• Transactions of the Korean Society of Automotive Engineers
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• v.21 no.3
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• pp.74-81
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• 2013

Due to its accuracy and efficiency, reduced kinetic mechanism of diesel surrogate is widely used as fuel model when applying 3-D diesel engine simulation. But for the well-developed prediction of diesel surrogate reduced kinetic mechanism, it is important to know some meaningful factors which affect to ignition delay time. Meanwhile, ignition delay time consists of two parts. One is the chemical ignition delay time related with the chemical reaction, and the other is the physical ignition delay time which is affected by physical behavior of the fuel droplet. Especially for chemical ignition delay time, chemical properties of each fuel were studied for a long time, but researches on their mixtures have not been done widely. So it is necessary to understand the chemical characteristics of their mixtures for more precise and detailed modeling of surrogate diesel oil. And it shows same ignition trend of paraffin mixture with those of single component, and shorter ignition delay at low/high initial temperature when mixing paraffin and toluene.

• The Korean Journal of Physiology and Pharmacology
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• v.16 no.5
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• pp.349-353
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• 2012

Activated T cells express inhibitory receptors such as CTLA-4 that can downregulate immune responses. Blockade of or genetic deficiency in CTLA-4 can result in autoimmunity. Therefore, strategies to increase the inhibitory function of CTLA-4 may be attractive in settings of undesirable T cell responses such as autoimmunity or transplant rejection. We have tested the hypothesis that transgenic constitutive expression of CTLA-4 can further attenuate immune responses when compared with normal inducible expression. Our results indicate that transgenic expression of CTLA-4 in mouse T cells (CTLA-4-Tg T cells) results in reduced cell cycle progression and increased apoptosis of TCR-stimulated T cells. CTLA-4-Tg T cells display reduced T cell proliferation in an in vivo model of graft versus host disease (GVHD). These results further our understanding of how CTLA-4 can be manipulated to inhibit immune responses and may help development of new therapeutic strategies for clinical settings of autoimmunity and transplantation.

• BMB Reports
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• v.38 no.5
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• pp.563-570
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• 2005

Tamoxifen citrate (TAM), is widely used for treatment of breast cancer. It showed a degree of hepatic carcinogenesis. The purpose of this study was to elucidate the antioxidant capacity of green tea (Camellia sinensis) extract (GTE) against TAM-induced liver injury. A model of liver injury in female rats was done by intraperitoneal injection of TAM in a dose of $45\;mg\;Kg^{-1}\;day^{-1}$, i.p. for 7 successive days. GTE in the concentration of 1.5%, was orally administered 4 days prior and 14 days after TAM-intoxication as a sole source of drinking water. The antioxidant flavonoid; epicatechin (a component of green tea) was not detectable in liver and blood of rats in either normal control or TAM-intoxicated group, however, TAM intoxication resulted in a significant decrease of its level in liver homogenate of tamoxifen-intoxicated rats. The model of TAM-intoxication elicited significant declines in the antioxidant enzymes (glutathione-S-transferase,glutathione peroxidase, superoxide dismutase and catalase) and reduced glutathione concomitant with significant elevations transaminase) levels. The oral administration of 1.5% GTE to TAM-intoxicated rats, produced significant increments in the antioxidant enzymes and reduced glutathione concomitant with significant decrements in TBARS and liver transaminases levels. The data obtained from this study speculated that 1.5% GTE has the capacity to scavenge free radical and can protect against oxidative stress induced by TAM intoxication. Supplementation of GTE could be useful in alleviating tamoxifen-induced liver injury in rats.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 2003.06a
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• pp.547-552
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• 2003

In mold machining, there are many concave machining regions where chatter and tool deflection occur since MRR (material removal rate) increases as curvature increases even though cutting speed and depth of cut are constant. Boolean operation between stock and tool model is widely used to compute MRR in NC milling simulation. In finish cutting, the side step is reduced to about 0.3mm and tool path length is sometimes over 300m. so Boolean operation takes long computation time and includes much error if the resolution of stock and tool model is larger than the side step. In this paper, curvature of CL(cutter location) surface and side step of tool path is used to compute the feedrate for constant MRR machining. The data structure of CL surface is Z-map generated from NC tool path. The algorithm to get local curvature from discrete data was developed and applied to compute local curvature of CL surface. The side step of tool path was computed by point density map which includes cutter location point density at each grid element. The feedrate computed from curvature and side step is inserted to new tool path to regulate MRR. The resultants wire applied to feedrate optimization system which generates new tool path with feedrate from NC codes for finish cutting. The system was applied to speaker mold machining. The finishing time was reduced to 12.6%. tool wear was reduced from 2mm to 1.1mm and chatter marks and over cut on corner were removed.

• Journal of Korean Tunnelling and Underground Space Association
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• v.4 no.2
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• pp.91-100
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• 2002

This paper presents the results of laboratory investigation on the deformation behavior of tunnel face reinforced with longitudinal pipes. A series of reduced-scale model tests was carried out to investigate the effect of reinforcement layout on the tunnel face axial displacement as well as the surface settlement. Among other things, the results of the model tests indicate that the axial displacement of tunnel face as well as the ground surface settlement can significantly be reduced by pre-reinforcing the tunnel face with longitudinal pipes, suggesting that the pre-reinforcing technique may effectively be used as a positive ground control method in the urban environments. Also illustrated is that the reinforcing effect is significantly influenced by the reinforcement layout. The implications of the findings from this study are discussed in a great detail.

• Structural Engineering and Mechanics
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• v.15 no.6
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• pp.669-683
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• 2003

The stochastic optimal nonlinear control of coupled adjacent building structures is studied based on the stochastic dynamical programming principle and the stochastic averaging method. The coupled structures with control devices under random seismic excitation are first condensed to form a reduced-order structural model for the control analysis. The stochastic averaging method is applied to the reduced model to yield stochastic differential equations for structural modal energies as controlled diffusion processes. Then a dynamical programming equation for the energy processes is established based on the stochastic dynamical programming principle, and solved to determine the optimal nonlinear control law. The seismic response mitigation of the coupled structures is achieved through the structural energy control and the dimension of the optimal control problem is reduced. The seismic excitation spectrum is taken into account according to the stochastic dynamical programming principle. Finally, the nonlinear controlled structural response is predicted by using the stochastic averaging method and compared with the uncontrolled structural response to evaluate the control efficacy. Numerical results are given to demonstrate the response mitigation capabilities of the proposed stochastic optimal control method for coupled adjacent building structures.

• Korean journal of food and cookery science
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• v.13 no.2
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• pp.185-191
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• 1997

The effects of five hydrated emulsifiers with or without specified proteins (flour, egg) and/or polydextrose on the reduced-calorie cake as baked product model systems were compared. The small molecule amphiphiles (SMA) used were monoglycerides (MG), sorbitan monostearate (SMS), polysorbate (PS) 60, sucrose ester (SE) F7O, and SE Fl60. All flour batters with each emulsifier and supplements had similar low foam drainages (0.00∼1.03$m\ell$) indicating those systems were fairly stable in the presence of flour protein. The cake batter using starch instead of flour without egg and polydextrose and with some emulsifiers had relatively large amount of drainages (4.20∼5.87$m\ell$). When the egg and polydextrose were added to the blank cake batters using starch, foam drainages tended to show relatively low scores (0.13∼1.48$m\ell$) indicating the cake batter dispersion system is stabilized. Starch cakes made with SE F70 without egg or polydextrose(blank) unexpectedly had high volume index of 199.

• International Journal of Aerospace System Engineering
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• v.2 no.1
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• pp.43-46
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• 2015

Aeroelastic gust response analysis plays an important role in design of aircrafts. For gust response analysis, frequency domain aerodynamics method has been typically used with generalized aerodynamic influence coefficient matrices at various reduced frequencies. However, it cannot be applied to the aeroservoelastic analysis, such as gust alleviation control. Time-domain state space (SS) models must be built. It attacks little attention that gust response analysis relies on continuous gust time-domain input signal in terms of its PSD function. The aim the current study is to provide a reduced-order modeling (ROM) method based on CFD to model gust responses for continuous gust responses for continuou gust inputs in time domain. The paper analyzed the gust response of AGARD445.6 wing subjected to the Dryden gust with ROMs and compared the difference between the rigid structure and elastic one. The results demonstrate that structure elastic effect effect should be considered in the design of aircraft.

• Earthquakes and Structures
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• v.23 no.2
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• pp.183-196
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• 2022

Reduced beam section (RBS) moment connections used in special moment resisting frames are currently limited to beam sections that are not larger than nominal depths of 920 mm, weight of 447 kg/m and flange thickness of 44 mm. Due to the higher demand for structural components with jumbo sections, which can potentially be applied in the transfer girders in long-span building structures, the newly available steel heavy members are promising. To address this issue, advanced numerical models are developed to fully evaluate the distribution of stresses and concentrations of plastic strains for such jumbo RBS connections. This paper first presents a brief overview of an experimental study on four specimens with large beam and column sections. Then, a numerical model that includes initial imperfections, residual stresses, geometric nonlinearity, and explicitly modeled welds is presented. The model is used to further explore the behavior of the test specimens, including distribution of stresses, distribution of plastic strains, stress triaxiality and potential for fracture. The results reveal that the stresses are highly non-uniform across the beam flange and, similarly, the plastic strains concentrate at the extreme fiber of the bottom flange. However, neither of these phenomena, which are primarily a function of beam flange thickness, is reflected in current design procedures.

• Tribology and Lubricants
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• v.40 no.1
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• pp.24-27
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• 2024

A monotype valve body for a dual clutch transmission has the potential to reduce costs, weight, and manufacturing time by modularizing various parts, including those of existing solenoid packs and valve bodies, into one through the application of super-precision die casting technology. However, this approach may lead to challenges such as reduced rigidity and increased interference due to modularization and compactness, impacting both product performance due to the reduced weight as well as durability and reliability. Unlike existing products, this approach requires a high-precision thin-wall block to avoid more complicated flow line formation, interference between flow lines, and leaks, as well as a strict quality requirement standard and precise inspections including detection of internal defects. To conduct precise inspections, we built an equivalent model corresponding to a driving distance of 300,000 km. Testing involved simulating actual road loads using a real vehicle and a chassis dynamometer in the FTP-75 mode (EPA Federal Test Procedure). The aim of the study was to establish a vehicle load-based part durability model for manufacturing a mono-type valve body and to develop fundamental technology for part weight reduction through preliminary design by introducing analytical weight reduction technology based on the derived results.