples of dried or saturated conditions showed the maximum relative error of about 20% and 13% respectively under the constant temperature condition. Therefore, it is necessary to use the material properties of rock measured under the coupled THM condition as input parameters for the numerical simulation of long-term performance assessment of a disposal repository

• Journal of Korea Water Resources Association
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• v.52 no.7
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• pp.463-473
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• 2019

This study compared the characteristics of the optimization technique and the water supply and demand forecast using K-WEAP (Korea-Water Evaluation and Planning System) model and MODSIM (Modified SIMYLD) model considering wtaer supply priority. Currently, The national water resources plan applied same priority for municipal, industrial and agricultural demand. the K-WEAP model performs the ratio allocation to satisfy the maximum satisfaction rate, whereas the MODSIM model should be applied to the water supply priority of demands. As a result of applying the priority, water shortage decreased by an average of $1,035,000m^3$ than same prioritized results. It is due to the increase of the return flow rate as the distribution of Municipal and industrial water increases. Comparing the analysis results of K-WEAP and MODSIM applying the priorities, the relative error was within 5.3% and the coefficient of determination ($R^2$) was 0.9999. In addition, if both models provide reasonable water balance analysis results, K-WEAP is superior to GUI convenience for model construction and data processing. However, MODSIM is more effective in simulation time efficiency. It is expected that it will be able to carry out analysis according to various scenarios using the model.