• 한국응용과학기술학회지
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• 제36권3호
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• pp.1028-1040
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• 2019

본 연구는 내리막 달리기(downhill running, DR) 후 초음파 영상분석을 이용해 대퇴사두근 무리(quadriceps group, QG) 내 근손상의 국소화 여부를 검증하고, DR 동안 운동 강도가 운동유발성 근손상(exercise-induced muscle damage, EIMD) 및 근육 반향세기 변화에 미치는 영향을 규명하려는 목적으로 수행되었다. 규칙적인 신체활동이 없는 건강한 남성 11명이 무작위 교차설계에 따라 서로 다른 강도[low-intensity DR session($50%HR_{max}$), LDR; high-intensity DR session($70%HR_{max}$), HDR]의 DR 운동을 수행하였다. DR 후 EIMD의 심각성은 혈청크레아틴 키나아제(creatine kinase, CK) 활성 수준 변화와 함께 신경근 기능 지수로서 무릎 신전근의 최대 수의적 등척성 수축(maximal voluntary isometric contraction, MVIC) 및 관절가동범위(range of motion, ROM) 변화를 통해 결정되었다. 회색조 분석을 적용한 근육 반향세기 평가는 DR에 따른 QG 내 국소 근육별(rectus femoris, RF; vastus lateralis, VL; vastus medialis, VM; vastus intermedius, VI) 손상 양상을 탐지하기 위해 활용되었다. 모든 세션에서 혈청 CK 활성 수준과 VL 및 VM의 근통증 정도는 운동 후 24시간째(RF의 경우 각각 LDR 24시간째와 HDR 48시간째) 최대에 이르렀으며, 혈청 CK 수준에서 운동 강도에 따른 유의한 차이(p<.05)가 나타난 반면 근통증에서 세션 간 통계적 차이는 없었다. 무릎 관절을 이용한 MVIC 및 ROM과 같은 신경근 기능 지표 및 VM을 제외한 모든 QG 근육 반향세기는 운동 직후 극적으로 감소 또는 증가 후 72시간까지 점진적 회복 양상을 나타내었다. 그러나 신경근 기능 지표에서 운동 강도에 따른 통계적 차이는 없었으나 RF 및 VL 반향세기에서 세션 내 및 세션 간 유의한 차이(p<.01)를 나타내었다. 본 연구의 결과로 ECC를 함유한 DR 운동 시 운동 강도는 DOMS 및 신경근 기능 지표에 부분적으로 영향을 미칠 가능성이 있으며, 특히 혈청 CK 수준과 함께 RF 및 VL의 근육 반향세기는 운동 강도의 영향을 직접적으로 반영한다는 사실을 알 수 있다. 또한, 현재 연구결과는 DR 동안 ECC를 겪는 QG 내 국소 근육 간 근손상 정도가 다를 수 있으며 초음파 근육 반향세기가 국소 근육의 EIMD 심각성을 차별화할 수 있는 유용한 평가기법임을 뒷받침하고 있다.

• 대한정형도수물리치료학회지
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• 제28권3호
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• pp.69-77
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• 2022

Background: Ankle sprains, and the resulting ankle instability worsen to chronic due to recurrent ankle injuries or sprains, 78% of which are accompanied by posture instability and damage due to changes in the position of the talus of the ankle. The purpose of this study is to investigate the immediate effect of applying MWM taping on the patient's muscle strength and balance ability in patients with chronic ankle instability. Methods: 15 people with MWM taping and 15 people with Kinesio taping were applied, and after applying the taping of the ankle, 10 minutes of walking treadmill and 10 times of forward lunge operation, the change in ankle muscle strength and balance ability was confirmed. The strength test of the ankle was performed using a test device called Biodex system 4 (USA) for the movement of the dorsi-flexion and plantar flexion of the foot, and the balance of the two groups was measured using Biodex balance system (USA) to test balance ability. Results: The comparison of muscle strength changes in the ankle does not show a significant increase in the group applying MWM compared to the group applying kinesio taping (p<.05). In the comparison of equilibrium capabilities, the MWM taping group also showed a significant increase in the MWM taping group compared to the kinesio taping group (p<.05). Conclusion: When applying MWM taping and kinesio taping to patients with chronic ankle instability, there was no significant difference in comparison of muscle strength changes, but there was a significant difference in comparison of balance ability.

• Journal of Korean Neurosurgical Society
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• 제46권3호
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• pp.273-276
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• 2009

A 54-year-old man experienced injury to the second finger of his left hand due to damage from a paintball gun shot 8 years prior, and the metacarpo-phalangeal joint was amputated. He gradually developed mechanical allodynia and burning pain, and there were trophic changes of the thenar muscle and he reported coldness on his left hand and forearm. A neuroma was found on the left second common digital nerve and was removed, but his symptoms continued despite various conservative treatments including a morphine infusion pump on his left arm. We therefore attempted median nerve stimulation to treat the chronic pain. The procedure was performed in two stages. The first procedure involved exposure of the median nerve on the mid-humerus level and placing of the electrode. The trial stimulation lasted for 7 days and the patient's symptoms improved. The second procedure involved implantation of a pulse generator on the left subclavian area. The mechanical allodynia and pain relief score, based on the visual analogue scale, decreased from 9 before surgery to 4 after surgery. The patient's activity improved markedly, but trophic changes and vasomotor symptom recovered only moderately. In conclusion, median nerve stimulation can improve chronic pain from complex regional pain syndrome type II.

• 대한한방내과학회지
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• 제38권5호
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• pp.769-777
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• 2017

Objective: Facial nerve palsy is caused by damage to the 7th cranial nerve. It is the main symptom of facial muscle paralysis on the affected side. Usually, recovery from this disease begins 2-3 weeks after onset and most patients recover in 4-8 weeks. If the patients cannot receive proper treatment, severe permanent impairments, both physical and mental, may remain, so this disease should be treated appropriately. In this study, a patient with facial nerve palsy was admitted to the Korean medicine hospital for treatment. We report on the patient's progress and the effects of treatment. Methods: We cured the patient with herbal medicines, acupuncture, herbal acupuncture therapy, and physical therapy. We used a numerical rating scale, the House Brackmann grading system, and a weighted regional grading system to assess symptom changes. Result: The patient with facial nerve palsy was hospitalized for 23 days and recovered from symptoms without significant problems on the face or in motor function.

• Archives of Pharmacal Research
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• 제10권1호
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• pp.42-49
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• 1987

This study is to evaluate the potential use of aclarubicin-loaded gelatin microspheres as an intravascular biodegradable drug delivery system for the regional cancer therapy. The diameter of the microspheres prepared by water in oil emulsion polymerization could be controlled by adjusting the stirring rate in the range of 10-50 $\mu$m : D(in $\mu$m) = -73.8 log (rpm) + 262.7. The addition of proteolytic enzyme increased the in vitro aclarubicin release but it did not change the amount of the initial burst release which reached about 45%. Microspheres injected intravenously into the mouse tail vein embolized only to the lung when observed by fluorescence microscopy. From histological examination following injection of gelatin microspheres into mouse femoral muscle, mild inflammation was observed from the appearance of neutrophils after 2 days and rapid repair process was confirmed thereafter. Biodegradation process of gelatin microspheres lodged on the pulmonary capillary bed was followed up by microscopic observation; degradation was taking place by about 36 hrs, followed by severe damage on the spheerical shape and microspheres was no longer found 10 days after injection.

• 대한한방내과학회지
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• 제39권5호
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• pp.1075-1083
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• 2018

Objective: Facial nerve palsy is caused by damage to the seventh cranial nerve. It is the main symptom of facial muscle paralysis on the affected side. If the patient cannot receive proper treatment, severe permanent impairments, both physical and mental, may result, so this disease must be treated appropriately. In this study, a patient with facial nerve palsy was admitted to a Korean medicine hospital for treatment. This case study reports on the patient's progress and the effects of the treatment. Methods: We treated the patient with herbal medicines, acupuncture, herbal acupuncture therapy, and physical therapy. The House-Brackmann Grading System and a weighted regional grading system were used to assess symptom changes. Results: The patient with facial nerve palsy was hospitalized for 50 days and recovered from symptoms without significant problems in the face or to motor function. Conclusion: This case report demonstrates the possibility of treating facial nerve palsy using Korean medicine.