• IMMUNE NETWORK
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• 제4권3호
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• pp.131-142
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• 2004

In recent years, adjuvants have received much attention because of the development of purified subunit and synthetic vaccines which are poor immunogens and require adjuvants to evoke the immune response. Therefore, immunologic adjuvants have been developed and testing for most of this century. During the last years much progress has been made on development, isolation and chemical synthesis of alternative adjuvants such as derivatives of muramyl dipeptide, monophosphoryl lipid A, liposomes, QS-21, MF-59 and immunostimulating complexes (ISCOMS). Biodegradable polymer microspheres are being evaluated for targeting antigens on mucosal surfaces and for controlled release of vaccines with an aim to reduce the number of doses required for primary immunization. The most common adjuvants for human use today are aluminum hydroxide and aluminum phosphate. Calcium phosphate and oil emulsions have been also used in human vaccination. The biggest issue with the use of adjuvants for human vaccines is the toxicity and adverse side effects of most of the adjuvant formulations. Other problems with the development of adjuvants include restricted adjuvanticity of certain formulations to a few antigens, use of aluminum adjuvants as reference adjuvant preparations under suboptimal conditions, non-availability of reliable animal models, use of non-standard assays and biological differences between animal models and humans leading to the failure of promising formulations to show adjuvanticity in clinical trials. The availability of hundreds of different adjuvants has prompted a need for identifying rational standards for selection of adjuvant formulations based on safety and sound immunological principles for human vaccines. The aim of the present review is to put the recent findings into a broader perspective to facilitate the application of these adjuvants in general and experimental vaccinology.

• Ecology and Resilient Infrastructure
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• 제4권1호
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• pp.3-11
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• 2017

본 논문은 연구대상 하천인 내성천에서 2013년 3월부터 본격적으로 영주댐이 담수되던 2016년 7월 중순까지 주요 관심 지점에 대한 각종 수문자료와 지형 측량 그리고 사진 모니터링 자료를 이용하여 사주에 형성된 식생의 변화를 분석하였다. 각 시기별 홍수사상이 사주에 형성된 식생의 매립 또는 제거에 어떤 영향을 주었는지 수위-단면 비교 그래프와 사진 모니터링 자료를 통해 알 수 있었다. 그 결과 모니터링 기간내 식생이 활착된 사주 위를 흐르던 홍수흐름이 식생의 매립 또는 제거에 기여한 결과를 판단할 수 있었으며 특히 2015년은 식생이 형성된 사주 위를 홍수흐름이 지나가지 않고 적절한 지하수위로 인해 수분 공급으로 식생이 번성한 것도 알 수 있었다. 영주댐의 담수가 시작되어 인위적인 조절이 되기 시작하면서 자연적인 흐름이 발생하던 시기와는 다른 양상이 발생할 것으로 예상된다. 본 연구는 향후 담수로 인한 조절 상황과 비교하는데 중요한 분석 자료로 판단된다.

• Nuclear Engineering and Technology
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• 제26권3호
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• pp.355-366
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• 1994

미국원자력규제위원회에서는 최근 안전해석에 최적전산코드의 사용을 허용하는 개정된 비상노심냉각계통 평가 규정을 제시하였다. 당 규정에서는 계통해석에 최적전산코드를 사용할 경우 불확실성 평가를 수행할 것을 요구하고 있다. 본 논문에서는 이러한 비상노심냉각계통의 규제요건을 만족하는 실제적인 최적평가방법론을 개발하여 대형냉각재상실사고에 적용하였다. 최적평가전산코드로는 RELAP5/MOD3.1을 개선한 RELAP5/MOD3/KAERI를 사용하였으며, 코드의 불확실성은 수개의 분리효과 및 총체효과 실험에 대한 평가를 수행함으로써 정량화 하였다. 적용대상 발전소로는 고리 3 & 4호기를 선정하였다. 민감도 분석을 통하여 응답방정식을 구성하였으며 각 응답방정식에 대하여 무작위 추출방식, Monte Carlo 방식으로 확률밀도함수를 구하였다. 최종 불확실성은 95%의 신뢰도로 정량화 하였으며 대형냉각재 상실사고시의 안전여유도에 대하여 논의하였다.

• Nuclear Engineering and Technology
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• 제52권6호
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• pp.1304-1317
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• 2020

The tubes in a heat exchanger, such as a steam generator (SG), are subjected to crossflow, and interaction between tubes and supports can happen, which can cause fretting wear of tubes. Although many experiments and models have been established, some detailed mechanisms are still not sufficiently clear. In this work, more attention is paid to obtain the regulation of impact and sliding in the complex process and many factors, such as excitation forces and clearances. The responses and contact forces were analyzed to obtain clear understanding of the influences of these factors. Room temperature tests in the air were established. The results show that the effect of clearance on the normal work rate is not monotonous and instead has two peaks. The force ratio can influence the normal work rate by changing the distribution of contact angles, which can result in higher sliding in the contact process. Fretting wear tests are conducted, and the wear surfaces are analyzed by a scanning electron microscope (SEM) and energy dispersive X-ray spectrometer (EDX). The results of this work can serve as a reference for impactsliding contact analysis between AVBs and tubes in steam generators.

• Journal of Oral Medicine and Pain
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• 제20권1호
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• pp.195-204
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• 1995

The purpose of this study was to evaluate effect of head posture change on initial occlusal contacts through measuring the distances between initial occlusal contacts and maximum intercuspal position at different head posture. Two special devices were designed and constructed. Mandibular movement replicator was used to assess reliability of the K6 diagnostic system(MKG; Myo-tronic Inc, Seatle, USA) and head posture calibrator was used to maintain the constant head posture during experiment. We measured difference of distance between initial occlusal contact and maximum intercuspal position with MKG in upright, supine, 45 degrees extension, 30 degrees flexion, 30 degrees right and left bending postion of the head. The Frankfurt horizontal plane was used as a reference plane. 21 adults aged from 23 to 25 were selected, who have normal or class I molar relationship, and have no symptoms on TMJ and masticatory muscles, and have restorations less than 3 surfaces on each tooth, and have no other prosthetic restoration. The obtained results were as follows : The mean absolute distances between initial occlusal contact and maximum intercuspal postion were 0.39(0.18mm in the upright position, 0.65(0.37mm in the supine position, 0.59(0.33mm in the 45 degree extension, 0.70(0.53mm in the 30 degrees flexion, 1.12(1.10mm in the 30 degrees right bending and 1.94(0.67mm in the 30 degrees left bending of the head. The positions of the initial occlusal contacts have a tendency to locate anterior, left and inferior to maximal intercuspal position in upright position, posterior and inferior in supine position and 45 degrees extension, anterior and inferior in 30 degrees flexion, right and inferior in 30 degrees right bending, and left and inferior in 30 degrees left bending of the head. There were significant differences among the initial occlusal contacts in each head postures(P<0.0001). Therefore, we need to check initial occlusal contacts in the altered head posture during occlusal analysis and adjustment of occlusal appliance and dental occlusion for diagnosis and treatment of temporomandibular disorder.

• Transactions on Electrical and Electronic Materials
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• 제8권1호
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• pp.5-10
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• 2007

Using a reference slurry, ammonium dodecyl sulfate (ADS), an anionic and environmentally friendly surfactant, was investigated as an alternative to BTA for its inhibition and lubrication characteristics. Results demonstrated that the inhibition efficiency of ADS was superior to that of BTA. Coefficient of friction (COF) was the lowest when the slurry contained ADS. This suggested that adsorbed ADS on the surface provided lubricating action thereby reducing the wear between the contacting surfaces. Temperature results were consistent with the COF and removal rate data. ADS showed the lowest temperature rise again confirming the softening effect of the adsorbed surfactant layer and less energy dissipation due to friction. Spectral analysis of shear force showed that increasing the pad-wafer sliding velocity at constant wafer pressure shifted the high frequency spectral peaks to lower frequencies while increasing the variance of the frictional force. Addition of ADS reduced the fluctuating component of the shear force and the extent of the pre-existing stick-slip phenomena caused by the kinematics of the process and collision event between pad asperities with the wafer. By contrast, in the case of BTA, there were no such observed benefits but instead undesirable effects were seen at some polishing conditions. This work underscored the importance of real-time force spectroscopy in elucidating the adsorption, lubrication and inhibition of additives in slurries in CMP.

• 대한화학회지
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• 제24권4호
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• pp.295-301
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• 1980

고체전해질 $RbAg_4I_5$의 단결정을 키워서 온도에 따른 전기전도율의 변화를 퍼텐티오메트릭 4-전극방법으로 측정하고 $Ag/RbAg_4I_5$, 계면에 대한 전기화학적 성질을 순환전압전류법으로 조사하였다. 25$^{\circ}C$에서 단결정의 비전기전도율은 $0.284\pm0.003 ohm^{-1}cm^{-1}이었고 \;Ag^+$이온의 이동에 대하여 계산된 활성화에너지는 1.70kcal/mol로서 다결정 시료에 대한 값들과 거의 일치하였다. 순환전압전류법 실험결과 은 기준전극에 대한 전위 0볼트 이하에서는 은 전극에서 $Ag^+$ 이온의 가역적환원이 일어났고 +0.67볼트 이상의 전위에서 요오드화 이온이 산화되어 요오드가 유리되었다. 은의 산화 전위에서 은 전극은 작은 양극전류만을 나타내었으나 환원전위에서 은 전극의 표면에 환원 석출된 은은 다시 양극 전위로 돌아갈 때 아주 큰 산화전류를 나타내었다.

• 대한치과보철학회지
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• 제28권1호
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• pp.95-122
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• 1990

This study was done to analyze the occlusal curve as one of the factors to be considered for maintenance of occlusal stability in the orthodontic and prosthodontic treatments. Sixty gnathological casts we.e obtained from 43 subjects with normal occlusion and 17 subjects with some of temporomandibular disorders. The occlusal surfaces of gnathologic casts were duplicated by using a Color kit SK-700 and tile reference points of X, Y coordinates were digitized by using the Summagraphic digitizer and 18AT computer system. The Z coordinates of cusp height were measured by 0.01mm measurable caliper. The mathematical computer program of least square method was used to analyze the occlusal curve arranged by three dimensional coordinates of X, Y, Z. The following results were obtained : 1. The occlusal curve of buccal and lingual cusp tips was fitted to the ellipse, and the occlusal curve of anterior teeth was fitted to a part of the circle in the analysis of conic sections. 2. The radius of Spee's curve showed individual differences, but was average 98.7mm in male subjects and 93.7mm in female subjects. 3. The radius fo Spee's curve according to the half of canine width showed the least coefficient of variation. 4. The radius of Spee's curve was not significantly relative to the lateral occlusal contacts on laterotrusion and the absence or presence of temporomandibular disorders. 5. The radius of Wilson's curve showed individual difference and the size of radius was followed by the order of 1st premolar, 2nd premolar, 2nd molar and 1st molar.

• 한국전산유체공학회지
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• 제22권1호
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• pp.88-94
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• 2017

The IR signal entering into a sensor is composed of the following components: the self-emitted component directly from the object surface, the reflected components of the solar and sky irradiance at the object surface, and the scattered component by the atmosphere without reference to any object surfaces. The self-emitted and reflected components from the object can be lowered by the atmospheric layer between the object and the IR sensor. The principle factors influencing the atmospheric transmittance are the air temperature, the relative humidity and the observation distance. Previous studies on IR signal transmission through the atmosphere are focused on uniform atmospheric conditions and the non-uniform nature of the atmosphere was not properly treated in modeling. In this study, we use the local atmospheric transmittance to simulate the non-uniform atmosphere in analyzing the IR signal from the object surface. The results show that the nonuniform analysis of the atmosphere becomes more important as the wavelength of IR signal increases.

• 한국콘텐츠학회논문지
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• 제16권7호
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• pp.659-666
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• 2016

현대 사회에서 색채가 인간에게 미치는 영향은 정신적 심리적 측면에서 중요한 요소로 나타나고 있다. 색채는 시지각적으로 인간의 마음에 일어나는 감정과 정서를 연출하여 메마른 감성을 치유하며, 환경은 표현된 색채에 따라 삶의 가치를 높여 주는 역할을 한다. 본 연구에서는 금속의 단조로운 색채표현을 해소하기 위한 측면으로 금속 장신구에 옻칠과 포슬린150물감을 사용하여 표현하는 방법을 응용시켜 다양한 색채변화를 나타내었다. 옻칠과 포슬린150물감의 금속시편을 제작하고 비교 분석하여 장 단점의 결과로 도출하였다. 장점은 이를 접목하는 방법은 금속 색채표현의 일반적인 방법에 비해 색채효과를 다양하게 표현할 수 있었고, 표면 코팅 역할을 하므로 기물의 변색을 방지하여 가변적 문제점을 보완해 줄 수 있었다. 단점은 옻칠은 체질에 따른 옻오름 현상이 나타나고, 포슬린150페인팅은 화학성분으로 식기류에 사용하면 건강에 해로울 수 있다. 이를 참고하여 작품에 적용하여 예술성과 실용성 구현에 기여하고자 한다.